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The map label for this gene is coxN [H]

Identifier: 110634816

GI number: 110634816

Start: 2653526

End: 2655301

Strand: Direct

Name: coxN [H]

Synonym: Meso_2475

Alternate gene names: 110634816

Gene position: 2653526-2655301 (Clockwise)

Preceding gene: 110634815

Following gene: 110634817

Centisome position: 60.14

GC content: 59.8

Gene sequence:

>1776_bases
ATGGTCGACGCCACGCCCCGAATGCATGAAGGCATTTCGCCCGCCGAAGTGCCTGAGCTGGAGCTTTATCACCCAAAAGG
CTGGTGGACGACCTATGTCTTCTCTCAGGATGCGAAGATAATCGCCATTCAGTATGCCGGCACAGCGATGGCAATCGGTC
TCGTTGCGCTGGTCCTTTCCTGGCTTATGCGCCTGCAGTTGGGCTTTCCCGGCACATTCGATTTCATCACGCCTGACGCC
TACTACCAGTTCATCACCATGCACGGCATGATCATGGTGATCTACCTGCTCACCGCTCTTTTCCTCGGCGGTTTCGGCAA
CTACCTGATCCCGCTCATGGTTGGCGCGCGGGACATGGTGTTCCCCTATGTCAACATGCTGAGCTACTGGATCTACCTAC
TCGCCGTGATCGTGCTGGTTGCAAGCTTCTTCGCACCAGGGGGGCCGACCGGCGCCGGCTGGACGCTTTATCCGCCGCAG
GCGATCCTCTCCGGCACGCCGGGCGGCCAGGACTGGGGCATCATCCTGATGCTCGCCTCGCTCATCCTCTTCATCATCGG
CTTCACCATGGGCGGGCTCAATTATGTGGTGACTGTCATTCAGGGCCGCACGCGCGGCATGACGCTGATGCGCATGCCCC
TCACCGTATGGGGTATCTTCACCGCGACCGTTATGGCGCTGCTCGCCTTCCCTGCGCTGTTCGTCGCCTGCGTCATGATG
CTGTTCGACCGGTTGCTCGGCACATCCTTCTTCATGCCGGCGCTGGTCGAAATGGGAGAGCAGCTTTCCTACGGCGGAGG
TAGCCCGATCCTGTTCCAGCACCTTTTCTGGTTCTTCGGCCATCCGGAAGTCTATATCGTCGCCCTGCCAGCCTTCGGCA
TTGTGTCGGACCTGATCTCGACCCACGCGCGGAAGAACATATTCGGCTACCGAATGATGGTCTGGGCCATCGTCGTTATC
GGCGCGCTCTCGTTCATCGTTTGGGCGCACCACATGTATGTCTCCGGCATGCACCCATGGTTCGGCTTCTTCTTTGCCAC
CACCACGCTCATCATCGCCATCCCGACGGCCATTAAGGTCTATAATTGGGTGCTCACCCTCTGGCGCGGGGACATCCATC
TGACGATCCCGATGCTCTTCGCGCTGGCCTTCATCGTCACCTTCGTCAATGGCGGGCTGACGGGCCTGTTCCTCGGCAAT
GTGGTGGTGGACGTGCCCTTGTCGGACACGATGTTCGTCGTTACCCATTTCCACATGGTAATGGGCGTGGCGCCGATCCT
CGTCATCTTCGGCGCGATTTATCACTGGTATCCGAAGATCACCGGCCGCATGCTCGACGAGTGGATGGGCCAGTTTCATT
TCTGGGTGACCTTCGTCGGCGCATACGCCATTTTCTTCCCCATGCATTATGTCGGCTTGGTGGGCGTGCCGCGGCGCTAT
GTGGAGATCGGCGAGTCGGCCTTCATTCCGCCATCGGTGCAGGATCTCAACGCCTTCATCACCGTGGCCGCTCTCATTGT
CGGCTTCGCCCAGATGGTGTTCCTTTTCAACCTCTTCTGGAGCCTGCGCTACGGCAGGGAAGCAGGCGGCAATCCATGGC
GCGCCACGAGCCTCGAATGGCAGACTCCAACAACACCGCCTCCGCATGGAAACTGGGGCGACGAGCGGCCGGTGGTCTAC
CGCTGGGCCTATGACTATTCGGTGCCGGGAGCACCGCAGGATTTCATCCCGCAGAACGATCCTTGGCCGCAAAAGGCTGT
CGCGGGGACGGCATGA

Upstream 100 bases:

>100_bases
GGCTGAGGAGGTCAAGCCGTGATCAGGGAGACCCAAGCATAGCGCAAGCAATTCCATTGCAGGCGGGATCAGCCTGCAAT
GGAGCCAGGGAGGATGAGCG

Downstream 100 bases:

>100_bases
GCGTCATCCTGGTCTTCATCCTCGTGGTGGCCGGATTCTCTTTCTGGTGGCTGCTCCAGCATCGGGTGCTGTCAAAGCCG
TGGCTTGAGCATGGCGTGCA

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MVDATPRMHEGISPAEVPELELYHPKGWWTTYVFSQDAKIIAIQYAGTAMAIGLVALVLSWLMRLQLGFPGTFDFITPDA
YYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWIYLLAVIVLVASFFAPGGPTGAGWTLYPPQ
AILSGTPGGQDWGIILMLASLILFIIGFTMGGLNYVVTVIQGRTRGMTLMRMPLTVWGIFTATVMALLAFPALFVACVMM
LFDRLLGTSFFMPALVEMGEQLSYGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVVI
GALSFIVWAHHMYVSGMHPWFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGN
VVVDVPLSDTMFVVTHFHMVMGVAPILVIFGAIYHWYPKITGRMLDEWMGQFHFWVTFVGAYAIFFPMHYVGLVGVPRRY
VEIGESAFIPPSVQDLNAFITVAALIVGFAQMVFLFNLFWSLRYGREAGGNPWRATSLEWQTPTTPPPHGNWGDERPVVY
RWAYDYSVPGAPQDFIPQNDPWPQKAVAGTA

Sequences:

>Translated_591_residues
MVDATPRMHEGISPAEVPELELYHPKGWWTTYVFSQDAKIIAIQYAGTAMAIGLVALVLSWLMRLQLGFPGTFDFITPDA
YYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWIYLLAVIVLVASFFAPGGPTGAGWTLYPPQ
AILSGTPGGQDWGIILMLASLILFIIGFTMGGLNYVVTVIQGRTRGMTLMRMPLTVWGIFTATVMALLAFPALFVACVMM
LFDRLLGTSFFMPALVEMGEQLSYGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVVI
GALSFIVWAHHMYVSGMHPWFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGN
VVVDVPLSDTMFVVTHFHMVMGVAPILVIFGAIYHWYPKITGRMLDEWMGQFHFWVTFVGAYAIFFPMHYVGLVGVPRRY
VEIGESAFIPPSVQDLNAFITVAALIVGFAQMVFLFNLFWSLRYGREAGGNPWRATSLEWQTPTTPPPHGNWGDERPVVY
RWAYDYSVPGAPQDFIPQNDPWPQKAVAGTA
>Mature_591_residues
MVDATPRMHEGISPAEVPELELYHPKGWWTTYVFSQDAKIIAIQYAGTAMAIGLVALVLSWLMRLQLGFPGTFDFITPDA
YYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYVNMLSYWIYLLAVIVLVASFFAPGGPTGAGWTLYPPQ
AILSGTPGGQDWGIILMLASLILFIIGFTMGGLNYVVTVIQGRTRGMTLMRMPLTVWGIFTATVMALLAFPALFVACVMM
LFDRLLGTSFFMPALVEMGEQLSYGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVVI
GALSFIVWAHHMYVSGMHPWFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGN
VVVDVPLSDTMFVVTHFHMVMGVAPILVIFGAIYHWYPKITGRMLDEWMGQFHFWVTFVGAYAIFFPMHYVGLVGVPRRY
VEIGESAFIPPSVQDLNAFITVAALIVGFAQMVFLFNLFWSLRYGREAGGNPWRATSLEWQTPTTPPPHGNWGDERPVVY
RWAYDYSVPGAPQDFIPQNDPWPQKAVAGTA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=532, Percent_Identity=38.1578947368421, Blast_Score=322, Evalue=8e-88,
Organism=Escherichia coli, GI1786634, Length=565, Percent_Identity=33.8053097345133, Blast_Score=305, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6226519, Length=500, Percent_Identity=38.4, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6226524, Length=335, Percent_Identity=39.4029850746269, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6226523, Length=257, Percent_Identity=35.7976653696498, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 66048; Mature: 66048

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDATPRMHEGISPAEVPELELYHPKGWWTTYVFSQDAKIIAIQYAGTAMAIGLVALVLS
CCCCCCCHHCCCCCCCCCCCEEECCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHH
WLMRLQLGFPGTFDFITPDAYYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMV
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
FPYVNMLSYWIYLLAVIVLVASFFAPGGPTGAGWTLYPPQAILSGTPGGQDWGIILMLAS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCCCCCCHHHHHHHHH
LILFIIGFTMGGLNYVVTVIQGRTRGMTLMRMPLTVWGIFTATVMALLAFPALFVACVMM
HHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDRLLGTSFFMPALVEMGEQLSYGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
THARKNIFGYRMMVWAIVVIGALSFIVWAHHMYVSGMHPWFGFFFATTTLIIAIPTAIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVVVDVPLSDTMFVVTHFHMV
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHEECCCEEEECCCCCHHHHHHHHHHH
MGVAPILVIFGAIYHWYPKITGRMLDEWMGQFHFWVTFVGAYAIFFPMHYVGLVGVPRRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VEIGESAFIPPSVQDLNAFITVAALIVGFAQMVFLFNLFWSLRYGREAGGNPWRATSLEW
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECC
QTPTTPPPHGNWGDERPVVYRWAYDYSVPGAPQDFIPQNDPWPQKAVAGTA
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDATPRMHEGISPAEVPELELYHPKGWWTTYVFSQDAKIIAIQYAGTAMAIGLVALVLS
CCCCCCCHHCCCCCCCCCCCEEECCCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHHHH
WLMRLQLGFPGTFDFITPDAYYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMV
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
FPYVNMLSYWIYLLAVIVLVASFFAPGGPTGAGWTLYPPQAILSGTPGGQDWGIILMLAS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCCCCCCHHHHHHHHH
LILFIIGFTMGGLNYVVTVIQGRTRGMTLMRMPLTVWGIFTATVMALLAFPALFVACVMM
HHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDRLLGTSFFMPALVEMGEQLSYGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLIS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
THARKNIFGYRMMVWAIVVIGALSFIVWAHHMYVSGMHPWFGFFFATTTLIIAIPTAIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YNWVLTLWRGDIHLTIPMLFALAFIVTFVNGGLTGLFLGNVVVDVPLSDTMFVVTHFHMV
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHEECCCEEEECCCCCHHHHHHHHHHH
MGVAPILVIFGAIYHWYPKITGRMLDEWMGQFHFWVTFVGAYAIFFPMHYVGLVGVPRRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VEIGESAFIPPSVQDLNAFITVAALIVGFAQMVFLFNLFWSLRYGREAGGNPWRATSLEW
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECC
QTPTTPPPHGNWGDERPVVYRWAYDYSVPGAPQDFIPQNDPWPQKAVAGTA
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]