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The map label for this gene is folP [H]

Identifier: 110679238

GI number: 110679238

Start: 1863920

End: 1864744

Strand: Direct

Name: folP [H]

Synonym: RD1_1951

Alternate gene names: 110679238

Gene position: 1863920-1864744 (Clockwise)

Preceding gene: 110679237

Following gene: 110679239

Centisome position: 45.1

GC content: 61.33

Gene sequence:

>825_bases
GTGGCCGGGCTCGACTTCAGCCAGCCACGCGTCATGGGGATATTAAATGTCACGCCGGACAGTTTTTCGGACGGGGGCAT
GCATAATTCGATTGCCGCCGCCCTGGCGGGTGCGGCGCAAATGACGGGTGTGGACATTCTCGACGTGGGGGGCGAATCTA
CGCGACCCGGTGCGCAGGTGGTGCCGCAAACAGAGGAAGTCCAACGGACCGCCCCGGTCATTCGTGCCCTGCGCGCGGCG
GGACACGCGATGACGATTTCGATCGACACCCGCAAGACATCTGTCGCCGAGGCTGCGCTGGATGCGGGGGCCACATTGGT
GAATGATGTTTCCGGCTTTACCTTTGATGTTGATCTGGCACCGCTTTGTGCTGCGCGGCAGGTTCCGGTTTGCGTGATGC
ATGCGCAGGGTGATCCGGCAACCATGCAGGAACGGCCTGTTTATGATGACGTGTTGCTGGATGTATACGATTTTCTGGCG
TTGCAAATTGACCGGCTGGTGCAAACCGGTGTGCCGCGCGACCGGATCATTGCCGACCCCGGAATTGGCTTTGGCAAGAC
GCTGGATCACAATCTGAGGCTGCTGTCGCATCTGTCCCTGTTTCATGCGTTGGGCGTGCCGATCCTGTTGGGGGCATCGC
GCAAAAAGTTCATCGGAACGCTCGGCGGGGCCGAAGAGGCGCGCGACCGGATGCCGGGGTCACTGGCGGTGGCGCTCGCG
GCTTTGAAACATGGGACACAAATTGTGCGCGTCCATGACGTGCCACAGACCCTGCAGGCCATTGCGCTTTGGCGCGCGGT
CGTGGCAGGACAGGGGCATGGATAA

Upstream 100 bases:

>100_bases
AGATATCGAGGTATTGGAGCGGGGGCGTCCATCGCAGGTCATTCCTGTCAGTGAGTTGCCAGCAGACGTCCTGACTTGCC
TGACGCGGGAAAGACCGGCG

Downstream 100 bases:

>100_bases
GCTTTTTGGAACGGATGGGGTGCGCGGCAAGGCCAATGAGCACCCGATGACAGCCGAGATGGCACTGCGTATCGGTGCTG
CGGTAGGTAAATACTTCAGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MAGLDFSQPRVMGILNVTPDSFSDGGMHNSIAAALAGAAQMTGVDILDVGGESTRPGAQVVPQTEEVQRTAPVIRALRAA
GHAMTISIDTRKTSVAEAALDAGATLVNDVSGFTFDVDLAPLCAARQVPVCVMHAQGDPATMQERPVYDDVLLDVYDFLA
LQIDRLVQTGVPRDRIIADPGIGFGKTLDHNLRLLSHLSLFHALGVPILLGASRKKFIGTLGGAEEARDRMPGSLAVALA
ALKHGTQIVRVHDVPQTLQAIALWRAVVAGQGHG

Sequences:

>Translated_274_residues
MAGLDFSQPRVMGILNVTPDSFSDGGMHNSIAAALAGAAQMTGVDILDVGGESTRPGAQVVPQTEEVQRTAPVIRALRAA
GHAMTISIDTRKTSVAEAALDAGATLVNDVSGFTFDVDLAPLCAARQVPVCVMHAQGDPATMQERPVYDDVLLDVYDFLA
LQIDRLVQTGVPRDRIIADPGIGFGKTLDHNLRLLSHLSLFHALGVPILLGASRKKFIGTLGGAEEARDRMPGSLAVALA
ALKHGTQIVRVHDVPQTLQAIALWRAVVAGQGHG
>Mature_273_residues
AGLDFSQPRVMGILNVTPDSFSDGGMHNSIAAALAGAAQMTGVDILDVGGESTRPGAQVVPQTEEVQRTAPVIRALRAAG
HAMTISIDTRKTSVAEAALDAGATLVNDVSGFTFDVDLAPLCAARQVPVCVMHAQGDPATMQERPVYDDVLLDVYDFLAL
QIDRLVQTGVPRDRIIADPGIGFGKTLDHNLRLLSHLSLFHALGVPILLGASRKKFIGTLGGAEEARDRMPGSLAVALAA
LKHGTQIVRVHDVPQTLQAIALWRAVVAGQGHG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=45.9558823529412, Blast_Score=231, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=30.9148264984227, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28800; Mature: 28669

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLDFSQPRVMGILNVTPDSFSDGGMHNSIAAALAGAAQMTGVDILDVGGESTRPGAQV
CCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
VPQTEEVQRTAPVIRALRAAGHAMTISIDTRKTSVAEAALDAGATLVNDVSGFTFDVDLA
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCEEEECCH
PLCAARQVPVCVMHAQGDPATMQERPVYDDVLLDVYDFLALQIDRLVQTGVPRDRIIADP
HHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECC
GIGFGKTLDHNLRLLSHLSLFHALGVPILLGASRKKFIGTLGGAEEARDRMPGSLAVALA
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCHHHHHHHCCHHHHHHHH
ALKHGTQIVRVHDVPQTLQAIALWRAVVAGQGHG
HHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AGLDFSQPRVMGILNVTPDSFSDGGMHNSIAAALAGAAQMTGVDILDVGGESTRPGAQV
CCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
VPQTEEVQRTAPVIRALRAAGHAMTISIDTRKTSVAEAALDAGATLVNDVSGFTFDVDLA
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCEEEECCH
PLCAARQVPVCVMHAQGDPATMQERPVYDDVLLDVYDFLALQIDRLVQTGVPRDRIIADP
HHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECC
GIGFGKTLDHNLRLLSHLSLFHALGVPILLGASRKKFIGTLGGAEEARDRMPGSLAVALA
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCHHHHHHHCCHHHHHHHH
ALKHGTQIVRVHDVPQTLQAIALWRAVVAGQGHG
HHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]