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The map label for this gene is iorB [H]

Identifier: 110677653

GI number: 110677653

Start: 245753

End: 247936

Strand: Direct

Name: iorB [H]

Synonym: RD1_0247

Alternate gene names: 110677653

Gene position: 245753-247936 (Clockwise)

Preceding gene: 110677652

Following gene: 110677654

Centisome position: 5.95

GC content: 61.63

Gene sequence:

>2184_bases
ATGCACGCCATCAAACCCGCGCATTCAAAGTCGAACGCAGATGCAACAGGCCCCTCGCGCCGCGCCTTTCTGGCCGGTGC
CACGGGTCTTGTCGTTGCCATGGCGCTTCCCATCAAAGGGCGCGCACAGGCTGTCGCAACGGCGCAGGCCGCATTCGCGC
CAAATGCCTTTATCCGGGTGTCGCCGGACAATATCGTCACAGTGCTCATCAAACACGTTGAGATGGGGCAAGGTGCAAAC
ACCGGACTGGCGATTCTTGCCGCTGAGGAAATGGATGCCGATTGGAGCCAGATCCGCGCAGAGCAGGCACCCGACGACCC
GTCCCTTTACGCAAATCTCGCCTTTGGGGTACAGGGCACGGGTGGGTCCACCGGCCTGTCGAACAGCTATATGACAATGC
GCGAGGCCGGGGCCACGGCGCGCGCGCTCCTCATCGAAGCTGCGGCACAGACTTGGGGTATCCCGGCCGGTGATGTTTCT
GTCTCGGCAGGTGTGGTCTCCAACGACGCGACAGGGCAAACCGCGACCTTCGGTGAGTTGGCAGAGCGCGCAGCGACACT
GCCCATGCCGCAGGATGTGACATTGAAAGACCCCTCTGAATTCAAGCTGATCGGCGCCGAAGGGATCACCCGACTTGATG
CGGCGGACAAAGCGCGCGGCAAGTCGACCTTCAGCATTGATGTCATGCGGGATGGAATGCAGGTGGTGACGGTGCTTCAC
CCCCCGAAATTCGGCGCTGTTTTGGCATCCTTTGATGCAACGGCGGCGCTTGACGTGCCCGGCGTGACGGCAGTGCACCA
GATTGCCAGCGGCGTTGCCGTTTACGGCGCGGATACATTTGCAGCCTTGCGTGGCAGAGATGCGCTGGTTGTACAGTGGG
ATGAAACAAACGCCGAAACGCGCTCATCACAGGAAATCGAAGAAGAGTTCCTGAAAGCGGCGCGCAGTCCGGCCCGCGTT
GCAGAAAACATCGGTGACGTCGATGCGGCTTTCGACCAGGCGGAACGCTCTTTTGAGGCGGAATACATCTTTCCATACCT
CGCGCATGCGGCAATGGAGCCCCTGGACGGCGTCGTTGAATGGACACCGGACCGTGTCGATGTCTGGTCCGCGATACAAA
TCCCGACCATCGCAGCACCGGTGTTCTCTTCAACCTTGGGCGTGGCACCCGAAGCCGTATCGCTTCACACGATGTACGCA
GGCGGCAGTTTTGGGCATCGGGCAACAGCGACCAATCACTTTGAAAATGAAATGGCGCAAGTGGCAGCGGCGGCAGGTCC
GGGATCCTACAAGCTGCAGTGGACCCGGGAAGATGATATGACCCAAGGGTACTACCGCCCCCTCACGGTGCACCGTTTCC
GCGGTGGTCTTGATGCCGATGGCAACATTACTGGCTGGGATAATACGGTTGCAAATCAATCTATTATGGCTGGCACCATG
TTTGAACAAGCCCTGATGGGCGATGGGCTTGATCGCACCTCTTACGAGGGATCGACCGATCTGCCATATGCGCTTCCGGC
GCGGCGGGTGTCCTGGGCGCAGATGCAGACCGGTGTGCCCGTTCTGTGGTGGCGCGCGGTCGGTCACACGCACACCGCCT
ATGCGACCGAGACTTTTCTTGACGAATTGCTGATCGCCGGTGGTCGCGACCCGGTTCAAGGGCGGCTTGATCTGATCACG
CAGGACCGTCCGCGCGATCGCGCGGTTCTGGAACGTGTCGCTGAAATGGCGCAGTGGAGTGGCCCCGGCACAGGCGAGCG
TCGCTATGGCGTCGCCTTGCATCGTTCCTTTGGCAGTTTCGTTGCACAGATTGCGGAAGTGGAAAACCGGGACGGGACCC
CGCACGTCACCCGCGTCTGGTGCGCGCTGGATTGCGGCGTGGCGGTGACACCGGATGTTGTGCGCGCGCAGATGGAAGGC
GGCATTGGGTTTGGCCTCAGCGCGGCGCTGTTCGAGCAGCTGACGCTGGAAGCTGGCGGCACCGTGCGGGAGCGTAACTT
TGACGCCTACCGTGTGCTTGGGCTGGAGGAGATGCCCGAGATCATGGTGGATATCATGCCAAGCGAAGTGGCGCCCACCG
GCGTCGGGGAACCCGGAACACCGCCGATTGCCGCTGCGGTCGGCAACGCCTGGCGCGCCCACACCGGACAAACTCCGCGA
CGGCTGCCGATCATCGGGGCATAG

Upstream 100 bases:

>100_bases
AATCGACGCCGCCATGGGGGCCAATATTTGCCGTTGCGCGACCTACGCGCGTATTCGCAAGGGCGTTCGCGCCGCTTCCG
ATAGCCTGGAGGCATAAACC

Downstream 100 bases:

>100_bases
TCGCGCAAAACCATAACACCAAGGCAAAGCGCGCAGTGCCTTGGTGGCGGTGGGTCGAGTTTTGGCTCACGCGACGTTTG
GCACGCGGAATTCCCGCTTT

Product: isoquinoline 1-oxidoreductase, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MHAIKPAHSKSNADATGPSRRAFLAGATGLVVAMALPIKGRAQAVATAQAAFAPNAFIRVSPDNIVTVLIKHVEMGQGAN
TGLAILAAEEMDADWSQIRAEQAPDDPSLYANLAFGVQGTGGSTGLSNSYMTMREAGATARALLIEAAAQTWGIPAGDVS
VSAGVVSNDATGQTATFGELAERAATLPMPQDVTLKDPSEFKLIGAEGITRLDAADKARGKSTFSIDVMRDGMQVVTVLH
PPKFGAVLASFDATAALDVPGVTAVHQIASGVAVYGADTFAALRGRDALVVQWDETNAETRSSQEIEEEFLKAARSPARV
AENIGDVDAAFDQAERSFEAEYIFPYLAHAAMEPLDGVVEWTPDRVDVWSAIQIPTIAAPVFSSTLGVAPEAVSLHTMYA
GGSFGHRATATNHFENEMAQVAAAAGPGSYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITGWDNTVANQSIMAGTM
FEQALMGDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFLDELLIAGGRDPVQGRLDLIT
QDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSFVAQIAEVENRDGTPHVTRVWCALDCGVAVTPDVVRAQMEG
GIGFGLSAALFEQLTLEAGGTVRERNFDAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPIAAAVGNAWRAHTGQTPR
RLPIIGA

Sequences:

>Translated_727_residues
MHAIKPAHSKSNADATGPSRRAFLAGATGLVVAMALPIKGRAQAVATAQAAFAPNAFIRVSPDNIVTVLIKHVEMGQGAN
TGLAILAAEEMDADWSQIRAEQAPDDPSLYANLAFGVQGTGGSTGLSNSYMTMREAGATARALLIEAAAQTWGIPAGDVS
VSAGVVSNDATGQTATFGELAERAATLPMPQDVTLKDPSEFKLIGAEGITRLDAADKARGKSTFSIDVMRDGMQVVTVLH
PPKFGAVLASFDATAALDVPGVTAVHQIASGVAVYGADTFAALRGRDALVVQWDETNAETRSSQEIEEEFLKAARSPARV
AENIGDVDAAFDQAERSFEAEYIFPYLAHAAMEPLDGVVEWTPDRVDVWSAIQIPTIAAPVFSSTLGVAPEAVSLHTMYA
GGSFGHRATATNHFENEMAQVAAAAGPGSYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITGWDNTVANQSIMAGTM
FEQALMGDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFLDELLIAGGRDPVQGRLDLIT
QDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSFVAQIAEVENRDGTPHVTRVWCALDCGVAVTPDVVRAQMEG
GIGFGLSAALFEQLTLEAGGTVRERNFDAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPIAAAVGNAWRAHTGQTPR
RLPIIGA
>Mature_727_residues
MHAIKPAHSKSNADATGPSRRAFLAGATGLVVAMALPIKGRAQAVATAQAAFAPNAFIRVSPDNIVTVLIKHVEMGQGAN
TGLAILAAEEMDADWSQIRAEQAPDDPSLYANLAFGVQGTGGSTGLSNSYMTMREAGATARALLIEAAAQTWGIPAGDVS
VSAGVVSNDATGQTATFGELAERAATLPMPQDVTLKDPSEFKLIGAEGITRLDAADKARGKSTFSIDVMRDGMQVVTVLH
PPKFGAVLASFDATAALDVPGVTAVHQIASGVAVYGADTFAALRGRDALVVQWDETNAETRSSQEIEEEFLKAARSPARV
AENIGDVDAAFDQAERSFEAEYIFPYLAHAAMEPLDGVVEWTPDRVDVWSAIQIPTIAAPVFSSTLGVAPEAVSLHTMYA
GGSFGHRATATNHFENEMAQVAAAAGPGSYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITGWDNTVANQSIMAGTM
FEQALMGDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFLDELLIAGGRDPVQGRLDLIT
QDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSFVAQIAEVENRDGTPHVTRVWCALDCGVAVTPDVVRAQMEG
GIGFGLSAALFEQLTLEAGGTVRERNFDAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPIAAAVGNAWRAHTGQTPR
RLPIIGA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012368
- InterPro:   IPR006311 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 77244; Mature: 77244

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAIKPAHSKSNADATGPSRRAFLAGATGLVVAMALPIKGRAQAVATAQAAFAPNAFIRV
CCCCCCCCCCCCCCCCCCCCEEEEECCHHEEEEEECCCCCCHHHHHHHHHHCCCCCEEEE
SPDNIVTVLIKHVEMGQGANTGLAILAAEEMDADWSQIRAEQAPDDPSLYANLAFGVQGT
CCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEEEEECC
GGSTGLSNSYMTMREAGATARALLIEAAAQTWGIPAGDVSVSAGVVSNDATGQTATFGEL
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEECCEECCCCCCCCCHHHHH
AERAATLPMPQDVTLKDPSEFKLIGAEGITRLDAADKARGKSTFSIDVMRDGMQVVTVLH
HHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEEECCCEEEEEEEC
PPKFGAVLASFDATAALDVPGVTAVHQIASGVAVYGADTFAALRGRDALVVQWDETNAET
CCCCCHHEECCCCCEEECCCCHHHHHHHHCCEEEECCCHHHHHCCCCEEEEEECCCCCCC
RSSQEIEEEFLKAARSPARVAENIGDVDAAFDQAERSFEAEYIFPYLAHAAMEPLDGVVE
CCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEE
WTPDRVDVWSAIQIPTIAAPVFSSTLGVAPEAVSLHTMYAGGSFGHRATATNHFENEMAQ
CCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
VAAAAGPGSYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITGWDNTVANQSIMAGTM
HHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHH
FEQALMGDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFL
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
DELLIAGGRDPVQGRLDLITQDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSF
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
VAQIAEVENRDGTPHVTRVWCALDCGVAVTPDVVRAQMEGGIGFGLSAALFEQLTLEAGG
HHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
TVRERNFDAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPIAAAVGNAWRAHTGQTPR
CEEECCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCC
RLPIIGA
CCCCCCC
>Mature Secondary Structure
MHAIKPAHSKSNADATGPSRRAFLAGATGLVVAMALPIKGRAQAVATAQAAFAPNAFIRV
CCCCCCCCCCCCCCCCCCCCEEEEECCHHEEEEEECCCCCCHHHHHHHHHHCCCCCEEEE
SPDNIVTVLIKHVEMGQGANTGLAILAAEEMDADWSQIRAEQAPDDPSLYANLAFGVQGT
CCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEEEEEEECC
GGSTGLSNSYMTMREAGATARALLIEAAAQTWGIPAGDVSVSAGVVSNDATGQTATFGEL
CCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEECCEECCCCCCCCCHHHHH
AERAATLPMPQDVTLKDPSEFKLIGAEGITRLDAADKARGKSTFSIDVMRDGMQVVTVLH
HHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEEECCCEEEEEEEC
PPKFGAVLASFDATAALDVPGVTAVHQIASGVAVYGADTFAALRGRDALVVQWDETNAET
CCCCCHHEECCCCCEEECCCCHHHHHHHHCCEEEECCCHHHHHCCCCEEEEEECCCCCCC
RSSQEIEEEFLKAARSPARVAENIGDVDAAFDQAERSFEAEYIFPYLAHAAMEPLDGVVE
CCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEE
WTPDRVDVWSAIQIPTIAAPVFSSTLGVAPEAVSLHTMYAGGSFGHRATATNHFENEMAQ
CCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
VAAAAGPGSYKLQWTREDDMTQGYYRPLTVHRFRGGLDADGNITGWDNTVANQSIMAGTM
HHHHCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHH
FEQALMGDGLDRTSYEGSTDLPYALPARRVSWAQMQTGVPVLWWRAVGHTHTAYATETFL
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
DELLIAGGRDPVQGRLDLITQDRPRDRAVLERVAEMAQWSGPGTGERRYGVALHRSFGSF
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
VAQIAEVENRDGTPHVTRVWCALDCGVAVTPDVVRAQMEGGIGFGLSAALFEQLTLEAGG
HHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
TVRERNFDAYRVLGLEEMPEIMVDIMPSEVAPTGVGEPGTPPIAAAVGNAWRAHTGQTPR
CEEECCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCCC
RLPIIGA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]