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The map label for this gene is trpE [H]

Identifier: 110680387

GI number: 110680387

Start: 3069265

End: 3070776

Strand: Direct

Name: trpE [H]

Synonym: RD1_3205

Alternate gene names: 110680387

Gene position: 3069265-3070776 (Clockwise)

Preceding gene: 110680386

Following gene: 110680388

Centisome position: 74.26

GC content: 62.43

Gene sequence:

>1512_bases
ATGGCACTCACACCTGATTTCGATGCGTTTGAGCAGGCCTACAGCACAGGGCTGAACCAGATCGTATACACCAGACTGGC
GGCCGACCTCGACACGCCGGTATCTCTGATGCTCAAGCTGACGGGGGCGCAGAAAGATGCCTTTGTGCTGGAATCCGTGA
CCGGGGGCGAGGTGCGCGGGCGCTATTCGATCATCGGGATGAAACCCGATCTGATCTGGCGCTGTCAGGGCAAGACCAGC
GAAATCAACCGCGCCGCGCGCTATGATGCCGATGCGTTTGAGCCGCTGGAGGGCAACCCGCTGGACCGGCTGCGCGATCT
GATCGCGGAGAGCAAGATCGACCTGCCGCTTGATTTGCCGCAGGCTGCTGCGGGTCTGTTCGGCTATCTCGGCTATGACA
TGGTGCGGCTGGTCGAACATCTGCCCGACATCAACCCCGACCCGCTGGGCCTGCCTGACGCGATCATGCTGCGCCCTTCG
GTGATTGCGGTGCTGGACGGCGTCAAGGGCGAGGTCACGGTAGTATCGCCTGCTTGGGTGTCTGACGGACAAACCGCCCG
CGCGGCTTATGCGCAGGCCGCCGAGCGTGTCATGGACGCCGTGCGCGATCTGGAGCGCGCGATGCCCATGGCCACCCGCG
ATCTGGGTGACGCGGATGCCCCCGGCGCGCCGGTCAGCAACTTTACCCACGAAGGCTACAAGGCCGCCGTGGAAAAGGCG
CGCGACTACATCTGTGCGGGCGATATTTTTCAGGTGGTCCCGGCACAGCGCTGGACGCAGGATTTCGCGCAGGATCCTTT
CGCGCTTTATCGTAGTTTGCGGCGCACGAACCCCTCGCCTTTCATGTTCTATTTCAATTTTGGCGGCTTTCAGGTGATCG
GGGCCAGCCCCGAAATTCTCGTGCGCGTCTTTGGCAATGAGGTCACGATCCGCCCCATCGCAGGCACCCGCCCGCGCGGC
AAGACACCGCAAGAGGACAACGCGCTCGAAGCGGATCTGCTGGCAGACAAGAAAGAGCTGGCGGAGCATCTGATGCTGCT
TGATCTGGGCCGCAATGACGTGGGCCGCGTGGCCAAGATCGGCACCGTCCGCCCCACCGAAGAGTTCATCGTCGAGCGCT
ACAGCCACGTGATGCATATTGTGTCCAATGTGGTGGGTGAGTTGCGGGAGGACGCCGATGCGCTGGATGCGTTCTTCGCA
GGGATGCCCGCGGGCACTGTGTCGGGGGCACCCAAGGTGCGCGCGATGGAGATCATTGACGAGTTGGAGCCTGAAAAACG
CGGTGTCTATGGCGGCGGCGTCGGCTATTTCAGCGCCGGTGGCGATATGGACATGTGCATCGCCCTGCGCACCGCCGTGG
TGCAGGACCAAAAGCTATACATTCAGGCCGGTGGCGGCGTTGTCTATGACAGCGACCCCGAGGCGGAATATCAGGAAACG
GTTCACAAATCGAACGCGATCCGACGCGCGGCGGCAGATGCTGCACGCTTCAGCGGTGAAGGCAACCGTTAG

Upstream 100 bases:

>100_bases
CATCTTCGAGGTTTTCGCAAATGATGTCGTCTTGCGCGCAGACCCGCAGATAAACCAACAGGCGCTGCAAGCGGTGCATG
TGAATTTCCCCTGATCCGCC

Downstream 100 bases:

>100_bases
GCCATGGCCCGCGCGCCATTTGAAATCGCGGGGAAAACGATCCTTGCCGGGACCTCGCAAACCGTTCACTTGCCGGTCTC
GATCCTGCCTGATCACACGC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MALTPDFDAFEQAYSTGLNQIVYTRLAADLDTPVSLMLKLTGAQKDAFVLESVTGGEVRGRYSIIGMKPDLIWRCQGKTS
EINRAARYDADAFEPLEGNPLDRLRDLIAESKIDLPLDLPQAAAGLFGYLGYDMVRLVEHLPDINPDPLGLPDAIMLRPS
VIAVLDGVKGEVTVVSPAWVSDGQTARAAYAQAAERVMDAVRDLERAMPMATRDLGDADAPGAPVSNFTHEGYKAAVEKA
RDYICAGDIFQVVPAQRWTQDFAQDPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEILVRVFGNEVTIRPIAGTRPRG
KTPQEDNALEADLLADKKELAEHLMLLDLGRNDVGRVAKIGTVRPTEEFIVERYSHVMHIVSNVVGELREDADALDAFFA
GMPAGTVSGAPKVRAMEIIDELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVVQDQKLYIQAGGGVVYDSDPEAEYQET
VHKSNAIRRAAADAARFSGEGNR

Sequences:

>Translated_503_residues
MALTPDFDAFEQAYSTGLNQIVYTRLAADLDTPVSLMLKLTGAQKDAFVLESVTGGEVRGRYSIIGMKPDLIWRCQGKTS
EINRAARYDADAFEPLEGNPLDRLRDLIAESKIDLPLDLPQAAAGLFGYLGYDMVRLVEHLPDINPDPLGLPDAIMLRPS
VIAVLDGVKGEVTVVSPAWVSDGQTARAAYAQAAERVMDAVRDLERAMPMATRDLGDADAPGAPVSNFTHEGYKAAVEKA
RDYICAGDIFQVVPAQRWTQDFAQDPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEILVRVFGNEVTIRPIAGTRPRG
KTPQEDNALEADLLADKKELAEHLMLLDLGRNDVGRVAKIGTVRPTEEFIVERYSHVMHIVSNVVGELREDADALDAFFA
GMPAGTVSGAPKVRAMEIIDELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVVQDQKLYIQAGGGVVYDSDPEAEYQET
VHKSNAIRRAAADAARFSGEGNR
>Mature_502_residues
ALTPDFDAFEQAYSTGLNQIVYTRLAADLDTPVSLMLKLTGAQKDAFVLESVTGGEVRGRYSIIGMKPDLIWRCQGKTSE
INRAARYDADAFEPLEGNPLDRLRDLIAESKIDLPLDLPQAAAGLFGYLGYDMVRLVEHLPDINPDPLGLPDAIMLRPSV
IAVLDGVKGEVTVVSPAWVSDGQTARAAYAQAAERVMDAVRDLERAMPMATRDLGDADAPGAPVSNFTHEGYKAAVEKAR
DYICAGDIFQVVPAQRWTQDFAQDPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEILVRVFGNEVTIRPIAGTRPRGK
TPQEDNALEADLLADKKELAEHLMLLDLGRNDVGRVAKIGTVRPTEEFIVERYSHVMHIVSNVVGELREDADALDAFFAG
MPAGTVSGAPKVRAMEIIDELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVVQDQKLYIQAGGGVVYDSDPEAEYQETV
HKSNAIRRAAADAARFSGEGNR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=376, Percent_Identity=39.0957446808511, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1788114, Length=445, Percent_Identity=33.2584269662921, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI87082077, Length=261, Percent_Identity=27.9693486590038, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786809, Length=227, Percent_Identity=28.1938325991189, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=500, Percent_Identity=38.4, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6324361, Length=287, Percent_Identity=27.1777003484321, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54827; Mature: 54696

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTPDFDAFEQAYSTGLNQIVYTRLAADLDTPVSLMLKLTGAQKDAFVLESVTGGEVRG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCC
RYSIIGMKPDLIWRCQGKTSEINRAARYDADAFEPLEGNPLDRLRDLIAESKIDLPLDLP
EEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCH
QAAAGLFGYLGYDMVRLVEHLPDINPDPLGLPDAIMLRPSVIAVLDGVKGEVTVVSPAWV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCEEEECCCCC
SDGQTARAAYAQAAERVMDAVRDLERAMPMATRDLGDADAPGAPVSNFTHEGYKAAVEKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
RDYICAGDIFQVVPAQRWTQDFAQDPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEIL
HHCEECCHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCHHEE
VRVFGNEVTIRPIAGTRPRGKTPQEDNALEADLLADKKELAEHLMLLDLGRNDVGRVAKI
EEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHC
GTVRPTEEFIVERYSHVMHIVSNVVGELREDADALDAFFAGMPAGTVSGAPKVRAMEIID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVVQDQKLYIQAGGGVVYDSDPEAEYQET
HCCHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCHHHHHH
VHKSNAIRRAAADAARFSGEGNR
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALTPDFDAFEQAYSTGLNQIVYTRLAADLDTPVSLMLKLTGAQKDAFVLESVTGGEVRG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCC
RYSIIGMKPDLIWRCQGKTSEINRAARYDADAFEPLEGNPLDRLRDLIAESKIDLPLDLP
EEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCH
QAAAGLFGYLGYDMVRLVEHLPDINPDPLGLPDAIMLRPSVIAVLDGVKGEVTVVSPAWV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHCCCCCCEEEECCCCC
SDGQTARAAYAQAAERVMDAVRDLERAMPMATRDLGDADAPGAPVSNFTHEGYKAAVEKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
RDYICAGDIFQVVPAQRWTQDFAQDPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEIL
HHCEECCHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCHHEE
VRVFGNEVTIRPIAGTRPRGKTPQEDNALEADLLADKKELAEHLMLLDLGRNDVGRVAKI
EEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHC
GTVRPTEEFIVERYSHVMHIVSNVVGELREDADALDAFFAGMPAGTVSGAPKVRAMEIID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEPEKRGVYGGGVGYFSAGGDMDMCIALRTAVVQDQKLYIQAGGGVVYDSDPEAEYQET
HCCHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCEEEECCCCCHHHHHH
VHKSNAIRRAAADAARFSGEGNR
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA