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The map label for this gene is iorA [H]

Identifier: 110677652

GI number: 110677652

Start: 245288

End: 245749

Strand: Direct

Name: iorA [H]

Synonym: RD1_0246

Alternate gene names: 110677652

Gene position: 245288-245749 (Clockwise)

Preceding gene: 110677651

Following gene: 110677653

Centisome position: 5.93

GC content: 58.87

Gene sequence:

>462_bases
ATGCCCACCACATTCAACGTTAATGGCAACCCGGTAACATTGGACGTCGATCCAGACATGCCACTCCTTTGGGCCTTGCG
GGATCATCTGAAGCTCACTGGGACGAAATATGGCTGCGGGATTGCCCAGTGCGGGTCCTGTACCGTAATGCTTGACGGGT
TTGCGGCGCGGTCCTGCGTTACAACCGTCGGGGATGTGGCGGGATCGCAGGTTCAGACAATCGAGGGTGTGGAAAGCGCC
GCCGCCCGCGCGGTACAGCAAGCTTGGACGACCCTGAATGTTGCGCAATGCGGCTATTGTCAGTCCGGTCAGGTCCTTGT
CGCAACTGAATTGCTGGAGAATACGCCCAAGCCGACCGATGAAGAAATCGACGCCGCCATGGGGGCCAATATTTGCCGTT
GCGCGACCTACGCGCGTATTCGCAAGGGCGTTCGCGCCGCTTCCGATAGCCTGGAGGCATAA

Upstream 100 bases:

>100_bases
CCAGCGTCCCGCCCTTGCCCGGCTTGACTTTGCCACGAACCGGCCAAGTTTATGACGTAACCAAAAGGTTAATCGCCCCG
GCTTTGAAAGGACGCACCCC

Downstream 100 bases:

>100_bases
ACCATGCACGCCATCAAACCCGCGCATTCAAAGTCGAACGCAGATGCAACAGGCCCCTCGCGCCGCGCCTTTCTGGCCGG
TGCCACGGGTCTTGTCGTTG

Product: isoquinoline 1-oxidoreductase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MPTTFNVNGNPVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTVMLDGFAARSCVTTVGDVAGSQVQTIEGVESA
AARAVQQAWTTLNVAQCGYCQSGQVLVATELLENTPKPTDEEIDAAMGANICRCATYARIRKGVRAASDSLEA

Sequences:

>Translated_153_residues
MPTTFNVNGNPVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTVMLDGFAARSCVTTVGDVAGSQVQTIEGVESA
AARAVQQAWTTLNVAQCGYCQSGQVLVATELLENTPKPTDEEIDAAMGANICRCATYARIRKGVRAASDSLEA
>Mature_152_residues
PTTFNVNGNPVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTVMLDGFAARSCVTTVGDVAGSQVQTIEGVESAA
ARAVQQAWTTLNVAQCGYCQSGQVLVATELLENTPKPTDEEIDAAMGANICRCATYARIRKGVRAASDSLEA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=154, Percent_Identity=39.6103896103896, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI71773480, Length=149, Percent_Identity=39.5973154362416, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1786480, Length=169, Percent_Identity=35.5029585798817, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1789232, Length=137, Percent_Identity=35.7664233576642, Blast_Score=85, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=148, Percent_Identity=41.8918918918919, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=40, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32566215, Length=163, Percent_Identity=38.0368098159509, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17737937, Length=160, Percent_Identity=35, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24647201, Length=161, Percent_Identity=32.9192546583851, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24647199, Length=156, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24647197, Length=167, Percent_Identity=34.1317365269461, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647195, Length=167, Percent_Identity=34.1317365269461, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647193, Length=157, Percent_Identity=33.7579617834395, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16100; Mature: 15969

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTFNVNGNPVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTVMLDGFAARSCV
CCCEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHH
TTVGDVAGSQVQTIEGVESAAARAVQQAWTTLNVAQCGYCQSGQVLVATELLENTPKPTD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCEEEEEHHHHCCCCCCC
EEIDAAMGANICRCATYARIRKGVRAASDSLEA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PTTFNVNGNPVTLDVDPDMPLLWALRDHLKLTGTKYGCGIAQCGSCTVMLDGFAARSCV
CCEECCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHH
TTVGDVAGSQVQTIEGVESAAARAVQQAWTTLNVAQCGYCQSGQVLVATELLENTPKPTD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCEEEEEHHHHCCCCCCC
EEIDAAMGANICRCATYARIRKGVRAASDSLEA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]