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The map label for this gene is pgi

Identifier: 110833797

GI number: 110833797

Start: 1048234

End: 1049880

Strand: Direct

Name: pgi

Synonym: ABO_0936

Alternate gene names: 110833797

Gene position: 1048234-1049880 (Clockwise)

Preceding gene: 110833796

Following gene: 110833798

Centisome position: 33.6

GC content: 54.04

Gene sequence:

>1647_bases
ATGGTGCCTGAACAAAATGATCTAACCGAGAGTTCGGTCTGGCTGCAGCTTGAAAACCTTGCACGTGAGGAAGGCTCTTT
GCATTTGTCTGATTTTTTCGTTCAAGAGCTGGGAAGGTGTGCCCATTTTTGCCTTGAGAGCGATGGCCTCTTGGTAGACT
TGAGCAAGCAGAGGGTGTCGTCTCATGCTCGTGATTTACTGGTGAGTTTGGCCGATGAACGGGGCCTTGATCGTTGGAGT
GAGGCGTTATTTGCCGGTGCAGAGGTGAATTGCACCGAGAACCGCAGTGCCAAGCACTGGTTGCTCCGTGATCCGTCTGA
TCAAGCTGCTGAGATCCATGGCCAGCTGGAGATCATGGACTCTATCGTCTCGCGCGTGTTGGAAGGTCAGTGGCGGGGTG
TATTGGGCGATGCGATTACGGATGTGGTTAATGTGGGCGTTGGGGGATCTGAATTGGGGCCGTTAATGGCGGCATTCGCG
CTGCATTCGACGCCCTTGGCAGAGGGAGAAGTGCGGCCCAGCCTTCATTTCGCATCGTCAATGGATGGCAGCCAGATTTC
CCAGGTGCTTCAGGAACTGAACCCGCGCACGACACTGGTGCTGGTGTCGTCTAAATCCTTTACTACTGTGGATACGTTGC
ACAACGCCAATACGGCACGTAGCTGGATGGCCCGTGCACTGGGGCTTGAAATGGATAACGAAGCGATGCTGCGTTGCCAT
TTTATTGGTATTTCCGCACAACCGGACAAGATGACCGCGTGGGGGATTCCATCGACTAACCAGTTACAGTTCTGGGATTG
GGTGGGCGGGCGTTATTCTTTGTGGTCTGCTATTGGTTTGCCCATTGCACTTACCGTGGGGATGCATGGGTTTCGTGAGT
TGCTGGCGGGTGCCCATGACATGGATCTCCACTTTCGCCAGCGCCCATGGCACGAGAATATTCCGGTTATGTTGGCTTTG
GTGGATGTGTGGAATATCAATTTTCTGGATATCCGCGCCCGTGCAGTGCTGCCCTACGATGGCCGCTTAAAATATCTGCC
TGCTTATCTAGAACAGTTAGAGATGGAGTCTAACGGGAAGAGTGTGTCGCGTAATGGCGACCCTGTGGATTACCACACCT
GTCCGGTGATTTGGGGTGAGGTTGGCCCGAATGCACAGCATGCCTTTTTCCAGTTGTTGCACCAGGGTACTCAGCCGGTG
GCGTGCGAGTTTTTGATGACCGCACGGCGCTATACCGAAAGCGCACATTCGGGTGCGGCGGTGGAATTGGAAGGCCAGCA
TGCTCTGTCTAACGCCAATTGCCTGGCTCAATCGCGTTTGTTGGCGTTTGGCGAGCAGGCTTTGGATTCAACGTTGGCTT
TGCCTGCTTACAAGCGTTATCGGGGTAATCAGCCCAGCACCACTCTGGTGCTGGATGAGTTGTCGCCTAGAACCCTTGGC
TCCTTGCTGGCCATGTATGAGCATAAGGTGTTTGCCCAAGCGGTGATTTGGGGAATTAACCCTTTTGATCAATGGGGCGT
GGAGATGGGTAAGGTGATTGCCACCGATATGTTGGCGGTTCTGGCGGACCCTGATGGCGCCCATGAGGTGGATGATTCCT
CACTGTCGTTAGCGCGCCATATCGCGTGCAAGCAAGCGACGCAATAA

Upstream 100 bases:

>100_bases
AGATGCGGACCGGGCTTATTCTCGATGGCCGTAATATTTATGACCCTGCATTTGTTAAGGCACAGGGGCTGGAATATCGT
GGAATTGGACGGAGCTAGGC

Downstream 100 bases:

>100_bases
CATTAAACACGAATGCAAATGGACAGAGCCCTCCCTTATCATGCTGTGCCAGCTGGTTGTGTGCTCTGTGCCTTACAAGG
ATGACATTAATGACTCACCC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MVPEQNDLTESSVWLQLENLAREEGSLHLSDFFVQELGRCAHFCLESDGLLVDLSKQRVSSHARDLLVSLADERGLDRWS
EALFAGAEVNCTENRSAKHWLLRDPSDQAAEIHGQLEIMDSIVSRVLEGQWRGVLGDAITDVVNVGVGGSELGPLMAAFA
LHSTPLAEGEVRPSLHFASSMDGSQISQVLQELNPRTTLVLVSSKSFTTVDTLHNANTARSWMARALGLEMDNEAMLRCH
FIGISAQPDKMTAWGIPSTNQLQFWDWVGGRYSLWSAIGLPIALTVGMHGFRELLAGAHDMDLHFRQRPWHENIPVMLAL
VDVWNINFLDIRARAVLPYDGRLKYLPAYLEQLEMESNGKSVSRNGDPVDYHTCPVIWGEVGPNAQHAFFQLLHQGTQPV
ACEFLMTARRYTESAHSGAAVELEGQHALSNANCLAQSRLLAFGEQALDSTLALPAYKRYRGNQPSTTLVLDELSPRTLG
SLLAMYEHKVFAQAVIWGINPFDQWGVEMGKVIATDMLAVLADPDGAHEVDDSSLSLARHIACKQATQ

Sequences:

>Translated_548_residues
MVPEQNDLTESSVWLQLENLAREEGSLHLSDFFVQELGRCAHFCLESDGLLVDLSKQRVSSHARDLLVSLADERGLDRWS
EALFAGAEVNCTENRSAKHWLLRDPSDQAAEIHGQLEIMDSIVSRVLEGQWRGVLGDAITDVVNVGVGGSELGPLMAAFA
LHSTPLAEGEVRPSLHFASSMDGSQISQVLQELNPRTTLVLVSSKSFTTVDTLHNANTARSWMARALGLEMDNEAMLRCH
FIGISAQPDKMTAWGIPSTNQLQFWDWVGGRYSLWSAIGLPIALTVGMHGFRELLAGAHDMDLHFRQRPWHENIPVMLAL
VDVWNINFLDIRARAVLPYDGRLKYLPAYLEQLEMESNGKSVSRNGDPVDYHTCPVIWGEVGPNAQHAFFQLLHQGTQPV
ACEFLMTARRYTESAHSGAAVELEGQHALSNANCLAQSRLLAFGEQALDSTLALPAYKRYRGNQPSTTLVLDELSPRTLG
SLLAMYEHKVFAQAVIWGINPFDQWGVEMGKVIATDMLAVLADPDGAHEVDDSSLSLARHIACKQATQ
>Mature_548_residues
MVPEQNDLTESSVWLQLENLAREEGSLHLSDFFVQELGRCAHFCLESDGLLVDLSKQRVSSHARDLLVSLADERGLDRWS
EALFAGAEVNCTENRSAKHWLLRDPSDQAAEIHGQLEIMDSIVSRVLEGQWRGVLGDAITDVVNVGVGGSELGPLMAAFA
LHSTPLAEGEVRPSLHFASSMDGSQISQVLQELNPRTTLVLVSSKSFTTVDTLHNANTARSWMARALGLEMDNEAMLRCH
FIGISAQPDKMTAWGIPSTNQLQFWDWVGGRYSLWSAIGLPIALTVGMHGFRELLAGAHDMDLHFRQRPWHENIPVMLAL
VDVWNINFLDIRARAVLPYDGRLKYLPAYLEQLEMESNGKSVSRNGDPVDYHTCPVIWGEVGPNAQHAFFQLLHQGTQPV
ACEFLMTARRYTESAHSGAAVELEGQHALSNANCLAQSRLLAFGEQALDSTLALPAYKRYRGNQPSTTLVLDELSPRTLG
SLLAMYEHKVFAQAVIWGINPFDQWGVEMGKVIATDMLAVLADPDGAHEVDDSSLSLARHIACKQATQ

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=550, Percent_Identity=40.7272727272727, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI296080693, Length=546, Percent_Identity=38.4615384615385, Blast_Score=355, Evalue=6e-98,
Organism=Escherichia coli, GI1790457, Length=557, Percent_Identity=40.754039497307, Blast_Score=420, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71996703, Length=561, Percent_Identity=37.0766488413547, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71996708, Length=561, Percent_Identity=37.0766488413547, Blast_Score=383, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319673, Length=527, Percent_Identity=37.3814041745731, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651916, Length=558, Percent_Identity=40.6810035842294, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24651914, Length=558, Percent_Identity=40.6810035842294, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17737445, Length=558, Percent_Identity=40.6810035842294, Blast_Score=417, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ALCBS (Q0VR14)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692656.1
- ProteinModelPortal:   Q0VR14
- SMR:   Q0VR14
- STRING:   Q0VR14
- GeneID:   4211325
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0936
- NMPDR:   fig|393595.12.peg.937
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   SFTTIDT
- PhylomeDB:   Q0VR14
- BioCyc:   ABOR393595:ABO_0936-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 60524; Mature: 60524

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 356-356 ACT_SITE 387-387 ACT_SITE 511-511

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPEQNDLTESSVWLQLENLAREEGSLHLSDFFVQELGRCAHFCLESDGLLVDLSKQRVS
CCCCCCCCCCHHHHEEHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHH
SHARDLLVSLADERGLDRWSEALFAGAEVNCTENRSAKHWLLRDPSDQAAEIHGQLEIMD
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
SIVSRVLEGQWRGVLGDAITDVVNVGVGGSELGPLMAAFALHSTPLAEGEVRPSLHFASS
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
MDGSQISQVLQELNPRTTLVLVSSKSFTTVDTLHNANTARSWMARALGLEMDNEAMLRCH
CCHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEE
FIGISAQPDKMTAWGIPSTNQLQFWDWVGGRYSLWSAIGLPIALTVGMHGFRELLAGAHD
EEEECCCCCCCEECCCCCCCCEEEEECCCCCHHHHHHHCCCCEEHHHHHHHHHHHCCCCC
MDLHFRQRPWHENIPVMLALVDVWNINFLDIRARAVLPYDGRLKYLPAYLEQLEMESNGK
CCCCCCCCCCCCCCCEEEEEEHHHCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
SVSRNGDPVDYHTCPVIWGEVGPNAQHAFFQLLHQGTQPVACEFLMTARRYTESAHSGAA
CCCCCCCCCCEEECCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCE
VELEGQHALSNANCLAQSRLLAFGEQALDSTLALPAYKRYRGNQPSTTLVLDELSPRTLG
EEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCHHHHH
SLLAMYEHKVFAQAVIWGINPFDQWGVEMGKVIATDMLAVLADPDGAHEVDDSSLSLARH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IACKQATQ
HHHHHCCC
>Mature Secondary Structure
MVPEQNDLTESSVWLQLENLAREEGSLHLSDFFVQELGRCAHFCLESDGLLVDLSKQRVS
CCCCCCCCCCHHHHEEHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHH
SHARDLLVSLADERGLDRWSEALFAGAEVNCTENRSAKHWLLRDPSDQAAEIHGQLEIMD
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
SIVSRVLEGQWRGVLGDAITDVVNVGVGGSELGPLMAAFALHSTPLAEGEVRPSLHFASS
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
MDGSQISQVLQELNPRTTLVLVSSKSFTTVDTLHNANTARSWMARALGLEMDNEAMLRCH
CCHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEE
FIGISAQPDKMTAWGIPSTNQLQFWDWVGGRYSLWSAIGLPIALTVGMHGFRELLAGAHD
EEEECCCCCCCEECCCCCCCCEEEEECCCCCHHHHHHHCCCCEEHHHHHHHHHHHCCCCC
MDLHFRQRPWHENIPVMLALVDVWNINFLDIRARAVLPYDGRLKYLPAYLEQLEMESNGK
CCCCCCCCCCCCCCCEEEEEEHHHCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
SVSRNGDPVDYHTCPVIWGEVGPNAQHAFFQLLHQGTQPVACEFLMTARRYTESAHSGAA
CCCCCCCCCCEEECCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCE
VELEGQHALSNANCLAQSRLLAFGEQALDSTLALPAYKRYRGNQPSTTLVLDELSPRTLG
EEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCHHHHH
SLLAMYEHKVFAQAVIWGINPFDQWGVEMGKVIATDMLAVLADPDGAHEVDDSSLSLARH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IACKQATQ
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA