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The map label for this gene is wzc [H]

Identifier: 110833768

GI number: 110833768

Start: 1013133

End: 1015343

Strand: Direct

Name: wzc [H]

Synonym: ABO_0907

Alternate gene names: 110833768

Gene position: 1013133-1015343 (Clockwise)

Preceding gene: 110833767

Following gene: 110833769

Centisome position: 32.47

GC content: 48.58

Gene sequence:

>2211_bases
ATGGCAGAAAATAACAGCATGAAACGGCATCTATCAGCTAACGATGCAGAGCCTGATATCGACTTCGCACTCCTGCTGGC
CGTGCTCGTGGAGCATTGGCTATTAATTGCATCCACGGCAGTGGTTGCGATGCTGGCAGCGATTAGCTATGTCATGTTTG
CCACGCCTATTTATAAAGGCGATGCGCTCTTACAGGTTGAGCAGAAAAGCAGTGGTGTGCCCGGCCTTTCTGAACTCAAT
CAGATGTTTGAGCAGGAATCCTCCACTGCGGCTGAAATTGAAATTCTTCGCTCGCGCATGATTCTCAGAGAGGTGATTTC
ACAGCTCAAAATGGATATTCAAGTCCAGCCTGAGCGAAATTCCCTGTGGGGAAAAATGACGGCTCCTGATCCTGCGCCGC
CTTTCTTACCTCGACCCGCATTTGCGGGTTATCGAGACAGCGAAACTTTTATAAAGGTCAGTGCCTTTAATGTGCCAGAC
CGTCTTTTGGGTCGATCATTCAAGATTATCGAGGAGAAAGGACAGCCGGCATTGTACTTTGAGGGCGGCCTTGTGGGTAC
GGCGCCTCTTGGAAAACCGATTATCAGTGAAGATGGAAGTGTGCGTTTGTTTATCACTGACTGGGTGTTTGGCGGCGAGC
CAGTCTTAATTACTCGTTTACCCGAAATCGCAGCGATTAACCGACTACGAGGGATGTTGTCAGTTCAAGAAATTGGGAAA
ACGGGTATGTTGTCCATGACAGCGACGGGGCCCGACAAGCAACAAATCAAAGCAGTTCTCGATACGATCAGCAACGTCTA
CGTATTGCAGAATATAGAGCGTCGTTCGGCAGAAGCGGAAAATAGCCTAGCGTTTCTTGGAAAACAATTGCCTGAAATTA
AGGAAAAATTGACGGCCGCAGAAGAAAAATTGAATGCCTATCGGTTGGAAAGTGAATCTGTGGATTTGACCATGGAAACA
CAATCAGTACTGGAACGAAGTGTGGGGCTGGAAGCAAAAATCAATGAGCTGAAAATCCAAGAAGGCGAAATTGCCAGCCG
CTTCACCCGCGAGCACCCCACCTACCAGACGTTAATCCGGCAGCGGAGGTCTCTGGTCGAAGAAAAAAACCAACTGGACC
AACAGATAAAAGATCTTCCTAAAACCCAGCAGGAAATACTACGTTTGATGCGCGATGTGGAAGTAACGCAGCAAATTTAT
GTTGGGCTACTTAACAAGACTCAAGAGCTGCGCATTCTTAAAGCCGGCACGGTGGGTAGTGTCCGCATAATTGATGAAGC
GCTAGTCCAGCCCGCCCCGATCAAACCCAAAAAATCTCTTGTCGTTGTTATTGCGACGATGCTTGGCGCGGGGGCTGCAG
CCGGCTTGGTTCTAATGCGGTCCCTTCTTAGTAAAGGTATTGAATCCCCAGAAAAACTGGAAGAGCAGGGGGTGTCTGTT
TACGCCGCTATACCATTGTCAGAACACCAGCAAAAAGCAGAACGCATGAGCTCATTGGTTAAGCGTCGCAAGAGCAGTAA
AGGCCTACATAGCATTCCTCTACTGGCGGATATTGATCCTAATGATCTTGCCATTGAAGCCTTGCGCAGCCTCCGTACTA
GCTTGCACTTTGCGATGATGGACGCCAGCAATAATATTCTTATGGTAGCTGGTCCAAGTCCTGGTGTGGGTAAATCATTT
GTGTCCGCGAACCTGGCCGCAGTATTGGCAAAAGCAGGCCAGAAGATTCTCGTCATTGATGCGGATATGCGCAAAGGACA
CTTGCATCGTTTTTTTGCGCGAGGCCATGAAATTGGATTGTCCGGGTATCTTTCAGGCCAGCACACCAAGGAAGAGATTA
TCCTTGCAACGGAGGATGATAACCTGCATTTAATTCCTCGTGGCAAGGCTCCGCCGAACCCGTCTGAACTGCTCATGCAT
GCGCGCTTTTCTAACTTAATGGAAGAGCTTAGCGATGAATATGATCTAGTGCTGATAGACACGCCCCCAATCCTTGCGGT
CACGGATTCTGCCATTATTGGACAGTTGGCGGGTAGCAGCCTGCTAGTCACACGTTATGGCGTTAACTCCGTTAAAGAAG
TGGACGCAGCCTTGACCCGCTTTGCCCAAAACAATGTTGAAATTAAAGGGGCGATCCTGAATTGCATGGAACGGCGGGCC
ACTAATGAATACAGCTACTACGCTTATGAATACAGTAAAAGTAACGATTAG

Upstream 100 bases:

>100_bases
GGATAGTGCCGCGCACGCGTGGGCTAAAAAAATTTAGGGATCAGGGGTAAGTAGGTAGAAAGTCCCAGGGTCGAGAAGTA
TACAACCGGTTTATAAACGA

Downstream 100 bases:

>100_bases
AATCGTTCCACTGTAGAAGCCTTCGTTGGCAGCGCGATAGGCGGTAATAACTAACCGATTGAAATCAGTGTAGGGGCCGG
TACAGACCGGAAAGGTAAGA

Product: tyrosine-protein kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 736; Mature: 735

Protein sequence:

>736_residues
MAENNSMKRHLSANDAEPDIDFALLLAVLVEHWLLIASTAVVAMLAAISYVMFATPIYKGDALLQVEQKSSGVPGLSELN
QMFEQESSTAAEIEILRSRMILREVISQLKMDIQVQPERNSLWGKMTAPDPAPPFLPRPAFAGYRDSETFIKVSAFNVPD
RLLGRSFKIIEEKGQPALYFEGGLVGTAPLGKPIISEDGSVRLFITDWVFGGEPVLITRLPEIAAINRLRGMLSVQEIGK
TGMLSMTATGPDKQQIKAVLDTISNVYVLQNIERRSAEAENSLAFLGKQLPEIKEKLTAAEEKLNAYRLESESVDLTMET
QSVLERSVGLEAKINELKIQEGEIASRFTREHPTYQTLIRQRRSLVEEKNQLDQQIKDLPKTQQEILRLMRDVEVTQQIY
VGLLNKTQELRILKAGTVGSVRIIDEALVQPAPIKPKKSLVVVIATMLGAGAAAGLVLMRSLLSKGIESPEKLEEQGVSV
YAAIPLSEHQQKAERMSSLVKRRKSSKGLHSIPLLADIDPNDLAIEALRSLRTSLHFAMMDASNNILMVAGPSPGVGKSF
VSANLAAVLAKAGQKILVIDADMRKGHLHRFFARGHEIGLSGYLSGQHTKEEIILATEDDNLHLIPRGKAPPNPSELLMH
ARFSNLMEELSDEYDLVLIDTPPILAVTDSAIIGQLAGSSLLVTRYGVNSVKEVDAALTRFAQNNVEIKGAILNCMERRA
TNEYSYYAYEYSKSND

Sequences:

>Translated_736_residues
MAENNSMKRHLSANDAEPDIDFALLLAVLVEHWLLIASTAVVAMLAAISYVMFATPIYKGDALLQVEQKSSGVPGLSELN
QMFEQESSTAAEIEILRSRMILREVISQLKMDIQVQPERNSLWGKMTAPDPAPPFLPRPAFAGYRDSETFIKVSAFNVPD
RLLGRSFKIIEEKGQPALYFEGGLVGTAPLGKPIISEDGSVRLFITDWVFGGEPVLITRLPEIAAINRLRGMLSVQEIGK
TGMLSMTATGPDKQQIKAVLDTISNVYVLQNIERRSAEAENSLAFLGKQLPEIKEKLTAAEEKLNAYRLESESVDLTMET
QSVLERSVGLEAKINELKIQEGEIASRFTREHPTYQTLIRQRRSLVEEKNQLDQQIKDLPKTQQEILRLMRDVEVTQQIY
VGLLNKTQELRILKAGTVGSVRIIDEALVQPAPIKPKKSLVVVIATMLGAGAAAGLVLMRSLLSKGIESPEKLEEQGVSV
YAAIPLSEHQQKAERMSSLVKRRKSSKGLHSIPLLADIDPNDLAIEALRSLRTSLHFAMMDASNNILMVAGPSPGVGKSF
VSANLAAVLAKAGQKILVIDADMRKGHLHRFFARGHEIGLSGYLSGQHTKEEIILATEDDNLHLIPRGKAPPNPSELLMH
ARFSNLMEELSDEYDLVLIDTPPILAVTDSAIIGQLAGSSLLVTRYGVNSVKEVDAALTRFAQNNVEIKGAILNCMERRA
TNEYSYYAYEYSKSND
>Mature_735_residues
AENNSMKRHLSANDAEPDIDFALLLAVLVEHWLLIASTAVVAMLAAISYVMFATPIYKGDALLQVEQKSSGVPGLSELNQ
MFEQESSTAAEIEILRSRMILREVISQLKMDIQVQPERNSLWGKMTAPDPAPPFLPRPAFAGYRDSETFIKVSAFNVPDR
LLGRSFKIIEEKGQPALYFEGGLVGTAPLGKPIISEDGSVRLFITDWVFGGEPVLITRLPEIAAINRLRGMLSVQEIGKT
GMLSMTATGPDKQQIKAVLDTISNVYVLQNIERRSAEAENSLAFLGKQLPEIKEKLTAAEEKLNAYRLESESVDLTMETQ
SVLERSVGLEAKINELKIQEGEIASRFTREHPTYQTLIRQRRSLVEEKNQLDQQIKDLPKTQQEILRLMRDVEVTQQIYV
GLLNKTQELRILKAGTVGSVRIIDEALVQPAPIKPKKSLVVVIATMLGAGAAAGLVLMRSLLSKGIESPEKLEEQGVSVY
AAIPLSEHQQKAERMSSLVKRRKSSKGLHSIPLLADIDPNDLAIEALRSLRTSLHFAMMDASNNILMVAGPSPGVGKSFV
SANLAAVLAKAGQKILVIDADMRKGHLHRFFARGHEIGLSGYLSGQHTKEEIILATEDDNLHLIPRGKAPPNPSELLMHA
RFSNLMEELSDEYDLVLIDTPPILAVTDSAIIGQLAGSSLLVTRYGVNSVKEVDAALTRFAQNNVEIKGAILNCMERRAT
NEYSYYAYEYSKSND

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=737, Percent_Identity=43.6906377204885, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1787216, Length=718, Percent_Identity=42.7576601671309, Blast_Score=535, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 81152; Mature: 81021

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENNSMKRHLSANDAEPDIDFALLLAVLVEHWLLIASTAVVAMLAAISYVMFATPIYKG
CCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DALLQVEQKSSGVPGLSELNQMFEQESSTAAEIEILRSRMILREVISQLKMDIQVQPERN
CEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
SLWGKMTAPDPAPPFLPRPAFAGYRDSETFIKVSAFNVPDRLLGRSFKIIEEKGQPALYF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCHHHHCCCCCEEEE
EGGLVGTAPLGKPIISEDGSVRLFITDWVFGGEPVLITRLPEIAAINRLRGMLSVQEIGK
CCCEEECCCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
TGMLSMTATGPDKQQIKAVLDTISNVYVLQNIERRSAEAENSLAFLGKQLPEIKEKLTAA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EEKLNAYRLESESVDLTMETQSVLERSVGLEAKINELKIQEGEIASRFTREHPTYQTLIR
HHHHHHHEECCCCCEEEEHHHHHHHHHCCCCEEHHHEEECCCHHHHHHHHCCCHHHHHHH
QRRSLVEEKNQLDQQIKDLPKTQQEILRLMRDVEVTQQIYVGLLNKTQELRILKAGTVGS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
VRIIDEALVQPAPIKPKKSLVVVIATMLGAGAAAGLVLMRSLLSKGIESPEKLEEQGVSV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEE
YAAIPLSEHQQKAERMSSLVKRRKSSKGLHSIPLLADIDPNDLAIEALRSLRTSLHFAMM
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHEEEE
DASNNILMVAGPSPGVGKSFVSANLAAVLAKAGQKILVIDADMRKGHLHRFFARGHEIGL
ECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCC
SGYLSGQHTKEEIILATEDDNLHLIPRGKAPPNPSELLMHARFSNLMEELSDEYDLVLID
EEEECCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
TPPILAVTDSAIIGQLAGSSLLVTRYGVNSVKEVDAALTRFAQNNVEIKGAILNCMERRA
CCCEEEEECHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHC
TNEYSYYAYEYSKSND
CCCCEEEEEEECCCCC
>Mature Secondary Structure 
AENNSMKRHLSANDAEPDIDFALLLAVLVEHWLLIASTAVVAMLAAISYVMFATPIYKG
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DALLQVEQKSSGVPGLSELNQMFEQESSTAAEIEILRSRMILREVISQLKMDIQVQPERN
CEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
SLWGKMTAPDPAPPFLPRPAFAGYRDSETFIKVSAFNVPDRLLGRSFKIIEEKGQPALYF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCHHHHCCCCCEEEE
EGGLVGTAPLGKPIISEDGSVRLFITDWVFGGEPVLITRLPEIAAINRLRGMLSVQEIGK
CCCEEECCCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
TGMLSMTATGPDKQQIKAVLDTISNVYVLQNIERRSAEAENSLAFLGKQLPEIKEKLTAA
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EEKLNAYRLESESVDLTMETQSVLERSVGLEAKINELKIQEGEIASRFTREHPTYQTLIR
HHHHHHHEECCCCCEEEEHHHHHHHHHCCCCEEHHHEEECCCHHHHHHHHCCCHHHHHHH
QRRSLVEEKNQLDQQIKDLPKTQQEILRLMRDVEVTQQIYVGLLNKTQELRILKAGTVGS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
VRIIDEALVQPAPIKPKKSLVVVIATMLGAGAAAGLVLMRSLLSKGIESPEKLEEQGVSV
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCEE
YAAIPLSEHQQKAERMSSLVKRRKSSKGLHSIPLLADIDPNDLAIEALRSLRTSLHFAMM
EEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHEEEE
DASNNILMVAGPSPGVGKSFVSANLAAVLAKAGQKILVIDADMRKGHLHRFFARGHEIGL
ECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCC
SGYLSGQHTKEEIILATEDDNLHLIPRGKAPPNPSELLMHARFSNLMEELSDEYDLVLID
EEEECCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
TPPILAVTDSAIIGQLAGSSLLVTRYGVNSVKEVDAALTRFAQNNVEIKGAILNCMERRA
CCCEEEEECHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHC
TNEYSYYAYEYSKSND
CCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]