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The map label for this gene is pgk

Identifier: 110635765

GI number: 110635765

Start: 3715235

End: 3716431

Strand: Reverse

Name: pgk

Synonym: Meso_3437

Alternate gene names: 110635765

Gene position: 3716431-3715235 (Counterclockwise)

Preceding gene: 110635766

Following gene: 110635764

Centisome position: 84.23

GC content: 59.9

Gene sequence:

>1197_bases
ATGGCCGGTTTCAAGACATTGGACGATTTGAAGGATGTAGCGGGAAAGCGTGTGCTTCTGCGCGTGGACTTGAATGTGCC
GGTAAAGGATGGGGAGGTTACGGACACGACCCGCATCGAGCGTGTTGCGCCGACCATTACGGAGCTTTCCGACAAGGGTG
CCAAGGTTATCTTGCTTGCCCATTTCGGTCGGCCCAAGGGCAAGCCGGATGCAGAGGCTTCTCTACAGCCGATTGCACAT
GCGGTGGAAGCAGTCCTCGATCGGCGCGTCCACTTCGCATCCAGCTGCATAGGCGAACCGGCGAAGAAGGCCGTGGACGA
AATGACGGGCGGGGACATCCTGCTTCTGGAAAACACCCGCTTTCACGCGGGCGAGGAAAAGAACGACCCGGAATTTACGA
AGGCGCTCGCGGCAAATGGCGACATCTATGTCAACGATGCCTTTTCTGCCGCCCATCGCGCGCATGCCTCGACGGAAGGG
CTGGCGCATCTCCTTCCCGCTTATGCGGGACGCACCATCCAGGCGGAGCTCGAAGCTCTCCAGCGCGGTCTTGGAGATCC
GAAACGCCCTGTGGTGGCGATCGTCGGCGGCGCGAAAGTCTCCACCAAAATCGATCTGCTCACCAATCTCGTGAAGAAGG
TCGACTGTCTCGTTATCGGAGGCGGGATGGCCAACACCTTCCTTGCAGCGCGCGGCACTTCCGTCGGCAAGTCGTTATGC
GAGCACGATCTTAGGGAAACAGCCAAACAGATCATGATCGATGCGGCTGAGGCCGGCTGTGCGATCATCCTGCCAGTCGA
CGCGGTGGTGGCACGGAAATTCGAAGCTGGGGCGGAAACCGAGACGGTCGACATCGACGCCGTGCCGGAAGATGCTATGA
TCCTCGATGTCGGGCCGAAGTCGGTCGAAAAGGTGAAAGAGTGGCTGGACCGGGCCGACACGCTGGTTTGGAATGGGCCT
CTCGGCGCTTTCGAGCTTTCGCCTTTCGACAAGGCTACCATGGAGGTAGCAAAGTATGCCGCCCGGCGAACCCGTGAGAG
CCTCCTGGTGTCGGTCGCAGGCGGCGGCGATACGGTAGCAGCACTCAACCAGGCGGATGTGTCTGATGACTTCAGCTATG
TCTCGACCGCCGGTGGCGCTTTCCTTGAGTGGATGGAAGGCAAGGACCTTCCGGGCGTTGCAGCGCTTCAGAAGTGA

Upstream 100 bases:

>100_bases
CCACGAAAGCAGAGGAAGGCATTCAGGAGTAAATCCCGCCTTGCGTGATGCCGGGCGGGCTGTATTTTCCCGCGCGTTGC
CAGTTCGAGGAGAGCAAGTC

Downstream 100 bases:

>100_bases
GTCGTTGCGCCGGGGAAATAATTCTTTACATTTCAATCGATTAGGGAGCTTTGTCCGGCATTCCGTTTTTTTGAGCCATC
TGATATTCGGCATGTGTTCA

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MAGFKTLDDLKDVAGKRVLLRVDLNVPVKDGEVTDTTRIERVAPTITELSDKGAKVILLAHFGRPKGKPDAEASLQPIAH
AVEAVLDRRVHFASSCIGEPAKKAVDEMTGGDILLLENTRFHAGEEKNDPEFTKALAANGDIYVNDAFSAAHRAHASTEG
LAHLLPAYAGRTIQAELEALQRGLGDPKRPVVAIVGGAKVSTKIDLLTNLVKKVDCLVIGGGMANTFLAARGTSVGKSLC
EHDLRETAKQIMIDAAEAGCAIILPVDAVVARKFEAGAETETVDIDAVPEDAMILDVGPKSVEKVKEWLDRADTLVWNGP
LGAFELSPFDKATMEVAKYAARRTRESLLVSVAGGGDTVAALNQADVSDDFSYVSTAGGAFLEWMEGKDLPGVAALQK

Sequences:

>Translated_398_residues
MAGFKTLDDLKDVAGKRVLLRVDLNVPVKDGEVTDTTRIERVAPTITELSDKGAKVILLAHFGRPKGKPDAEASLQPIAH
AVEAVLDRRVHFASSCIGEPAKKAVDEMTGGDILLLENTRFHAGEEKNDPEFTKALAANGDIYVNDAFSAAHRAHASTEG
LAHLLPAYAGRTIQAELEALQRGLGDPKRPVVAIVGGAKVSTKIDLLTNLVKKVDCLVIGGGMANTFLAARGTSVGKSLC
EHDLRETAKQIMIDAAEAGCAIILPVDAVVARKFEAGAETETVDIDAVPEDAMILDVGPKSVEKVKEWLDRADTLVWNGP
LGAFELSPFDKATMEVAKYAARRTRESLLVSVAGGGDTVAALNQADVSDDFSYVSTAGGAFLEWMEGKDLPGVAALQK
>Mature_397_residues
AGFKTLDDLKDVAGKRVLLRVDLNVPVKDGEVTDTTRIERVAPTITELSDKGAKVILLAHFGRPKGKPDAEASLQPIAHA
VEAVLDRRVHFASSCIGEPAKKAVDEMTGGDILLLENTRFHAGEEKNDPEFTKALAANGDIYVNDAFSAAHRAHASTEGL
AHLLPAYAGRTIQAELEALQRGLGDPKRPVVAIVGGAKVSTKIDLLTNLVKKVDCLVIGGGMANTFLAARGTSVGKSLCE
HDLRETAKQIMIDAAEAGCAIILPVDAVVARKFEAGAETETVDIDAVPEDAMILDVGPKSVEKVKEWLDRADTLVWNGPL
GAFELSPFDKATMEVAKYAARRTRESLLVSVAGGGDTVAALNQADVSDDFSYVSTAGGAFLEWMEGKDLPGVAALQK

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family

Homologues:

Organism=Homo sapiens, GI4505763, Length=412, Percent_Identity=41.2621359223301, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI31543397, Length=411, Percent_Identity=40.1459854014599, Blast_Score=272, Evalue=5e-73,
Organism=Escherichia coli, GI1789294, Length=394, Percent_Identity=44.4162436548223, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17508823, Length=406, Percent_Identity=41.871921182266, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319857, Length=407, Percent_Identity=38.5749385749386, Blast_Score=256, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24581203, Length=404, Percent_Identity=42.0792079207921, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17136394, Length=403, Percent_Identity=40.1985111662531, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): PGK_MESSB (Q11CR7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675973.1
- ProteinModelPortal:   Q11CR7
- SMR:   Q11CR7
- STRING:   Q11CR7
- GeneID:   4181482
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3437
- NMPDR:   fig|266779.1.peg.1092
- eggNOG:   COG0126
- HOGENOM:   HBG453500
- OMA:   DCIGDEV
- PhylomeDB:   Q11CR7
- ProtClustDB:   PRK00073
- BioCyc:   MSP266779:MESO_3437-MONOMER
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_00145
- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824
- Gene3D:   G3DSA:3.40.50.1270
- Gene3D:   G3DSA:3.40.50.1260
- PANTHER:   PTHR11406
- PIRSF:   PIRSF000724
- PRINTS:   PR00477

Pfam domain/function: PF00162 PGK; SSF53748 PGK

EC number: =2.7.2.3

Molecular weight: Translated: 42215; Mature: 42083

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: BINDING 38-38 BINDING 120-120 BINDING 153-153 BINDING 203-203 BINDING 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFKTLDDLKDVAGKRVLLRVDLNVPVKDGEVTDTTRIERVAPTITELSDKGAKVILLA
CCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
HFGRPKGKPDAEASLQPIAHAVEAVLDRRVHFASSCIGEPAKKAVDEMTGGDILLLENTR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCC
FHAGEEKNDPEFTKALAANGDIYVNDAFSAAHRAHASTEGLAHLLPAYAGRTIQAELEAL
CCCCCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH
QRGLGDPKRPVVAIVGGAKVSTKIDLLTNLVKKVDCLVIGGGMANTFLAARGTSVGKSLC
HHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCHHHHHHH
EHDLRETAKQIMIDAAEAGCAIILPVDAVVARKFEAGAETETVDIDAVPEDAMILDVGPK
HHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCHH
SVEKVKEWLDRADTLVWNGPLGAFELSPFDKATMEVAKYAARRTRESLLVSVAGGGDTVA
HHHHHHHHHHHHCEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEE
ALNQADVSDDFSYVSTAGGAFLEWMEGKDLPGVAALQK
ECCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure 
AGFKTLDDLKDVAGKRVLLRVDLNVPVKDGEVTDTTRIERVAPTITELSDKGAKVILLA
CCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
HFGRPKGKPDAEASLQPIAHAVEAVLDRRVHFASSCIGEPAKKAVDEMTGGDILLLENTR
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCC
FHAGEEKNDPEFTKALAANGDIYVNDAFSAAHRAHASTEGLAHLLPAYAGRTIQAELEAL
CCCCCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH
QRGLGDPKRPVVAIVGGAKVSTKIDLLTNLVKKVDCLVIGGGMANTFLAARGTSVGKSLC
HHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHCCCHHHHHHH
EHDLRETAKQIMIDAAEAGCAIILPVDAVVARKFEAGAETETVDIDAVPEDAMILDVGPK
HHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCHH
SVEKVKEWLDRADTLVWNGPLGAFELSPFDKATMEVAKYAARRTRESLLVSVAGGGDTVA
HHHHHHHHHHHHCEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCEE
ALNQADVSDDFSYVSTAGGAFLEWMEGKDLPGVAALQK
ECCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA