Click here to switch to the map view.

The map label for this gene is fabI [H]

Identifier: 110681061

GI number: 110681061

Start: 3789816

End: 3790607

Strand: Direct

Name: fabI [H]

Synonym: RD1_3925

Alternate gene names: 110681061

Gene position: 3789816-3790607 (Clockwise)

Preceding gene: 110681060

Following gene: 110681062

Centisome position: 91.69

GC content: 60.23

Gene sequence:

>792_bases
ATGTCAGGTCTTTTAGCAGGAAAACGCGGGCTGGTCATGGGAGTTGCCAACGAGCGTTCGATCGCATGGGGCATCGCACG
GTCGATGGCGGCCGCCGGTGCGGAACTGGCGTTCACCTATCAGGGGGAAGCTTTCGGCTCGCGCCTTGCCCCGCTCGCGG
CTTCTGTCGGGTCGGACTTCATGGTCGATGTGGATGTCACCGACGACGCGTCCCTGGACAACGCCTTCCGACAACTGTCG
GCGCGTTGGCCGACGATGGATTTTCTGGTGCATGCCATCGCGTTTTCGGACAAATCCGAACTGACAGGGCGGTTCCTCAA
CACCAGTCGCGAGAACTTCAAGCAGACGATGGACATCAGCGCCTATTCGTTTCTGGAGGTGGCGCGTCGCGCGCATCCCA
TGATGGTTGAAAATGGTGGCACGCTGATGACGCTGACCTATCAGGGCAGCAATACCGTCGTGCCGAATTACAATGTGATG
GGTGTAGCAAAAGCCGCGTTGGAAAGTGCGACCCGCTATCTTGCGAACGACCTTGGCCCGGAGGGCATCCGCGTGAATGC
AATCTCTCCCGGTCCGATGAAAACGCTCGCCGGGGCGGCCATCGGCGGGGCGCGCAAAACCTATAAACACACCGACCAAA
ACGCCCCTCTGCGCTCAAACGCGACGCTGGATGCGGTCGGCGGCACAGCGGTCTATCTCGCGTCAGATGCAGGAGCCTGC
ACCACCGGCGAAATCATACATGTCGACGGGGGGTATCATATCCTCGGGATGCCGCAGGGCGAGAACCTGTAA

Upstream 100 bases:

>100_bases
CGATAACGCGGGCCTTGATTCCGTCATGACAAATTCATTTGGGTTTGGCGGCACCAACGGGTCAATGATCCTGTCGAAAT
ATCTGGGGTAGGAGAGCATC

Downstream 100 bases:

>100_bases
TCCGGGCACAATCTCTTACTGCCCTTCGCCGTCAAAGCGCAGGGCGCTTCGCCTGCGCCCGACCGGCAATACATGCGTAA
AGGGCGGTCGCTGGCAGCGC

Product: enoyl-(acyl-carrier-protein) reductase, putative

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 2 [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSGLLAGKRGLVMGVANERSIAWGIARSMAAAGAELAFTYQGEAFGSRLAPLAASVGSDFMVDVDVTDDASLDNAFRQLS
ARWPTMDFLVHAIAFSDKSELTGRFLNTSRENFKQTMDISAYSFLEVARRAHPMMVENGGTLMTLTYQGSNTVVPNYNVM
GVAKAALESATRYLANDLGPEGIRVNAISPGPMKTLAGAAIGGARKTYKHTDQNAPLRSNATLDAVGGTAVYLASDAGAC
TTGEIIHVDGGYHILGMPQGENL

Sequences:

>Translated_263_residues
MSGLLAGKRGLVMGVANERSIAWGIARSMAAAGAELAFTYQGEAFGSRLAPLAASVGSDFMVDVDVTDDASLDNAFRQLS
ARWPTMDFLVHAIAFSDKSELTGRFLNTSRENFKQTMDISAYSFLEVARRAHPMMVENGGTLMTLTYQGSNTVVPNYNVM
GVAKAALESATRYLANDLGPEGIRVNAISPGPMKTLAGAAIGGARKTYKHTDQNAPLRSNATLDAVGGTAVYLASDAGAC
TTGEIIHVDGGYHILGMPQGENL
>Mature_262_residues
SGLLAGKRGLVMGVANERSIAWGIARSMAAAGAELAFTYQGEAFGSRLAPLAASVGSDFMVDVDVTDDASLDNAFRQLSA
RWPTMDFLVHAIAFSDKSELTGRFLNTSRENFKQTMDISAYSFLEVARRAHPMMVENGGTLMTLTYQGSNTVVPNYNVMG
VAKAALESATRYLANDLGPEGIRVNAISPGPMKTLAGAAIGGARKTYKHTDQNAPLRSNATLDAVGGTAVYLASDAGACT
TGEIIHVDGGYHILGMPQGENL

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=27.1653543307087, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI10190704, Length=214, Percent_Identity=28.0373831775701, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787545, Length=260, Percent_Identity=47.3076923076923, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=28.1853281853282, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=27.5193798449612, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=25.6, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=23.2824427480916, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=162, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=198, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=24.8995983935743, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=157, Percent_Identity=26.1146496815287, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=212, Percent_Identity=29.2452830188679, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=207, Percent_Identity=27.0531400966184, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571526, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=24.7474747474747, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=26.6393442622951, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644337, Length=196, Percent_Identity=25.5102040816327, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27731; Mature: 27600

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLAGKRGLVMGVANERSIAWGIARSMAAAGAELAFTYQGEAFGSRLAPLAASVGSDF
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCE
MVDVDVTDDASLDNAFRQLSARWPTMDFLVHAIAFSDKSELTGRFLNTSRENFKQTMDIS
EEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCH
AYSFLEVARRAHPMMVENGGTLMTLTYQGSNTVVPNYNVMGVAKAALESATRYLANDLGP
HHHHHHHHHHCCCEEEECCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
EGIRVNAISPGPMKTLAGAAIGGARKTYKHTDQNAPLRSNATLDAVGGTAVYLASDAGAC
CCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCCCCC
TTGEIIHVDGGYHILGMPQGENL
CCCCEEEECCCEEEEECCCCCCC
>Mature Secondary Structure 
SGLLAGKRGLVMGVANERSIAWGIARSMAAAGAELAFTYQGEAFGSRLAPLAASVGSDF
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCE
MVDVDVTDDASLDNAFRQLSARWPTMDFLVHAIAFSDKSELTGRFLNTSRENFKQTMDIS
EEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCH
AYSFLEVARRAHPMMVENGGTLMTLTYQGSNTVVPNYNVMGVAKAALESATRYLANDLGP
HHHHHHHHHHCCCEEEECCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
EGIRVNAISPGPMKTLAGAAIGGARKTYKHTDQNAPLRSNATLDAVGGTAVYLASDAGAC
CCEEEEEECCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCCCCC
TTGEIIHVDGGYHILGMPQGENL
CCCCEEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]