Click here to switch to the map view.

The map label for this gene is metC [H]

Identifier: 110634723

GI number: 110634723

Start: 2536257

End: 2537438

Strand: Direct

Name: metC [H]

Synonym: Meso_2381

Alternate gene names: 110634723

Gene position: 2536257-2537438 (Clockwise)

Preceding gene: 110634721

Following gene: 110634724

Centisome position: 57.48

GC content: 61.84

Gene sequence:

>1182_bases
ATGAGAAAGTTGAGCCGTTGCGTTCATCAGCCTGCCGTTTTGCATGATGGCTTTGTCAGCCTGATGCCAGCGACCCATCG
CGCCTCCACGATCGTTTTCGAAACGGCGCAGGACTATCGCGACCGCAAGAGGCGAGGCCCGGACGGCTACAGCTATGGGC
TGAACGGCACGCCGACGAGCCGCACGCTGGAAGCTCAGATCGCAGCGCTGGAAGGGGCCGCTCATTGCACCTTGATGCCT
TCCGGGATGTCGGCGATCAGCCTGATCGCGTTGTCGGTCCTCAAGCAAGGAGACCGGATTCTCATCCCGGATACTGTCTA
TCCGCCGGTCAAAAACTTTTGCGCCACATTTCTGGCGGGGATCGGCATTGCACATGACATCTACCACGCTGACTGCAGCG
ATCTTGAGGACCTGATCGGCCCGGACGTGCGGCTGATTTGGGCGGAATCTCCTGGTTCGACGACAATGGAAGTTCAGGAC
CTGCGGGCGATCGCCACATTGGGTCGCAGACACGGCATCCTCACGGGATGCGACAATACCTGGGCCACGCCGCTGTTGCT
GCAGCCTTTGGCTTTGGGCATTGATTTTTCGATGCAGGCGCTGACCAAATATGCCAGCGGCCATTCCGATATTCTCATGG
GTTCGGTCGCGGTGAACGACCCCGCGCTCAACGCCAAACTAAAGGAAACCCGGACCATAATGGGAATCGGCGTGTCCCCG
GATGATTGCAGCCTGGTGCTGCGTGGCCTGTGCACCTTGGGGGTGCGGCTCGCGCATGTGGGACGGACGGGGCTAAATCT
GGCCCAGCACCTCAAGGCGTTTGCCAGCGTCTCCCGCGTACTTCACTCCGCATTCCCCGAGTGTGAGGGACACGAGATCT
GGGAGCGGGAGGCCCAGGGCTATACGGGCACCTTCAGCGCCGAGGTGCGCGTCCCCTCCCCCGCGGTTCTCGACGAGGCG
ATCGGGTTGTCGCGCTTCTTCGCCATCGGCGCCTCCTGGGGCGGCACCCATAGCCTGATCGCCCCGATGACGGTGGATGA
CACGCGCAAGTGGCCGCGGGTTCCCGGAGCGACTTACATCCGGCTGAGCATCGGGCTCGAGGACGAAAGGGATCTGCGCG
AGGATCTGGACCGCATCTTCGGATATCTTGACGCGGCTCTGGTGGAGACAGCCGCCCAATGA

Upstream 100 bases:

>100_bases
ACTGCCGTTGACAATGAAAATAGCGATCCGTACAAGAGAGAAACAGCGTTACGATAATAGTTACATAAGTGACCGCTCAG
GTAAATCCAAGGATCACACG

Downstream 100 bases:

>100_bases
ACTACTATCTCCGCAGACTGGCTGTCGCGATCGCCACAGTGCTGATCTCGTCCAGCCTGGTCTTCTTCGCCATTCGCATT
CTCCCAGGCGATCCGGTCAT

Product: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRKLSRCVHQPAVLHDGFVSLMPATHRASTIVFETAQDYRDRKRRGPDGYSYGLNGTPTSRTLEAQIAALEGAAHCTLMP
SGMSAISLIALSVLKQGDRILIPDTVYPPVKNFCATFLAGIGIAHDIYHADCSDLEDLIGPDVRLIWAESPGSTTMEVQD
LRAIATLGRRHGILTGCDNTWATPLLLQPLALGIDFSMQALTKYASGHSDILMGSVAVNDPALNAKLKETRTIMGIGVSP
DDCSLVLRGLCTLGVRLAHVGRTGLNLAQHLKAFASVSRVLHSAFPECEGHEIWEREAQGYTGTFSAEVRVPSPAVLDEA
IGLSRFFAIGASWGGTHSLIAPMTVDDTRKWPRVPGATYIRLSIGLEDERDLREDLDRIFGYLDAALVETAAQ

Sequences:

>Translated_393_residues
MRKLSRCVHQPAVLHDGFVSLMPATHRASTIVFETAQDYRDRKRRGPDGYSYGLNGTPTSRTLEAQIAALEGAAHCTLMP
SGMSAISLIALSVLKQGDRILIPDTVYPPVKNFCATFLAGIGIAHDIYHADCSDLEDLIGPDVRLIWAESPGSTTMEVQD
LRAIATLGRRHGILTGCDNTWATPLLLQPLALGIDFSMQALTKYASGHSDILMGSVAVNDPALNAKLKETRTIMGIGVSP
DDCSLVLRGLCTLGVRLAHVGRTGLNLAQHLKAFASVSRVLHSAFPECEGHEIWEREAQGYTGTFSAEVRVPSPAVLDEA
IGLSRFFAIGASWGGTHSLIAPMTVDDTRKWPRVPGATYIRLSIGLEDERDLREDLDRIFGYLDAALVETAAQ
>Mature_393_residues
MRKLSRCVHQPAVLHDGFVSLMPATHRASTIVFETAQDYRDRKRRGPDGYSYGLNGTPTSRTLEAQIAALEGAAHCTLMP
SGMSAISLIALSVLKQGDRILIPDTVYPPVKNFCATFLAGIGIAHDIYHADCSDLEDLIGPDVRLIWAESPGSTTMEVQD
LRAIATLGRRHGILTGCDNTWATPLLLQPLALGIDFSMQALTKYASGHSDILMGSVAVNDPALNAKLKETRTIMGIGVSP
DDCSLVLRGLCTLGVRLAHVGRTGLNLAQHLKAFASVSRVLHSAFPECEGHEIWEREAQGYTGTFSAEVRVPSPAVLDEA
IGLSRFFAIGASWGGTHSLIAPMTVDDTRKWPRVPGATYIRLSIGLEDERDLREDLDRIFGYLDAALVETAAQ

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=329, Percent_Identity=35.8662613981763, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI299473759, Length=329, Percent_Identity=33.434650455927, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI25453487, Length=325, Percent_Identity=31.6923076923077, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1789383, Length=364, Percent_Identity=35.7142857142857, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1790375, Length=368, Percent_Identity=30.9782608695652, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17538055, Length=342, Percent_Identity=30.9941520467836, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=345, Percent_Identity=31.5942028985507, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=373, Percent_Identity=28.686327077748, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=323, Percent_Identity=40.2476780185758, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319307, Length=345, Percent_Identity=28.9855072463768, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6321254, Length=390, Percent_Identity=25.8974358974359, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321904, Length=280, Percent_Identity=26.0714285714286, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323333, Length=383, Percent_Identity=23.7597911227154, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI19922554, Length=343, Percent_Identity=33.2361516034985, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42515; Mature: 42515

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLSRCVHQPAVLHDGFVSLMPATHRASTIVFETAQDYRDRKRRGPDGYSYGLNGTPTS
CCHHHHHHCCCHHHHCCHHHHCCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCC
RTLEAQIAALEGAAHCTLMPSGMSAISLIALSVLKQGDRILIPDTVYPPVKNFCATFLAG
CHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
IGIAHDIYHADCSDLEDLIGPDVRLIWAESPGSTTMEVQDLRAIATLGRRHGILTGCDNT
HHHHHHHHHCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEECCCCC
WATPLLLQPLALGIDFSMQALTKYASGHSDILMGSVAVNDPALNAKLKETRTIMGIGVSP
CCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHCCEEEEECCCC
DDCSLVLRGLCTLGVRLAHVGRTGLNLAQHLKAFASVSRVLHSAFPECEGHEIWEREAQG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
YTGTFSAEVRVPSPAVLDEAIGLSRFFAIGASWGGTHSLIAPMTVDDTRKWPRVPGATYI
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECEECCCCCCCCCCCCCEEE
RLSIGLEDERDLREDLDRIFGYLDAALVETAAQ
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLSRCVHQPAVLHDGFVSLMPATHRASTIVFETAQDYRDRKRRGPDGYSYGLNGTPTS
CCHHHHHHCCCHHHHCCHHHHCCCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCC
RTLEAQIAALEGAAHCTLMPSGMSAISLIALSVLKQGDRILIPDTVYPPVKNFCATFLAG
CHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
IGIAHDIYHADCSDLEDLIGPDVRLIWAESPGSTTMEVQDLRAIATLGRRHGILTGCDNT
HHHHHHHHHCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCEEECCCCC
WATPLLLQPLALGIDFSMQALTKYASGHSDILMGSVAVNDPALNAKLKETRTIMGIGVSP
CCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHCCEEEEECCCC
DDCSLVLRGLCTLGVRLAHVGRTGLNLAQHLKAFASVSRVLHSAFPECEGHEIWEREAQG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
YTGTFSAEVRVPSPAVLDEAIGLSRFFAIGASWGGTHSLIAPMTVDDTRKWPRVPGATYI
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECEECCCCCCCCCCCCCEEE
RLSIGLEDERDLREDLDRIFGYLDAALVETAAQ
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]