Click here to switch to the map view.

The map label for this gene is algC [H]

Identifier: 110833798

GI number: 110833798

Start: 1049961

End: 1051343

Strand: Direct

Name: algC [H]

Synonym: ABO_0937

Alternate gene names: 110833798

Gene position: 1049961-1051343 (Clockwise)

Preceding gene: 110833797

Following gene: 110833799

Centisome position: 33.65

GC content: 53.29

Gene sequence:

>1383_bases
ATGACATTAATGACTCACCCCATTCCCGCTTCGATTTTTCGTGCTTACGATATTCGCGGTATTTATAACGAAACGCTCAC
GGATGCATGGGCTTATGAAATTGGTCGGGCGATTGGGTCCGAGGTGCAAGCTCAAGGACAGACGGCCATCGCTATAGGGC
GAGATGGGCGCTTGTCTGGTCCCGCTTTGTTGCAGGCCTTGAGTGAGGGTGTTCAGTCCACGGGGTGCGCAGTAGTGAAT
GTGGGGTTGGTACCGACGCCTGTGCTGTATTTTGCAACGCATCATATTGAGGGGCTCAATTCCGGTGTGATGCTGACTGG
TAGCCATAACCCGGGCAATTACAATGGTTTTAAAATTGTAATTGACGGTGTGACACTCTCGGGTGAACGCATTCAGGCGT
TGCATCGCAGAATTGTAGATCAGCGCTTTGCTGAAGGGCAGGGCGAGTATCGTGAGCAGGATGTGCTGGTGGACTACCAG
GCTGCGTTTTTGAGCGCCCATAGCCTAGCGCGACCTATGAAGGTGGTTGTGGATTGTGGCAATGGCATCACTGGTTTACA
GGCACCGCAAGTGCTTGAGGCGTTAGGGTGTGAGGTTGTGCCGCTGTTCACTGACGTGGACGGCACCTTCCCGAATCATC
ACCCGGACCCGGGTGACCTCAACAATTTGCAGGATTTAATTGCTAGCGTAAAAGCAGAAAAGGCCGACCTTGGATTGGCT
TTTGATGGTGACGGCGATCGGGTTGGGGTTGTTACACCTGCTGGAGAGGTGGTGTATCCGGATATTCTGCTAATGGCGCT
GGCAGAGGATATGGTGAGCAGGCATCCCGGCGCAAAAGTTATTTTTGATGTGAAGTGCACAGGCTCCCTGTTCGACGTGA
TTAGGGACGCCGGGGGGGAGCCAGAAATGTGGCAAACCGGACACTCCCTTATCAAAGCACGCATGAAAGAAACCGGTGCC
TTGTTAGCAGGAGAGATGAGTGGGCATATCTTTTTTGCTGAAGATTGGTACGGCTTTGATGATGCCTTGGTGGCTGCTGC
CAGGATACTGGGTATCATCAGCCGAACAGAGGGAGGCGCGGAGGCCCTTTTCGGGCGCTACCCGGTGCTGTGCACGACCC
CGGAAATCAATATCAATGTGACGGACGAGAACAAATTCCGTATCGTGGAATATCTGCAGACGAATGCGGAGTTCGGCGAA
GGCGAGCGCCGCGTCATTGATGGTATCCGTATGGATTATGCCGATGGTTGGGGCCTGTGTCGGGCCTCCAATACTTCGCC
GAAGTTAGTGTTGCGTTTTGAGGCAGATAACGATGAAGCCCTAGGCCGAATTCGTGACTTGTTCGAGGTTAACGTAAGCA
AAGCGATGGCCGCGGTGGGTTAA

Upstream 100 bases:

>100_bases
GCAAGCAAGCGACGCAATAACATTAAACACGAATGCAAATGGACAGAGCCCTCCCTTATCATGCTGTGCCAGCTGGTTGT
GTGCTCTGTGCCTTACAAGG

Downstream 100 bases:

>100_bases
TTCTACGATTGGCTTGGCTGTTTAATTTCAACGGGTGGTGGCAGCTCAGGCGATAACCTTGGAACAGGATGATGAATCAT
GAGCAAAGTATTGGTCACCG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTLMTHPIPASIFRAYDIRGIYNETLTDAWAYEIGRAIGSEVQAQGQTAIAIGRDGRLSGPALLQALSEGVQSTGCAVVN
VGLVPTPVLYFATHHIEGLNSGVMLTGSHNPGNYNGFKIVIDGVTLSGERIQALHRRIVDQRFAEGQGEYREQDVLVDYQ
AAFLSAHSLARPMKVVVDCGNGITGLQAPQVLEALGCEVVPLFTDVDGTFPNHHPDPGDLNNLQDLIASVKAEKADLGLA
FDGDGDRVGVVTPAGEVVYPDILLMALAEDMVSRHPGAKVIFDVKCTGSLFDVIRDAGGEPEMWQTGHSLIKARMKETGA
LLAGEMSGHIFFAEDWYGFDDALVAAARILGIISRTEGGAEALFGRYPVLCTTPEININVTDENKFRIVEYLQTNAEFGE
GERRVIDGIRMDYADGWGLCRASNTSPKLVLRFEADNDEALGRIRDLFEVNVSKAMAAVG

Sequences:

>Translated_460_residues
MTLMTHPIPASIFRAYDIRGIYNETLTDAWAYEIGRAIGSEVQAQGQTAIAIGRDGRLSGPALLQALSEGVQSTGCAVVN
VGLVPTPVLYFATHHIEGLNSGVMLTGSHNPGNYNGFKIVIDGVTLSGERIQALHRRIVDQRFAEGQGEYREQDVLVDYQ
AAFLSAHSLARPMKVVVDCGNGITGLQAPQVLEALGCEVVPLFTDVDGTFPNHHPDPGDLNNLQDLIASVKAEKADLGLA
FDGDGDRVGVVTPAGEVVYPDILLMALAEDMVSRHPGAKVIFDVKCTGSLFDVIRDAGGEPEMWQTGHSLIKARMKETGA
LLAGEMSGHIFFAEDWYGFDDALVAAARILGIISRTEGGAEALFGRYPVLCTTPEININVTDENKFRIVEYLQTNAEFGE
GERRVIDGIRMDYADGWGLCRASNTSPKLVLRFEADNDEALGRIRDLFEVNVSKAMAAVG
>Mature_459_residues
TLMTHPIPASIFRAYDIRGIYNETLTDAWAYEIGRAIGSEVQAQGQTAIAIGRDGRLSGPALLQALSEGVQSTGCAVVNV
GLVPTPVLYFATHHIEGLNSGVMLTGSHNPGNYNGFKIVIDGVTLSGERIQALHRRIVDQRFAEGQGEYREQDVLVDYQA
AFLSAHSLARPMKVVVDCGNGITGLQAPQVLEALGCEVVPLFTDVDGTFPNHHPDPGDLNNLQDLIASVKAEKADLGLAF
DGDGDRVGVVTPAGEVVYPDILLMALAEDMVSRHPGAKVIFDVKCTGSLFDVIRDAGGEPEMWQTGHSLIKARMKETGAL
LAGEMSGHIFFAEDWYGFDDALVAAARILGIISRTEGGAEALFGRYPVLCTTPEININVTDENKFRIVEYLQTNAEFGEG
ERRVIDGIRMDYADGWGLCRASNTSPKLVLRFEADNDEALGRIRDLFEVNVSKAMAAVG

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=461, Percent_Identity=32.3210412147505, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1789566, Length=438, Percent_Identity=27.8538812785388, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 49636; Mature: 49505

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLMTHPIPASIFRAYDIRGIYNETLTDAWAYEIGRAIGSEVQAQGQTAIAIGRDGRLSG
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
PALLQALSEGVQSTGCAVVNVGLVPTPVLYFATHHIEGLNSGVMLTGSHNPGNYNGFKIV
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEE
IDGVTLSGERIQALHRRIVDQRFAEGQGEYREQDVLVDYQAAFLSAHSLARPMKVVVDCG
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEEEECC
NGITGLQAPQVLEALGCEVVPLFTDVDGTFPNHHPDPGDLNNLQDLIASVKAEKADLGLA
CCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEE
FDGDGDRVGVVTPAGEVVYPDILLMALAEDMVSRHPGAKVIFDVKCTGSLFDVIRDAGGE
ECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCC
PEMWQTGHSLIKARMKETGALLAGEMSGHIFFAEDWYGFDDALVAAARILGIISRTEGGA
CHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCH
EALFGRYPVLCTTPEININVTDENKFRIVEYLQTNAEFGEGERRVIDGIRMDYADGWGLC
HHHHCCCCEEEECCEEEEEECCCCCEEEHHHHHCCCCCCCCCHHHHHHHHEECCCCCCEE
RASNTSPKLVLRFEADNDEALGRIRDLFEVNVSKAMAAVG
ECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLMTHPIPASIFRAYDIRGIYNETLTDAWAYEIGRAIGSEVQAQGQTAIAIGRDGRLSG
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
PALLQALSEGVQSTGCAVVNVGLVPTPVLYFATHHIEGLNSGVMLTGSHNPGNYNGFKIV
HHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEE
IDGVTLSGERIQALHRRIVDQRFAEGQGEYREQDVLVDYQAAFLSAHSLARPMKVVVDCG
EEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEEEECC
NGITGLQAPQVLEALGCEVVPLFTDVDGTFPNHHPDPGDLNNLQDLIASVKAEKADLGLA
CCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCEE
FDGDGDRVGVVTPAGEVVYPDILLMALAEDMVSRHPGAKVIFDVKCTGSLFDVIRDAGGE
ECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHCCCCC
PEMWQTGHSLIKARMKETGALLAGEMSGHIFFAEDWYGFDDALVAAARILGIISRTEGGA
CHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCH
EALFGRYPVLCTTPEININVTDENKFRIVEYLQTNAEFGEGERRVIDGIRMDYADGWGLC
HHHHCCCCEEEECCEEEEEECCCCCEEEHHHHHCCCCCCCCCHHHHHHHHEECCCCCCEE
RASNTSPKLVLRFEADNDEALGRIRDLFEVNVSKAMAAVG
ECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]