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The map label for this gene is proW [H]

Identifier: 110679135

GI number: 110679135

Start: 1766308

End: 1767849

Strand: Direct

Name: proW [H]

Synonym: RD1_1841

Alternate gene names: 110679135

Gene position: 1766308-1767849 (Clockwise)

Preceding gene: 110679133

Following gene: 110679136

Centisome position: 42.74

GC content: 57.98

Gene sequence:

>1542_bases
ATGATGGACGCATCCGTAAATCCGCTTGATGATCCCAACAGCGAAGCCGCAATCGCCTATGCCGAAGAGCGGCGCGATAA
CATTCGCAGCTTTGTGCGAACCAACCCTGACTATTACATCGCGAATTTCAACAAGATCGGGGCTTCCGCCCGCTTTACGC
CGACGTTCAATCTGATGGCGGGCATATTTGGCCCGGTTTGGTTCGGGGCGCGCGGGCTTTGGTCCTGGGCGCTGCCTTTT
CTGATCCTCGAAGTCTTGGCGCTGGTGCAGATTGCGCGTGGTCTTTTCGGCGATCTCGGCGCTGATGCGATGGCGCGGAT
TGCCTCTATCGAGGGCACATTGGAATTGCGCCGCCAGCAGCTCGCAGCCGCGATCGAGTCCGGCTCGGACAGGGTAGATG
CATTCCGCCGAGCGGTTGACGGTTTGGAAAACAATATTGATGCCATGCGCGATGAAGCAGCAGCGATGGCCGCACAGGGG
CCGCAGATTGCATTGATCGGTCTTGGTATTCTGATCGTGGCGAAAGCCGCACAAGCCATCGTTGCCAATTGGGCGCTTGA
GGCGCGGTTTTCTGATTGGGTGTCTGATCGCACGATCCGGTCGGCCATGCCGATATCGCATATCGTGCTCAGCGCGATTT
TCATGGCTCTGATCGTTCTGGCGGCGATGTTGCACTACAGTTTCCCCGGACGATTTGATCTGCTGGACAACTTCCCGACA
AATGCGGATATCCGGCTCACCAGTATCGACAAGGTCGAGGGGTTCTTTAATTGGGCTGTGTTGAACGGGGATGCCCTTTT
TGATGCGATCACCTTTGTGATCCGGCTCTTGCTGGATGCCTTGGAGGTTGTCTTTGTCAGCACGCCGTGGATTGTCATCG
CTGCCCTGATCATCCTGCTGACATGGCTGACGGCGGGTGTCCGCATGGCGATTTGGTCGGGTGCTTTCCTGTCCTATATG
GGGCTGCTGGGCTTTTGGGAAAAAGCGATGACAACCCTTGCCTTGCTGGGCACTGCGGCCTGCTTGTCCATCCTGATTGG
TATCCCGCTGGGAATGTTTGCGGCCCGGCGTCCGCGGTTTTACGCAGCCATTCAGCCGATCATGGACTTCATGCAGACCA
TGCCCGCCTTTGTTTTTATGATCCCCGTCATCGCGTTCTTCGGCACGGGCAAGCCCGCGGCTGTGGTGACAACGATGATC
TTTGGCGGCACGCCCGTGGTGCGTCTGACCGTTCTGGGGCTGCGGGGGGTTCCCGAAAGCGTTCGAGAGGCGGCAATCTC
ATTTGGTGCCAACAAGTGGTATCTGCTGACACGGGTGGATCTGCCGCTCGCCAGCCCGTCGATACGCGCGGGCATTAACC
AGACCATCATGCTGTCCCTGGCGATGGTCGTCGTTGCATCGTTGATCGGGGCCAAGGGTCTTGGCGAAGACGTGCTGGAG
GCCTTGCAATACGCCAATGTGGGGCAGGGGATTCTGGCGGGCTTTGCGATCCTGTTCTGTGCCATGATCCTTGACCGAAT
TGTGCAGGGCAAGCGCAAGTGA

Upstream 100 bases:

>100_bases
ACGATGAAAACCCGATCCTTGTGCAGGATGCCGGCACTGATGTTGGTATTGTCACGCGCGCTGATCTGCTGCGAACCGTG
ATCGAAGGAACAGAGGTATC

Downstream 100 bases:

>100_bases
CACCTCTGGTGATGGTGCATGGTTTCATGGGCGGCAGCGCACAATGGGCCGGAGAGGTCGCGCGGCTCTCGGACATACGC
GAGGTGATTGCACTCGATCT

Product: glycine betaine/L-proline transport system permease, putative

Products: ADP; phosphate; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MMDASVNPLDDPNSEAAIAYAEERRDNIRSFVRTNPDYYIANFNKIGASARFTPTFNLMAGIFGPVWFGARGLWSWALPF
LILEVLALVQIARGLFGDLGADAMARIASIEGTLELRRQQLAAAIESGSDRVDAFRRAVDGLENNIDAMRDEAAAMAAQG
PQIALIGLGILIVAKAAQAIVANWALEARFSDWVSDRTIRSAMPISHIVLSAIFMALIVLAAMLHYSFPGRFDLLDNFPT
NADIRLTSIDKVEGFFNWAVLNGDALFDAITFVIRLLLDALEVVFVSTPWIVIAALIILLTWLTAGVRMAIWSGAFLSYM
GLLGFWEKAMTTLALLGTAACLSILIGIPLGMFAARRPRFYAAIQPIMDFMQTMPAFVFMIPVIAFFGTGKPAAVVTTMI
FGGTPVVRLTVLGLRGVPESVREAAISFGANKWYLLTRVDLPLASPSIRAGINQTIMLSLAMVVVASLIGAKGLGEDVLE
ALQYANVGQGILAGFAILFCAMILDRIVQGKRK

Sequences:

>Translated_513_residues
MMDASVNPLDDPNSEAAIAYAEERRDNIRSFVRTNPDYYIANFNKIGASARFTPTFNLMAGIFGPVWFGARGLWSWALPF
LILEVLALVQIARGLFGDLGADAMARIASIEGTLELRRQQLAAAIESGSDRVDAFRRAVDGLENNIDAMRDEAAAMAAQG
PQIALIGLGILIVAKAAQAIVANWALEARFSDWVSDRTIRSAMPISHIVLSAIFMALIVLAAMLHYSFPGRFDLLDNFPT
NADIRLTSIDKVEGFFNWAVLNGDALFDAITFVIRLLLDALEVVFVSTPWIVIAALIILLTWLTAGVRMAIWSGAFLSYM
GLLGFWEKAMTTLALLGTAACLSILIGIPLGMFAARRPRFYAAIQPIMDFMQTMPAFVFMIPVIAFFGTGKPAAVVTTMI
FGGTPVVRLTVLGLRGVPESVREAAISFGANKWYLLTRVDLPLASPSIRAGINQTIMLSLAMVVVASLIGAKGLGEDVLE
ALQYANVGQGILAGFAILFCAMILDRIVQGKRK
>Mature_513_residues
MMDASVNPLDDPNSEAAIAYAEERRDNIRSFVRTNPDYYIANFNKIGASARFTPTFNLMAGIFGPVWFGARGLWSWALPF
LILEVLALVQIARGLFGDLGADAMARIASIEGTLELRRQQLAAAIESGSDRVDAFRRAVDGLENNIDAMRDEAAAMAAQG
PQIALIGLGILIVAKAAQAIVANWALEARFSDWVSDRTIRSAMPISHIVLSAIFMALIVLAAMLHYSFPGRFDLLDNFPT
NADIRLTSIDKVEGFFNWAVLNGDALFDAITFVIRLLLDALEVVFVSTPWIVIAALIILLTWLTAGVRMAIWSGAFLSYM
GLLGFWEKAMTTLALLGTAACLSILIGIPLGMFAARRPRFYAAIQPIMDFMQTMPAFVFMIPVIAFFGTGKPAAVVTTMI
FGGTPVVRLTVLGLRGVPESVREAAISFGANKWYLLTRVDLPLASPSIRAGINQTIMLSLAMVVVASLIGAKGLGEDVLE
ALQYANVGQGILAGFAILFCAMILDRIVQGKRK

Specific function: Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline [H]

COG id: COG4176

COG function: function code E; ABC-type proline/glycine betaine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789033, Length=281, Percent_Identity=39.1459074733096, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788449, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788451, Length=189, Percent_Identity=26.984126984127, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 55607; Mature: 55607

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDASVNPLDDPNSEAAIAYAEERRDNIRSFVRTNPDYYIANFNKIGASARFTPTFNLMA
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCHHHHHH
GIFGPVWFGARGLWSWALPFLILEVLALVQIARGLFGDLGADAMARIASIEGTLELRRQQ
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LAAAIESGSDRVDAFRRAVDGLENNIDAMRDEAAAMAAQGPQIALIGLGILIVAKAAQAI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
VANWALEARFSDWVSDRTIRSAMPISHIVLSAIFMALIVLAAMLHYSFPGRFDLLDNFPT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCC
NADIRLTSIDKVEGFFNWAVLNGDALFDAITFVIRLLLDALEVVFVSTPWIVIAALIILL
CCCEEEEEHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TWLTAGVRMAIWSGAFLSYMGLLGFWEKAMTTLALLGTAACLSILIGIPLGMFAARRPRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YAAIQPIMDFMQTMPAFVFMIPVIAFFGTGKPAAVVTTMIFGGTPVVRLTVLGLRGVPES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHH
VREAAISFGANKWYLLTRVDLPLASPSIRAGINQTIMLSLAMVVVASLIGAKGLGEDVLE
HHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
ALQYANVGQGILAGFAILFCAMILDRIVQGKRK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMDASVNPLDDPNSEAAIAYAEERRDNIRSFVRTNPDYYIANFNKIGASARFTPTFNLMA
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCHHHHHH
GIFGPVWFGARGLWSWALPFLILEVLALVQIARGLFGDLGADAMARIASIEGTLELRRQQ
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LAAAIESGSDRVDAFRRAVDGLENNIDAMRDEAAAMAAQGPQIALIGLGILIVAKAAQAI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHH
VANWALEARFSDWVSDRTIRSAMPISHIVLSAIFMALIVLAAMLHYSFPGRFDLLDNFPT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCC
NADIRLTSIDKVEGFFNWAVLNGDALFDAITFVIRLLLDALEVVFVSTPWIVIAALIILL
CCCEEEEEHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TWLTAGVRMAIWSGAFLSYMGLLGFWEKAMTTLALLGTAACLSILIGIPLGMFAARRPRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YAAIQPIMDFMQTMPAFVFMIPVIAFFGTGKPAAVVTTMIFGGTPVVRLTVLGLRGVPES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHH
VREAAISFGANKWYLLTRVDLPLASPSIRAGINQTIMLSLAMVVVASLIGAKGLGEDVLE
HHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
ALQYANVGQGILAGFAILFCAMILDRIVQGKRK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-proline [Periplasm]; H2O [C]

Specific reaction: ATP + L-proline [Periplasm] + H2O = ADP + phosphate + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2649479; 9205837; 9278503 [H]