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The map label for this gene is hppD [H]

Identifier: 110679125

GI number: 110679125

Start: 1755006

End: 1756100

Strand: Direct

Name: hppD [H]

Synonym: RD1_1830

Alternate gene names: 110679125

Gene position: 1755006-1756100 (Clockwise)

Preceding gene: 110679122

Following gene: 110679127

Centisome position: 42.46

GC content: 56.53

Gene sequence:

>1095_bases
ATGGGTCCTTTCCCGCACAATGCCCCGAAATCGCAGATCACGGAGGAAAACCCGGTAGGCACAGATGGGTTTGAGTTTGT
GGAATTTTCGCACCCTGAGCCCGAGGCGCTGCGCAGACTTTTTGCGCAGATGGGATATCGCCATGTAGCGACGCATAAGA
CGCGTCAGATCGAGCTTTGGCAGCAAGGCGACATTACCTACGTGCTGAACGCGGACCCGGACAGTTTCGCCGCCGGCTTT
GTTCAGGATCACGGACCCTGTGCGCCGTCCATGGGCTGGCGCGTGGCGGATGCGCAGGTGGCGTTTGATCATGCGGTTTC
CAAAGGGGCCGTGCCTTATGAGGGCAGTGGCAAGGTGCTGGATGTGCCAGCGATCATCGGGATCGGTGGGTCGCTGTTGT
ATTTTGTCGACCAGTATCACGACACCAGCCCCTACAACGCTGAATATGATTGGCTGCAGCCTTCAAAACCGGCGGGTGTC
GGGTTCTATTATCTCGATCACCTGACCCATAATGTCCACAAGGGCAATATGGATAAATGGTTCCGATTCTACCGTGATCT
GTTCAATTTCCGCGAGGTTCGGTTCTTTGACATCGAAGGGAAATATACCGGCCTGCTGAGCCGGGCGCTGACGTCCCCCT
GCGGGCGCATCCGTATCCCGATCAATGAAGACCGCGGCGAGACCGGGCAGATCGTCTCTTACCTCAGGAAGTATAAGGGT
GAGGGCATTCAGCATATCGCCGTGGGTGCGCATGATATCTATGACAGCACCGACGCGATTGCCGTGCGGGGTGTGAAATT
CATGCCCGGCCCTCCCGACAGCTATTACGCCTTGAGCCACGAGCGTGTCGCCGGCCATGAAGAGCCAATCGACCGGATGA
AGGCGCACGGCATCCTCATTGATGGCGAAGGGGTCGTGGATGGTGGCGAAACCAAGATCCTGCTTCAGATCTTTTCCAAA
ACCGTGATCGGCCCGATCTTTTTCGAGTTCATTCAGCGCAAGGGCGACGATGGCTTTGGGGAGGGCAATTTCAAAGCGCT
GTTCGAGAGCATCGAACAGGAACAGATCGCAATCGGAGAGATCGCCGCAGAATAA

Upstream 100 bases:

>100_bases
GAGTGCGACCCTGAAATTCGCGCAATCATTGCGGCAAGAAACTGCTAAATTTTGCCTTCATAGGCGTAATCATGCGCAAA
ATCCGCAAGGAGAACTGGAA

Downstream 100 bases:

>100_bases
CGCCCCCGGGTCAGCCGCGCGGCATTTTCAACACGATCGCGCGGCCGCTTTTCTGATACCGCAGTTCCGCATCGCCAATG
GCGGATACCCGGCCACCGTC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MGPFPHNAPKSQITEENPVGTDGFEFVEFSHPEPEALRRLFAQMGYRHVATHKTRQIELWQQGDITYVLNADPDSFAAGF
VQDHGPCAPSMGWRVADAQVAFDHAVSKGAVPYEGSGKVLDVPAIIGIGGSLLYFVDQYHDTSPYNAEYDWLQPSKPAGV
GFYYLDHLTHNVHKGNMDKWFRFYRDLFNFREVRFFDIEGKYTGLLSRALTSPCGRIRIPINEDRGETGQIVSYLRKYKG
EGIQHIAVGAHDIYDSTDAIAVRGVKFMPGPPDSYYALSHERVAGHEEPIDRMKAHGILIDGEGVVDGGETKILLQIFSK
TVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQIAIGEIAAE

Sequences:

>Translated_364_residues
MGPFPHNAPKSQITEENPVGTDGFEFVEFSHPEPEALRRLFAQMGYRHVATHKTRQIELWQQGDITYVLNADPDSFAAGF
VQDHGPCAPSMGWRVADAQVAFDHAVSKGAVPYEGSGKVLDVPAIIGIGGSLLYFVDQYHDTSPYNAEYDWLQPSKPAGV
GFYYLDHLTHNVHKGNMDKWFRFYRDLFNFREVRFFDIEGKYTGLLSRALTSPCGRIRIPINEDRGETGQIVSYLRKYKG
EGIQHIAVGAHDIYDSTDAIAVRGVKFMPGPPDSYYALSHERVAGHEEPIDRMKAHGILIDGEGVVDGGETKILLQIFSK
TVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQIAIGEIAAE
>Mature_363_residues
GPFPHNAPKSQITEENPVGTDGFEFVEFSHPEPEALRRLFAQMGYRHVATHKTRQIELWQQGDITYVLNADPDSFAAGFV
QDHGPCAPSMGWRVADAQVAFDHAVSKGAVPYEGSGKVLDVPAIIGIGGSLLYFVDQYHDTSPYNAEYDWLQPSKPAGVG
FYYLDHLTHNVHKGNMDKWFRFYRDLFNFREVRFFDIEGKYTGLLSRALTSPCGRIRIPINEDRGETGQIVSYLRKYKGE
GIQHIAVGAHDIYDSTDAIAVRGVKFMPGPPDSYYALSHERVAGHEEPIDRMKAHGILIDGEGVVDGGETKILLQIFSKT
VIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQIAIGEIAAE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI14249394, Length=371, Percent_Identity=25.8760107816712, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI285002264, Length=357, Percent_Identity=27.4509803921569, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4504477, Length=357, Percent_Identity=27.4509803921569, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17555220, Length=215, Percent_Identity=37.6744186046512, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550752, Length=205, Percent_Identity=29.2682926829268, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24667510, Length=347, Percent_Identity=28.8184438040346, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21356105, Length=305, Percent_Identity=29.5081967213115, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 40650; Mature: 40519

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPFPHNAPKSQITEENPVGTDGFEFVEFSHPEPEALRRLFAQMGYRHVATHKTRQIELW
CCCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHCCCEEEEEE
QQGDITYVLNADPDSFAAGFVQDHGPCAPSMGWRVADAQVAFDHAVSKGAVPYEGSGKVL
ECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHCCCCCCCCCCCEE
DVPAIIGIGGSLLYFVDQYHDTSPYNAEYDWLQPSKPAGVGFYYLDHLTHNVHKGNMDKW
ECCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
FRFYRDLFNFREVRFFDIEGKYTGLLSRALTSPCGRIRIPINEDRGETGQIVSYLRKYKG
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCC
EGIQHIAVGAHDIYDSTDAIAVRGVKFMPGPPDSYYALSHERVAGHEEPIDRMKAHGILI
CCEEEEEECCHHHCCCCCCEEEECEEECCCCCCCCEEECCHHHCCCCCHHHHHHHCEEEE
DGEGVVDGGETKILLQIFSKTVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQIAIGE
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEHHH
IAAE
HCCC
>Mature Secondary Structure 
GPFPHNAPKSQITEENPVGTDGFEFVEFSHPEPEALRRLFAQMGYRHVATHKTRQIELW
CCCCCCCCHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHCCCEEEEEE
QQGDITYVLNADPDSFAAGFVQDHGPCAPSMGWRVADAQVAFDHAVSKGAVPYEGSGKVL
ECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHCCCCCCCCCCCEE
DVPAIIGIGGSLLYFVDQYHDTSPYNAEYDWLQPSKPAGVGFYYLDHLTHNVHKGNMDKW
ECCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
FRFYRDLFNFREVRFFDIEGKYTGLLSRALTSPCGRIRIPINEDRGETGQIVSYLRKYKG
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCC
EGIQHIAVGAHDIYDSTDAIAVRGVKFMPGPPDSYYALSHERVAGHEEPIDRMKAHGILI
CCEEEEEECCHHHCCCCCCEEEECEEECCCCCCCCEEECCHHHCCCCCHHHHHHHCEEEE
DGEGVVDGGETKILLQIFSKTVIGPIFFEFIQRKGDDGFGEGNFKALFESIEQEQIAIGE
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEHHH
IAAE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA