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The map label for this gene is panB

Identifier: 110634900

GI number: 110634900

Start: 2748338

End: 2749183

Strand: Direct

Name: panB

Synonym: Meso_2559

Alternate gene names: 110634900

Gene position: 2748338-2749183 (Clockwise)

Preceding gene: 110634895

Following gene: 110634901

Centisome position: 62.29

GC content: 63.83

Gene sequence:

>846_bases
ATGAGTGCAACCGGAGGAGCGAAATCCTTCACCCCGCCGGACATCGCCAAGGCCAAAGGCAAGGCGCCGATCGTTTGTCT
CACTGCCTACACGACGCCCATTGCGCGCCTTCTCGATCCGCATTGCGACGTGGTTCTCGTGGGCGACAGCGTGGGCATGG
TGATGCACGGGCTGCCCTCCACGCTGGGCGTGACGCTGGACATGATGATCATGCATGGGAAAGCGGTGCGCCGAGGCCTG
GAAAGGGCCTTGATGGTCGTCGACATGCCCTTCGGCAGCTATGAGGAAGGGCCGGAACAGGCTTTTCGCAATGCAGCACG
CGTGATGGCGGAGACCGGCTGCGCGGCTGTCAAGCTCGAAGGCGGAGAGAGCATGGCCGAGACGATCCGCTTCCTGACCG
GCCGTGGCATACCGGTGATGGCCCATGTGGGTCTGACGCCACAGGCCGTGAACGCTTTCGGCGGTTATCAGGTCCAAGGA
CGGGGCGAAGACGGCGACCGCGTGATGCGTGACGCGCAAGCAGTGGCCAAGGCCGGCGCCTTCTCCGTGGTCCTGGAAAA
GGTGCCCGAGCCGCTCGCCCGCCGGATCACCAAGGAAATCCCTATCCCCACCATCGGCATCGGGGCTTCCCCCGCCTGCG
ACGGGCAGGTTTTGGTGGTAGACGACATGCTCGGGATGTTCACCGATTTCCGCCCGAAATTCGTCAAGCGCTATGCGGAA
CTGGCGGAAGCCGCCGAGGCCGGAATCGCCGCCTATGCAAAAGATGTGCGGCAGCGCCGTTTTCCGGCGCCGGAACATGT
ATTCAGCGATATGCCCAAGCCGGTGAAGGGAGGCGAGGCAGCGTGA

Upstream 100 bases:

>100_bases
CGTGCAGCCTGACCGGCAGAAGTGAAGCAAATTTTTCTTCGCAAGCGCACAAAACTGTGCGAAATGGCGGCACCAGCAGT
TGCCTCTGGAGGAAATAGTC

Downstream 100 bases:

>100_bases
GTGTCCCAATTTTCCGCACGGTGAAGGAATTACGCGCGGCGGTGGCGGATTGGCGCCGTGATGGGCTTCGCGTCGGCGTC
GTACCTACGATGGGTGCGCT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSATGGAKSFTPPDIAKAKGKAPIVCLTAYTTPIARLLDPHCDVVLVGDSVGMVMHGLPSTLGVTLDMMIMHGKAVRRGL
ERALMVVDMPFGSYEEGPEQAFRNAARVMAETGCAAVKLEGGESMAETIRFLTGRGIPVMAHVGLTPQAVNAFGGYQVQG
RGEDGDRVMRDAQAVAKAGAFSVVLEKVPEPLARRITKEIPIPTIGIGASPACDGQVLVVDDMLGMFTDFRPKFVKRYAE
LAEAAEAGIAAYAKDVRQRRFPAPEHVFSDMPKPVKGGEAA

Sequences:

>Translated_281_residues
MSATGGAKSFTPPDIAKAKGKAPIVCLTAYTTPIARLLDPHCDVVLVGDSVGMVMHGLPSTLGVTLDMMIMHGKAVRRGL
ERALMVVDMPFGSYEEGPEQAFRNAARVMAETGCAAVKLEGGESMAETIRFLTGRGIPVMAHVGLTPQAVNAFGGYQVQG
RGEDGDRVMRDAQAVAKAGAFSVVLEKVPEPLARRITKEIPIPTIGIGASPACDGQVLVVDDMLGMFTDFRPKFVKRYAE
LAEAAEAGIAAYAKDVRQRRFPAPEHVFSDMPKPVKGGEAA
>Mature_280_residues
SATGGAKSFTPPDIAKAKGKAPIVCLTAYTTPIARLLDPHCDVVLVGDSVGMVMHGLPSTLGVTLDMMIMHGKAVRRGLE
RALMVVDMPFGSYEEGPEQAFRNAARVMAETGCAAVKLEGGESMAETIRFLTGRGIPVMAHVGLTPQAVNAFGGYQVQGR
GEDGDRVMRDAQAVAKAGAFSVVLEKVPEPLARRITKEIPIPTIGIGASPACDGQVLVVDDMLGMFTDFRPKFVKRYAEL
AEAAEAGIAAYAKDVRQRRFPAPEHVFSDMPKPVKGGEAA

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=252, Percent_Identity=47.2222222222222, Blast_Score=206, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319653, Length=257, Percent_Identity=38.5214007782101, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_MESSB (Q11F82)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_675108.1
- ProteinModelPortal:   Q11F82
- SMR:   Q11F82
- STRING:   Q11F82
- GeneID:   4182974
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2559
- NMPDR:   fig|266779.1.peg.1528
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   DMMIAHG
- PhylomeDB:   Q11F82
- ProtClustDB:   PRK00311
- BioCyc:   MSP266779:MESO_2559-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 29783; Mature: 29652

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: ACT_SITE 186-186 BINDING 88-88 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATGGAKSFTPPDIAKAKGKAPIVCLTAYTTPIARLLDPHCDVVLVGDSVGMVMHGLPS
CCCCCCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHCCCCCEEEECCCHHHHHHCCCH
TLGVTLDMMIMHGKAVRRGLERALMVVDMPFGSYEEGPEQAFRNAARVMAETGCAAVKLE
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEC
GGESMAETIRFLTGRGIPVMAHVGLTPQAVNAFGGYQVQGRGEDGDRVMRDAQAVAKAGA
CCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
FSVVLEKVPEPLARRITKEIPIPTIGIGASPACDGQVLVVDDMLGMFTDFRPKFVKRYAE
HHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHH
LAEAAEAGIAAYAKDVRQRRFPAPEHVFSDMPKPVKGGEAA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SATGGAKSFTPPDIAKAKGKAPIVCLTAYTTPIARLLDPHCDVVLVGDSVGMVMHGLPS
CCCCCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHCCCCCEEEECCCHHHHHHCCCH
TLGVTLDMMIMHGKAVRRGLERALMVVDMPFGSYEEGPEQAFRNAARVMAETGCAAVKLE
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEC
GGESMAETIRFLTGRGIPVMAHVGLTPQAVNAFGGYQVQGRGEDGDRVMRDAQAVAKAGA
CCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHH
FSVVLEKVPEPLARRITKEIPIPTIGIGASPACDGQVLVVDDMLGMFTDFRPKFVKRYAE
HHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHH
LAEAAEAGIAAYAKDVRQRRFPAPEHVFSDMPKPVKGGEAA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA