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The map label for this gene is glpK

Identifier: 110833575

GI number: 110833575

Start: 801751

End: 803244

Strand: Direct

Name: glpK

Synonym: ABO_0714

Alternate gene names: 110833575

Gene position: 801751-803244 (Clockwise)

Preceding gene: 110833574

Following gene: 110833576

Centisome position: 25.7

GC content: 58.1

Gene sequence:

>1494_bases
ATGCCTTATATCCTTTCCATCGACCAGGGCACTACCAGTTCAAGGGCGATTGTGTTCGACGCCAATGGGCACGCTTGCGG
GCAGGCTCAGAAAGAGTTTCGCCAGTATTTTCCCGAGGATGGCTGGGTGGAACACGACGCCATGGAAATCTGGAATGATA
CCTTGGCCATGTGTCAGCAAGCCTTGCGCAATGCCCGGGTAGAAGCGCAGCAATTGGTGGCCATTGGTATTACCAATCAG
CGTGAAACTACGGTGTTGTGGGATCGCGAGACCGGTGACCCGTTGGCCCGGGCAATTGTTTGGCAGGATCGTCGTACGGC
GTCTACCTGTGAAGCGTTGCGTGATCAGGGTCATGAAAATCAGGTGCGTAGCAAAACAGGTTTGTTGCTGGATCCATACT
TCTCCGCTACCAAGTTGGCCTGGTTGCTGGATAACGTCCCCAATGCGCGTCAGCGTGCAGAAGCCGGAGAGTTGGCTTTT
GGCACTATCGATAGCTGGCTGTTGTGGCAACTGACCCGTGGCAAGGTGCACGCTACTGACGCCACCAATGCGTCGCGTAC
CTTATTGTTCAATATTCATGAGCAATGCTGGGATGAAGAGCTGCTGACATTATTCAATGTGCCTGCATCGGTATTGCCCG
ACGTGCGCGACAGTGCCGCTGATTTCGGTACCACCTGCCCGGAATTGTTGGGCGCGGCGGTGCCGGTGACCGGTATTGCC
GGTGATCAGCAGGCGGCGTTGGTGGGGCAGGCTTGTTTTGCTCCGGGGATGGTGAAAAGCACCTATGGCACCGGCTGCTT
TATGGTCATGAATACGGGTGAGGCGGTGGAATCCCATAACCGCTTACTGACCACCGTGGGCTATCGCCTCAATGGCAAAA
CCACCTATGCACTGGAGGGCTCTATTTTTGTGGCTGGAGCGGCGATTCAGTGGCTACGAGATGGCTTGCATTTAATTCGG
GATGCCAGAGAAACCGAAGCCCTGGCCCGCCGCGTCGGTTCTGCCGGAGGCGTGTATCTGGTGCCGGCCTTTACTGGCTT
GGGCGCACCGTGGTGGGACCCCCATGCTCGGGGAGCCTTAATGGGGTTGACCCGTGATACTGGGATTGCCGAGGTGGTCA
CCGCGGGGCTGGAGGCCGTGTGTTATCAATCGCGGGATTTGCTGGATGCTATGGCGGCGGATTGTGGCACCCGGCCGACC
ACCCTGCGGGTGGATGGTGGAATGGTGGTGAATAACTGGCTGAGCCAGACCTTGTCGGATGTGCTGGGCGTCTGTGTGGA
CCGACCGGTAGTCACCGAAACCACGGCCTTGGGGGCTGCCTATCTGGCTGGCCTGGGGGTCGGGTTGTATGCATCACTGG
AATCCATAGCAGAGCAATGGCGTTGTGAACGGGGCTTTTCCCCCGCGCTGGCTGAGCCGGAGCGGCAGAAGCGCTATCAA
GGGTGGCGGGATGCGGTGGCTCGAGTTTGTCAGACCTCACGGGGTGCTAATTGA

Upstream 100 bases:

>100_bases
CAATGTGTCATCCGGTCTTCATTTAAAATACGCTTTCCATGCTATCTCGTGGCATTTGTTTGATTTCTACCCCCATATGC
ATAACAAGGTTAGACGAGCC

Downstream 100 bases:

>100_bases
TGGCTAACTTGCATAAACGTTAAGGATTTCGCTGGCAGTAAAGAGCGCTTTATAACGATGGACGGTTCGGTTTTGGGGAT
GATCAAACTGTGACGTAGTC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MPYILSIDQGTTSSRAIVFDANGHACGQAQKEFRQYFPEDGWVEHDAMEIWNDTLAMCQQALRNARVEAQQLVAIGITNQ
RETTVLWDRETGDPLARAIVWQDRRTASTCEALRDQGHENQVRSKTGLLLDPYFSATKLAWLLDNVPNARQRAEAGELAF
GTIDSWLLWQLTRGKVHATDATNASRTLLFNIHEQCWDEELLTLFNVPASVLPDVRDSAADFGTTCPELLGAAVPVTGIA
GDQQAALVGQACFAPGMVKSTYGTGCFMVMNTGEAVESHNRLLTTVGYRLNGKTTYALEGSIFVAGAAIQWLRDGLHLIR
DARETEALARRVGSAGGVYLVPAFTGLGAPWWDPHARGALMGLTRDTGIAEVVTAGLEAVCYQSRDLLDAMAADCGTRPT
TLRVDGGMVVNNWLSQTLSDVLGVCVDRPVVTETTALGAAYLAGLGVGLYASLESIAEQWRCERGFSPALAEPERQKRYQ
GWRDAVARVCQTSRGAN

Sequences:

>Translated_497_residues
MPYILSIDQGTTSSRAIVFDANGHACGQAQKEFRQYFPEDGWVEHDAMEIWNDTLAMCQQALRNARVEAQQLVAIGITNQ
RETTVLWDRETGDPLARAIVWQDRRTASTCEALRDQGHENQVRSKTGLLLDPYFSATKLAWLLDNVPNARQRAEAGELAF
GTIDSWLLWQLTRGKVHATDATNASRTLLFNIHEQCWDEELLTLFNVPASVLPDVRDSAADFGTTCPELLGAAVPVTGIA
GDQQAALVGQACFAPGMVKSTYGTGCFMVMNTGEAVESHNRLLTTVGYRLNGKTTYALEGSIFVAGAAIQWLRDGLHLIR
DARETEALARRVGSAGGVYLVPAFTGLGAPWWDPHARGALMGLTRDTGIAEVVTAGLEAVCYQSRDLLDAMAADCGTRPT
TLRVDGGMVVNNWLSQTLSDVLGVCVDRPVVTETTALGAAYLAGLGVGLYASLESIAEQWRCERGFSPALAEPERQKRYQ
GWRDAVARVCQTSRGAN
>Mature_496_residues
PYILSIDQGTTSSRAIVFDANGHACGQAQKEFRQYFPEDGWVEHDAMEIWNDTLAMCQQALRNARVEAQQLVAIGITNQR
ETTVLWDRETGDPLARAIVWQDRRTASTCEALRDQGHENQVRSKTGLLLDPYFSATKLAWLLDNVPNARQRAEAGELAFG
TIDSWLLWQLTRGKVHATDATNASRTLLFNIHEQCWDEELLTLFNVPASVLPDVRDSAADFGTTCPELLGAAVPVTGIAG
DQQAALVGQACFAPGMVKSTYGTGCFMVMNTGEAVESHNRLLTTVGYRLNGKTTYALEGSIFVAGAAIQWLRDGLHLIRD
ARETEALARRVGSAGGVYLVPAFTGLGAPWWDPHARGALMGLTRDTGIAEVVTAGLEAVCYQSRDLLDAMAADCGTRPTT
LRVDGGMVVNNWLSQTLSDVLGVCVDRPVVTETTALGAAYLAGLGVGLYASLESIAEQWRCERGFSPALAEPERQKRYQG
WRDAVARVCQTSRGAN

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI189409120, Length=500, Percent_Identity=47.2, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI4504007, Length=500, Percent_Identity=47.2, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI42794763, Length=505, Percent_Identity=46.9306930693069, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI41393575, Length=501, Percent_Identity=47.1057884231537, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=32.0079522862823, Blast_Score=306, Evalue=3e-83,
Organism=Escherichia coli, GI1790361, Length=488, Percent_Identity=54.5081967213115, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1787789, Length=530, Percent_Identity=27.1698113207547, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789987, Length=503, Percent_Identity=26.2425447316103, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790005, Length=514, Percent_Identity=24.3190661478599, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789168, Length=486, Percent_Identity=21.8106995884774, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17535599, Length=503, Percent_Identity=41.7495029821074, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71986140, Length=514, Percent_Identity=25.4863813229572, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71986147, Length=295, Percent_Identity=28.8135593220339, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321755, Length=547, Percent_Identity=34.5521023765996, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17864214, Length=504, Percent_Identity=45.0396825396825, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24654573, Length=432, Percent_Identity=46.7592592592593, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655555, Length=496, Percent_Identity=39.9193548387097, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24655560, Length=496, Percent_Identity=39.9193548387097, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24655570, Length=496, Percent_Identity=39.9193548387097, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24655574, Length=496, Percent_Identity=39.9193548387097, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24655565, Length=496, Percent_Identity=39.9193548387097, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI19922058, Length=522, Percent_Identity=32.3754789272031, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24652871, Length=489, Percent_Identity=33.1288343558282, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24656367, Length=512, Percent_Identity=26.953125, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI21357867, Length=525, Percent_Identity=25.9047619047619, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24656372, Length=345, Percent_Identity=28.1159420289855, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=26.8965517241379, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GLPK_ALCBS (Q0VRN6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692434.1
- ProteinModelPortal:   Q0VRN6
- SMR:   Q0VRN6
- STRING:   Q0VRN6
- GeneID:   4211193
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0714
- NMPDR:   fig|393595.12.peg.715
- eggNOG:   COG0554
- HOGENOM:   HBG511469
- OMA:   KDTEITA
- PhylomeDB:   Q0VRN6
- BioCyc:   ABOR393595:ABO_0714-MONOMER
- HAMAP:   MF_00186
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999
- PANTHER:   PTHR10196
- PANTHER:   PTHR10196:SF9
- TIGRFAMs:   TIGR01311

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.30

Molecular weight: Translated: 54057; Mature: 53925

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: BINDING 11-11 BINDING 15-15 BINDING 81-81 BINDING 133-133 BINDING 242-242 BINDING 264-264 BINDING 306-306

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYILSIDQGTTSSRAIVFDANGHACGQAQKEFRQYFPEDGWVEHDAMEIWNDTLAMCQQ
CCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ALRNARVEAQQLVAIGITNQRETTVLWDRETGDPLARAIVWQDRRTASTCEALRDQGHEN
HHHHHHHCHHHEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHH
QVRSKTGLLLDPYFSATKLAWLLDNVPNARQRAEAGELAFGTIDSWLLWQLTRGKVHATD
HHHHHCCCEECCCHHHHHHHHHHHCCCCHHHHHCCCCEEECCHHHHHHHHHHCCEEEECC
ATNASRTLLFNIHEQCWDEELLTLFNVPASVLPDVRDSAADFGTTCPELLGAAVPVTGIA
CCCCCCEEEEEEHHHHCHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHCCCCCCCCCC
GDQQAALVGQACFAPGMVKSTYGTGCFMVMNTGEAVESHNRLLTTVGYRLNGKTTYALEG
CCCHHHHHHHHHHCCCCHHHCCCCEEEEEEECCHHHHHCCCEEEEECEEECCCEEEEECC
SIFVAGAAIQWLRDGLHLIRDARETEALARRVGSAGGVYLVPAFTGLGAPWWDPHARGAL
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCCEE
MGLTRDTGIAEVVTAGLEAVCYQSRDLLDAMAADCGTRPTTLRVDGGMVVNNWLSQTLSD
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHH
VLGVCVDRPVVTETTALGAAYLAGLGVGLYASLESIAEQWRCERGFSPALAEPERQKRYQ
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC
GWRDAVARVCQTSRGAN
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PYILSIDQGTTSSRAIVFDANGHACGQAQKEFRQYFPEDGWVEHDAMEIWNDTLAMCQQ
CEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ALRNARVEAQQLVAIGITNQRETTVLWDRETGDPLARAIVWQDRRTASTCEALRDQGHEN
HHHHHHHCHHHEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHH
QVRSKTGLLLDPYFSATKLAWLLDNVPNARQRAEAGELAFGTIDSWLLWQLTRGKVHATD
HHHHHCCCEECCCHHHHHHHHHHHCCCCHHHHHCCCCEEECCHHHHHHHHHHCCEEEECC
ATNASRTLLFNIHEQCWDEELLTLFNVPASVLPDVRDSAADFGTTCPELLGAAVPVTGIA
CCCCCCEEEEEEHHHHCHHHHHHHHCCCHHHCCCHHHHHHHCCCCCHHHHCCCCCCCCCC
GDQQAALVGQACFAPGMVKSTYGTGCFMVMNTGEAVESHNRLLTTVGYRLNGKTTYALEG
CCCHHHHHHHHHHCCCCHHHCCCCEEEEEEECCHHHHHCCCEEEEECEEECCCEEEEECC
SIFVAGAAIQWLRDGLHLIRDARETEALARRVGSAGGVYLVPAFTGLGAPWWDPHARGAL
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCCEE
MGLTRDTGIAEVVTAGLEAVCYQSRDLLDAMAADCGTRPTTLRVDGGMVVNNWLSQTLSD
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHH
VLGVCVDRPVVTETTALGAAYLAGLGVGLYASLESIAEQWRCERGFSPALAEPERQKRYQ
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHC
GWRDAVARVCQTSRGAN
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA