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The map label for this gene is idnD [H]

Identifier: 110678390

GI number: 110678390

Start: 1010849

End: 1011895

Strand: Reverse

Name: idnD [H]

Synonym: RD1_1048

Alternate gene names: 110678390

Gene position: 1011895-1010849 (Counterclockwise)

Preceding gene: 110678391

Following gene: 110678389

Centisome position: 24.48

GC content: 59.22

Gene sequence:

>1047_bases
GTGACCACCACAATTTGCAGACTTCACAGCAAAGGTGACTTGCGCGTTGAGGAGATCGCTTCACCGCCTCTGGAAGCGGG
CGACGTCGCGGTCGAAATTGCGCGCGGTGGCATCTGCGGATCAGACCTGCACTATTTCCAGCATGGTGGCTTTGGCCCGG
TGCGCGTGAAAGAACCCATCATTCTGGGCCACGAAATCGCGGGCGTCGTGAAATCGGTCGCACCGGGCGTCACCGCTGTG
GAACCGGGCGACAAAGTCGCGGTGAACCCCAGCCAGCCCTGCAATGATTGCCATTTCTGCACCCGCGAGGAATACCAGCA
TTGCCTGAACATGCGGTTTCTGGGCTCGGCCAGAACCTTTCCCCACGTGCAGGGGGGATTTCGCAGCATTCTGCCGGTGC
AAGCATCCCAATGCGTCAAAGTGAGCGCACACACCGATATCGCACATGCCGCCTGCGCCGAGCCGCTGGCGGTTTGTCTG
CATGCTGCAAATCAGGCGGGCGATCTGGCGGGCAAACGCGTTCTGGTCACCGGGGCCGGGCCGATTGGCGCGTTATGTGT
TGCTGTGGCCAAGGCACGGGGTGCATCGAATATCGTGGTGACGGATCTTGTTGATTTCACCCTGTCCAACGCGAGCAAAA
TGGGGGCAACGCACTGCATCAATATCGCGACATCAGCCGACCTGATGGACGCCTTCAGGTCGCCCGAACAACAATTCGAT
GTTGTGTTCGAATGCTCCGGTGCGGAGGCCGCGATTGCTATGGCGATTGAATTTGTCCGCCCGCGCGGCACATTGGTTCA
GGTCGGCGTCGCGGGGAGCCTGAATATCCCCATCAACGCCATTGTCGGAAAAGAAGTTTCGCTGAAGGGCACGCACCGTT
TCCACCCTGAATTTGCCGATGCGGTCCGGATGATCGACGAAGGGGTGATCGACGTCGCCCCCATGATCACGCAGGTCTTT
CCGGTGGAACAGGCACATGAGGCATTTGCGACCACGCTGGATCGCAACAAATCAATCAAGGTGCAGCTGTCGTTCCAGAG
CGTCTGA

Upstream 100 bases:

>100_bases
GTTTATCGCGACAAACATCATCGTTCTGTTGATGGTGTCCTACTTCCCCCCGCTGGCGACCTGGTTGCCCTCTGTCCTTA
TACCGTAAAAGGAGGTTTTC

Downstream 100 bases:

>100_bases
CGAAATACCTGAAGTATCAAGTATCACGTTGAAATCTTTGATTTCAGGCAGCGCCACGTGAACGAGGTTTGCCACGCAGC
GAATTGGCGGGGTCCCTGCG

Product: L-idonate 5-dehydrogenase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTTTICRLHSKGDLRVEEIASPPLEAGDVAVEIARGGICGSDLHYFQHGGFGPVRVKEPIILGHEIAGVVKSVAPGVTAV
EPGDKVAVNPSQPCNDCHFCTREEYQHCLNMRFLGSARTFPHVQGGFRSILPVQASQCVKVSAHTDIAHAACAEPLAVCL
HAANQAGDLAGKRVLVTGAGPIGALCVAVAKARGASNIVVTDLVDFTLSNASKMGATHCINIATSADLMDAFRSPEQQFD
VVFECSGAEAAIAMAIEFVRPRGTLVQVGVAGSLNIPINAIVGKEVSLKGTHRFHPEFADAVRMIDEGVIDVAPMITQVF
PVEQAHEAFATTLDRNKSIKVQLSFQSV

Sequences:

>Translated_348_residues
MTTTICRLHSKGDLRVEEIASPPLEAGDVAVEIARGGICGSDLHYFQHGGFGPVRVKEPIILGHEIAGVVKSVAPGVTAV
EPGDKVAVNPSQPCNDCHFCTREEYQHCLNMRFLGSARTFPHVQGGFRSILPVQASQCVKVSAHTDIAHAACAEPLAVCL
HAANQAGDLAGKRVLVTGAGPIGALCVAVAKARGASNIVVTDLVDFTLSNASKMGATHCINIATSADLMDAFRSPEQQFD
VVFECSGAEAAIAMAIEFVRPRGTLVQVGVAGSLNIPINAIVGKEVSLKGTHRFHPEFADAVRMIDEGVIDVAPMITQVF
PVEQAHEAFATTLDRNKSIKVQLSFQSV
>Mature_347_residues
TTTICRLHSKGDLRVEEIASPPLEAGDVAVEIARGGICGSDLHYFQHGGFGPVRVKEPIILGHEIAGVVKSVAPGVTAVE
PGDKVAVNPSQPCNDCHFCTREEYQHCLNMRFLGSARTFPHVQGGFRSILPVQASQCVKVSAHTDIAHAACAEPLAVCLH
AANQAGDLAGKRVLVTGAGPIGALCVAVAKARGASNIVVTDLVDFTLSNASKMGATHCINIATSADLMDAFRSPEQQFDV
VFECSGAEAAIAMAIEFVRPRGTLVQVGVAGSLNIPINAIVGKEVSLKGTHRFHPEFADAVRMIDEGVIDVAPMITQVFP
VEQAHEAFATTLDRNKSIKVQLSFQSV

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=34.7953216374269, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI4501933, Length=383, Percent_Identity=28.4595300261097, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI34577061, Length=379, Percent_Identity=29.023746701847, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501929, Length=376, Percent_Identity=28.1914893617021, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=27.6881720430108, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71743840, Length=372, Percent_Identity=27.6881720430108, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156523966, Length=354, Percent_Identity=26.271186440678, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4501939, Length=354, Percent_Identity=26.271186440678, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI71565154, Length=277, Percent_Identity=28.8808664259928, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=43.3544303797468, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=29.3948126801153, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1790045, Length=347, Percent_Identity=28.2420749279539, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788407, Length=320, Percent_Identity=30, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788075, Length=354, Percent_Identity=29.3785310734463, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787863, Length=342, Percent_Identity=27.1929824561404, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=27.7456647398844, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87082125, Length=351, Percent_Identity=26.7806267806268, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=25.2604166666667, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081918, Length=294, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=332, Percent_Identity=36.4457831325301, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=33.433734939759, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17562584, Length=317, Percent_Identity=25.2365930599369, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=25.7309941520468, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=294, Percent_Identity=25.1700680272109, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=332, Percent_Identity=35.2409638554217, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319955, Length=332, Percent_Identity=35.2409638554217, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=31.547619047619, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319257, Length=375, Percent_Identity=29.6, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=372, Percent_Identity=28.2258064516129, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323729, Length=282, Percent_Identity=29.7872340425532, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=265, Percent_Identity=27.9245283018868, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=351, Percent_Identity=25.9259259259259, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=270, Percent_Identity=25.9259259259259, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=270, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737897, Length=345, Percent_Identity=32.7536231884058, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17137530, Length=345, Percent_Identity=31.8840579710145, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=28.2666666666667, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221457811, Length=332, Percent_Identity=21.9879518072289, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45550770, Length=332, Percent_Identity=21.9879518072289, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551930, Length=332, Percent_Identity=21.9879518072289, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 36765; Mature: 36633

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTICRLHSKGDLRVEEIASPPLEAGDVAVEIARGGICGSDLHYFQHGGFGPVRVKEPI
CCCEEEEECCCCCEEHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEECCCE
ILGHEIAGVVKSVAPGVTAVEPGDKVAVNPSQPCNDCHFCTREEYQHCLNMRFLGSARTF
EECHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHCEEEECCCCCC
PHVQGGFRSILPVQASQCVKVSAHTDIAHAACAEPLAVCLHAANQAGDLAGKRVLVTGAG
CCCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
PIGALCVAVAKARGASNIVVTDLVDFTLSNASKMGATHCINIATSADLMDAFRSPEQQFD
HHHHHHHHHHHHCCCCCEEEEHHHHHHHCCHHHCCCCEEEEECCHHHHHHHHCCCCHHEE
VVFECSGAEAAIAMAIEFVRPRGTLVQVGVAGSLNIPINAIVGKEVSLKGTHRFHPEFAD
EEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCHHHH
AVRMIDEGVIDVAPMITQVFPVEQAHEAFATTLDRNKSIKVQLSFQSV
HHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEEECC
>Mature Secondary Structure 
TTTICRLHSKGDLRVEEIASPPLEAGDVAVEIARGGICGSDLHYFQHGGFGPVRVKEPI
CCEEEEECCCCCEEHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCEEECCCE
ILGHEIAGVVKSVAPGVTAVEPGDKVAVNPSQPCNDCHFCTREEYQHCLNMRFLGSARTF
EECHHHHHHHHHHCCCCEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHCEEEECCCCCC
PHVQGGFRSILPVQASQCVKVSAHTDIAHAACAEPLAVCLHAANQAGDLAGKRVLVTGAG
CCCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCC
PIGALCVAVAKARGASNIVVTDLVDFTLSNASKMGATHCINIATSADLMDAFRSPEQQFD
HHHHHHHHHHHHCCCCCEEEEHHHHHHHCCHHHCCCCEEEEECCHHHHHHHHCCCCHHEE
VVFECSGAEAAIAMAIEFVRPRGTLVQVGVAGSLNIPINAIVGKEVSLKGTHRFHPEFAD
EEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCHHHH
AVRMIDEGVIDVAPMITQVFPVEQAHEAFATTLDRNKSIKVQLSFQSV
HHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]