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The map label for this gene is pgsA1 [H]

Identifier: 110634315

GI number: 110634315

Start: 2106217

End: 2106774

Strand: Reverse

Name: pgsA1 [H]

Synonym: Meso_1965

Alternate gene names: 110634315

Gene position: 2106774-2106217 (Counterclockwise)

Preceding gene: 110634319

Following gene: 110634314

Centisome position: 47.75

GC content: 58.06

Gene sequence:

>558_bases
TTGACCATTCCCAATTTCATTACGCTGTTGCGCTTCCTGCTCGTTCCCGCGGTTATCTTCGCACTTCTCACCGGTGAGGT
GGAATGGGCGTTTGCCGGGTTTGTTTTTGCGGCTGTTTCAGACGGGGTCGACGGTTTCATCGCCCGCCAGTTCAACCAGA
AGAGCGAGTTGGGCGCCTATCTCGACCCGATGGCGGACAAGCTGTTGCTCGTCAGCGTCTTCGTGGTTCTGGGATATATG
GGAAACCTGCCGCTTTGGCTGGTTGTGGCCGCTGTCTCCCGTGACGGGCTCATCGTCGGCGGCGTTCTCCTTTCCGCCGT
TATGGATCAACCCGTGGCGATGAAGCCGCTGTTGATCTCGAAAGCCAATACACTGGTGCAACTCCTGCTCGCCGCGGTGG
TGCTCGCAGGACTTACCTTTGATTTCTCGCTCGGGCTCCTCTATCCCGGTCTCGTCTATTTTTCCGGGCTCTTGACCGTG
GCCTCAGGCGCGGCCTATCTCGTGAACTGGATCAAGCATATGGGCGGTCATGTCGATACCGGCACCTCGGGACAGTGA

Upstream 100 bases:

>100_bases
ACCAAATCTCACTCTTGCGGTGCCACGCAAGCACAGCCATTTATTCCGGCACGCGCTGCGTCGTCGAGGATAATGAAGGG
GCTATCAGAGAGGAACCGGA

Downstream 100 bases:

>100_bases
GGCGGCGCCGCGCCGGGCGCTCGTTCGGCACGTCAGCTTTTGGCTCATCGCCGCCGCGATCCTGATTCTCTTTCTTTATG
TGTTCAGTTCCATCCTGCTG

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MTIPNFITLLRFLLVPAVIFALLTGEVEWAFAGFVFAAVSDGVDGFIARQFNQKSELGAYLDPMADKLLLVSVFVVLGYM
GNLPLWLVVAAVSRDGLIVGGVLLSAVMDQPVAMKPLLISKANTLVQLLLAAVVLAGLTFDFSLGLLYPGLVYFSGLLTV
ASGAAYLVNWIKHMGGHVDTGTSGQ

Sequences:

>Translated_185_residues
MTIPNFITLLRFLLVPAVIFALLTGEVEWAFAGFVFAAVSDGVDGFIARQFNQKSELGAYLDPMADKLLLVSVFVVLGYM
GNLPLWLVVAAVSRDGLIVGGVLLSAVMDQPVAMKPLLISKANTLVQLLLAAVVLAGLTFDFSLGLLYPGLVYFSGLLTV
ASGAAYLVNWIKHMGGHVDTGTSGQ
>Mature_184_residues
TIPNFITLLRFLLVPAVIFALLTGEVEWAFAGFVFAAVSDGVDGFIARQFNQKSELGAYLDPMADKLLLVSVFVVLGYMG
NLPLWLVVAAVSRDGLIVGGVLLSAVMDQPVAMKPLLISKANTLVQLLLAAVVLAGLTFDFSLGLLYPGLVYFSGLLTVA
SGAAYLVNWIKHMGGHVDTGTSGQ

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=181, Percent_Identity=33.1491712707182, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI10092647, Length=181, Percent_Identity=33.1491712707182, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1788220, Length=176, Percent_Identity=32.9545454545455, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984834, Length=183, Percent_Identity=35.5191256830601, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71984838, Length=183, Percent_Identity=35.5191256830601, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24650130, Length=185, Percent_Identity=32.972972972973, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24650126, Length=185, Percent_Identity=32.972972972973, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24650128, Length=185, Percent_Identity=32.972972972973, Blast_Score=93, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 19620; Mature: 19488

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPNFITLLRFLLVPAVIFALLTGEVEWAFAGFVFAAVSDGVDGFIARQFNQKSELGAY
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHH
LDPMADKLLLVSVFVVLGYMGNLPLWLVVAAVSRDGLIVGGVLLSAVMDQPVAMKPLLIS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHH
KANTLVQLLLAAVVLAGLTFDFSLGLLYPGLVYFSGLLTVASGAAYLVNWIKHMGGHVDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
GTSGQ
CCCCC
>Mature Secondary Structure 
TIPNFITLLRFLLVPAVIFALLTGEVEWAFAGFVFAAVSDGVDGFIARQFNQKSELGAY
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHH
LDPMADKLLLVSVFVVLGYMGNLPLWLVVAAVSRDGLIVGGVLLSAVMDQPVAMKPLLIS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHH
KANTLVQLLLAAVVLAGLTFDFSLGLLYPGLVYFSGLLTVASGAAYLVNWIKHMGGHVDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
GTSGQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]