Click here to switch to the map view.

The map label for this gene is fhs

Identifier: 110634553

GI number: 110634553

Start: 2352263

End: 2353942

Strand: Reverse

Name: fhs

Synonym: Meso_2204

Alternate gene names: 110634553

Gene position: 2353942-2352263 (Counterclockwise)

Preceding gene: 110634554

Following gene: 110634549

Centisome position: 53.35

GC content: 61.43

Gene sequence:

>1680_bases
ATGGCAGATGTGAAGTCAGATATCGAGATCGCCCGCGCGGCGAGGAAGAAGCCGATCCAGGAGATTGGGGCGGGGCTGGG
CATCGCGTCTGAGCACCTTCTGCCTTACGGCCACGACAAGGCGAAGGTGTCGGCCGAGTTTATCGCTGAGGCTCGAAAAA
GGCCGGACGGAAGGCTGATCCTCGTCACCGCGATTAATCCGACCCCGGCAGGCGAGGGCAAGACGACCACAACGGTCGGC
CTTGGCGACGGCCTCAACCGCATCGGCAAGAAGGCGATCGTCTGCATCCGCGAAGCCTCGCTCGGCCCCTGCTTCGGCAT
GAAGGGCGGGGCGGCGGGCGGCGGTTACGCGCAGGTGATCCCGATGGAAGACATCAACCTCCACTTCACCGGCGATTTTC
ATGCGGTCACCTCCGCCCACAATCTGCTCTCTGCCCTGATCGACAACCACATCTATTGGGGAAATGAGCTTGGCATCGAC
ACGCGCCGGGTGACCTGGCGGCGCGTGATGGATATGAACGACCGCGCGCTGCGTGAGATCGTCTGCTCCCTCGGCGGTGT
CGCCAACGGCTATCCGCGCGAAGGGGGATTTGACATCACCGTCGCCTCGGAGGTGATGGCGATCCTTTGCCTGGCAAAGG
ATCTCGGCGATCTCGAAAAACGGCTGGGTGACATCATCGTCGCCTACCGGCGCGACAAAAGCCCTGTCTTCGCGCGCGAC
CTCAAGGCCGACGGAGCGATGGCCGTCCTCCTCAGGGATGCGTTGCAGCCGAACCTGGTTCAGACGCTGGAAAACAACCC
GGCCTTCGTCCATGGCGGGCCTTTCGCCAATATTGCCCATGGCTGCAATTCAGTGATGGCCACGAGCACTGCGCTGAAAC
TGGCGGACTATGTGGTCACGGAAGCGGGGTTTGGGGCGGACCTCGGCGCCGAGAAGTTCTTCGATATCAAATGCCGGAAG
ACCGGTCTTAAGCCTGCCGCGGCGGTCATCGTTGCTACCGTGCGCGCGCTTAAAATGAATGGAGGCGTGAAGAAGGAAGA
TCTCGGCGCGGAAGATGTCGATGCCCTCATCAGGGGATGCGCCAATCTTGGCCGTCACATCGAAAACATAAAGCAGTTCG
GCGTTCCAGCTATCGTTGCCATCAACCATTTTGAAACCGACACTCCGGCGGAAATAGAGGCCGTGAGGGCCTATGTGGGG
GCGCAAGGCGAAGAGGCGGTGCTTTGCCGGCATTGGGCGGAAGGCTCGGCCGGCATCGAGGAACTGGCTCATAAGGTCGT
GGCGTTGGCGGAGAGCCGCGCTTCCCAGTTCGCACCGCTCTATCCCGACAACATGCCGCTGTTCGAAAAGATCAATACGA
TCGTGCGGCGGATCTACCGAGGTTCACGCGCGGTGGCCGACGGCACCGTGCTCGCCCAGCTTAAGCAATGGGAAGACCAG
GGCTATGGGCATCTTCCGGTCTGCATGGCCAAGACCCAATATTCCTTCTCCACCGATTCCAATCTGCGCGGGGCGCCGGT
GGATCACGTCGTCCCGGTGCGGGAAGTGCGGCTTTCCGCAGGGGCCGGCTTCGTGGTCGCGATCTGCGGTGAGATCATGA
CCATGCCGGGCCTGCCGCGCGCGCCCTCGGCCGAGAAGATATTTCTCAATGAGGCCGGCTACATAGAAGGTCTTTTTTAA

Upstream 100 bases:

>100_bases
ACTAGGAAGTAGCGAATAGCGGATTGGGCCGGTTGACAGGCCCGCGCCCATTCGGGCCATCTATTCGCTAATTCCTACTT
GCTATTCGCGGGGGGTGCTC

Downstream 100 bases:

>100_bases
TCAGAACAATAGGTCAGGCCGCGTTTGGGCCCGGATCATCTCCGTCCGGACGCTTTAGAGACTTCTGGTGAAGGCCGGTT
TCCGCCTGATTTCCACCTTC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MADVKSDIEIARAARKKPIQEIGAGLGIASEHLLPYGHDKAKVSAEFIAEARKRPDGRLILVTAINPTPAGEGKTTTTVG
LGDGLNRIGKKAIVCIREASLGPCFGMKGGAAGGGYAQVIPMEDINLHFTGDFHAVTSAHNLLSALIDNHIYWGNELGID
TRRVTWRRVMDMNDRALREIVCSLGGVANGYPREGGFDITVASEVMAILCLAKDLGDLEKRLGDIIVAYRRDKSPVFARD
LKADGAMAVLLRDALQPNLVQTLENNPAFVHGGPFANIAHGCNSVMATSTALKLADYVVTEAGFGADLGAEKFFDIKCRK
TGLKPAAAVIVATVRALKMNGGVKKEDLGAEDVDALIRGCANLGRHIENIKQFGVPAIVAINHFETDTPAEIEAVRAYVG
AQGEEAVLCRHWAEGSAGIEELAHKVVALAESRASQFAPLYPDNMPLFEKINTIVRRIYRGSRAVADGTVLAQLKQWEDQ
GYGHLPVCMAKTQYSFSTDSNLRGAPVDHVVPVREVRLSAGAGFVVAICGEIMTMPGLPRAPSAEKIFLNEAGYIEGLF

Sequences:

>Translated_559_residues
MADVKSDIEIARAARKKPIQEIGAGLGIASEHLLPYGHDKAKVSAEFIAEARKRPDGRLILVTAINPTPAGEGKTTTTVG
LGDGLNRIGKKAIVCIREASLGPCFGMKGGAAGGGYAQVIPMEDINLHFTGDFHAVTSAHNLLSALIDNHIYWGNELGID
TRRVTWRRVMDMNDRALREIVCSLGGVANGYPREGGFDITVASEVMAILCLAKDLGDLEKRLGDIIVAYRRDKSPVFARD
LKADGAMAVLLRDALQPNLVQTLENNPAFVHGGPFANIAHGCNSVMATSTALKLADYVVTEAGFGADLGAEKFFDIKCRK
TGLKPAAAVIVATVRALKMNGGVKKEDLGAEDVDALIRGCANLGRHIENIKQFGVPAIVAINHFETDTPAEIEAVRAYVG
AQGEEAVLCRHWAEGSAGIEELAHKVVALAESRASQFAPLYPDNMPLFEKINTIVRRIYRGSRAVADGTVLAQLKQWEDQ
GYGHLPVCMAKTQYSFSTDSNLRGAPVDHVVPVREVRLSAGAGFVVAICGEIMTMPGLPRAPSAEKIFLNEAGYIEGLF
>Mature_558_residues
ADVKSDIEIARAARKKPIQEIGAGLGIASEHLLPYGHDKAKVSAEFIAEARKRPDGRLILVTAINPTPAGEGKTTTTVGL
GDGLNRIGKKAIVCIREASLGPCFGMKGGAAGGGYAQVIPMEDINLHFTGDFHAVTSAHNLLSALIDNHIYWGNELGIDT
RRVTWRRVMDMNDRALREIVCSLGGVANGYPREGGFDITVASEVMAILCLAKDLGDLEKRLGDIIVAYRRDKSPVFARDL
KADGAMAVLLRDALQPNLVQTLENNPAFVHGGPFANIAHGCNSVMATSTALKLADYVVTEAGFGADLGAEKFFDIKCRKT
GLKPAAAVIVATVRALKMNGGVKKEDLGAEDVDALIRGCANLGRHIENIKQFGVPAIVAINHFETDTPAEIEAVRAYVGA
QGEEAVLCRHWAEGSAGIEELAHKVVALAESRASQFAPLYPDNMPLFEKINTIVRRIYRGSRAVADGTVLAQLKQWEDQG
YGHLPVCMAKTQYSFSTDSNLRGAPVDHVVPVREVRLSAGAGFVVAICGEIMTMPGLPRAPSAEKIFLNEAGYIEGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=41.5458937198068, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI36796743, Length=625, Percent_Identity=42.4, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=633, Percent_Identity=42.1800947867299, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17568739, Length=633, Percent_Identity=42.1800947867299, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.9297124600639, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=41.390205371248, Blast_Score=448, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24645718, Length=621, Percent_Identity=42.9951690821256, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17137370, Length=621, Percent_Identity=42.9951690821256, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI62472483, Length=621, Percent_Identity=42.9951690821256, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551871, Length=621, Percent_Identity=42.9951690821256, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_MESSB (Q11G79)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674761.1
- ProteinModelPortal:   Q11G79
- SMR:   Q11G79
- STRING:   Q11G79
- GeneID:   4181898
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_2204
- NMPDR:   fig|266779.1.peg.1786
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q11G79
- ProtClustDB:   PRK13505
- BioCyc:   MSP266779:MESO_2204-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59887; Mature: 59755

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVKSDIEIARAARKKPIQEIGAGLGIASEHLLPYGHDKAKVSAEFIAEARKRPDGRLI
CCCCHHHHHHHHHHHCCCHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
LVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPCFGMKGGAAGGGYAQVI
EEEEECCCCCCCCCCEEEEECCCCHHHHCHHEEEEEECCCCCCCCCCCCCCCCCCCEEEE
PMEDINLHFTGDFHAVTSAHNLLSALIDNHIYWGNELGIDTRRVTWRRVMDMNDRALREI
EECCCEEEECCCHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCHHHHHHH
VCSLGGVANGYPREGGFDITVASEVMAILCLAKDLGDLEKRLGDIIVAYRRDKSPVFARD
HHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
LKADGAMAVLLRDALQPNLVQTLENNPAFVHGGPFANIAHGCNSVMATSTALKLADYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFFDIKCRKTGLKPAAAVIVATVRALKMNGGVKKEDLGAEDVDALIRGC
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ANLGRHIENIKQFGVPAIVAINHFETDTPAEIEAVRAYVGAQGEEAVLCRHWAEGSAGIE
HHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEHHCCCCCCCHH
ELAHKVVALAESRASQFAPLYPDNMPLFEKINTIVRRIYRGSRAVADGTVLAQLKQWEDQ
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GYGHLPVCMAKTQYSFSTDSNLRGAPVDHVVPVREVRLSAGAGFVVAICGEIMTMPGLPR
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCC
APSAEKIFLNEAGYIEGLF
CCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
ADVKSDIEIARAARKKPIQEIGAGLGIASEHLLPYGHDKAKVSAEFIAEARKRPDGRLI
CCCHHHHHHHHHHHCCCHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEE
LVTAINPTPAGEGKTTTTVGLGDGLNRIGKKAIVCIREASLGPCFGMKGGAAGGGYAQVI
EEEEECCCCCCCCCCEEEEECCCCHHHHCHHEEEEEECCCCCCCCCCCCCCCCCCCEEEE
PMEDINLHFTGDFHAVTSAHNLLSALIDNHIYWGNELGIDTRRVTWRRVMDMNDRALREI
EECCCEEEECCCHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCHHHHHHH
VCSLGGVANGYPREGGFDITVASEVMAILCLAKDLGDLEKRLGDIIVAYRRDKSPVFARD
HHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
LKADGAMAVLLRDALQPNLVQTLENNPAFVHGGPFANIAHGCNSVMATSTALKLADYVVT
CCCCCHHHHHHHHHCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EAGFGADLGAEKFFDIKCRKTGLKPAAAVIVATVRALKMNGGVKKEDLGAEDVDALIRGC
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
ANLGRHIENIKQFGVPAIVAINHFETDTPAEIEAVRAYVGAQGEEAVLCRHWAEGSAGIE
HHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEHHCCCCCCCHH
ELAHKVVALAESRASQFAPLYPDNMPLFEKINTIVRRIYRGSRAVADGTVLAQLKQWEDQ
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GYGHLPVCMAKTQYSFSTDSNLRGAPVDHVVPVREVRLSAGAGFVVAICGEIMTMPGLPR
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCC
APSAEKIFLNEAGYIEGLF
CCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA