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The map label for this gene is groL [H]

Identifier: 110634711

GI number: 110634711

Start: 2520405

End: 2521928

Strand: Reverse

Name: groL [H]

Synonym: Meso_2368

Alternate gene names: 110634711

Gene position: 2521928-2520405 (Counterclockwise)

Preceding gene: 110634712

Following gene: 110634709

Centisome position: 57.15

GC content: 67.06

Gene sequence:

>1524_bases
ATGCGGCGCATCATGGCGTCCGATGCAGCGCTCGTGGCGCGTGTCATCGCCTCGAGCATGGGGCCGGGAGGCTGTCATGT
CGCAATCGAGCGCAGCTACGGCAATCCGGTCGCACGCGACGCCGTCAGCGTGGTTCGCGCACTGGCCGGCGGCCCCGACA
GCATCTCTCCCGGTCAGCGGCTTCTGCGTGAGGCCGTCATGGAGGTCCATCAGACCTGGGGCGACGGCGGAAGCACGGTG
GCGATTGTCGTTTCGTCGCTCCTGCGGAGCATCACCAGGCTGTGCGCTGGCCAAATTGATCGCCTTGAACTGGGGCAGGG
GGTTCGAACCGCGCTCGCGCAGGCCCGCGATCGCTTGATCGCGGACAGCCGCCCGGTGGTCGAGGACCGCGAACTCCTTT
GTCTCACCACCACTGCTGCACAGGACAAGGCGCTGGGCGGCCTGGCGATGCAGGCATTGCGGCGAGCCGGGATGGAGGGC
CAGGTCAGCGTGCAGGTCTCGCCGGAAGGCGGCGACCGGCTCGAAGCCGACCATGGCTTTCGCGTTCCGCCGCTTGCGGC
GCCGCTTGGGTTCAGCAAAGGGCTGGCGCTGAACCAGCTGGAACGCCCTTTCGTGCTGCTGCTGGACGAAACACTGCCCG
GCTTCGACCCGCTTGGTCCTCTTCTCGACAAGGTTCTACGGACGGAACGCCCTTTGCTGATCGTATGCCAGGGCGGCGCC
CCCGCAGCAATTCAGGCGATCAACCAGAACCGAAGGCAAGGTGGCATGGCCACCGCCCTCGTCACAGCGCCTCCGCGTCC
CGACCAGCGGGAGGAACTACTGGAGGATCTGGCGGTGCTGTGCGGCGGGTTGGTCACTGGATCCCACCGCGGAGTGCCGC
TGGCATCCGTCGATATTGACATGCTGGGTTCGCTCGACGAAGCCATCTTCGGTGCGGCGGATACCGTTCTCAAGCCAGAC
CACACATCAGGGATCTCGAAACGTCTCGAGATCCTGCGCCGGAGGCGGGAATCGGCACCCCCGCAGGAGGTCGAGGCGCT
GCGTCAACGCATTGCCCGGCTGAGCGGCCACCTGGTATCTCTGATGATCGGGGGTGCGACGGGGCTGGAGGCGACCGACA
GGCGCGACCGTTGCGAAAGCGCGCTCAAGTCAGGCCGTGCCGGGCTGGTCGGCGGCTACGTGGCGGGCGGCGGCGCGGCG
CTGGCGCGCGCGGCGGCGGCGATCACCGTTTCGCCCGAGGCTACGGTGGGCGCGATGGCAGGCGCGCGCATTGTGCAGGA
GGCTCTGCGGCAGCCCTGCTCGACCATCGCTCGCAATGCAGGCCATTCGTCGCCGGCTGCGGTTGCGGCTCTTTTGGCTG
AAGCCGATCCCGACATCTGCTTCGACCTGCGCACATCTCGGTTTGGAAACATGCTGGACTTGGGCCTGTGCGACGCGGCG
GCGCCCCTGGTGCATGGGTTGACGGTAGCCCAATCGATCACACGGAGCTTCCTGGATGCTGAAATCCTGCTTATCCGGCG
CTGA

Upstream 100 bases:

>100_bases
GGCGGCGTGAAGCCAGCCTCGCCGCCATCCTTGGCGTGGCACGGTGACGGGAGCTTTACGGACGGACATGGCGCGCGACT
TCATTTTTGCCGGGGATGAC

Downstream 100 bases:

>100_bases
TCCGAGCGGCGCGCCGCCTGCGATCCGATCTTTTTCAGCCCGGCGACCAGCCCAGATCGCGCGAGACGGTGTCGGCGGCG
GCCACCACGATGGGCGCGAC

Product: chaperonin Cpn60/TCP-1

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MRRIMASDAALVARVIASSMGPGGCHVAIERSYGNPVARDAVSVVRALAGGPDSISPGQRLLREAVMEVHQTWGDGGSTV
AIVVSSLLRSITRLCAGQIDRLELGQGVRTALAQARDRLIADSRPVVEDRELLCLTTTAAQDKALGGLAMQALRRAGMEG
QVSVQVSPEGGDRLEADHGFRVPPLAAPLGFSKGLALNQLERPFVLLLDETLPGFDPLGPLLDKVLRTERPLLIVCQGGA
PAAIQAINQNRRQGGMATALVTAPPRPDQREELLEDLAVLCGGLVTGSHRGVPLASVDIDMLGSLDEAIFGAADTVLKPD
HTSGISKRLEILRRRRESAPPQEVEALRQRIARLSGHLVSLMIGGATGLEATDRRDRCESALKSGRAGLVGGYVAGGGAA
LARAAAAITVSPEATVGAMAGARIVQEALRQPCSTIARNAGHSSPAAVAALLAEADPDICFDLRTSRFGNMLDLGLCDAA
APLVHGLTVAQSITRSFLDAEILLIRR

Sequences:

>Translated_507_residues
MRRIMASDAALVARVIASSMGPGGCHVAIERSYGNPVARDAVSVVRALAGGPDSISPGQRLLREAVMEVHQTWGDGGSTV
AIVVSSLLRSITRLCAGQIDRLELGQGVRTALAQARDRLIADSRPVVEDRELLCLTTTAAQDKALGGLAMQALRRAGMEG
QVSVQVSPEGGDRLEADHGFRVPPLAAPLGFSKGLALNQLERPFVLLLDETLPGFDPLGPLLDKVLRTERPLLIVCQGGA
PAAIQAINQNRRQGGMATALVTAPPRPDQREELLEDLAVLCGGLVTGSHRGVPLASVDIDMLGSLDEAIFGAADTVLKPD
HTSGISKRLEILRRRRESAPPQEVEALRQRIARLSGHLVSLMIGGATGLEATDRRDRCESALKSGRAGLVGGYVAGGGAA
LARAAAAITVSPEATVGAMAGARIVQEALRQPCSTIARNAGHSSPAAVAALLAEADPDICFDLRTSRFGNMLDLGLCDAA
APLVHGLTVAQSITRSFLDAEILLIRR
>Mature_507_residues
MRRIMASDAALVARVIASSMGPGGCHVAIERSYGNPVARDAVSVVRALAGGPDSISPGQRLLREAVMEVHQTWGDGGSTV
AIVVSSLLRSITRLCAGQIDRLELGQGVRTALAQARDRLIADSRPVVEDRELLCLTTTAAQDKALGGLAMQALRRAGMEG
QVSVQVSPEGGDRLEADHGFRVPPLAAPLGFSKGLALNQLERPFVLLLDETLPGFDPLGPLLDKVLRTERPLLIVCQGGA
PAAIQAINQNRRQGGMATALVTAPPRPDQREELLEDLAVLCGGLVTGSHRGVPLASVDIDMLGSLDEAIFGAADTVLKPD
HTSGISKRLEILRRRRESAPPQEVEALRQRIARLSGHLVSLMIGGATGLEATDRRDRCESALKSGRAGLVGGYVAGGGAA
LARAAAAITVSPEATVGAMAGARIVQEALRQPCSTIARNAGHSSPAAVAALLAEADPDICFDLRTSRFGNMLDLGLCDAA
APLVHGLTVAQSITRSFLDAEILLIRR

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=517, Percent_Identity=27.2727272727273, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI31542947, Length=517, Percent_Identity=27.2727272727273, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1790586, Length=502, Percent_Identity=26.2948207171315, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17555558, Length=494, Percent_Identity=27.5303643724696, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI193210679, Length=169, Percent_Identity=33.1360946745562, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323288, Length=508, Percent_Identity=25.3937007874016, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45550936, Length=494, Percent_Identity=29.7570850202429, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45550132, Length=494, Percent_Identity=29.7570850202429, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45550935, Length=494, Percent_Identity=29.7570850202429, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24641193, Length=517, Percent_Identity=27.6595744680851, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24641191, Length=517, Percent_Identity=27.6595744680851, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17864606, Length=519, Percent_Identity=25.8188824662813, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24584129, Length=524, Percent_Identity=26.3358778625954, Blast_Score=133, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19921262, Length=524, Percent_Identity=26.3358778625954, Blast_Score=133, Evalue=4e-31,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 53097; Mature: 53097

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRIMASDAALVARVIASSMGPGGCHVAIERSYGNPVARDAVSVVRALAGGPDSISPGQR
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
LLREAVMEVHQTWGDGGSTVAIVVSSLLRSITRLCAGQIDRLELGQGVRTALAQARDRLI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
ADSRPVVEDRELLCLTTTAAQDKALGGLAMQALRRAGMEGQVSVQVSPEGGDRLEADHGF
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
RVPPLAAPLGFSKGLALNQLERPFVLLLDETLPGFDPLGPLLDKVLRTERPLLIVCQGGA
CCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCC
PAAIQAINQNRRQGGMATALVTAPPRPDQREELLEDLAVLCGGLVTGSHRGVPLASVDID
CHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
MLGSLDEAIFGAADTVLKPDHTSGISKRLEILRRRRESAPPQEVEALRQRIARLSGHLVS
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LMIGGATGLEATDRRDRCESALKSGRAGLVGGYVAGGGAALARAAAAITVSPEATVGAMA
HHCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHEEEECCCHHHHHHH
GARIVQEALRQPCSTIARNAGHSSPAAVAALLAEADPDICFDLRTSRFGNMLDLGLCDAA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECHHHHCCCCHHHHHHHHH
APLVHGLTVAQSITRSFLDAEILLIRR
HHHHHHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MRRIMASDAALVARVIASSMGPGGCHVAIERSYGNPVARDAVSVVRALAGGPDSISPGQR
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
LLREAVMEVHQTWGDGGSTVAIVVSSLLRSITRLCAGQIDRLELGQGVRTALAQARDRLI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
ADSRPVVEDRELLCLTTTAAQDKALGGLAMQALRRAGMEGQVSVQVSPEGGDRLEADHGF
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCC
RVPPLAAPLGFSKGLALNQLERPFVLLLDETLPGFDPLGPLLDKVLRTERPLLIVCQGGA
CCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCC
PAAIQAINQNRRQGGMATALVTAPPRPDQREELLEDLAVLCGGLVTGSHRGVPLASVDID
CHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
MLGSLDEAIFGAADTVLKPDHTSGISKRLEILRRRRESAPPQEVEALRQRIARLSGHLVS
HHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LMIGGATGLEATDRRDRCESALKSGRAGLVGGYVAGGGAALARAAAAITVSPEATVGAMA
HHCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHEEEECCCHHHHHHH
GARIVQEALRQPCSTIARNAGHSSPAAVAALLAEADPDICFDLRTSRFGNMLDLGLCDAA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECHHHHCCCCHHHHHHHHH
APLVHGLTVAQSITRSFLDAEILLIRR
HHHHHHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA