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The map label for this gene is hmp [H]

Identifier: 110834980

GI number: 110834980

Start: 2424756

End: 2425979

Strand: Reverse

Name: hmp [H]

Synonym: ABO_2119

Alternate gene names: 110834980

Gene position: 2425979-2424756 (Counterclockwise)

Preceding gene: 110834982

Following gene: 110834977

Centisome position: 77.75

GC content: 54.82

Gene sequence:

>1224_bases
ATGCTTACCCAGAGCCAACTGGCTGTTATTAAACAAACCGTTCCTGTGCTGCAGGAAAATGGAGAGACGCTCACTCGGCA
TTTCTATGCGCGTATGTTTCGGGAAAACCCGGAGGTGCAAGCGTTTTTTAATCCGGCCCATCAGCAGGCCGGAACCCAGC
AGCGCGCTCTGGCTGGTGCTATTTGTGCCTATGCCCAGCACGTCGATAACCCGGCTGCACTGGCGGATGCCGTGGAATTG
ATTGCCCAGAAACACGTTTCTTTGGGGATTCAGCCACAGCACTATCCCATTGTTGGTGCAAACCTGCTGGCCTCCATTCA
AGAAGTGCTGGGGATCGATGAATCGTCGGAAATTATTGATGCCTGGGCGGCGGCTTACGGTGCACTGGCGGATATTTTTA
TTGGGCGTGAAGGAGCGCTGTATCAGCACCAGCAAGATACTTTCGGATGGCAGGGTTTCAAGCCCTTTGTTGTCGCTCGC
CGTGAGCAGGAAAGTGAGAATATTGTTTCTCTTTATCTTGCTCGCCAAGATGGGGAGGCACTGCAGCCACATCAGCCTGG
CCAGTACATTACTGTGCGGGTGACGCCGCCGGGTGGGCTACCGGTAATGCGTAACTACAGCTTGTCCTGTGCGCCGGGGG
AAAGCCATTACCGAATTAGTGTGAAACGGGAGCGAGCCCTCGCTGACGAAGCGCCCGATGGGGTGTGCTCCGGTTATATC
CATGAGCATCTTCAGGAAGGTGATGTTGTCGAGGTGGCGCCACCCTGTGGTGAATTTACCCTGGCCGATGCGAATGCTGA
GGGAGTGCCATTAGTGTTAGTTGCCGGTGGGGTGGGCGTCACGCCGCTGCTCTCGATGCTACATGGGGCGCTGGCTCACC
AACAGGGTCGTGAAGTGATCTTTATCCAGTGTGCCCTGAATGGCGCTGTTCGGCCTTTTGCTGCAGAGTTGCAGCAGTTG
GCGGACAACCACGATAACTTGCATTGTCATGTTCGTTATAGTGAGCCGTCTGCCCAGGACCAGGAGAAGGTTGACTTTGA
CAGCACAGGGTTTCTGGATTGCGCATTGCTGGATCAGCTGGTGGGCGATCGCCGCGCAGAGTATTATTTTTGTGGTCCGG
TACCGATGCTCAAAGCGGTGTATGGGCTGTTGCAGGATAAAGGTGTGGACGATGCCGATATCCATTATGAGTTCTTTGGA
CCGGCAGAAGGACTTGCGGCGTAA

Upstream 100 bases:

>100_bases
TGAGTTGCATGGCTTGACCTCCAAAAAATGAGTATCTAATATGCCCATTTAAAAGAGGCATGTAAAATGCCTATTATTGG
TCGCCAACAGGAGTCACGCC

Downstream 100 bases:

>100_bases
ATAGCAAGCTGTTGCGGATTAGCGTGCAAACCCACTGTGCCAACTTAATCGGTAGGAGGGCACACTCAACCACGTGTTAG
CCGTTTTTGATATGACGCTA

Product: nitric oxide dioxygenase

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLTQSQLAVIKQTVPVLQENGETLTRHFYARMFRENPEVQAFFNPAHQQAGTQQRALAGAICAYAQHVDNPAALADAVEL
IAQKHVSLGIQPQHYPIVGANLLASIQEVLGIDESSEIIDAWAAAYGALADIFIGREGALYQHQQDTFGWQGFKPFVVAR
REQESENIVSLYLARQDGEALQPHQPGQYITVRVTPPGGLPVMRNYSLSCAPGESHYRISVKRERALADEAPDGVCSGYI
HEHLQEGDVVEVAPPCGEFTLADANAEGVPLVLVAGGVGVTPLLSMLHGALAHQQGREVIFIQCALNGAVRPFAAELQQL
ADNHDNLHCHVRYSEPSAQDQEKVDFDSTGFLDCALLDQLVGDRRAEYYFCGPVPMLKAVYGLLQDKGVDDADIHYEFFG
PAEGLAA

Sequences:

>Translated_407_residues
MLTQSQLAVIKQTVPVLQENGETLTRHFYARMFRENPEVQAFFNPAHQQAGTQQRALAGAICAYAQHVDNPAALADAVEL
IAQKHVSLGIQPQHYPIVGANLLASIQEVLGIDESSEIIDAWAAAYGALADIFIGREGALYQHQQDTFGWQGFKPFVVAR
REQESENIVSLYLARQDGEALQPHQPGQYITVRVTPPGGLPVMRNYSLSCAPGESHYRISVKRERALADEAPDGVCSGYI
HEHLQEGDVVEVAPPCGEFTLADANAEGVPLVLVAGGVGVTPLLSMLHGALAHQQGREVIFIQCALNGAVRPFAAELQQL
ADNHDNLHCHVRYSEPSAQDQEKVDFDSTGFLDCALLDQLVGDRRAEYYFCGPVPMLKAVYGLLQDKGVDDADIHYEFFG
PAEGLAA
>Mature_407_residues
MLTQSQLAVIKQTVPVLQENGETLTRHFYARMFRENPEVQAFFNPAHQQAGTQQRALAGAICAYAQHVDNPAALADAVEL
IAQKHVSLGIQPQHYPIVGANLLASIQEVLGIDESSEIIDAWAAAYGALADIFIGREGALYQHQQDTFGWQGFKPFVVAR
REQESENIVSLYLARQDGEALQPHQPGQYITVRVTPPGGLPVMRNYSLSCAPGESHYRISVKRERALADEAPDGVCSGYI
HEHLQEGDVVEVAPPCGEFTLADANAEGVPLVLVAGGVGVTPLLSMLHGALAHQQGREVIFIQCALNGAVRPFAAELQQL
ADNHDNLHCHVRYSEPSAQDQEKVDFDSTGFLDCALLDQLVGDRRAEYYFCGPVPMLKAVYGLLQDKGVDDADIHYEFFG
PAEGLAA

Specific function: Possesses Dihydropteridine Reductase Activity. Also Has Nitric Oxide Dioxygenase Activity. Seems To Reduces The Complexed Fe(3+) Iron Of Siderophores To Fe(2+), Thus Releasing It From The Chelator. [C]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=404, Percent_Identity=39.6039603960396, Blast_Score=287, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6321673, Length=410, Percent_Identity=35.1219512195122, Blast_Score=227, Evalue=3e-60,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR001834
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 44348; Mature: 44348

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQSQLAVIKQTVPVLQENGETLTRHFYARMFRENPEVQAFFNPAHQQAGTQQRALAGA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHCCCHHHHHHHH
ICAYAQHVDNPAALADAVELIAQKHVSLGIQPQHYPIVGANLLASIQEVLGIDESSEIID
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHH
AWAAAYGALADIFIGREGALYQHQQDTFGWQGFKPFVVARREQESENIVSLYLARQDGEA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHEEEECCCCCCCEEEEEEEECCCCC
LQPHQPGQYITVRVTPPGGLPVMRNYSLSCAPGESHYRISVKRERALADEAPDGVCSGYI
CCCCCCCCEEEEEEECCCCCCCEECCEEEECCCCCCEEEEEEHHHHHHCCCCCHHHHHHH
HEHLQEGDVVEVAPPCGEFTLADANAEGVPLVLVAGGVGVTPLLSMLHGALAHQQGREVI
HHHCCCCCEEEECCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEE
FIQCALNGAVRPFAAELQQLADNHDNLHCHVRYSEPSAQDQEKVDFDSTGFLDCALLDQL
EEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHCCCCCCCCHHHHHHHHH
VGDRRAEYYFCGPVPMLKAVYGLLQDKGVDDADIHYEFFGPAEGLAA
HCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MLTQSQLAVIKQTVPVLQENGETLTRHFYARMFRENPEVQAFFNPAHQQAGTQQRALAGA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHCCCHHHHHHHH
ICAYAQHVDNPAALADAVELIAQKHVSLGIQPQHYPIVGANLLASIQEVLGIDESSEIID
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHH
AWAAAYGALADIFIGREGALYQHQQDTFGWQGFKPFVVARREQESENIVSLYLARQDGEA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHEEEECCCCCCCEEEEEEEECCCCC
LQPHQPGQYITVRVTPPGGLPVMRNYSLSCAPGESHYRISVKRERALADEAPDGVCSGYI
CCCCCCCCEEEEEEECCCCCCCEECCEEEECCCCCCEEEEEEHHHHHHCCCCCHHHHHHH
HEHLQEGDVVEVAPPCGEFTLADANAEGVPLVLVAGGVGVTPLLSMLHGALAHQQGREVI
HHHCCCCCEEEECCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEE
FIQCALNGAVRPFAAELQQLADNHDNLHCHVRYSEPSAQDQEKVDFDSTGFLDCALLDQL
EEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHCCCCCCCCHHHHHHHHH
VGDRRAEYYFCGPVPMLKAVYGLLQDKGVDDADIHYEFFGPAEGLAA
HCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]