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The map label for this gene is vacB [H]

Identifier: 110835054

GI number: 110835054

Start: 2501466

End: 2503952

Strand: Reverse

Name: vacB [H]

Synonym: ABO_2193

Alternate gene names: 110835054

Gene position: 2503952-2501466 (Counterclockwise)

Preceding gene: 110835056

Following gene: 110835053

Centisome position: 80.25

GC content: 56.45

Gene sequence:

>2487_bases
ATGTCAAATTCCTTTTCAAAAAAACCTTCGATGACCTCAAAGAAACGCTATAGCGATCCCCATGCCGACCGAGAGGCGGA
AAAGTACGAGAACCCCGTTCCCAGCCGGGAGTTGATTCTGGATGTGCTCAATGATCAGGGTAAGCCCCTGTCGTTTGAGC
TGCTGGCTCAGCTGCTGGAAGTGGATGAAGAGGGGGAAGTCGGACTGGATCGTCGTATCAAGGCCATGCTTCGTGACGCT
CAGCTGGTTCAGAACCGCAACGGTAAAGTCGGCGTGGTGTCTCGTATGGACCTTATTGCCGGTCGAGTGCAAGGCCATAA
AGATGGCTTTGGCTTTCTGATTCCTGACGACAAAACGCAAGGCGACCTGTTTCTAGCGCCCCGGCAGATGGAAAACGTCA
TGGACGGTGACCGGGTGCTGGTCAGCAACGCGGGCTATAACCGCTTTGGCAAGAAAGAGGCCCGCATCGTTGAGATCACC
GAACGGGTGGCCACCGAAGTGATCGGTCGTTATTCCCGGGAAGCGGGAATCAGCTTTATTGAGCCAGAAAATCGCCGCAT
TACCAAAGAAGTCCTGATCGAAGACAAAAACGGCATCAAGCCGAATCCGGGCGATCATGTCCGTGCCACCATTACCCAAT
ACCCCAGCCGAGACCACCATGTATTGGTTCGACTGGAAGAAATTATTGCTACCCCGGACGAGGCAGGCATGGAAGTAGAA
GTGGCGCTACGCCGTTTTGAAATTCCTCATGTTTGGCCGGAAGGGGTGGAGGCCGCCGCTGAGAAATTCGGTGACAAGGT
TCCTCATGAGCCCAAGGCCCACAGGGTGGATCTACGTGATCTTCCGCTGGTAACCATTGATGACGAAACCGCCCGAGATT
TCGATGATGCAGTCTATGTAGAGCGTCGTCCCCGCGGTGGTTGGCGCTTGATCGTGGCCATCGCCGATGTGAGTCATTAT
GTGCAGCCAGGCTCCGAGTTGGATCAGGAGGCGGCCAAGCGCGGCAACTCAGTGTATTTCCCCAATCGGGTGATTCCGAT
GTTGCCGGAGGCGCTGTCCAACGGGTTGTGTTCCCTGAACCCCCATGTGGACCGTCTGTGCCTGTATTGCGATATGAAGA
TTTCTGCCAACGGCCGCCTCACCCGGTTTATTTTCCGTGAAGGGGTGATGCGCTCGCGGCACCGTCTGACTTACAACAAG
GTCGGCGCGATCATTGAAGAGCCTGAGTCCGAGCTGGCGCAGGACACCGTGGCCAGCCTGGACGATGAGTCCCTGGACAT
GATCTGGTCGTTCCATGAAATGTTCCTGGCCCTGCGCCGTCGTCGCGCAGAGCGCGGAGCCATCGATTTCGACAGCGATG
ACACCCGCATCATTTACGACGAGAACAAAAAGATTGAAGCCATTGTGCCGGTGCAGCGCAATGTGGCGCATATCATGATT
GAGGAGGCCATGCTGGCCGCCAACATCTGTTCCGCTAAATTGCTGGAAAAAGCCGGTGTGCCGGCGCTTTACCGTAACCA
TGAGCCGCCCAAGGAAGAGCGCCTGAGCAAGTTGCAGCAATTTCTGGGTGGGTTGGGCTTGAGTATCGCTTGGTCGGAAG
GGGCGGCGCCAAAGCCGTATGTCTTCCAGGACCTGCGCGAAGAAATTCTGGAGCGCCCGGATCGCAACGTGATCCAGACC
ATGATGTTGCGCACCATGAGCCAGGCCAAGTACGAGGCCGAGAACAAGGGGCACTTTGGGTTAGCGTACAAGGCGTATAC
CCATTTCACTTCGCCGATTCGCCGTTACCCGGATTTATTGGTGCACCGTGCCATCCGCTTCCTGATTCGCAGCAATGGTG
AGCCGAACCACGTGGATAACCCTGGCAATTTGCCGGAAATCCCGCGTCAGAAAATCCTGCCTTATAACCAGGCGGATATG
GTGGCCATTGGTGAGCAGTGCTCCATGACTGAGCGGCGTGCGGATGAGGCCACCCGTGATGTGGTGTCCTGGCTCAAATG
CCAGTTCATGGAGGCACACCTGGGGCAGGTGTTTGAGGGTGCCATCAGTGGTGTGGCCAGTTTTGGGTTGTTCGTGCAGC
TTAGTGATCTGCATATTGATGGCTTAGTGCATGTGGCGAACCTGGATAGCGACTACTACCACTTTGACGAAGTGAGCCTT
ACTCTCACCGGTGAAAGTACTGGTCGCCAGTTCGGATTGGGCGATGCGGTCACAGTCTGTGTGGCGGCGGTGCACACGGA
AGACCGTAAGATTGACTTGCAGTTGGAGTCCTTTACCCCCAGCGGCAAAGGCCGGCCCAAAGCTGCCAGCAAGAAAAAGC
CGTCCGGTGGCAGAGGCAAAGGTGGGCGCTCTGGGAATGCCGGCAAGGCAGAGTCGGGCCAGTCCGAACGGGAAAAGTTG
GCCAAGGGCGATATCCCCAAGGCTAAGGCCAAGCGCAAGGGCCCGCCCCGCGGTAAAAAGGCCGCGCGCCGCACCAAAAA
AAGCTAA

Upstream 100 bases:

>100_bases
GCGTGTCTACCAATTTCACCACCTCGGCTTTGCTATGCATTGACTAAATTTATTAGCCGTTCATCGCGAAAGCGGGTGCA
TTCTAGTATATGATGGCCCA

Downstream 100 bases:

>100_bases
CGGCATTGCCCGTAGGGGCGTCGATTGGGTCGCGAATAGATTGCCTTGATGGCATTAATGCGCGGCTTAAGCGCTGCTCC
TGCGTTTTGATTCCATTTTC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R [H]

Number of amino acids: Translated: 828; Mature: 827

Protein sequence:

>828_residues
MSNSFSKKPSMTSKKRYSDPHADREAEKYENPVPSRELILDVLNDQGKPLSFELLAQLLEVDEEGEVGLDRRIKAMLRDA
QLVQNRNGKVGVVSRMDLIAGRVQGHKDGFGFLIPDDKTQGDLFLAPRQMENVMDGDRVLVSNAGYNRFGKKEARIVEIT
ERVATEVIGRYSREAGISFIEPENRRITKEVLIEDKNGIKPNPGDHVRATITQYPSRDHHVLVRLEEIIATPDEAGMEVE
VALRRFEIPHVWPEGVEAAAEKFGDKVPHEPKAHRVDLRDLPLVTIDDETARDFDDAVYVERRPRGGWRLIVAIADVSHY
VQPGSELDQEAAKRGNSVYFPNRVIPMLPEALSNGLCSLNPHVDRLCLYCDMKISANGRLTRFIFREGVMRSRHRLTYNK
VGAIIEEPESELAQDTVASLDDESLDMIWSFHEMFLALRRRRAERGAIDFDSDDTRIIYDENKKIEAIVPVQRNVAHIMI
EEAMLAANICSAKLLEKAGVPALYRNHEPPKEERLSKLQQFLGGLGLSIAWSEGAAPKPYVFQDLREEILERPDRNVIQT
MMLRTMSQAKYEAENKGHFGLAYKAYTHFTSPIRRYPDLLVHRAIRFLIRSNGEPNHVDNPGNLPEIPRQKILPYNQADM
VAIGEQCSMTERRADEATRDVVSWLKCQFMEAHLGQVFEGAISGVASFGLFVQLSDLHIDGLVHVANLDSDYYHFDEVSL
TLTGESTGRQFGLGDAVTVCVAAVHTEDRKIDLQLESFTPSGKGRPKAASKKKPSGGRGKGGRSGNAGKAESGQSEREKL
AKGDIPKAKAKRKGPPRGKKAARRTKKS

Sequences:

>Translated_828_residues
MSNSFSKKPSMTSKKRYSDPHADREAEKYENPVPSRELILDVLNDQGKPLSFELLAQLLEVDEEGEVGLDRRIKAMLRDA
QLVQNRNGKVGVVSRMDLIAGRVQGHKDGFGFLIPDDKTQGDLFLAPRQMENVMDGDRVLVSNAGYNRFGKKEARIVEIT
ERVATEVIGRYSREAGISFIEPENRRITKEVLIEDKNGIKPNPGDHVRATITQYPSRDHHVLVRLEEIIATPDEAGMEVE
VALRRFEIPHVWPEGVEAAAEKFGDKVPHEPKAHRVDLRDLPLVTIDDETARDFDDAVYVERRPRGGWRLIVAIADVSHY
VQPGSELDQEAAKRGNSVYFPNRVIPMLPEALSNGLCSLNPHVDRLCLYCDMKISANGRLTRFIFREGVMRSRHRLTYNK
VGAIIEEPESELAQDTVASLDDESLDMIWSFHEMFLALRRRRAERGAIDFDSDDTRIIYDENKKIEAIVPVQRNVAHIMI
EEAMLAANICSAKLLEKAGVPALYRNHEPPKEERLSKLQQFLGGLGLSIAWSEGAAPKPYVFQDLREEILERPDRNVIQT
MMLRTMSQAKYEAENKGHFGLAYKAYTHFTSPIRRYPDLLVHRAIRFLIRSNGEPNHVDNPGNLPEIPRQKILPYNQADM
VAIGEQCSMTERRADEATRDVVSWLKCQFMEAHLGQVFEGAISGVASFGLFVQLSDLHIDGLVHVANLDSDYYHFDEVSL
TLTGESTGRQFGLGDAVTVCVAAVHTEDRKIDLQLESFTPSGKGRPKAASKKKPSGGRGKGGRSGNAGKAESGQSEREKL
AKGDIPKAKAKRKGPPRGKKAARRTKKS
>Mature_827_residues
SNSFSKKPSMTSKKRYSDPHADREAEKYENPVPSRELILDVLNDQGKPLSFELLAQLLEVDEEGEVGLDRRIKAMLRDAQ
LVQNRNGKVGVVSRMDLIAGRVQGHKDGFGFLIPDDKTQGDLFLAPRQMENVMDGDRVLVSNAGYNRFGKKEARIVEITE
RVATEVIGRYSREAGISFIEPENRRITKEVLIEDKNGIKPNPGDHVRATITQYPSRDHHVLVRLEEIIATPDEAGMEVEV
ALRRFEIPHVWPEGVEAAAEKFGDKVPHEPKAHRVDLRDLPLVTIDDETARDFDDAVYVERRPRGGWRLIVAIADVSHYV
QPGSELDQEAAKRGNSVYFPNRVIPMLPEALSNGLCSLNPHVDRLCLYCDMKISANGRLTRFIFREGVMRSRHRLTYNKV
GAIIEEPESELAQDTVASLDDESLDMIWSFHEMFLALRRRRAERGAIDFDSDDTRIIYDENKKIEAIVPVQRNVAHIMIE
EAMLAANICSAKLLEKAGVPALYRNHEPPKEERLSKLQQFLGGLGLSIAWSEGAAPKPYVFQDLREEILERPDRNVIQTM
MLRTMSQAKYEAENKGHFGLAYKAYTHFTSPIRRYPDLLVHRAIRFLIRSNGEPNHVDNPGNLPEIPRQKILPYNQADMV
AIGEQCSMTERRADEATRDVVSWLKCQFMEAHLGQVFEGAISGVASFGLFVQLSDLHIDGLVHVANLDSDYYHFDEVSLT
LTGESTGRQFGLGDAVTVCVAAVHTEDRKIDLQLESFTPSGKGRPKAASKKKPSGGRGKGGRSGNAGKAESGQSEREKLA
KGDIPKAKAKRKGPPRGKKAARRTKKS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=367, Percent_Identity=31.3351498637602, Blast_Score=174, Evalue=4e-43,
Organism=Homo sapiens, GI190014623, Length=435, Percent_Identity=31.0344827586207, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI190014625, Length=533, Percent_Identity=28.5178236397749, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI19115966, Length=477, Percent_Identity=27.2536687631027, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI219521928, Length=477, Percent_Identity=27.2536687631027, Blast_Score=143, Evalue=6e-34,
Organism=Escherichia coli, GI87082383, Length=741, Percent_Identity=47.2334682860999, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=674, Percent_Identity=28.3382789317507, Blast_Score=184, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17553506, Length=421, Percent_Identity=32.3040380047506, Blast_Score=192, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=549, Percent_Identity=27.6867030965392, Blast_Score=166, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324552, Length=505, Percent_Identity=29.5049504950495, Blast_Score=170, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323943, Length=367, Percent_Identity=23.433242506812, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649634, Length=392, Percent_Identity=31.6326530612245, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19922976, Length=358, Percent_Identity=30.4469273743017, Blast_Score=154, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24654597, Length=358, Percent_Identity=30.4469273743017, Blast_Score=154, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24654592, Length=351, Percent_Identity=30.7692307692308, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 92914; Mature: 92783

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSFSKKPSMTSKKRYSDPHADREAEKYENPVPSRELILDVLNDQGKPLSFELLAQLLE
CCCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHC
VDEEGEVGLDRRIKAMLRDAQLVQNRNGKVGVVSRMDLIAGRVQGHKDGFGFLIPDDKTQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEECCCCCC
GDLFLAPRQMENVMDGDRVLVSNAGYNRFGKKEARIVEITERVATEVIGRYSREAGISFI
CCEEECCHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
EPENRRITKEVLIEDKNGIKPNPGDHVRATITQYPSRDHHVLVRLEEIIATPDEAGMEVE
CCCCCEEHHHHHEECCCCCCCCCCCCEEEEHHHCCCCCCEEEEEEHHHHCCCCCCCCCCE
VALRRFEIPHVWPEGVEAAAEKFGDKVPHEPKAHRVDLRDLPLVTIDDETARDFDDAVYV
EHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCEEE
ERRPRGGWRLIVAIADVSHYVQPGSELDQEAAKRGNSVYFPNRVIPMLPEALSNGLCSLN
EECCCCCCEEEEEEECHHHHHCCCHHHHHHHHHCCCEEECCCCCHHHCHHHHCCCCCCCC
PHVDRLCLYCDMKISANGRLTRFIFREGVMRSRHRLTYNKVGAIIEEPESELAQDTVASL
CCHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHC
DDESLDMIWSFHEMFLALRRRRAERGAIDFDSDDTRIIYDENKKIEAIVPVQRNVAHIMI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHH
EEAMLAANICSAKLLEKAGVPALYRNHEPPKEERLSKLQQFLGGLGLSIAWSEGAAPKPY
HHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
VFQDLREEILERPDRNVIQTMMLRTMSQAKYEAENKGHFGLAYKAYTHFTSPIRRYPDLL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
VHRAIRFLIRSNGEPNHVDNPGNLPEIPRQKILPYNQADMVAIGEQCSMTERRADEATRD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHH
VVSWLKCQFMEAHLGQVFEGAISGVASFGLFVQLSDLHIDGLVHVANLDSDYYHFDEVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECEEECCEEEEEECCCCCEEECCEEE
TLTGESTGRQFGLGDAVTVCVAAVHTEDRKIDLQLESFTPSGKGRPKAASKKKPSGGRGK
EEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GGRSGNAGKAESGQSEREKLAKGDIPKAKAKRKGPPRGKKAARRTKKS
CCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SNSFSKKPSMTSKKRYSDPHADREAEKYENPVPSRELILDVLNDQGKPLSFELLAQLLE
CCCCCCCCCCCHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHC
VDEEGEVGLDRRIKAMLRDAQLVQNRNGKVGVVSRMDLIAGRVQGHKDGFGFLIPDDKTQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEECCCCCC
GDLFLAPRQMENVMDGDRVLVSNAGYNRFGKKEARIVEITERVATEVIGRYSREAGISFI
CCEEECCHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
EPENRRITKEVLIEDKNGIKPNPGDHVRATITQYPSRDHHVLVRLEEIIATPDEAGMEVE
CCCCCEEHHHHHEECCCCCCCCCCCCEEEEHHHCCCCCCEEEEEEHHHHCCCCCCCCCCE
VALRRFEIPHVWPEGVEAAAEKFGDKVPHEPKAHRVDLRDLPLVTIDDETARDFDDAVYV
EHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCEEE
ERRPRGGWRLIVAIADVSHYVQPGSELDQEAAKRGNSVYFPNRVIPMLPEALSNGLCSLN
EECCCCCCEEEEEEECHHHHHCCCHHHHHHHHHCCCEEECCCCCHHHCHHHHCCCCCCCC
PHVDRLCLYCDMKISANGRLTRFIFREGVMRSRHRLTYNKVGAIIEEPESELAQDTVASL
CCHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHC
DDESLDMIWSFHEMFLALRRRRAERGAIDFDSDDTRIIYDENKKIEAIVPVQRNVAHIMI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHH
EEAMLAANICSAKLLEKAGVPALYRNHEPPKEERLSKLQQFLGGLGLSIAWSEGAAPKPY
HHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCH
VFQDLREEILERPDRNVIQTMMLRTMSQAKYEAENKGHFGLAYKAYTHFTSPIRRYPDLL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
VHRAIRFLIRSNGEPNHVDNPGNLPEIPRQKILPYNQADMVAIGEQCSMTERRADEATRD
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHH
VVSWLKCQFMEAHLGQVFEGAISGVASFGLFVQLSDLHIDGLVHVANLDSDYYHFDEVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECEEECCEEEEEECCCCCEEECCEEE
TLTGESTGRQFGLGDAVTVCVAAVHTEDRKIDLQLESFTPSGKGRPKAASKKKPSGGRGK
EEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GGRSGNAGKAESGQSEREKLAKGDIPKAKAKRKGPPRGKKAARRTKKS
CCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]