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The map label for this gene is fabB [H]

Identifier: 110681060

GI number: 110681060

Start: 3788577

End: 3789806

Strand: Direct

Name: fabB [H]

Synonym: RD1_3924

Alternate gene names: 110681060

Gene position: 3788577-3789806 (Clockwise)

Preceding gene: 162139370

Following gene: 110681061

Centisome position: 91.66

GC content: 61.22

Gene sequence:

>1230_bases
ATGCGCCGTGTCGTCGTGACAGGTCTGGGCATCGTCTCATCCATCGGAAACAACGCCGACGAAGTTCTGGCCGCGCTCAA
GGCCGGCACCAGTGGCATCACCGCAAGCCCTGAGATGAGCGAACACGGCTTTCGCAGCCAGATCGCGGGGACGCTGAAGA
TTGATGTGACCGAACATATCGACAAGCGCGCGCTGCGCTTCATGGGGCCGGGTGCGGCTTATGCCTATATCGCCATGGGG
CAAGCCATCGCCGACGCGGGACTGGACGAGAACACGATCAGCAACCCGCGTACCGGCCTTGTTGCGGGCTCTGGTGGGCC
ATCGACCTCAGCGATGCTGACCGCCCATGAGGTGGTAAAGAAAACCGGCGCGACCAAGCGGATCGGCCCCTTTGCGGTGC
CAAAGTGCATGTCCTCCACGGTCAGCGCTAACCTCGCGACCGCCTACAAGATCAAGGGCATCAACTATTCGATCACCTCC
GCCTGCTCGACCTCGCTTCATTGTATCGGCAACGCAGCGGAGCAGATCATGCTCGGCAAGCAGGATGTCATGTTCGCAGG
CGGCGGCGAGGAACTCGACTGGACGCTGTCGTGCCTTTTCGACGCCATGGGCGCGATGAGCAGCAAGTATAACGACACGC
CGGAACAGGCCAGCCGCGCTTTTGACGCCAACCGCGACGGGTTTGTGATTTCAGGCGGTGGCGGCATCGTGGTGCTGGAA
GATCTGGACCACGCCCTGGCACGAGGTGCGACGATCTACGGAGAAGTTACGGGATACGCAGCCACATCTGACGGGCACGA
CATGGTCGCCCCTTCTGGTGAAGGTGGCGAACGCGCAATGCGTCTGGCGCTGAGCACCCTGCCCGAGGGGCGCAAGGTCG
GTTATATCAACGCGCATGGCACATCCACGCCCGTGGGTGACGTGGGCGAGATCGAGGCGGTGCGCCGTGTCTTTGGCACA
GGCACCACGCCACCGGTCAGTTCAACCAAGTCCCTGACGGGTCACGCACAGGGCGCCGCCGGCGCGTTGGAGGCCATCTT
CAGCCTGCTGATGCTCAAACATGACTTCATGGCAAAATCCGTCAATGTGGAGACACTGGATCCCGCGCTGACGCCTTCGG
AGATCGTGCTGGAACGTGTCGATAACGCGGGCCTTGATTCCGTCATGACAAATTCATTTGGGTTTGGCGGCACCAACGGG
TCAATGATCCTGTCGAAATATCTGGGGTAG

Upstream 100 bases:

>100_bases
CGTGTGGAGGCAGATGGGGAAACCATCTATCGGGTTACAGATATGAAGGTCGCGCTCTCCGAGAGTTGAGGCAGCGCCGC
GAGAAATAAAGGAGTGCGCC

Downstream 100 bases:

>100_bases
GAGAGCATCATGTCAGGTCTTTTAGCAGGAAAACGCGGGCTGGTCATGGGAGTTGCCAACGAGCGTTCGATCGCATGGGG
CATCGCACGGTCGATGGCGG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRRVVVTGLGIVSSIGNNADEVLAALKAGTSGITASPEMSEHGFRSQIAGTLKIDVTEHIDKRALRFMGPGAAYAYIAMG
QAIADAGLDENTISNPRTGLVAGSGGPSTSAMLTAHEVVKKTGATKRIGPFAVPKCMSSTVSANLATAYKIKGINYSITS
ACSTSLHCIGNAAEQIMLGKQDVMFAGGGEELDWTLSCLFDAMGAMSSKYNDTPEQASRAFDANRDGFVISGGGGIVVLE
DLDHALARGATIYGEVTGYAATSDGHDMVAPSGEGGERAMRLALSTLPEGRKVGYINAHGTSTPVGDVGEIEAVRRVFGT
GTTPPVSSTKSLTGHAQGAAGALEAIFSLLMLKHDFMAKSVNVETLDPALTPSEIVLERVDNAGLDSVMTNSFGFGGTNG
SMILSKYLG

Sequences:

>Translated_409_residues
MRRVVVTGLGIVSSIGNNADEVLAALKAGTSGITASPEMSEHGFRSQIAGTLKIDVTEHIDKRALRFMGPGAAYAYIAMG
QAIADAGLDENTISNPRTGLVAGSGGPSTSAMLTAHEVVKKTGATKRIGPFAVPKCMSSTVSANLATAYKIKGINYSITS
ACSTSLHCIGNAAEQIMLGKQDVMFAGGGEELDWTLSCLFDAMGAMSSKYNDTPEQASRAFDANRDGFVISGGGGIVVLE
DLDHALARGATIYGEVTGYAATSDGHDMVAPSGEGGERAMRLALSTLPEGRKVGYINAHGTSTPVGDVGEIEAVRRVFGT
GTTPPVSSTKSLTGHAQGAAGALEAIFSLLMLKHDFMAKSVNVETLDPALTPSEIVLERVDNAGLDSVMTNSFGFGGTNG
SMILSKYLG
>Mature_409_residues
MRRVVVTGLGIVSSIGNNADEVLAALKAGTSGITASPEMSEHGFRSQIAGTLKIDVTEHIDKRALRFMGPGAAYAYIAMG
QAIADAGLDENTISNPRTGLVAGSGGPSTSAMLTAHEVVKKTGATKRIGPFAVPKCMSSTVSANLATAYKIKGINYSITS
ACSTSLHCIGNAAEQIMLGKQDVMFAGGGEELDWTLSCLFDAMGAMSSKYNDTPEQASRAFDANRDGFVISGGGGIVVLE
DLDHALARGATIYGEVTGYAATSDGHDMVAPSGEGGERAMRLALSTLPEGRKVGYINAHGTSTPVGDVGEIEAVRRVFGT
GTTPPVSSTKSLTGHAQGAAGALEAIFSLLMLKHDFMAKSVNVETLDPALTPSEIVLERVDNAGLDSVMTNSFGFGGTNG
SMILSKYLG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=427, Percent_Identity=32.5526932084309, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI41872631, Length=343, Percent_Identity=28.2798833819242, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=36.094674556213, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788663, Length=407, Percent_Identity=57.7395577395577, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=38.1995133819951, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=32.6139088729017, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=40.1544401544402, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=352, Percent_Identity=26.9886363636364, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=27.1739130434783, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=31.4031180400891, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=35.1543942992874, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=27.2189349112426, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=27.2189349112426, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=23.7209302325581, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42180; Mature: 42180

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGNNADEVLAALKAGTSGITASPEMSEHGFRSQIAGTLKIDVTEHI
CCEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHCCEEEEEEHHHHH
DKRALRFMGPGAAYAYIAMGQAIADAGLDENTISNPRTGLVAGSGGPSTSAMLTAHEVVK
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHH
KTGATKRIGPFAVPKCMSSTVSANLATAYKIKGINYSITSACSTSLHCIGNAAEQIMLGK
HCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEHHHHHCCHHHHHHHHHHHHHCCC
QDVMFAGGGEELDWTLSCLFDAMGAMSSKYNDTPEQASRAFDANRDGFVISGGGGIVVLE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEEH
DLDHALARGATIYGEVTGYAATSDGHDMVAPSGEGGERAMRLALSTLPEGRKVGYINAHG
HHHHHHHCCCEEEEEEECEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
TSTPVGDVGEIEAVRRVFGTGTTPPVSSTKSLTGHAQGAAGALEAIFSLLMLKHDFMAKS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
VNVETLDPALTPSEIVLERVDNAGLDSVMTNSFGFGGTNGSMILSKYLG
CCCEECCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGNNADEVLAALKAGTSGITASPEMSEHGFRSQIAGTLKIDVTEHI
CCEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHCCEEEEEEHHHHH
DKRALRFMGPGAAYAYIAMGQAIADAGLDENTISNPRTGLVAGSGGPSTSAMLTAHEVVK
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHH
KTGATKRIGPFAVPKCMSSTVSANLATAYKIKGINYSITSACSTSLHCIGNAAEQIMLGK
HCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEHHHHHCCHHHHHHHHHHHHHCCC
QDVMFAGGGEELDWTLSCLFDAMGAMSSKYNDTPEQASRAFDANRDGFVISGGGGIVVLE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEEEH
DLDHALARGATIYGEVTGYAATSDGHDMVAPSGEGGERAMRLALSTLPEGRKVGYINAHG
HHHHHHHCCCEEEEEEECEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
TSTPVGDVGEIEAVRRVFGTGTTPPVSSTKSLTGHAQGAAGALEAIFSLLMLKHDFMAKS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
VNVETLDPALTPSEIVLERVDNAGLDSVMTNSFGFGGTNGSMILSKYLG
CCCEECCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]