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The map label for this gene is hutH [H]

Identifier: 110634962

GI number: 110634962

Start: 2834898

End: 2836448

Strand: Reverse

Name: hutH [H]

Synonym: Meso_2628

Alternate gene names: 110634962

Gene position: 2836448-2834898 (Counterclockwise)

Preceding gene: 110634963

Following gene: 110634961

Centisome position: 64.28

GC content: 64.93

Gene sequence:

>1551_bases
ATGCTGGCGTCGCGCACCGTTCTCGAACTAAAGGGCAAGCCGTTCAGCTTTGCCCAATTGGCGAGCATAGCAGCCGGCAA
GGTCGAGCTGACCGCCGATGACGAGGCGATGCGGCGAGTGCGCGCGGCGCGACGGGTCCTCGAAGACCATATCGCGGCCG
GCCACCCGGTTTATGGTGCGACAACAGGCGTCGGCGCGATGAAGGATGTGTCCTGGACCGCTGCCGATCAGGACCTGTTC
AATTTCAGCCTTGTCCACGCGCATAGTTTCGGGACCGGCGAGACCTTTTCGCCAGCGGTTATCCGCAGCGCTATGGCGAT
CCGCATCAATATGGCCCTGAACGGGCATGTCGGTGTCTCCGGCGAATTGGTCGATATCTATCTGGCCATGATGCGTGCCG
ATCTGGTGCCCGTGGTGCGGCGCACCGGTTCGATCGGCTGCGCCGATATCGGGCTTATGGGCCAGATTGGCGCAGTGCTG
ACCGGGGCAGGGGAGGTGTATGCCCGCGGCCATCGCATGCCGGCAGAGCTGGCGCTGTCCCAGGCGGGCATCGTACCCAT
GATCTTTGCGCCACGCGACAGCCTCGCCTCCATTTCCACCAATGCTATCGCCTATGCCGCAGCCGCTCATGCCATACGCG
AGGCGGCCGGCGTGTTCCGCATGGCGCTGGCTGTCGGGCTGACCTCGGCGGGGGCTCTGGGCGCCTCACGCGACCCCTGG
CTGGCCGCTAGCCAGCTGGATGGGGCGTGCAAGGCAATTGTGGGAGCCTGGCTCTACGACAATGCGGAAGTTTGGGGATG
GTCCGAAGCCACCCATGTGCAGGACCCGTTGAGCCTGCGCATGATGGCGCAGGTGTTCGGGGCGGCTTTTGATGGGCTCG
TTGCGGCCGGGCGCACCATCTTGGCGGCAACCGGCCGTACCGACGACAATCCGGTAGTGGTCAATGGCCGGGTTCTGACT
TCGGGCGGATCGCTGCCGCTCGATGTCACGCTTTTCCTGCAAACGGCGCAACTGGCTATCGCTCATGTGGCGCGCAACGG
CTTCAACCGTTGCGTGCTGCTGGGCAATGGCGGGCGGCGCGGCCTGCCGGTCAATCTGGTGCCACATGGCGAGATTGCCA
CCGGCATGGGACCGGTCATCAAGTTGGCGGGCGCATTGTTCGCGCGAGTTCTGTCGCTGGCCTCGCCAGTTTCCGCCCAG
ATCATGGTGCTGGCGGACGGGCAGGAGGACGAAGCGACATTCCTGCCGCTGGTGGTGGAGCGCCTCGAACAGCAGGTGTC
GGCCTTGCGCCAACTTGCGGCGCTCGAAGGCGTGCTCACCGCGCAGGCCATCGACATTACCGGGGACGCGCCAAAGGGTG
TTGCCAAGCTGATCTATGACCTGGTGCGCACCCGCGCTGGCTTCCAGCGCGCGGACCGGCCGCTATCGCAGGAAATCGAG
GCCATCGAGAGCGGTCTGGCTGCGGAGGCGAGCATGGCGGGATTGCTGAGCCTTGCGAGCCTCCCGGAGATCGACGGCTT
CTTCGCTCTCGATCCTAGTCTGTCGTCGTAA

Upstream 100 bases:

>100_bases
CCGGTTCCGCTAGCAACATCTCCCGTTCCGAATTTAGGATATCACCGGTGTGAGGCCAATCCAGTAGTGCTGGGTCATCA
TTGGGGATGGCTTCTGGGCA

Downstream 100 bases:

>100_bases
GGAGCGAGCCGCGGGAAACCGACCCTGGGTTGGGACCCGCAACTGGGAGGAATTGGGTGCCGGACGACGTGGAGAGCCAG
GGCGCCCGTTGGGCACGAAT

Product: phenylalanine/histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MLASRTVLELKGKPFSFAQLASIAAGKVELTADDEAMRRVRAARRVLEDHIAAGHPVYGATTGVGAMKDVSWTAADQDLF
NFSLVHAHSFGTGETFSPAVIRSAMAIRINMALNGHVGVSGELVDIYLAMMRADLVPVVRRTGSIGCADIGLMGQIGAVL
TGAGEVYARGHRMPAELALSQAGIVPMIFAPRDSLASISTNAIAYAAAAHAIREAAGVFRMALAVGLTSAGALGASRDPW
LAASQLDGACKAIVGAWLYDNAEVWGWSEATHVQDPLSLRMMAQVFGAAFDGLVAAGRTILAATGRTDDNPVVVNGRVLT
SGGSLPLDVTLFLQTAQLAIAHVARNGFNRCVLLGNGGRRGLPVNLVPHGEIATGMGPVIKLAGALFARVLSLASPVSAQ
IMVLADGQEDEATFLPLVVERLEQQVSALRQLAALEGVLTAQAIDITGDAPKGVAKLIYDLVRTRAGFQRADRPLSQEIE
AIESGLAAEASMAGLLSLASLPEIDGFFALDPSLSS

Sequences:

>Translated_516_residues
MLASRTVLELKGKPFSFAQLASIAAGKVELTADDEAMRRVRAARRVLEDHIAAGHPVYGATTGVGAMKDVSWTAADQDLF
NFSLVHAHSFGTGETFSPAVIRSAMAIRINMALNGHVGVSGELVDIYLAMMRADLVPVVRRTGSIGCADIGLMGQIGAVL
TGAGEVYARGHRMPAELALSQAGIVPMIFAPRDSLASISTNAIAYAAAAHAIREAAGVFRMALAVGLTSAGALGASRDPW
LAASQLDGACKAIVGAWLYDNAEVWGWSEATHVQDPLSLRMMAQVFGAAFDGLVAAGRTILAATGRTDDNPVVVNGRVLT
SGGSLPLDVTLFLQTAQLAIAHVARNGFNRCVLLGNGGRRGLPVNLVPHGEIATGMGPVIKLAGALFARVLSLASPVSAQ
IMVLADGQEDEATFLPLVVERLEQQVSALRQLAALEGVLTAQAIDITGDAPKGVAKLIYDLVRTRAGFQRADRPLSQEIE
AIESGLAAEASMAGLLSLASLPEIDGFFALDPSLSS
>Mature_516_residues
MLASRTVLELKGKPFSFAQLASIAAGKVELTADDEAMRRVRAARRVLEDHIAAGHPVYGATTGVGAMKDVSWTAADQDLF
NFSLVHAHSFGTGETFSPAVIRSAMAIRINMALNGHVGVSGELVDIYLAMMRADLVPVVRRTGSIGCADIGLMGQIGAVL
TGAGEVYARGHRMPAELALSQAGIVPMIFAPRDSLASISTNAIAYAAAAHAIREAAGVFRMALAVGLTSAGALGASRDPW
LAASQLDGACKAIVGAWLYDNAEVWGWSEATHVQDPLSLRMMAQVFGAAFDGLVAAGRTILAATGRTDDNPVVVNGRVLT
SGGSLPLDVTLFLQTAQLAIAHVARNGFNRCVLLGNGGRRGLPVNLVPHGEIATGMGPVIKLAGALFARVLSLASPVSAQ
IMVLADGQEDEATFLPLVVERLEQQVSALRQLAALEGVLTAQAIDITGDAPKGVAKLIYDLVRTRAGFQRADRPLSQEIE
AIESGLAAEASMAGLLSLASLPEIDGFFALDPSLSS

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=498, Percent_Identity=24.6987951807229, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567831, Length=527, Percent_Identity=27.3244781783681, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53716; Mature: 53716

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLASRTVLELKGKPFSFAQLASIAAGKVELTADDEAMRRVRAARRVLEDHIAAGHPVYGA
CCCCCCEEEECCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCC
TTGVGAMKDVSWTAADQDLFNFSLVHAHSFGTGETFSPAVIRSAMAIRINMALNGHVGVS
CCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCHHHHHHEEEEEEEEEECCCCCCC
GELVDIYLAMMRADLVPVVRRTGSIGCADIGLMGQIGAVLTGAGEVYARGHRMPAELALS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHHH
QAGIVPMIFAPRDSLASISTNAIAYAAAAHAIREAAGVFRMALAVGLTSAGALGASRDPW
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LAASQLDGACKAIVGAWLYDNAEVWGWSEATHVQDPLSLRMMAQVFGAAFDGLVAAGRTI
EEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
LAATGRTDDNPVVVNGRVLTSGGSLPLDVTLFLQTAQLAIAHVARNGFNRCVLLGNGGRR
EEECCCCCCCCEEEECEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GLPVNLVPHGEIATGMGPVIKLAGALFARVLSLASPVSAQIMVLADGQEDEATFLPLVVE
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHH
RLEQQVSALRQLAALEGVLTAQAIDITGDAPKGVAKLIYDLVRTRAGFQRADRPLSQEIE
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AIESGLAAEASMAGLLSLASLPEIDGFFALDPSLSS
HHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
>Mature Secondary Structure
MLASRTVLELKGKPFSFAQLASIAAGKVELTADDEAMRRVRAARRVLEDHIAAGHPVYGA
CCCCCCEEEECCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCC
TTGVGAMKDVSWTAADQDLFNFSLVHAHSFGTGETFSPAVIRSAMAIRINMALNGHVGVS
CCCCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCHHHHHHEEEEEEEEEECCCCCCC
GELVDIYLAMMRADLVPVVRRTGSIGCADIGLMGQIGAVLTGAGEVYARGHRMPAELALS
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHHH
QAGIVPMIFAPRDSLASISTNAIAYAAAAHAIREAAGVFRMALAVGLTSAGALGASRDPW
HCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LAASQLDGACKAIVGAWLYDNAEVWGWSEATHVQDPLSLRMMAQVFGAAFDGLVAAGRTI
EEHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEE
LAATGRTDDNPVVVNGRVLTSGGSLPLDVTLFLQTAQLAIAHVARNGFNRCVLLGNGGRR
EEECCCCCCCCEEEECEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCC
GLPVNLVPHGEIATGMGPVIKLAGALFARVLSLASPVSAQIMVLADGQEDEATFLPLVVE
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHH
RLEQQVSALRQLAALEGVLTAQAIDITGDAPKGVAKLIYDLVRTRAGFQRADRPLSQEIE
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AIESGLAAEASMAGLLSLASLPEIDGFFALDPSLSS
HHHCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11121031 [H]