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The map label for this gene is argH [H]

Identifier: 110634963

GI number: 110634963

Start: 2836770

End: 2838269

Strand: Reverse

Name: argH [H]

Synonym: Meso_2629

Alternate gene names: 110634963

Gene position: 2838269-2836770 (Counterclockwise)

Preceding gene: 110634964

Following gene: 110634962

Centisome position: 64.32

GC content: 59.6

Gene sequence:

>1500_bases
ATGACTGAGAATACAGCCACCCTCATACGCACCGCTAACGGCCGGCTGACCGAGCCCATGGTCGGCGGATTGGACCGGTA
TGATTCACGGACGGTCGAGACCAAGCTGGAGGCGGTTCACGCATTCGACAAGGCCCATCTCGTCATGCTGGTCGAGCAAG
GGCTTGTGGGGCGGCAGGACGGCGCACTTATGCTGAGCGCGCTCCGTCATATGGAAAAGGAAGGTGCCGTCGCCACCAGG
ATGCGCGTGGGTGGGGCGCTGCATTCGGGCGAATATTACCTGACTGAGCGGCTGGGCCCCAAACTGGGTGGCACTATCCA
TCTTGGCAGGAGTTCGGCCGATCTTGCCGGTGTGAGCAGGAGAATAGTTCTCAGAACGGCTGTACTTTCCATGGCAAGGC
AACTGATTGACGTGCAGTTGACCATTCTCAATACAGCGCCCGACCATCTCGATTGCATCATACCTGCTTACACCCATGGA
CAGCCCGCGCAGCCCACCACCTATGCACATTGGCTGATGATGTGGGCAAACGTGTTTCACCGGGATACGCAGCGGCTGCT
GGGCGGTCTCGACCGGCTTAACTTGTCGCCTGCCGGCGCCGCTGTGGCGACCGGCACTGACTTTGCCATCGATCGGAGCC
GTGTCGCGACATTGCTCGGATTTGACGGCATCCTCGTCAATACGATGGATGCCACATTGAGCAACGACGTGTTTGCCGAA
TATGTGTCGATCTTTTCCTTGCTCTGCGCGAATATGGGCCGCTTGGCGGAGGATTTGCTGTTCTGGTCCACCCAGGAAGC
AGGCATAGCCGTTATTCCAGACCGCTTCTGCGACACCAGTTCGATCATGTCACAGAAGAGGAATCCGAGCTTTCTGCATG
AATTGCGCGCCATGGGCGCTGAAGCGGCCTCCACTTTGCTGTTGGTAAGCGGAACAGAGTTCGGAACCACCGGGCAGTCA
GTGCACGCGCGAAAGACGGCAGAAAACGCCGTCTGGGCACTCGTCGGCAAAATCATCAAGCGCTTGCCACAGATGGCCGA
TCTCATCGCCAGCACCGAAATCGATCCACAACGCGCCATGCGCCTTACGGAAAACAGCTGGAGCCAGGCGACCGATGTCG
CGAGTGCCTTGGTGCGGCATCTCGGGCTGAACTGGCGTGAAGCCCACCATGTCGTTTCGATCCTCGTTCGACTTGCGACC
GAGCGGCGCCTGCCGCCCGACCAAGTGGATCTCGCTTTGTTGCGAACAGCGCTGGCAGAAGCGCAAATTGCCGCCGAGGA
CCTCGACGGCTTTGACATTGCCGATGCTGTCGATGTGCGCGCCTTTGTGGAGCGCAGGACGAACGAAGGAAGTCCTGCTC
CCTCCGCCGTGACGAGCAGCGCCGCCTGTCTCCTGGGCATCACGACTGCGCAGCAGGCAAAGGTGGAAGCTGCGGAGCGC
ACCGTTGCCGAGGCGTCGAAAGCGCTCGAAAGCGCCATCGATTCGATCGTGAATGACTAA

Upstream 100 bases:

>100_bases
GCTTCCCGAGCAGGTGCGGACGTCGCTGATAAGGCATTTGCGGGGCAGGTGACCCCATGGCGTGCCGTTACCCATTCCAA
CTCGCCCCACAGGTAGGATC

Downstream 100 bases:

>100_bases
ATGGATATAAAGAAGGGGAAAGGTTGAGCGAACTTCCCCCGGAGAAGTGGCCATCATCAATCCCTGATGTGGAGAGGGGG
CCAGCTTGGATGTCGCTCAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MTENTATLIRTANGRLTEPMVGGLDRYDSRTVETKLEAVHAFDKAHLVMLVEQGLVGRQDGALMLSALRHMEKEGAVATR
MRVGGALHSGEYYLTERLGPKLGGTIHLGRSSADLAGVSRRIVLRTAVLSMARQLIDVQLTILNTAPDHLDCIIPAYTHG
QPAQPTTYAHWLMMWANVFHRDTQRLLGGLDRLNLSPAGAAVATGTDFAIDRSRVATLLGFDGILVNTMDATLSNDVFAE
YVSIFSLLCANMGRLAEDLLFWSTQEAGIAVIPDRFCDTSSIMSQKRNPSFLHELRAMGAEAASTLLLVSGTEFGTTGQS
VHARKTAENAVWALVGKIIKRLPQMADLIASTEIDPQRAMRLTENSWSQATDVASALVRHLGLNWREAHHVVSILVRLAT
ERRLPPDQVDLALLRTALAEAQIAAEDLDGFDIADAVDVRAFVERRTNEGSPAPSAVTSSAACLLGITTAQQAKVEAAER
TVAEASKALESAIDSIVND

Sequences:

>Translated_499_residues
MTENTATLIRTANGRLTEPMVGGLDRYDSRTVETKLEAVHAFDKAHLVMLVEQGLVGRQDGALMLSALRHMEKEGAVATR
MRVGGALHSGEYYLTERLGPKLGGTIHLGRSSADLAGVSRRIVLRTAVLSMARQLIDVQLTILNTAPDHLDCIIPAYTHG
QPAQPTTYAHWLMMWANVFHRDTQRLLGGLDRLNLSPAGAAVATGTDFAIDRSRVATLLGFDGILVNTMDATLSNDVFAE
YVSIFSLLCANMGRLAEDLLFWSTQEAGIAVIPDRFCDTSSIMSQKRNPSFLHELRAMGAEAASTLLLVSGTEFGTTGQS
VHARKTAENAVWALVGKIIKRLPQMADLIASTEIDPQRAMRLTENSWSQATDVASALVRHLGLNWREAHHVVSILVRLAT
ERRLPPDQVDLALLRTALAEAQIAAEDLDGFDIADAVDVRAFVERRTNEGSPAPSAVTSSAACLLGITTAQQAKVEAAER
TVAEASKALESAIDSIVND
>Mature_498_residues
TENTATLIRTANGRLTEPMVGGLDRYDSRTVETKLEAVHAFDKAHLVMLVEQGLVGRQDGALMLSALRHMEKEGAVATRM
RVGGALHSGEYYLTERLGPKLGGTIHLGRSSADLAGVSRRIVLRTAVLSMARQLIDVQLTILNTAPDHLDCIIPAYTHGQ
PAQPTTYAHWLMMWANVFHRDTQRLLGGLDRLNLSPAGAAVATGTDFAIDRSRVATLLGFDGILVNTMDATLSNDVFAEY
VSIFSLLCANMGRLAEDLLFWSTQEAGIAVIPDRFCDTSSIMSQKRNPSFLHELRAMGAEAASTLLLVSGTEFGTTGQSV
HARKTAENAVWALVGKIIKRLPQMADLIASTEIDPQRAMRLTENSWSQATDVASALVRHLGLNWREAHHVVSILVRLATE
RRLPPDQVDLALLRTALAEAQIAAEDLDGFDIADAVDVRAFVERRTNEGSPAPSAVTSSAACLLGITTAQQAKVEAAERT
VAEASKALESAIDSIVND

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=398, Percent_Identity=28.1407035175879, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI68303542, Length=398, Percent_Identity=28.1407035175879, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI68303547, Length=394, Percent_Identity=28.1725888324873, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI68303549, Length=398, Percent_Identity=26.1306532663317, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=27.6785714285714, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321806, Length=441, Percent_Identity=28.3446712018141, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221473854, Length=465, Percent_Identity=28.6021505376344, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI78706858, Length=465, Percent_Identity=28.6021505376344, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53949; Mature: 53818

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENTATLIRTANGRLTEPMVGGLDRYDSRTVETKLEAVHAFDKAHLVMLVEQGLVGRQD
CCCCCEEEEEECCCCCCCHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GALMLSALRHMEKEGAVATRMRVGGALHSGEYYLTERLGPKLGGTIHLGRSSADLAGVSR
HHHHHHHHHHHHHCCCHHHHHHHCCEEECCCEEEHHHCCCCCCCEEEECCCCHHHHHHHH
RIVLRTAVLSMARQLIDVQLTILNTAPDHLDCIIPAYTHGQPAQPTTYAHWLMMWANVFH
HHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
RDTQRLLGGLDRLNLSPAGAAVATGTDFAIDRSRVATLLGFDGILVNTMDATLSNDVFAE
HHHHHHHCCHHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHH
YVSIFSLLCANMGRLAEDLLFWSTQEAGIAVIPDRFCDTSSIMSQKRNPSFLHELRAMGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHCCCHHHHHHCCCCHHHHHHHHHHCH
EAASTLLLVSGTEFGTTGQSVHARKTAENAVWALVGKIIKRLPQMADLIASTEIDPQRAM
HHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RLTENSWSQATDVASALVRHLGLNWREAHHVVSILVRLATERRLPPDQVDLALLRTALAE
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AQIAAEDLDGFDIADAVDVRAFVERRTNEGSPAPSAVTSSAACLLGITTAQQAKVEAAER
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHEEEECHHHHHHHHHHHH
TVAEASKALESAIDSIVND
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TENTATLIRTANGRLTEPMVGGLDRYDSRTVETKLEAVHAFDKAHLVMLVEQGLVGRQD
CCCCEEEEEECCCCCCCHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GALMLSALRHMEKEGAVATRMRVGGALHSGEYYLTERLGPKLGGTIHLGRSSADLAGVSR
HHHHHHHHHHHHHCCCHHHHHHHCCEEECCCEEEHHHCCCCCCCEEEECCCCHHHHHHHH
RIVLRTAVLSMARQLIDVQLTILNTAPDHLDCIIPAYTHGQPAQPTTYAHWLMMWANVFH
HHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
RDTQRLLGGLDRLNLSPAGAAVATGTDFAIDRSRVATLLGFDGILVNTMDATLSNDVFAE
HHHHHHHCCHHHCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHH
YVSIFSLLCANMGRLAEDLLFWSTQEAGIAVIPDRFCDTSSIMSQKRNPSFLHELRAMGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHCCCHHHHHHCCCCHHHHHHHHHHCH
EAASTLLLVSGTEFGTTGQSVHARKTAENAVWALVGKIIKRLPQMADLIASTEIDPQRAM
HHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RLTENSWSQATDVASALVRHLGLNWREAHHVVSILVRLATERRLPPDQVDLALLRTALAE
HHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AQIAAEDLDGFDIADAVDVRAFVERRTNEGSPAPSAVTSSAACLLGITTAQQAKVEAAER
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHEEEECHHHHHHHHHHHH
TVAEASKALESAIDSIVND
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA