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The map label for this gene is dnaX [H]

Identifier: 110678389

GI number: 110678389

Start: 1008911

End: 1010659

Strand: Reverse

Name: dnaX [H]

Synonym: RD1_1047

Alternate gene names: 110678389

Gene position: 1010659-1008911 (Counterclockwise)

Preceding gene: 110678390

Following gene: 110678388

Centisome position: 24.45

GC content: 63.35

Gene sequence:

>1749_bases
ATGTCCGAAACACCGCACGCCCCCTATCAGGTTCTGGCGCGTAAATACCGCCCAGAGACCTTTGCCGACCTTGTTGGGCA
GGACGCGATGGTTCAGACGCTGAAAAACGCGTTTGAAGCGGACCGCATCGCGCAGGCTTTCATCATGACCGGCATCCGCG
GCACCGGTAAGACAACGACCGCCCGGATCATTGCCAAGGGCATGAACTGCATCGGCCCGGACGGCACGGGCAGGCCTACG
ACCGACCCCTGCGGGACCTGTGAACATTGCACCGCCATCATGGAAGGCCGCCACGTCGATGTGATGGAAATGGACGCGGC
GTCCAATACCGGGGTCGCGAACATCCGGGAAATCATCGATTCCGTCCACTACCGTGCTGCATCGGCCCGCTACAAAGTCT
ATATCATCGACGAAGTGCACATGCTGTCCACCGGCGCATTCAACGCGCTGCTCAAAACGCTGGAAGAGCCGCCGGAACAT
GTGAAATTCATCTTTGCCACCACGGAAATCCGCAAGGTGCCTGTGACCGTGCTGTCGCGTTGCCAGCGGTTTGACCTGCG
CCGCATCGAACCCGAGGTCATGATTGATCTGATGCGCAAAATTGCGACTGCCGAAGGGGCCGAAATCGCGCAGGACGCCA
TGGCTCTGATCGCGCGCGCGGCTGAAGGCTCCGCGCGGGATGCGACCTCGCTGCTGGATCAGGCCATCAGCCACGGCGCG
GGAGAGACAACAGCCGCGCAGGTGCGCGCCATGCTTGGACTGGCCGATCGCGGGCGGGTGCTGGACCTGTTTGACATGAT
CCTGCGCGGGGATACTGCGGGCGCGCTCACCGAACTGTCGGCACAATATGCCGAAGGGGCCGACCCGATGGCCGTGCTGC
GCGATCTGGCGGAGATCACCCATTGGGTGTCGGTGGTCAAGATCACCCCCGAAGCCGCCGAAGACCCCACCGTATCGCCC
GACGAACGCAGCCGCGGCCTTGAGATGGCGGGAGCCTTGCCCATGCGCGTGTTGACGCGGCTGTGGCAGATGCTGCTGAA
AGCCCTGGACGAAGTGGCAAGTGCCCCCAACGCAATGATGGCCGCCGAGATGGCGATCATCCGGCTAACCCATGTGGCGG
ATTTGCCCACGCCCGGCGAGTTGGTCCGCCAGCTCAAGGCGGACAACCCTCCGGCCCCCGCGCGCGGCAACACCGCCACG
CAAAGCCCGGCACCGCAGGGCACAAACGCAACCGCCCATGCCACGGCAAGACCCGCGCCCCCGTCCGGTTCCGGCACGGT
GGCGGCCCTTGCCGAGCAGCCGAATGAAGCCCTCGCGCGGTTTGTGAGCTTTGATCATGTGGTCGAACTGATCCGCGCCA
ACCGGGACGTAAAGCTCTTGGTTGAGGTCGAAGGCTGCGTGCGGCTGGCGCAATACCAACCCGGCCGGATCGAATTTGCA
CCGACAGAAAACGCGCCCGCCGATCTGGCGCAACGGCTTGGGCAGCGGCTGCAACTCTGGACCGGCAATCGCTGGGCCGT
CACAATTGTGAATGATGCATCCGCGCCGACGATTGCCGAAAAGCGAGACGCCGCCGAACTTGATCTGCAAAGCAAAGCGC
TCGAACACCCTTTGATGCAAGCGGTTCTGACGCAGTTTCCCAAGGCCCGCATCACCTCCATCAAAACCCCAGAGCAGATC
GCGGCAGCCGCCGTTGCGAATGCCCTGCCGGAGGTCGAAGACGAGTGGGACCCCTTCGAGGACAGTTGA

Upstream 100 bases:

>100_bases
GGGTCCCTGCGGCACTTCTTTGCCAAGTGCCGTTGTTCTTGGACGCGCTGCGCCTTAGTCTGCCAATCGTCGCTCCGATT
CCGTTCCAGCAAGGCTTTTC

Downstream 100 bases:

>100_bases
GCCCCTTGCGAGGGCGCCTCAAAACACGCATATCAAACGTAACGGATCACATAAGGACACAGCAGATGCTCAAAGGACTA
GGTTCACTCGGCGATATGGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MSETPHAPYQVLARKYRPETFADLVGQDAMVQTLKNAFEADRIAQAFIMTGIRGTGKTTTARIIAKGMNCIGPDGTGRPT
TDPCGTCEHCTAIMEGRHVDVMEMDAASNTGVANIREIIDSVHYRAASARYKVYIIDEVHMLSTGAFNALLKTLEEPPEH
VKFIFATTEIRKVPVTVLSRCQRFDLRRIEPEVMIDLMRKIATAEGAEIAQDAMALIARAAEGSARDATSLLDQAISHGA
GETTAAQVRAMLGLADRGRVLDLFDMILRGDTAGALTELSAQYAEGADPMAVLRDLAEITHWVSVVKITPEAAEDPTVSP
DERSRGLEMAGALPMRVLTRLWQMLLKALDEVASAPNAMMAAEMAIIRLTHVADLPTPGELVRQLKADNPPAPARGNTAT
QSPAPQGTNATAHATARPAPPSGSGTVAALAEQPNEALARFVSFDHVVELIRANRDVKLLVEVEGCVRLAQYQPGRIEFA
PTENAPADLAQRLGQRLQLWTGNRWAVTIVNDASAPTIAEKRDAAELDLQSKALEHPLMQAVLTQFPKARITSIKTPEQI
AAAAVANALPEVEDEWDPFEDS

Sequences:

>Translated_582_residues
MSETPHAPYQVLARKYRPETFADLVGQDAMVQTLKNAFEADRIAQAFIMTGIRGTGKTTTARIIAKGMNCIGPDGTGRPT
TDPCGTCEHCTAIMEGRHVDVMEMDAASNTGVANIREIIDSVHYRAASARYKVYIIDEVHMLSTGAFNALLKTLEEPPEH
VKFIFATTEIRKVPVTVLSRCQRFDLRRIEPEVMIDLMRKIATAEGAEIAQDAMALIARAAEGSARDATSLLDQAISHGA
GETTAAQVRAMLGLADRGRVLDLFDMILRGDTAGALTELSAQYAEGADPMAVLRDLAEITHWVSVVKITPEAAEDPTVSP
DERSRGLEMAGALPMRVLTRLWQMLLKALDEVASAPNAMMAAEMAIIRLTHVADLPTPGELVRQLKADNPPAPARGNTAT
QSPAPQGTNATAHATARPAPPSGSGTVAALAEQPNEALARFVSFDHVVELIRANRDVKLLVEVEGCVRLAQYQPGRIEFA
PTENAPADLAQRLGQRLQLWTGNRWAVTIVNDASAPTIAEKRDAAELDLQSKALEHPLMQAVLTQFPKARITSIKTPEQI
AAAAVANALPEVEDEWDPFEDS
>Mature_581_residues
SETPHAPYQVLARKYRPETFADLVGQDAMVQTLKNAFEADRIAQAFIMTGIRGTGKTTTARIIAKGMNCIGPDGTGRPTT
DPCGTCEHCTAIMEGRHVDVMEMDAASNTGVANIREIIDSVHYRAASARYKVYIIDEVHMLSTGAFNALLKTLEEPPEHV
KFIFATTEIRKVPVTVLSRCQRFDLRRIEPEVMIDLMRKIATAEGAEIAQDAMALIARAAEGSARDATSLLDQAISHGAG
ETTAAQVRAMLGLADRGRVLDLFDMILRGDTAGALTELSAQYAEGADPMAVLRDLAEITHWVSVVKITPEAAEDPTVSPD
ERSRGLEMAGALPMRVLTRLWQMLLKALDEVASAPNAMMAAEMAIIRLTHVADLPTPGELVRQLKADNPPAPARGNTATQ
SPAPQGTNATAHATARPAPPSGSGTVAALAEQPNEALARFVSFDHVVELIRANRDVKLLVEVEGCVRLAQYQPGRIEFAP
TENAPADLAQRLGQRLQLWTGNRWAVTIVNDASAPTIAEKRDAAELDLQSKALEHPLMQAVLTQFPKARITSIKTPEQIA
AAAVANALPEVEDEWDPFEDS

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=274, Percent_Identity=25.9124087591241, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI194306571, Length=277, Percent_Identity=25.6317689530686, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI194306567, Length=277, Percent_Identity=25.6317689530686, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4506491, Length=243, Percent_Identity=22.6337448559671, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI31881687, Length=243, Percent_Identity=22.6337448559671, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306569, Length=188, Percent_Identity=27.1276595744681, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786676, Length=360, Percent_Identity=43.0555555555556, Blast_Score=293, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17554730, Length=225, Percent_Identity=25.3333333333333, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=237, Percent_Identity=24.4725738396624, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=275, Percent_Identity=23.2727272727273, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859927, Length=237, Percent_Identity=24.8945147679325, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921076, Length=276, Percent_Identity=23.1884057971014, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62889; Mature: 62758

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETPHAPYQVLARKYRPETFADLVGQDAMVQTLKNAFEADRIAQAFIMTGIRGTGKTTT
CCCCCCCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ARIIAKGMNCIGPDGTGRPTTDPCGTCEHCTAIMEGRHVDVMEMDAASNTGVANIREIID
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHH
SVHYRAASARYKVYIIDEVHMLSTGAFNALLKTLEEPPEHVKFIFATTEIRKVPVTVLSR
HHHHHHHCCEEEEEEEECHHHHHHHHHHHHHHHHHCCHHHEEEEEEEHHHHHHHHHHHHH
CQRFDLRRIEPEVMIDLMRKIATAEGAEIAQDAMALIARAAEGSARDATSLLDQAISHGA
HHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
GETTAAQVRAMLGLADRGRVLDLFDMILRGDTAGALTELSAQYAEGADPMAVLRDLAEIT
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
HWVSVVKITPEAAEDPTVSPDERSRGLEMAGALPMRVLTRLWQMLLKALDEVASAPNAMM
HHHHHEEECCCCCCCCCCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
AAEMAIIRLTHVADLPTPGELVRQLKADNPPAPARGNTATQSPAPQGTNATAHATARPAP
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSGSGTVAALAEQPNEALARFVSFDHVVELIRANRDVKLLVEVEGCVRLAQYQPGRIEFA
CCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCEEEC
PTENAPADLAQRLGQRLQLWTGNRWAVTIVNDASAPTIAEKRDAAELDLQSKALEHPLMQ
CCCCCHHHHHHHHHHHHEEEECCEEEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHH
AVLTQFPKARITSIKTPEQIAAAAVANALPEVEDEWDPFEDS
HHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SETPHAPYQVLARKYRPETFADLVGQDAMVQTLKNAFEADRIAQAFIMTGIRGTGKTTT
CCCCCCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
ARIIAKGMNCIGPDGTGRPTTDPCGTCEHCTAIMEGRHVDVMEMDAASNTGVANIREIID
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHH
SVHYRAASARYKVYIIDEVHMLSTGAFNALLKTLEEPPEHVKFIFATTEIRKVPVTVLSR
HHHHHHHCCEEEEEEEECHHHHHHHHHHHHHHHHHCCHHHEEEEEEEHHHHHHHHHHHHH
CQRFDLRRIEPEVMIDLMRKIATAEGAEIAQDAMALIARAAEGSARDATSLLDQAISHGA
HHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
GETTAAQVRAMLGLADRGRVLDLFDMILRGDTAGALTELSAQYAEGADPMAVLRDLAEIT
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
HWVSVVKITPEAAEDPTVSPDERSRGLEMAGALPMRVLTRLWQMLLKALDEVASAPNAMM
HHHHHEEECCCCCCCCCCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
AAEMAIIRLTHVADLPTPGELVRQLKADNPPAPARGNTATQSPAPQGTNATAHATARPAP
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSGSGTVAALAEQPNEALARFVSFDHVVELIRANRDVKLLVEVEGCVRLAQYQPGRIEFA
CCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCEEEC
PTENAPADLAQRLGQRLQLWTGNRWAVTIVNDASAPTIAEKRDAAELDLQSKALEHPLMQ
CCCCCHHHHHHHHHHHHEEEECCEEEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHH
AVLTQFPKARITSIKTPEQIAAAAVANALPEVEDEWDPFEDS
HHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]