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The map label for this gene is panC

Identifier: 110634901

GI number: 110634901

Start: 2749180

End: 2750034

Strand: Direct

Name: panC

Synonym: Meso_2560

Alternate gene names: 110634901

Gene position: 2749180-2750034 (Clockwise)

Preceding gene: 110634900

Following gene: 110634902

Centisome position: 62.31

GC content: 64.33

Gene sequence:

>855_bases
GTGAGTGTCCCAATTTTCCGCACGGTGAAGGAATTACGCGCGGCGGTGGCGGATTGGCGCCGTGATGGGCTTCGCGTCGG
CGTCGTACCTACGATGGGTGCGCTGCATGAAGGGCATCTGAGCCTCGTGCGCGCGGCCCTGGCGAACACGGACCGGGTAA
TCGTCACTCTGTTCGTCAATCCGAAACAATTCAACAATGCAGGCGATCTCGCCGCCTATCCCCGCACGGAAAAGGAGGAT
GCCGCCAAGCTCGCCCCGCTCGGCGCCCACATGCTCTATGCACCGGATGGCGCAGAGATGTATCCGAACGGATTTTCCAC
AACGGTCTCGGTGAGCGGCGTGAGCGAGGGCCTTTGCGGCGCCTTCCGGCCCGGCCACTTCGACGGGGTGGCGACCGTGG
TCACGAAGCTGCTCCTGCAGACCGGGGCCGACCTTGCCTTTTTCGGCGAGAAGGATTTTCAGCAGCTGCACGTGGTGCGC
CGGCTAACCCGAGACCTCGATATACCCACGCAGATCATCGCTTGCCCGACGGTGCGCGAAGCGGATGGGCTTGCCCTCTC
TTCCCGAAATGTGCGGCTTTCGGCTGACGACCGCCGCAATGCTCCGAAGCTCGCCGAAGCGCTCTTTGCCGCCGCCGGCC
GCCTGGCGGAGGGCACGCCTGTAGCCGAGGTGCTGCCCAATGCCCGCGATGCGATACTCGCAGCGGGCTATCAGGAGGTT
GAATATCTCGAACTGCGGGGAGAGGATGACCTTGCTCCGCTTTCCGGCCTCGATAGGCCGGCGCGGCTGCTCGTTGCCGC
GTGGATCGGTGGAGTTCGCCTCATCGACAATCTGCCGGTTGCGCAGCCTGCCTGA

Upstream 100 bases:

>100_bases
GAATCGCCGCCTATGCAAAAGATGTGCGGCAGCGCCGTTTTCCGGCGCCGGAACATGTATTCAGCGATATGCCCAAGCCG
GTGAAGGGAGGCGAGGCAGC

Downstream 100 bases:

>100_bases
GAGGCCAATCACTGCTTTCGCTGCTTGACAAGCCAGGGCACTCCTCGCAAGATCAAACCATCACCAGGGGGGCCCGGACA
ACGGGCTGAGATACCGCTGG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MSVPIFRTVKELRAAVADWRRDGLRVGVVPTMGALHEGHLSLVRAALANTDRVIVTLFVNPKQFNNAGDLAAYPRTEKED
AAKLAPLGAHMLYAPDGAEMYPNGFSTTVSVSGVSEGLCGAFRPGHFDGVATVVTKLLLQTGADLAFFGEKDFQQLHVVR
RLTRDLDIPTQIIACPTVREADGLALSSRNVRLSADDRRNAPKLAEALFAAAGRLAEGTPVAEVLPNARDAILAAGYQEV
EYLELRGEDDLAPLSGLDRPARLLVAAWIGGVRLIDNLPVAQPA

Sequences:

>Translated_284_residues
MSVPIFRTVKELRAAVADWRRDGLRVGVVPTMGALHEGHLSLVRAALANTDRVIVTLFVNPKQFNNAGDLAAYPRTEKED
AAKLAPLGAHMLYAPDGAEMYPNGFSTTVSVSGVSEGLCGAFRPGHFDGVATVVTKLLLQTGADLAFFGEKDFQQLHVVR
RLTRDLDIPTQIIACPTVREADGLALSSRNVRLSADDRRNAPKLAEALFAAAGRLAEGTPVAEVLPNARDAILAAGYQEV
EYLELRGEDDLAPLSGLDRPARLLVAAWIGGVRLIDNLPVAQPA
>Mature_283_residues
SVPIFRTVKELRAAVADWRRDGLRVGVVPTMGALHEGHLSLVRAALANTDRVIVTLFVNPKQFNNAGDLAAYPRTEKEDA
AKLAPLGAHMLYAPDGAEMYPNGFSTTVSVSGVSEGLCGAFRPGHFDGVATVVTKLLLQTGADLAFFGEKDFQQLHVVRR
LTRDLDIPTQIIACPTVREADGLALSSRNVRLSADDRRNAPKLAEALFAAAGRLAEGTPVAEVLPNARDAILAAGYQEVE
YLELRGEDDLAPLSGLDRPARLLVAAWIGGVRLIDNLPVAQPA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=276, Percent_Identity=43.8405797101449, Blast_Score=217, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6322046, Length=311, Percent_Identity=35.3697749196142, Blast_Score=159, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_MESSB (Q11F81)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675109.1
- ProteinModelPortal:   Q11F81
- SMR:   Q11F81
- STRING:   Q11F81
- GeneID:   4182975
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2560
- NMPDR:   fig|266779.1.peg.1529
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q11F81
- ProtClustDB:   PRK00380
- BioCyc:   MSP266779:MESO_2560-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30423; Mature: 30292

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: ACT_SITE 39-39 BINDING 63-63 BINDING 63-63 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPIFRTVKELRAAVADWRRDGLRVGVVPTMGALHEGHLSLVRAALANTDRVIVTLFVN
CCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEC
PKQFNNAGDLAAYPRTEKEDAAKLAPLGAHMLYAPDGAEMYPNGFSTTVSVSGVSEGLCG
HHHCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCC
AFRPGHFDGVATVVTKLLLQTGADLAFFGEKDFQQLHVVRRLTRDLDIPTQIIACPTVRE
CCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCHHEEECCCCCC
ADGLALSSRNVRLSADDRRNAPKLAEALFAAAGRLAEGTPVAEVLPNARDAILAAGYQEV
CCCCEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHCCCHHE
EYLELRGEDDLAPLSGLDRPARLLVAAWIGGVRLIDNLPVAQPA
EEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SVPIFRTVKELRAAVADWRRDGLRVGVVPTMGALHEGHLSLVRAALANTDRVIVTLFVN
CCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEC
PKQFNNAGDLAAYPRTEKEDAAKLAPLGAHMLYAPDGAEMYPNGFSTTVSVSGVSEGLCG
HHHCCCCCCCCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCC
AFRPGHFDGVATVVTKLLLQTGADLAFFGEKDFQQLHVVRRLTRDLDIPTQIIACPTVRE
CCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCHHEEECCCCCC
ADGLALSSRNVRLSADDRRNAPKLAEALFAAAGRLAEGTPVAEVLPNARDAILAAGYQEV
CCCCEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHCCCHHE
EYLELRGEDDLAPLSGLDRPARLLVAAWIGGVRLIDNLPVAQPA
EEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA