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The map label for this gene is hyuB

Identifier: 110833581

GI number: 110833581

Start: 809277

End: 810770

Strand: Direct

Name: hyuB

Synonym: ABO_0720

Alternate gene names: NA

Gene position: 809277-810770 (Clockwise)

Preceding gene: 110833577

Following gene: 110833582

Centisome position: 25.94

GC content: 60.17

Gene sequence:

>1494_bases
ATGGGTGCGGTATTGCGCCTGAGTGCGCTGTCCCCGAACATCAAGGACCGACTCGACTTTTCCTGTGCTATTTTTGATGC
CCAAGGTCGGCTGTGCGCCCAGGCGGCCCATATCCCGGTGCATCTTGGGTCCATGGCTTATGCCATGGCGGATCTGGTCA
CGGGCAGAGAGTGGCAGGCAGAAGATCTGATGGTGGTGAATGATCCCTATTTGGGTGGCACGCATTTGCCGGATGTAACG
GTGGTTGCGCCGGTATTTCAGTCGCAGACCCTAATGGGCTTCACTGTGACCCGGGCCCACCATGCGAATATTGGTGCCCA
CAGCCCTGGATCCATGCCGGTATCTACCCATCTGGAGCAAGAAGGGATTGTTATTGCTCCCAGTTGGCTAAAACGCGCAG
GGCAATGGCAGGTGCCTTTGTGCCGGCGCCTAGCCGGGCTGGAGGAGCACGGGACGTTGCCGGTAGAGACTCCGCGTTTT
GCCGACTTTTCTGCCCAGGCTAGTGCCTGTGAGGCGGGTGCCCGGCGTTTGGCGGAGCTGGCCGATCAGCAATTTGATCT
GGTGGCGGCCTTTGATGCCCTCAATGCGTATGGTGAAAAGCGTGCTCGCGCTCGCATCGCGACCCTGCCGGATGGTTGTT
ACCGGTTCCAGGATTACATGGACGACGATGGCCAAGGCCAGCAGGGCATCCTCATTACCGTCAGCCTCACGATTTGCGGA
GATCAGGCCTCTCTGGATTTTAGTGGCACGGCAGATCAGGTGGCGGGAAATATCAATTGCCCGTTGTCCGTGGCAGCCGC
AGCGGTCTATTACTGCTTTCGCTGCTTGATGGACGATGACGTGCCTGCCTGCGATGGTCTCTTTCGGCCTATAAAGCTGT
CCGCTCCGCCAGGCTCGTTGCTCAATGCCCGCCGCCCGGCGGCGGTGGCTGCCGGCAATGTGGAAACCAGTTCACGGGTG
GTGGATGTGGTGCTGGGTGCGCTGGCTCAGGCGGCGCCGGAGGCAATTCCCGCAGCCAGTCAGGGAACCATGAATAATGT
GGCTATGGGCGCTGGCGGTGACAATGGCTGGGATTATTACGAAACCATGGCCGGTGGTACGGGCGCTCATGCTGGTGGCC
CTGGGCTGTCGGCGGTGCACAGTCATATGACTAATACTCTTAATACGCCAGTCGAAAGCCTTGAGTCTCACTATCCGCTG
AGGGTGCACCGTTATCAATTGCGCAGGGGCAGTGGGGGGAGTGGGCAGTTTATGGGGGGCGAGGGCTTGGTCCGTGAGTT
GGAGTTCTTGGCTGATGCCCAGGTCACCCTGCTTACTGAGCGTCGCCTTTTCGCTCCCTGGGGGCTGGCCGGCGGGCAGA
GTGGAGCGGTGGGGGAAAACCGCCATAACGGCCGGTTGTTGCCACCGAAAGCTAGCTTCACCGCTCGCCCCGGTGATCGG
TTGTTAGTGGCTTCACCCGGCGGTGGCGGGTATCGCGGCAGGGAATGCAAATGA

Upstream 100 bases:

>100_bases
GATTTTCGCTATCAACTATTCATTATTGACTGCCTATTGCCCTATGAATCCTGTCCAGCTGAGTATTTTTGCCAACCGCC
TTGGCGGTATCTGTGAGGAA

Downstream 100 bases:

>100_bases
GAACTATAGCATATTGATATTGATTCTTTTTCGTTATATCTTCTGCGCGCTTACATTATTTACATTTGCGTCGGGAAGGG
AAAAGTCATGTATTTGCAGC

Product: N-methylhydantoinase B

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MGAVLRLSALSPNIKDRLDFSCAIFDAQGRLCAQAAHIPVHLGSMAYAMADLVTGREWQAEDLMVVNDPYLGGTHLPDVT
VVAPVFQSQTLMGFTVTRAHHANIGAHSPGSMPVSTHLEQEGIVIAPSWLKRAGQWQVPLCRRLAGLEEHGTLPVETPRF
ADFSAQASACEAGARRLAELADQQFDLVAAFDALNAYGEKRARARIATLPDGCYRFQDYMDDDGQGQQGILITVSLTICG
DQASLDFSGTADQVAGNINCPLSVAAAAVYYCFRCLMDDDVPACDGLFRPIKLSAPPGSLLNARRPAAVAAGNVETSSRV
VDVVLGALAQAAPEAIPAASQGTMNNVAMGAGGDNGWDYYETMAGGTGAHAGGPGLSAVHSHMTNTLNTPVESLESHYPL
RVHRYQLRRGSGGSGQFMGGEGLVRELEFLADAQVTLLTERRLFAPWGLAGGQSGAVGENRHNGRLLPPKASFTARPGDR
LLVASPGGGGYRGRECK

Sequences:

>Translated_497_residues
MGAVLRLSALSPNIKDRLDFSCAIFDAQGRLCAQAAHIPVHLGSMAYAMADLVTGREWQAEDLMVVNDPYLGGTHLPDVT
VVAPVFQSQTLMGFTVTRAHHANIGAHSPGSMPVSTHLEQEGIVIAPSWLKRAGQWQVPLCRRLAGLEEHGTLPVETPRF
ADFSAQASACEAGARRLAELADQQFDLVAAFDALNAYGEKRARARIATLPDGCYRFQDYMDDDGQGQQGILITVSLTICG
DQASLDFSGTADQVAGNINCPLSVAAAAVYYCFRCLMDDDVPACDGLFRPIKLSAPPGSLLNARRPAAVAAGNVETSSRV
VDVVLGALAQAAPEAIPAASQGTMNNVAMGAGGDNGWDYYETMAGGTGAHAGGPGLSAVHSHMTNTLNTPVESLESHYPL
RVHRYQLRRGSGGSGQFMGGEGLVRELEFLADAQVTLLTERRLFAPWGLAGGQSGAVGENRHNGRLLPPKASFTARPGDR
LLVASPGGGGYRGRECK
>Mature_496_residues
GAVLRLSALSPNIKDRLDFSCAIFDAQGRLCAQAAHIPVHLGSMAYAMADLVTGREWQAEDLMVVNDPYLGGTHLPDVTV
VAPVFQSQTLMGFTVTRAHHANIGAHSPGSMPVSTHLEQEGIVIAPSWLKRAGQWQVPLCRRLAGLEEHGTLPVETPRFA
DFSAQASACEAGARRLAELADQQFDLVAAFDALNAYGEKRARARIATLPDGCYRFQDYMDDDGQGQQGILITVSLTICGD
QASLDFSGTADQVAGNINCPLSVAAAAVYYCFRCLMDDDVPACDGLFRPIKLSAPPGSLLNARRPAAVAAGNVETSSRVV
DVVLGALAQAAPEAIPAASQGTMNNVAMGAGGDNGWDYYETMAGGTGAHAGGPGLSAVHSHMTNTLNTPVESLESHYPLR
VHRYQLRRGSGGSGQFMGGEGLVRELEFLADAQVTLLTERRLFAPWGLAGGQSGAVGENRHNGRLLPPKASFTARPGDRL
LVASPGGGGYRGRECK

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=528, Percent_Identity=42.4242424242424, Blast_Score=311, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI133901900, Length=523, Percent_Identity=39.3881453154876, Blast_Score=312, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI133901902, Length=511, Percent_Identity=38.747553816047, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6322634, Length=533, Percent_Identity=37.7110694183865, Blast_Score=335, Evalue=8e-93,
Organism=Drosophila melanogaster, GI45550492, Length=523, Percent_Identity=39.5793499043977, Blast_Score=298, Evalue=5e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 52523; Mature: 52392

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAVLRLSALSPNIKDRLDFSCAIFDAQGRLCAQAAHIPVHLGSMAYAMADLVTGREWQA
CCCEEEEECCCCCHHHHCCEEEEEECCCCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCCC
EDLMVVNDPYLGGTHLPDVTVVAPVFQSQTLMGFTVTRAHHANIGAHSPGSMPVSTHLEQ
CCEEEEECCCCCCCCCCCCEEEEHHHCCCEEEEEEEEEECCCCCCCCCCCCCCHHHCCCC
EGIVIAPSWLKRAGQWQVPLCRRLAGLEEHGTLPVETPRFADFSAQASACEAGARRLAEL
CCEEECCHHHHCCCCCCCHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADQQFDLVAAFDALNAYGEKRARARIATLPDGCYRFQDYMDDDGQGQQGILITVSLTICG
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCEEEEEEEEEEC
DQASLDFSGTADQVAGNINCPLSVAAAAVYYCFRCLMDDDVPACDGLFRPIKLSAPPGSL
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHH
LNARRPAAVAAGNVETSSRVVDVVLGALAQAAPEAIPAASQGTMNNVAMGAGGDNGWDYY
HCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEECCCCCCCCHHH
ETMAGGTGAHAGGPGLSAVHSHMTNTLNTPVESLESHYPLRVHRYQLRRGSGGSGQFMGG
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEEEEECCCCCCCCCEECC
EGLVRELEFLADAQVTLLTERRLFAPWGLAGGQSGAVGENRHNGRLLPPKASFTARPGDR
HHHHHHHHHHHCCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCE
LLVASPGGGGYRGRECK
EEEECCCCCCCCCCCCC
>Mature Secondary Structure 
GAVLRLSALSPNIKDRLDFSCAIFDAQGRLCAQAAHIPVHLGSMAYAMADLVTGREWQA
CCEEEEECCCCCHHHHCCEEEEEECCCCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCCC
EDLMVVNDPYLGGTHLPDVTVVAPVFQSQTLMGFTVTRAHHANIGAHSPGSMPVSTHLEQ
CCEEEEECCCCCCCCCCCCEEEEHHHCCCEEEEEEEEEECCCCCCCCCCCCCCHHHCCCC
EGIVIAPSWLKRAGQWQVPLCRRLAGLEEHGTLPVETPRFADFSAQASACEAGARRLAEL
CCEEECCHHHHCCCCCCCHHHHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ADQQFDLVAAFDALNAYGEKRARARIATLPDGCYRFQDYMDDDGQGQQGILITVSLTICG
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCEEEEEEEEEEC
DQASLDFSGTADQVAGNINCPLSVAAAAVYYCFRCLMDDDVPACDGLFRPIKLSAPPGSL
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHH
LNARRPAAVAAGNVETSSRVVDVVLGALAQAAPEAIPAASQGTMNNVAMGAGGDNGWDYY
HCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCEEECCCCCCCCHHH
ETMAGGTGAHAGGPGLSAVHSHMTNTLNTPVESLESHYPLRVHRYQLRRGSGGSGQFMGG
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCEEEEEEEECCCCCCCCCEECC
EGLVRELEFLADAQVTLLTERRLFAPWGLAGGQSGAVGENRHNGRLLPPKASFTARPGDR
HHHHHHHHHHHCCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCE
LLVASPGGGGYRGRECK
EEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]