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The map label for this gene is ribB [H]

Identifier: 110679098

GI number: 110679098

Start: 1730594

End: 1731718

Strand: Direct

Name: ribB [H]

Synonym: RD1_1801

Alternate gene names: 110679098

Gene position: 1730594-1731718 (Clockwise)

Preceding gene: 110679097

Following gene: 110679099

Centisome position: 41.87

GC content: 61.6

Gene sequence:

>1125_bases
ATGACATTTGAAACATCCGGCCCAGTTGAGCGTGAGCTGCGCGACAGCATCTCACCCATCGAAGCGATCATCGAGGATGC
CCGTCACGGTCGGATGTTCATTCTGGTCGATCATGAAGATCGCGAGAATGAAGGCGACCTCGTGATCCCCGCACAATTTG
CCGACGCGCAGGCGATCAACTTCATGGCCACCCATGGCCGTGGGCTCATCTGCCTGCCCATGACCTCGGAGCGCATCGAA
ACGCTGGGTCTGCCGATGATGGCGGTCAACAATTCGTCGCGCCATGAGACGGCCTTCACCGTGTCGATCGAGGCGCGCGA
AGGGGTGAGCACCGGCATATCCGCCCCTGACAGGGCGCTGACGGTCGCCATCGCCATTGATGAGGACAAGGGGCAGGCGG
ATATCGCCACGCCGGGGCATATCTTCCCGCTGCGCGCGCGCACGGGTGGCGTACTGGCGCGGGCCGGGCATACCGAAGCC
GCAGTTGATATCAGCCGCTTGGCCGGGCTGCATCCCTCGGGCGTGATTTGCGAAATCATGAAACCGGATGGTGAAATGGC
GCGTCTGCCGGATCTTGTGAGTTTTGCGCAGGAACACGGCCTGAAGATCGGCACGATCAGCGATCTGATTGCCTATCGCC
ACAAACACGACAATCTGCTGCGCCAGCGGGACGAGCGGATGGTCACTTCCGCCTTTGGCGGTGAGTGGTGCATGCGGATT
TTCTCCGATGAGATGACCGGCACGGATCACGTCATGCTGTCCAAGGGCGATATTTCGACGCCGGAACCGGTGCTTGTGCG
CACCCACGCTCTGAACGCGTTGGAAGACGTTCTGGGCCTTGGTCCAAGCCCGGCGGATGAGTTGCCTCGCGCCATGCAGA
TCATCGCCGAGGAAGGGCGCGGCGCGGTCCTGCTGTTTCGCGAACCGCACCCGAAACTGCGTCTGGACGGTGATGAGGAC
GACGGCCCGCGCACGATCAAACGCACCGGTGTGGGCGCGCAGATCATGTCGACCATGGGGCTGCACGAACTGATCCTGCT
GACCGACAGCCCGCAAACGAAATACCTGGGGCTTGAAGCCTACAACCTCTCCATCGTCGGGACCCGCCCGATTACAAAGG
ACTGA

Upstream 100 bases:

>100_bases
GCGCGTCTTGCGGAAATGCCTGCGCATTGAACCGGGGGCGGCTGGTCAAGCCTTGCCGCTTGGTCTATGAGCCTGTCCCA
GACAAAGAGGCGTGCATGCT

Downstream 100 bases:

>100_bases
ACCATGGCCGCACATGAACAGCACCACGTCTTGCCGCGTCCGACATTCGAAAAGCCGGTGAAGATTCTGATCGTGGTCGC
TCCCTATTACAAGGACATCG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTFETSGPVERELRDSISPIEAIIEDARHGRMFILVDHEDRENEGDLVIPAQFADAQAINFMATHGRGLICLPMTSERIE
TLGLPMMAVNNSSRHETAFTVSIEAREGVSTGISAPDRALTVAIAIDEDKGQADIATPGHIFPLRARTGGVLARAGHTEA
AVDISRLAGLHPSGVICEIMKPDGEMARLPDLVSFAQEHGLKIGTISDLIAYRHKHDNLLRQRDERMVTSAFGGEWCMRI
FSDEMTGTDHVMLSKGDISTPEPVLVRTHALNALEDVLGLGPSPADELPRAMQIIAEEGRGAVLLFREPHPKLRLDGDED
DGPRTIKRTGVGAQIMSTMGLHELILLTDSPQTKYLGLEAYNLSIVGTRPITKD

Sequences:

>Translated_374_residues
MTFETSGPVERELRDSISPIEAIIEDARHGRMFILVDHEDRENEGDLVIPAQFADAQAINFMATHGRGLICLPMTSERIE
TLGLPMMAVNNSSRHETAFTVSIEAREGVSTGISAPDRALTVAIAIDEDKGQADIATPGHIFPLRARTGGVLARAGHTEA
AVDISRLAGLHPSGVICEIMKPDGEMARLPDLVSFAQEHGLKIGTISDLIAYRHKHDNLLRQRDERMVTSAFGGEWCMRI
FSDEMTGTDHVMLSKGDISTPEPVLVRTHALNALEDVLGLGPSPADELPRAMQIIAEEGRGAVLLFREPHPKLRLDGDED
DGPRTIKRTGVGAQIMSTMGLHELILLTDSPQTKYLGLEAYNLSIVGTRPITKD
>Mature_373_residues
TFETSGPVERELRDSISPIEAIIEDARHGRMFILVDHEDRENEGDLVIPAQFADAQAINFMATHGRGLICLPMTSERIET
LGLPMMAVNNSSRHETAFTVSIEAREGVSTGISAPDRALTVAIAIDEDKGQADIATPGHIFPLRARTGGVLARAGHTEAA
VDISRLAGLHPSGVICEIMKPDGEMARLPDLVSFAQEHGLKIGTISDLIAYRHKHDNLLRQRDERMVTSAFGGEWCMRIF
SDEMTGTDHVMLSKGDISTPEPVLVRTHALNALEDVLGLGPSPADELPRAMQIIAEEGRGAVLLFREPHPKLRLDGDEDD
GPRTIKRTGVGAQIMSTMGLHELILLTDSPQTKYLGLEAYNLSIVGTRPITKD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=47.979797979798, Blast_Score=204, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=38.6473429951691, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40742; Mature: 40611

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFETSGPVERELRDSISPIEAIIEDARHGRMFILVDHEDRENEGDLVIPAQFADAQAIN
CCCCCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCEE
FMATHGRGLICLPMTSERIETLGLPMMAVNNSSRHETAFTVSIEAREGVSTGISAPDRAL
EEEECCCEEEEECCCHHHHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCEE
TVAIAIDEDKGQADIATPGHIFPLRARTGGVLARAGHTEAAVDISRLAGLHPSGVICEIM
EEEEEEECCCCCEECCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEE
KPDGEMARLPDLVSFAQEHGLKIGTISDLIAYRHKHDNLLRQRDERMVTSAFGGEWCMRI
CCCCCHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FSDEMTGTDHVMLSKGDISTPEPVLVRTHALNALEDVLGLGPSPADELPRAMQIIAEEGR
HHHCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GAVLLFREPHPKLRLDGDEDDGPRTIKRTGVGAQIMSTMGLHELILLTDSPQTKYLGLEA
CEEEEEECCCCCEEECCCCCCCCCEEECCCCCHHHHHHCCCEEEEEEECCCCCEEEEEEE
YNLSIVGTRPITKD
EEEEEEECCCCCCC
>Mature Secondary Structure 
TFETSGPVERELRDSISPIEAIIEDARHGRMFILVDHEDRENEGDLVIPAQFADAQAIN
CCCCCCCHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCEE
FMATHGRGLICLPMTSERIETLGLPMMAVNNSSRHETAFTVSIEAREGVSTGISAPDRAL
EEEECCCEEEEECCCHHHHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCEE
TVAIAIDEDKGQADIATPGHIFPLRARTGGVLARAGHTEAAVDISRLAGLHPSGVICEIM
EEEEEEECCCCCEECCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEE
KPDGEMARLPDLVSFAQEHGLKIGTISDLIAYRHKHDNLLRQRDERMVTSAFGGEWCMRI
CCCCCHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FSDEMTGTDHVMLSKGDISTPEPVLVRTHALNALEDVLGLGPSPADELPRAMQIIAEEGR
HHHCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GAVLLFREPHPKLRLDGDEDDGPRTIKRTGVGAQIMSTMGLHELILLTDSPQTKYLGLEA
CEEEEEECCCCCEEECCCCCCCCCEEECCCCCHHHHHHCCCEEEEEEECCCCCEEEEEEE
YNLSIVGTRPITKD
EEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA