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The map label for this gene is bah [H]

Identifier: 110635274

GI number: 110635274

Start: 3203440

End: 3204303

Strand: Reverse

Name: bah [H]

Synonym: Meso_2945

Alternate gene names: 110635274

Gene position: 3204303-3203440 (Counterclockwise)

Preceding gene: 110635275

Following gene: 110635271

Centisome position: 72.62

GC content: 55.67

Gene sequence:

>864_bases
ATGAGGAGCGCGGCAGGAAAATCCGCCAACGGCTATCTTGAAGGGAGGGAAGCCTTCGCAACGTTTATTGAGTCACTTGG
CCAGACATTCGACGCGGCCTCTGAGCCCATCGAGGCCAATGGCGTTCCGGGTTTGTGGATCTATCACTCCGACAAGAAGG
AGAGATCGGCGAATGTCATATTGTACATACATGGTGGCGGATTCTACAGCGGTTCCAGTGAAACGCATAAATATCTGGGG
GAGGCGCTGGCAAAGAGCGCGGCGACGGACGTGGTGGCAATCGATTACCGCCGTATGCCCGAACATGTTTATCCCTCCCA
GATCCAGGATGCGGTCATCAGCTTCTCATGGCTTGTCGAGCAAGGCTACGAACCTGAAAGAATTTCGATCGCAGGCGATT
CCGCGGGAGGCAACATTGTCCTCGAAGCTGCCCTGTATTTGAGGGATCGCGGAATGGGGCGTCCGGCATCCTTGGTTATG
TTAAGCCCGATTGCGGATTTGAACGCGACGGGGCAATCGGCGGAAGAAAATGCCTCCCGCGACAAACTCCTCACCCGCAA
CGGTATTTTGAAGGTTACCGAGACGTATATGGCAGGGAAGGATCCGGCCAGTCCCGATGCATCTCCAATCAATGCGCAGC
TAACCGATTTGCCCCCGATCTTCATGCAGGTGGGTGCGGGTGAGCTCCTTCTGGACGATACGCTCTCCATTGCCCGAAAC
GCTGCGACGGCCGACGTTTCCGTGACGCTGGAAGTCTGGCCGCACGTGACGCATCAGTGGCAGCTTTACCCTCAACTTCT
TCCTGAAGCCAAAGACTCGATCGACAGCATCGGGCGCTTTGTGTCAGCTCATTTCAGTCACTAA

Upstream 100 bases:

>100_bases
AAGATTACTACTTGCCAAAATCACTTTTGCGCTTCTGGCATATTCCCATTTGCCCGCATATGCAGGCCCGTCCACCAGTT
CAATGGAGCAGATCGACTCG

Downstream 100 bases:

>100_bases
GCGAAACTTACACTGCGTCGCGTCGGCGAAGAGCCAGCAATCAGCATTCAATGGTTATTGCCAAGTTCTTCCGCCGACGC
AGCAGGGCTAATGCGGCTCC

Product: Alpha/beta hydrolase fold-3

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRSAAGKSANGYLEGREAFATFIESLGQTFDAASEPIEANGVPGLWIYHSDKKERSANVILYIHGGGFYSGSSETHKYLG
EALAKSAATDVVAIDYRRMPEHVYPSQIQDAVISFSWLVEQGYEPERISIAGDSAGGNIVLEAALYLRDRGMGRPASLVM
LSPIADLNATGQSAEENASRDKLLTRNGILKVTETYMAGKDPASPDASPINAQLTDLPPIFMQVGAGELLLDDTLSIARN
AATADVSVTLEVWPHVTHQWQLYPQLLPEAKDSIDSIGRFVSAHFSH

Sequences:

>Translated_287_residues
MRSAAGKSANGYLEGREAFATFIESLGQTFDAASEPIEANGVPGLWIYHSDKKERSANVILYIHGGGFYSGSSETHKYLG
EALAKSAATDVVAIDYRRMPEHVYPSQIQDAVISFSWLVEQGYEPERISIAGDSAGGNIVLEAALYLRDRGMGRPASLVM
LSPIADLNATGQSAEENASRDKLLTRNGILKVTETYMAGKDPASPDASPINAQLTDLPPIFMQVGAGELLLDDTLSIARN
AATADVSVTLEVWPHVTHQWQLYPQLLPEAKDSIDSIGRFVSAHFSH
>Mature_287_residues
MRSAAGKSANGYLEGREAFATFIESLGQTFDAASEPIEANGVPGLWIYHSDKKERSANVILYIHGGGFYSGSSETHKYLG
EALAKSAATDVVAIDYRRMPEHVYPSQIQDAVISFSWLVEQGYEPERISIAGDSAGGNIVLEAALYLRDRGMGRPASLVM
LSPIADLNATGQSAEENASRDKLLTRNGILKVTETYMAGKDPASPDASPINAQLTDLPPIFMQVGAGELLLDDTLSIARN
AATADVSVTLEVWPHVTHQWQLYPQLLPEAKDSIDSIGRFVSAHFSH

Specific function: This protein removes the N-acetyl group from bialaphos as one of the final steps of the bialaphos biosynthetic pathway [H]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=179, Percent_Identity=27.3743016759777, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI206597554, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786682, Length=238, Percent_Identity=26.890756302521, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72001146, Length=115, Percent_Identity=36.5217391304348, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533410, Length=111, Percent_Identity=30.6306306306306, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533412, Length=111, Percent_Identity=30.6306306306306, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656084, Length=109, Percent_Identity=30.2752293577982, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656076, Length=109, Percent_Identity=30.2752293577982, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130169, Length=109, Percent_Identity=30.2752293577982, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 31009; Mature: 31009

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01173 LIPASE_GDXG_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSAAGKSANGYLEGREAFATFIESLGQTFDAASEPIEANGVPGLWIYHSDKKERSANVI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEE
LYIHGGGFYSGSSETHKYLGEALAKSAATDVVAIDYRRMPEHVYPSQIQDAVISFSWLVE
EEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHH
QGYEPERISIAGDSAGGNIVLEAALYLRDRGMGRPASLVMLSPIADLNATGQSAEENASR
CCCCCCEEEEECCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHCCCH
DKLLTRNGILKVTETYMAGKDPASPDASPINAQLTDLPPIFMQVGAGELLLDDTLSIARN
HHHHHCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEHHHHHHHHC
AATADVSVTLEVWPHVTHQWQLYPQLLPEAKDSIDSIGRFVSAHFSH
CCCCEEEEEEEECCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSAAGKSANGYLEGREAFATFIESLGQTFDAASEPIEANGVPGLWIYHSDKKERSANVI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEE
LYIHGGGFYSGSSETHKYLGEALAKSAATDVVAIDYRRMPEHVYPSQIQDAVISFSWLVE
EEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHH
QGYEPERISIAGDSAGGNIVLEAALYLRDRGMGRPASLVMLSPIADLNATGQSAEENASR
CCCCCCEEEEECCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHCCCH
DKLLTRNGILKVTETYMAGKDPASPDASPINAQLTDLPPIFMQVGAGELLLDDTLSIARN
HHHHHCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEHHHHHHHHC
AATADVSVTLEVWPHVTHQWQLYPQLLPEAKDSIDSIGRFVSAHFSH
CCCCEEEEEEEECCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2066341 [H]