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The map label for this gene is aroA

Identifier: 110635935

GI number: 110635935

Start: 3892566

End: 3893915

Strand: Reverse

Name: aroA

Synonym: Meso_3609

Alternate gene names: 110635935

Gene position: 3893915-3892566 (Counterclockwise)

Preceding gene: 110635937

Following gene: 110635934

Centisome position: 88.25

GC content: 63.48

Gene sequence:

>1350_bases
ATGAACCATCATCTTCCCAGCCGCCCCGCGCGCAGCCGCCAGTCGCAGGGCCTTAAAGGTAATCTGCGCGTGCCGGGTGA
CAAGTCCATTTCGCACCGGGCGCTGATGTTCGGAGGCCTCGCCTCGGGCGAGACGCGCATCTCTGGGCTGCTCGAAGGCG
AGGACGTGCTGCGGACGGCCGAAGCGATGAGGGCGATGGGCGCGCAGATCGACCGCCGGGACGGGACCTGGACCATCCGT
GGGGTCGGCAATGGCTGCCTTCTGGAGCCGGAGGCGCCGCTCGATTTTGGCAATGCGGGTACGGGTTCGCGCCTTACAAT
GGGTCTTGTCGGCACTTATGACATGACGACCCGCTTCACTGGCGACGCATCGCTTTCCAAGCGGCCCATGGGCCGGGTGC
TTAATCCGCTGCGCGAAATGGGCACCCAGGTGCTGCAGGCAGAGCCGGGGGACCGGCTGCCGATCACGCTGCGCGGGCCG
AAACATGCCACGCCGATAAACTACCGCGTGCCGATGGCCTCCGCCCAGGTGAAGTCGGCCGTGCTGCTTGCCGGCCTCAA
CACGCCGGGCGTCACAACGGTGATCGAACCGGTAATGACGCGCGACCATACGGAGAAGATGCTTTCGGGGTTCGGTGCTG
CCATCCAGATCGAGACGGATAAAGAGGGCGCGCGCCACATCAGTATTCAGGGGCAGGGCACGCTCAAAGGGCAGGTGATC
GCAGTGCCGGGCGACCCTTCTTCCGCCGCGTTTCCTCTTGTGGCGGCGCTCATTGTGCCGGGGTCAGACATCCTTATCGA
GAATGTACTGATGAATCCGACCCGCACCGGCCTTATCTTGACGCTGCAGGAGATGGGCGCGGATATCGAACTTCTGAATC
GCCGCTCCGCCGGCGGCGAGGATGTGGCGGATCTCCGCGTGCGATCCTCGGCGCTGAAGGGCGTGACGGTTCCCGCTTCG
CGCGCGCCATCCATGATAGACGAGTACCCAATTTTGGCCGTGGCTGCGAGTTTGGCGGAAGGCGAGACGGTGATGCTGGG
GCTTGAGGAGCTGCGCGTTAAGGAATCCGATCGCCTGTCCGCGGTTGCCGAGGGGCTCAAGGTGAATGGCATCGACTGCA
CGGAGGGCAAGGATACGCTTACGGTGCGTGGCAGGCCAGAGGGTAAGGGTCTTGGCGGGGCGACCGTGACTACTCACCTT
GATCACCGCATTGCGATGGCCTTTCTGGTGCTGGGCCTGGCGAGCGAAAGGCCCGTTAGCGTGGACGATCAGTCGATGAT
TGCGACCAGTTTTCCGGAATTCATGGACCTGATGACCGGGCTGGGGGCAGAAATCGAGGATAGGGATTAA

Upstream 100 bases:

>100_bases
GCTAATTGCAAGGCTTTGCGCAGCCCCGCTTTCCTGGGGGATGACCGGCAATTTGCGACGTGCTAGAGCCACACCACAAA
TGGCCCTGGAGAGAACGCGC

Downstream 100 bases:

>100_bases
CAACTATGGCTGACGCGAAAGTGGCGATGGTCATCGGCGGCGGCAGCGGCATCGGGGCTGCAGGCGCGCGCCGGCTGGCC
GAAGACGGGTACTCGGTGGC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MNHHLPSRPARSRQSQGLKGNLRVPGDKSISHRALMFGGLASGETRISGLLEGEDVLRTAEAMRAMGAQIDRRDGTWTIR
GVGNGCLLEPEAPLDFGNAGTGSRLTMGLVGTYDMTTRFTGDASLSKRPMGRVLNPLREMGTQVLQAEPGDRLPITLRGP
KHATPINYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLSGFGAAIQIETDKEGARHISIQGQGTLKGQVI
AVPGDPSSAAFPLVAALIVPGSDILIENVLMNPTRTGLILTLQEMGADIELLNRRSAGGEDVADLRVRSSALKGVTVPAS
RAPSMIDEYPILAVAASLAEGETVMLGLEELRVKESDRLSAVAEGLKVNGIDCTEGKDTLTVRGRPEGKGLGGATVTTHL
DHRIAMAFLVLGLASERPVSVDDQSMIATSFPEFMDLMTGLGAEIEDRD

Sequences:

>Translated_449_residues
MNHHLPSRPARSRQSQGLKGNLRVPGDKSISHRALMFGGLASGETRISGLLEGEDVLRTAEAMRAMGAQIDRRDGTWTIR
GVGNGCLLEPEAPLDFGNAGTGSRLTMGLVGTYDMTTRFTGDASLSKRPMGRVLNPLREMGTQVLQAEPGDRLPITLRGP
KHATPINYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLSGFGAAIQIETDKEGARHISIQGQGTLKGQVI
AVPGDPSSAAFPLVAALIVPGSDILIENVLMNPTRTGLILTLQEMGADIELLNRRSAGGEDVADLRVRSSALKGVTVPAS
RAPSMIDEYPILAVAASLAEGETVMLGLEELRVKESDRLSAVAEGLKVNGIDCTEGKDTLTVRGRPEGKGLGGATVTTHL
DHRIAMAFLVLGLASERPVSVDDQSMIATSFPEFMDLMTGLGAEIEDRD
>Mature_449_residues
MNHHLPSRPARSRQSQGLKGNLRVPGDKSISHRALMFGGLASGETRISGLLEGEDVLRTAEAMRAMGAQIDRRDGTWTIR
GVGNGCLLEPEAPLDFGNAGTGSRLTMGLVGTYDMTTRFTGDASLSKRPMGRVLNPLREMGTQVLQAEPGDRLPITLRGP
KHATPINYRVPMASAQVKSAVLLAGLNTPGVTTVIEPVMTRDHTEKMLSGFGAAIQIETDKEGARHISIQGQGTLKGQVI
AVPGDPSSAAFPLVAALIVPGSDILIENVLMNPTRTGLILTLQEMGADIELLNRRSAGGEDVADLRVRSSALKGVTVPAS
RAPSMIDEYPILAVAASLAEGETVMLGLEELRVKESDRLSAVAEGLKVNGIDCTEGKDTLTVRGRPEGKGLGGATVTTHL
DHRIAMAFLVLGLASERPVSVDDQSMIATSFPEFMDLMTGLGAEIEDRD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=432, Percent_Identity=28.9351851851852, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320332, Length=471, Percent_Identity=26.963906581741, Blast_Score=110, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_MESSB (Q11C97)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_676143.1
- ProteinModelPortal:   Q11C97
- SMR:   Q11C97
- STRING:   Q11C97
- GeneID:   4181206
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3609
- NMPDR:   fig|266779.1.peg.927
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- BioCyc:   MSP266779:MESO_3609-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 47577; Mature: 47577

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHHLPSRPARSRQSQGLKGNLRVPGDKSISHRALMFGGLASGETRISGLLEGEDVLRTA
CCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCEEEEECCCCCCCHHHHEEECCHHHHHHH
EAMRAMGAQIDRRDGTWTIRGVGNGCLLEPEAPLDFGNAGTGSRLTMGLVGTYDMTTRFT
HHHHHHCCCEECCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEEEC
GDASLSKRPMGRVLNPLREMGTQVLQAEPGDRLPITLRGPKHATPINYRVPMASAQVKSA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEECCCCHHHHCCE
VLLAGLNTPGVTTVIEPVMTRDHTEKMLSGFGAAIQIETDKEGARHISIQGQGTLKGQVI
EEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCEEEE
AVPGDPSSAAFPLVAALIVPGSDILIENVLMNPTRTGLILTLQEMGADIELLNRRSAGGE
EECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEHHHHCCCEEEHHCCCCCCC
DVADLRVRSSALKGVTVPASRAPSMIDEYPILAVAASLAEGETVMLGLEELRVKESDRLS
CHHHHHHHHHHHCCEECCCCCCCCHHHCCCHHHHHHHHCCCCEEEEEHHHHHCCCCHHHH
AVAEGLKVNGIDCTEGKDTLTVRGRPEGKGLGGATVTTHLDHRIAMAFLVLGLASERPVS
HHHCCCEECCEECCCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCC
VDDQSMIATSFPEFMDLMTGLGAEIEDRD
CCCCHHHHHCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNHHLPSRPARSRQSQGLKGNLRVPGDKSISHRALMFGGLASGETRISGLLEGEDVLRTA
CCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCEEEEECCCCCCCHHHHEEECCHHHHHHH
EAMRAMGAQIDRRDGTWTIRGVGNGCLLEPEAPLDFGNAGTGSRLTMGLVGTYDMTTRFT
HHHHHHCCCEECCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEEEC
GDASLSKRPMGRVLNPLREMGTQVLQAEPGDRLPITLRGPKHATPINYRVPMASAQVKSA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEECCCCHHHHCCE
VLLAGLNTPGVTTVIEPVMTRDHTEKMLSGFGAAIQIETDKEGARHISIQGQGTLKGQVI
EEEEECCCCCHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCEEEE
AVPGDPSSAAFPLVAALIVPGSDILIENVLMNPTRTGLILTLQEMGADIELLNRRSAGGE
EECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEHHHHCCCEEEHHCCCCCCC
DVADLRVRSSALKGVTVPASRAPSMIDEYPILAVAASLAEGETVMLGLEELRVKESDRLS
CHHHHHHHHHHHCCEECCCCCCCCHHHCCCHHHHHHHHCCCCEEEEEHHHHHCCCCHHHH
AVAEGLKVNGIDCTEGKDTLTVRGRPEGKGLGGATVTTHLDHRIAMAFLVLGLASERPVS
HHHCCCEECCEECCCCCCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCC
VDDQSMIATSFPEFMDLMTGLGAEIEDRD
CCCCHHHHHCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA