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The map label for this gene is wbpO [H]

Identifier: 110833769

GI number: 110833769

Start: 1015447

End: 1016721

Strand: Direct

Name: wbpO [H]

Synonym: ABO_0908

Alternate gene names: 110833769

Gene position: 1015447-1016721 (Clockwise)

Preceding gene: 110833768

Following gene: 110833770

Centisome position: 32.54

GC content: 52.08

Gene sequence:

>1275_bases
ATGGAATTGGGTGATATTAAGTTAGCCGTTATCGGTTTGGGCTACGTGGGTTTGCCGTTGGCTGTGGAATTTGGTAAACG
TCGTTCAGTCATTGGTTTTGACATCAACAAGCCACGCATTGATGCGTTGAACGATGGCCATGATGCTACGCTGGAAGTGG
ATGATGAAGAGCTTGCATCGGCTAACCAATTAACCTTTAGTGCTGATCCAGCCAGCCTGCGTGACTGCAACGTTTACATC
GTTACTGTGCCTACGCCGATTGATGAGCATAAACGGCCTGACCTAACGCCATTGGTAAAGGCGTCAGAAACCATCGGCAA
GACGCTCAAAAAAGGCGATATTGTCATCTACGAATCCACCGTCTATCCGGGTGCCACAGAAGAAGATTGCGTGCCTGTGT
TGGAGAAGGTTTCCGGGCTGGTCTTCAACAAGGACTTCTTCGCCGGTTATAGCCCAGAGCGTATCAACCCAGGTGATAAA
GAGCATCGTGTTACTACGATCACCAAAGTCACATCCGGCTCTACCCCGGAAGTGGCGGAACTGGTGGACCAAATTTACGC
CTCCATTATCACCGCCGGCACCCACAAGGCGTCCAGTATCAAGGTGGCCGAAGCCGCAAAGGTTATCGAAAATACTCAGC
GTGATCTGAATATCGCCTTGGTTAACGAACTCTCGATGATTTTTAATCGAATGGGAGTAGACACCGAGGAAGTGCTGCAG
GCCGCAGGCACCAAATGGAATTTTTTACCCTTCCGGCCAGGCTTGGTGGGCGGGCATTGTATCGGTGTAGACCCTTATTA
CCTCACGCATAAAGCCCAATCGATAGGCTACCACCCGGAAGTCATACTTGCTGGGCGTCGAATTAACGATGCCATGGGCC
GCCATGTGGCAAGCGAGCTGGTTAAGGCTATGCTCACCCGTAGCATTCAGGTTAACGGTTCCCGAGTCCTGGTTATGGGG
CTTACCTTCAAGGAAAACTGCCCGGACCTGCGTAACACGCGTGTGGTCGACGTGGTGAAAGAGCTGCAGGACTACAACAT
CCAGGTAGACGTTCATGATCCCTGGATTAACGCTGCAGAGTCCCAACACGAATACGGCATCACGCCAGTAGCAACGCCAG
AGATGGAGGCCTACGACGCCATCCTTCTAGCCGTGGGCCACAACCAGTTCAAAGCCATGGGCTCCCAGGCTATCAGAGGC
TTCGGCAAACCCGAGCATATCCTGTATGACCTGAAATACAGCCTCCCCAAGGAAGAGGTGGACCTAAGGTTGTGA

Upstream 100 bases:

>100_bases
CGTTCCACTGTAGAAGCCTTCGTTGGCAGCGCGATAGGCGGTAATAACTAACCGATTGAAATCAGTGTAGGGGCCGGTAC
AGACCGGAAAGGTAAGAGTA

Downstream 100 bases:

>100_bases
AGGAACGTTGCTAGCTGTGGGCCACTAGGGAAGAAACCCATAGGCCTGAGCGATGAGAAGGCGCGTACGAAGCGCGGCCC
GGTAGAGTAGACGGAGCGGA

Product: capsular polysaccharide biosynthesis protein/UDP-glucose dehydrogenase/GDP mannose family protein, putati

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MELGDIKLAVIGLGYVGLPLAVEFGKRRSVIGFDINKPRIDALNDGHDATLEVDDEELASANQLTFSADPASLRDCNVYI
VTVPTPIDEHKRPDLTPLVKASETIGKTLKKGDIVIYESTVYPGATEEDCVPVLEKVSGLVFNKDFFAGYSPERINPGDK
EHRVTTITKVTSGSTPEVAELVDQIYASIITAGTHKASSIKVAEAAKVIENTQRDLNIALVNELSMIFNRMGVDTEEVLQ
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEVILAGRRINDAMGRHVASELVKAMLTRSIQVNGSRVLVMG
LTFKENCPDLRNTRVVDVVKELQDYNIQVDVHDPWINAAESQHEYGITPVATPEMEAYDAILLAVGHNQFKAMGSQAIRG
FGKPEHILYDLKYSLPKEEVDLRL

Sequences:

>Translated_424_residues
MELGDIKLAVIGLGYVGLPLAVEFGKRRSVIGFDINKPRIDALNDGHDATLEVDDEELASANQLTFSADPASLRDCNVYI
VTVPTPIDEHKRPDLTPLVKASETIGKTLKKGDIVIYESTVYPGATEEDCVPVLEKVSGLVFNKDFFAGYSPERINPGDK
EHRVTTITKVTSGSTPEVAELVDQIYASIITAGTHKASSIKVAEAAKVIENTQRDLNIALVNELSMIFNRMGVDTEEVLQ
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEVILAGRRINDAMGRHVASELVKAMLTRSIQVNGSRVLVMG
LTFKENCPDLRNTRVVDVVKELQDYNIQVDVHDPWINAAESQHEYGITPVATPEMEAYDAILLAVGHNQFKAMGSQAIRG
FGKPEHILYDLKYSLPKEEVDLRL
>Mature_424_residues
MELGDIKLAVIGLGYVGLPLAVEFGKRRSVIGFDINKPRIDALNDGHDATLEVDDEELASANQLTFSADPASLRDCNVYI
VTVPTPIDEHKRPDLTPLVKASETIGKTLKKGDIVIYESTVYPGATEEDCVPVLEKVSGLVFNKDFFAGYSPERINPGDK
EHRVTTITKVTSGSTPEVAELVDQIYASIITAGTHKASSIKVAEAAKVIENTQRDLNIALVNELSMIFNRMGVDTEEVLQ
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEVILAGRRINDAMGRHVASELVKAMLTRSIQVNGSRVLVMG
LTFKENCPDLRNTRVVDVVKELQDYNIQVDVHDPWINAAESQHEYGITPVATPEMEAYDAILLAVGHNQFKAMGSQAIRG
FGKPEHILYDLKYSLPKEEVDLRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=404, Percent_Identity=30.4455445544554, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788340, Length=364, Percent_Identity=21.978021978022, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560350, Length=382, Percent_Identity=24.869109947644, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46606; Mature: 46606

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGDIKLAVIGLGYVGLPLAVEFGKRRSVIGFDINKPRIDALNDGHDATLEVDDEELAS
CCCCCEEEEEEECCHHCCHHEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHCC
ANQLTFSADPASLRDCNVYIVTVPTPIDEHKRPDLTPLVKASETIGKTLKKGDIVIYEST
CCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECC
VYPGATEEDCVPVLEKVSGLVFNKDFFAGYSPERINPGDKEHRVTTITKVTSGSTPEVAE
CCCCCCCHHHHHHHHHHCCEEECCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHH
LVDQIYASIITAGTHKASSIKVAEAAKVIENTQRDLNIALVNELSMIFNRMGVDTEEVLQ
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCHHHHHH
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEVILAGRRINDAMGRHVASEL
HCCCCCCEECCCCCCCCCEEECCCCEEEEECHHHCCCCCCEEEECCCHHHHHHHHHHHHH
VKAMLTRSIQVNGSRVLVMGLTFKENCPDLRNTRVVDVVKELQDYNIQVDVHDPWINAAE
HHHHHHHCEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCC
SQHEYGITPVATPEMEAYDAILLAVGHNQFKAMGSQAIRGFGKPEHILYDLKYSLPKEEV
CCCCCCCCCCCCCCCHHHCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHC
DLRL
CCCC
>Mature Secondary Structure
MELGDIKLAVIGLGYVGLPLAVEFGKRRSVIGFDINKPRIDALNDGHDATLEVDDEELAS
CCCCCEEEEEEECCHHCCHHEEECCCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHCC
ANQLTFSADPASLRDCNVYIVTVPTPIDEHKRPDLTPLVKASETIGKTLKKGDIVIYEST
CCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECC
VYPGATEEDCVPVLEKVSGLVFNKDFFAGYSPERINPGDKEHRVTTITKVTSGSTPEVAE
CCCCCCCHHHHHHHHHHCCEEECCHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHH
LVDQIYASIITAGTHKASSIKVAEAAKVIENTQRDLNIALVNELSMIFNRMGVDTEEVLQ
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCHHHHHH
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGYHPEVILAGRRINDAMGRHVASEL
HCCCCCCEECCCCCCCCCEEECCCCEEEEECHHHCCCCCCEEEECCCHHHHHHHHHHHHH
VKAMLTRSIQVNGSRVLVMGLTFKENCPDLRNTRVVDVVKELQDYNIQVDVHDPWINAAE
HHHHHHHCEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCC
SQHEYGITPVATPEMEAYDAILLAVGHNQFKAMGSQAIRGFGKPEHILYDLKYSLPKEEV
CCCCCCCCCCCCCCCHHHCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHC
DLRL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]