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The map label for this gene is argH [H]

Identifier: 110634709

GI number: 110634709

Start: 2517941

End: 2519473

Strand: Reverse

Name: argH [H]

Synonym: Meso_2366

Alternate gene names: 110634709

Gene position: 2519473-2517941 (Counterclockwise)

Preceding gene: 110634711

Following gene: 110634708

Centisome position: 57.1

GC content: 65.1

Gene sequence:

>1533_bases
ATGCTAGACGCCAGTAGCGCGGGTGGCTCTGCTGCCCCATCCGAGCCGTTGTTGACCGATGCGCGACTGGGAAAGAAGCC
GGCCGACCGTCTTCAGCGGCACTATCTCCAGGCGACCTTGAAGCGTGAGGAGAACAAGTTCGACCAGATCATCGCCGTCG
ATCAGGCCCATGCGGTGATGTTGACGGAACAGGGTATTATTCCCCGCGCAACGGGGACGGCCCTACTGGTCCAGCTGTCC
AAGCTGCGGCGCGAGGATGTCGGCATAGACGTGATGCGCGGCAGCATGTTGCTGCAGATCGAAGGGCACCTGGCCAGCAA
GACCGGAAACGAAGCCGCTGGCGCGCTCTCGACTGGGCGAAGCCGCATTGATCAGGGCGCGACCTTTCGCAGACTCTACG
AACGCCAGGCAATTATCGCGGTCCTTACCGAGCTGATCGACCTGGAAGCCGCCGTGATTGCGCAAGCTGCAAATCATATC
GACACCATCATGCCGGGATACACCCACCTACAGCCATCTCAGCCCTGGGTCTTCGGCCACTATCTTCTCGGTGTGGCGGA
GCGGCTGGATATAGATCTCGTCCGGCTGGAGAGGGCCTACGCGGCGGTCAATCTCTGCCCGTTGGGAACAGTGGGAGGCA
GCGGCTCGACGTGGCCGCTGGATCGGCATCGCGTGGCCAGCCTTCTGGGCTTCGACGGTATCGTCGAAAACGCGCGTCTG
GGACGGGACATCCAGTACACGGGCGACATCGCCGCGGCGGCCTCGATGCTTATGGCGACGCTGAACGACCTGGCGACGGA
CCTGCAGCTATGGTCGATGCAGGAGTTCGGATTTGTCGAGCTGGACGCCGGCTATTGCGGCACCAGCAGCATCTTCCCGC
AGAAGAAGAATCCGGTGGCGCTCGAAGGCGTCCGCTCGGCGGCGGCCGGCGCGGTTCAATGGGTGGGCAACGTGCTGGCG
GTCTCGCGCGGGGTCGGCTCCGGCGACCTGGCGCTGCGAGGGGCGGCATTCCTGGACACGGCGCTGCAGAGCACGGCCCA
GATGTGCGATCTGATGACTGGAGTGATGGAGACGCTGATCGTGCATAAGGACCGAATGGCCGAAAGGGCGGGCGAGGGCG
GCACCACGGCAAGCAATCTCGCCGATACGCTGGTGCGCGAGCTGGGCCTTTCCTATCGGGCGGCCCACCATGCGGTCGGA
AGATTCGTGCGGGTCTGCCTGGAGCGCAACCTCCCGTTGACGGGCGTCAGAGCGTCCGAATTCCATGAAATGGCCGGCCT
GGCCGACCAGCCCCGCCTCAGTGACGAGCAGCTTGCGGTTGCTTTGGATCCCGCCGGTTTCGTGCGGAGATGCCGGACGC
CCGGTGGGGTCGCTCCCGAAGAGGTCGCGCGGCTGCACGCGGCCGCCGTCGAGCGGCTGGGTGAAAGCCGCGCGCGTCTG
GAAGCGCGGATCGCTGCCTTGAATAGCGCGGAGCGAAAGCGGGCGGCGGCCATAGCGGCCATTTTGAACGCGCCGGAGGC
GGCAACCCGATGA

Upstream 100 bases:

>100_bases
GGAAACGTGAAGCAAAGGCAAGGGGGGCACACGCATTGACAGGAATAGCGCACTACTCTACAAATAGGAACAACGTTCCT
AATTTAGGTACATCACCATC

Downstream 100 bases:

>100_bases
GCCGGCGCGATCTGGATCAACTGTCCCTGGCCTCTCAGCTTCGATCGCGGGTTTTTGCGCGAGGGCCGAACTTCGACGCG
CTTATCACGTCCGACCCCGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MLDASSAGGSAAPSEPLLTDARLGKKPADRLQRHYLQATLKREENKFDQIIAVDQAHAVMLTEQGIIPRATGTALLVQLS
KLRREDVGIDVMRGSMLLQIEGHLASKTGNEAAGALSTGRSRIDQGATFRRLYERQAIIAVLTELIDLEAAVIAQAANHI
DTIMPGYTHLQPSQPWVFGHYLLGVAERLDIDLVRLERAYAAVNLCPLGTVGGSGSTWPLDRHRVASLLGFDGIVENARL
GRDIQYTGDIAAAASMLMATLNDLATDLQLWSMQEFGFVELDAGYCGTSSIFPQKKNPVALEGVRSAAAGAVQWVGNVLA
VSRGVGSGDLALRGAAFLDTALQSTAQMCDLMTGVMETLIVHKDRMAERAGEGGTTASNLADTLVRELGLSYRAAHHAVG
RFVRVCLERNLPLTGVRASEFHEMAGLADQPRLSDEQLAVALDPAGFVRRCRTPGGVAPEEVARLHAAAVERLGESRARL
EARIAALNSAERKRAAAIAAILNAPEAATR

Sequences:

>Translated_510_residues
MLDASSAGGSAAPSEPLLTDARLGKKPADRLQRHYLQATLKREENKFDQIIAVDQAHAVMLTEQGIIPRATGTALLVQLS
KLRREDVGIDVMRGSMLLQIEGHLASKTGNEAAGALSTGRSRIDQGATFRRLYERQAIIAVLTELIDLEAAVIAQAANHI
DTIMPGYTHLQPSQPWVFGHYLLGVAERLDIDLVRLERAYAAVNLCPLGTVGGSGSTWPLDRHRVASLLGFDGIVENARL
GRDIQYTGDIAAAASMLMATLNDLATDLQLWSMQEFGFVELDAGYCGTSSIFPQKKNPVALEGVRSAAAGAVQWVGNVLA
VSRGVGSGDLALRGAAFLDTALQSTAQMCDLMTGVMETLIVHKDRMAERAGEGGTTASNLADTLVRELGLSYRAAHHAVG
RFVRVCLERNLPLTGVRASEFHEMAGLADQPRLSDEQLAVALDPAGFVRRCRTPGGVAPEEVARLHAAAVERLGESRARL
EARIAALNSAERKRAAAIAAILNAPEAATR
>Mature_510_residues
MLDASSAGGSAAPSEPLLTDARLGKKPADRLQRHYLQATLKREENKFDQIIAVDQAHAVMLTEQGIIPRATGTALLVQLS
KLRREDVGIDVMRGSMLLQIEGHLASKTGNEAAGALSTGRSRIDQGATFRRLYERQAIIAVLTELIDLEAAVIAQAANHI
DTIMPGYTHLQPSQPWVFGHYLLGVAERLDIDLVRLERAYAAVNLCPLGTVGGSGSTWPLDRHRVASLLGFDGIVENARL
GRDIQYTGDIAAAASMLMATLNDLATDLQLWSMQEFGFVELDAGYCGTSSIFPQKKNPVALEGVRSAAAGAVQWVGNVLA
VSRGVGSGDLALRGAAFLDTALQSTAQMCDLMTGVMETLIVHKDRMAERAGEGGTTASNLADTLVRELGLSYRAAHHAVG
RFVRVCLERNLPLTGVRASEFHEMAGLADQPRLSDEQLAVALDPAGFVRRCRTPGGVAPEEVARLHAAAVERLGESRARL
EARIAALNSAERKRAAAIAAILNAPEAATR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=321, Percent_Identity=33.0218068535826, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI68303542, Length=321, Percent_Identity=33.0218068535826, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI68303547, Length=318, Percent_Identity=33.0188679245283, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI68303549, Length=321, Percent_Identity=31.1526479750779, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1790398, Length=379, Percent_Identity=32.4538258575198, Blast_Score=166, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321806, Length=321, Percent_Identity=33.0218068535826, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221473854, Length=456, Percent_Identity=28.9473684210526, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI78706858, Length=456, Percent_Identity=28.9473684210526, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54513; Mature: 54513

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDASSAGGSAAPSEPLLTDARLGKKPADRLQRHYLQATLKREENKFDQIIAVDQAHAVM
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEE
LTEQGIIPRATGTALLVQLSKLRREDVGIDVMRGSMLLQIEGHLASKTGNEAAGALSTGR
EECCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCHHCCCCCHHHHHHHHHH
SRIDQGATFRRLYERQAIIAVLTELIDLEAAVIAQAANHIDTIMPGYTHLQPSQPWVFGH
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHH
YLLGVAERLDIDLVRLERAYAAVNLCPLGTVGGSGSTWPLDRHRVASLLGFDGIVENARL
HHHHHHHHCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GRDIQYTGDIAAAASMLMATLNDLATDLQLWSMQEFGFVELDAGYCGTSSIFPQKKNPVA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCH
LEGVRSAAAGAVQWVGNVLAVSRGVGSGDLALRGAAFLDTALQSTAQMCDLMTGVMETLI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHKDRMAERAGEGGTTASNLADTLVRELGLSYRAAHHAVGRFVRVCLERNLPLTGVRASE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FHEMAGLADQPRLSDEQLAVALDPAGFVRRCRTPGGVAPEEVARLHAAAVERLGESRARL
HHHHHCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EARIAALNSAERKRAAAIAAILNAPEAATR
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MLDASSAGGSAAPSEPLLTDARLGKKPADRLQRHYLQATLKREENKFDQIIAVDQAHAVM
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEE
LTEQGIIPRATGTALLVQLSKLRREDVGIDVMRGSMLLQIEGHLASKTGNEAAGALSTGR
EECCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCHHCCCCCHHHHHHHHHH
SRIDQGATFRRLYERQAIIAVLTELIDLEAAVIAQAANHIDTIMPGYTHLQPSQPWVFGH
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHH
YLLGVAERLDIDLVRLERAYAAVNLCPLGTVGGSGSTWPLDRHRVASLLGFDGIVENARL
HHHHHHHHCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GRDIQYTGDIAAAASMLMATLNDLATDLQLWSMQEFGFVELDAGYCGTSSIFPQKKNPVA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCH
LEGVRSAAAGAVQWVGNVLAVSRGVGSGDLALRGAAFLDTALQSTAQMCDLMTGVMETLI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHKDRMAERAGEGGTTASNLADTLVRELGLSYRAAHHAVGRFVRVCLERNLPLTGVRASE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FHEMAGLADQPRLSDEQLAVALDPAGFVRRCRTPGGVAPEEVARLHAAAVERLGESRARL
HHHHHCCCCCCCCCCCCEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EARIAALNSAERKRAAAIAAILNAPEAATR
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA