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The map label for this gene is paaH [H]

Identifier: 110635275

GI number: 110635275

Start: 3204566

End: 3206023

Strand: Reverse

Name: paaH [H]

Synonym: Meso_2946

Alternate gene names: 110635275

Gene position: 3206023-3204566 (Counterclockwise)

Preceding gene: 110635276

Following gene: 110635274

Centisome position: 72.66

GC content: 60.36

Gene sequence:

>1458_bases
ATGATGACGGAAATTCCTAATACTTGCAGCATTGGCGTCATCGGTGCGGGCACCATGGGCGCGGGCATCGCGCAGGTTGC
GGCGGCTGCCGGGCACAAGGTGCTGCTGTTCGATGTCGCGAGCGGAGCCGCCGCGTCAGGCCTTGAGCGCACCGCCAAAG
AACTAGCCACACTGGTCAAGCGCGGCAAAATGGAACAGAAGCGTGCCGAGGAGATCATCGGCAGGATCACCATCGCTGAA
AAATTGGAGGATCTGGCGCCTGCCGCGCTGACGGTCGAAGCGATTGTCGAACGCCTGGACGTCAAGCAGAAAGTCTTTGC
CCAGCTTGAAGCCATCCTTGCGGAGGATGCTATCCTGGCCACCAATACCTCCTCGATCTCGATCACCGCGATTGGCGCCG
CACTTAAACGCCCGGAGCGTTTGGTGGGCATGCATTTTTTCAACCCGGCGCCCATTATGAAACTTGTCGAGGTCGTCTCG
GGACTGGCCACCTCGCCCGAGGTCGCCCAGATCACTCATGCCACCGCAAGGGCATGGGGCAAGACGGCGGTCCATGTGAA
ATCCACGCCTGGCTTCATCGTCAACAGGGTCGCGCGGGCTTTCTATGGTGAGCCTCTGCGTCTGGCTGAGGAGGGGATGG
CCGACATTGCTACGCTCGACGCTCTCATGCGAGAAGGTGGTGGCTTTCGGATGGGGGCATTTCAGCTGATGGATCTCATC
GGCAATGACATAAATTATGCCGTCAGTACCTCTGTTTTCGAAGCATATCACTACGAGCCTCGCTTCCGCCCCTCTCTCAT
GCAGCGCGAGCTTGTTGATGCCGGGCGGTTCGGAAGGAAAACCGGGCATGGTTTCTACTCCTATGCCGGCGATGGGCCGG
ACGTCACTCCGGCCACGTTGGCCCGTTCCGCCACGTCAAGCTGGGCGCCGCTGGATCTTGGCGGCGAGCAGTGGCGCCAG
GATGTGTTGATCGCCCTAACCGATGGGCGAACCGCGATGCAACGTGCACAAGAGGAAGGGCGTCCAGCGATAATACTGGA
CCTTTGCGCGGAGGCGCCCGAGAAGGGACGCGTAGGCTTTGCGACCTCGCCTGATGTGCCGAATGGTGTTCGCGCGGCGC
TGGTGGCAACGCTTGCTGGGCAAGGTTACAGCGCTACTGAGTTGCCGGATCGGCCGGGGCTGGTCGTTATGCGGACGCTA
GCACTGATTGCAAATGAAGCCTTCGAGGCGGTGTTGCAAGGTGTCGCTGACGAAGAGAGTATCGATTTGGCCATGCGGTT
CGGCGTGAACTATCCACGCGGACCGATCGAATGGGCTCGCGACATCGGCCTCGCGCGCATTCTAGCGGTTCTCGATCAGT
TAATGACTATGACGGGCGACATGCGCTACCGGGCATCGTTCGCGCTGCGCAAGGCTGTTATGGAAGAAGGCTGGGACCGG
GAGGTTAGCGCGGCTTAA

Upstream 100 bases:

>100_bases
CGGTTGCCGCTATCGCGCGCTGCCGAGGCGTTTGAGGCAGTCGCGATGGGCGATGCACGTGGAAAGATAATTCTACTGCC
GGAAACTCATTGAAAGAAGA

Downstream 100 bases:

>100_bases
GTCAGTTTATCCCGAACCCCGCGGGCTCGCCGCACCCCGCGATGACAGCGTTTCAAGCAACTCGTGGGGGAGGGGGCAAC
GATGGTGCTGGGCATTGTCG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MMTEIPNTCSIGVIGAGTMGAGIAQVAAAAGHKVLLFDVASGAAASGLERTAKELATLVKRGKMEQKRAEEIIGRITIAE
KLEDLAPAALTVEAIVERLDVKQKVFAQLEAILAEDAILATNTSSISITAIGAALKRPERLVGMHFFNPAPIMKLVEVVS
GLATSPEVAQITHATARAWGKTAVHVKSTPGFIVNRVARAFYGEPLRLAEEGMADIATLDALMREGGGFRMGAFQLMDLI
GNDINYAVSTSVFEAYHYEPRFRPSLMQRELVDAGRFGRKTGHGFYSYAGDGPDVTPATLARSATSSWAPLDLGGEQWRQ
DVLIALTDGRTAMQRAQEEGRPAIILDLCAEAPEKGRVGFATSPDVPNGVRAALVATLAGQGYSATELPDRPGLVVMRTL
ALIANEAFEAVLQGVADEESIDLAMRFGVNYPRGPIEWARDIGLARILAVLDQLMTMTGDMRYRASFALRKAVMEEGWDR
EVSAA

Sequences:

>Translated_485_residues
MMTEIPNTCSIGVIGAGTMGAGIAQVAAAAGHKVLLFDVASGAAASGLERTAKELATLVKRGKMEQKRAEEIIGRITIAE
KLEDLAPAALTVEAIVERLDVKQKVFAQLEAILAEDAILATNTSSISITAIGAALKRPERLVGMHFFNPAPIMKLVEVVS
GLATSPEVAQITHATARAWGKTAVHVKSTPGFIVNRVARAFYGEPLRLAEEGMADIATLDALMREGGGFRMGAFQLMDLI
GNDINYAVSTSVFEAYHYEPRFRPSLMQRELVDAGRFGRKTGHGFYSYAGDGPDVTPATLARSATSSWAPLDLGGEQWRQ
DVLIALTDGRTAMQRAQEEGRPAIILDLCAEAPEKGRVGFATSPDVPNGVRAALVATLAGQGYSATELPDRPGLVVMRTL
ALIANEAFEAVLQGVADEESIDLAMRFGVNYPRGPIEWARDIGLARILAVLDQLMTMTGDMRYRASFALRKAVMEEGWDR
EVSAA
>Mature_485_residues
MMTEIPNTCSIGVIGAGTMGAGIAQVAAAAGHKVLLFDVASGAAASGLERTAKELATLVKRGKMEQKRAEEIIGRITIAE
KLEDLAPAALTVEAIVERLDVKQKVFAQLEAILAEDAILATNTSSISITAIGAALKRPERLVGMHFFNPAPIMKLVEVVS
GLATSPEVAQITHATARAWGKTAVHVKSTPGFIVNRVARAFYGEPLRLAEEGMADIATLDALMREGGGFRMGAFQLMDLI
GNDINYAVSTSVFEAYHYEPRFRPSLMQRELVDAGRFGRKTGHGFYSYAGDGPDVTPATLARSATSSWAPLDLGGEQWRQ
DVLIALTDGRTAMQRAQEEGRPAIILDLCAEAPEKGRVGFATSPDVPNGVRAALVATLAGQGYSATELPDRPGLVVMRTL
ALIANEAFEAVLQGVADEESIDLAMRFGVNYPRGPIEWARDIGLARILAVLDQLMTMTGDMRYRASFALRKAVMEEGWDR
EVSAA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=284, Percent_Identity=40.4929577464789, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI296179427, Length=301, Percent_Identity=38.2059800664452, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=33.4519572953737, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=31.2925170068027, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=31.2925170068027, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=30.0847457627119, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1787661, Length=482, Percent_Identity=43.9834024896266, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1790281, Length=272, Percent_Identity=33.4558823529412, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788682, Length=266, Percent_Identity=31.203007518797, Blast_Score=128, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=38.6206896551724, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=37.0242214532872, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=34.8432055749129, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=36.2676056338028, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=36.2676056338028, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=36.2676056338028, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=30.3886925795053, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=309, Percent_Identity=29.7734627831715, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17558304, Length=284, Percent_Identity=34.5070422535211, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=34.2756183745583, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=34.2756183745583, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=34.2756183745583, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45549573, Length=223, Percent_Identity=30.9417040358744, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129993, Length=227, Percent_Identity=29.0748898678414, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 51927; Mature: 51927

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTEIPNTCSIGVIGAGTMGAGIAQVAAAAGHKVLLFDVASGAAASGLERTAKELATLVK
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
RGKMEQKRAEEIIGRITIAEKLEDLAPAALTVEAIVERLDVKQKVFAQLEAILAEDAILA
HCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TNTSSISITAIGAALKRPERLVGMHFFNPAPIMKLVEVVSGLATSPEVAQITHATARAWG
ECCCCEEEEEHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
KTAVHVKSTPGFIVNRVARAFYGEPLRLAEEGMADIATLDALMREGGGFRMGAFQLMDLI
CEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GNDINYAVSTSVFEAYHYEPRFRPSLMQRELVDAGRFGRKTGHGFYSYAGDGPDVTPATL
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHH
ARSATSSWAPLDLGGEQWRQDVLIALTDGRTAMQRAQEEGRPAIILDLCAEAPEKGRVGF
HHHCCCCCCCCCCCHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEEEHHHCCCCCCCCCC
ATSPDVPNGVRAALVATLAGQGYSATELPDRPGLVVMRTLALIANEAFEAVLQGVADEES
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
IDLAMRFGVNYPRGPIEWARDIGLARILAVLDQLMTMTGDMRYRASFALRKAVMEEGWDR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
EVSAA
CCCCC
>Mature Secondary Structure
MMTEIPNTCSIGVIGAGTMGAGIAQVAAAAGHKVLLFDVASGAAASGLERTAKELATLVK
CCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
RGKMEQKRAEEIIGRITIAEKLEDLAPAALTVEAIVERLDVKQKVFAQLEAILAEDAILA
HCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TNTSSISITAIGAALKRPERLVGMHFFNPAPIMKLVEVVSGLATSPEVAQITHATARAWG
ECCCCEEEEEHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
KTAVHVKSTPGFIVNRVARAFYGEPLRLAEEGMADIATLDALMREGGGFRMGAFQLMDLI
CEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GNDINYAVSTSVFEAYHYEPRFRPSLMQRELVDAGRFGRKTGHGFYSYAGDGPDVTPATL
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHH
ARSATSSWAPLDLGGEQWRQDVLIALTDGRTAMQRAQEEGRPAIILDLCAEAPEKGRVGF
HHHCCCCCCCCCCCHHHHCCCEEEEEECCHHHHHHHHHCCCCEEEEEHHHCCCCCCCCCC
ATSPDVPNGVRAALVATLAGQGYSATELPDRPGLVVMRTLALIANEAFEAVLQGVADEES
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
IDLAMRFGVNYPRGPIEWARDIGLARILAVLDQLMTMTGDMRYRASFALRKAVMEEGWDR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
EVSAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]