Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 110633993

GI number: 110633993

Start: 1767877

End: 1769082

Strand: Direct

Name: moeA [H]

Synonym: Meso_1641

Alternate gene names: 110633993

Gene position: 1767877-1769082 (Clockwise)

Preceding gene: 110633992

Following gene: 110633994

Centisome position: 40.07

GC content: 63.1

Gene sequence:

>1206_bases
ATGGCGCTGCTTCGCGTTGAAGATGCCCTCCGGCGTGCGCTTGATGGAATAGATATCCTTCCTGCCGAGGAAGTGCCGCT
TGCCGAGGCGGCAGAGCGTATCCTTGCATGCGATTTGAAAGCGCGGCGCACGCAGCCACCTTTCGATGCCTCCGCCATGG
ATGGTTATGCCGTTCGCGCCGCTGATATCGAGAGCCCGCCTGCCACGCTGGCCGTTATCGGTGAATCCGCCGCGGGACTG
CGCTTTTCCGGCCGTGTCGGGCCTGGAGAAGCCGTGCGCATCTTTACGGGCGCGCCAGTTCCCGTCGGGGCAGATACAAT
TCTCCTCCAGGAAAACGCCTCTGCGCTGGAAGCGGACCGTATCAGCGCGCTGGAGCCTGCGCTCCCCGGCCGCCATATCC
GCATCGCGGGACTCGATTTCAAGGAGAGCGATGTTCTCCTTGGAAAAGGCCGGCTGCTCGACCCGGCAGCCATTGCGCTT
GCTGCGGCTGGCGGACATGCGCAGTTGCCTGTCGTCCGTCGTCCTCTGGTGGCGCTGATCGCGACCGGCGACGAGCTGGT
TCCACCCGATACCGTGCCGGGGGCCGATCAGATCATTGCCTCGAACCATTTTGGAATTGGCGCCCTGGCAAAGCTCGATG
GCGCCGATGTGCTCGATCTCGGGATCGTTCCGGACCAACAGCACGCGATCGCCGGCGCGGCCCGAAGCGCTCTTGAGGCG
GGGGCGCATATCGTCGTTACGCTGGGCGGCGCGTCGGTAGGAGAGCGCGATCTGGTGCGTCAAGTGCTTACAGACGAAGG
CATGGAACTGGATTTCTGGAAAATCGCCATGCGTCCGGGAAAGCCGCTGATGTTCGGCCGTTTTGGAGAGACGCGCGTTC
TCGGGCTGCCAGGCAACCCCGTCTCCAGCTTCATCTGCGCCCATCTTTTCCTGCGTCCGATGATCGCCCGGCTTTCGGGC
CGAATCTTTCGCGCGGATCTTCGTCCCGCCAAGCTCGGCAAGGCTCTCAAGGCGAACGACGAGCGGCAGGATTATCTTCG
CGCTCTCGTCGAAGAGCACACGGATGGTTCCGTCGCTACCCCTTTCGAGACGCAGGATTCGTCCATGCTGACAACGCTCG
CCAGGTCCAACGGCCTGATAATCCGCGAGCCGCATGCTCCAGCGGCAGAAGCAGGCACCCTGTGCACGGTTTTGATGCTG
CGCTGA

Upstream 100 bases:

>100_bases
ATGGCGAAGGCGCTGGACAAGGCCATGGTCATCACGGACATCCGCCTTGTGGAGAAGCGGGGCGGCAAGTCGGGAACCTG
GCGCATGGAGGACGCCGGTC

Downstream 100 bases:

>100_bases
GAGTGCGCGGGAATAACCATTTGATTTTGATGTTGCGGAACACAACTCGAACATATAGTGTATGTTCTGGGTTTGTTTAT
GACTGATTCCGGGTGGGTCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALLRVEDALRRALDGIDILPAEEVPLAEAAERILACDLKARRTQPPFDASAMDGYAVRAADIESPPATLAVIGESAAGL
RFSGRVGPGEAVRIFTGAPVPVGADTILLQENASALEADRISALEPALPGRHIRIAGLDFKESDVLLGKGRLLDPAAIAL
AAAGGHAQLPVVRRPLVALIATGDELVPPDTVPGADQIIASNHFGIGALAKLDGADVLDLGIVPDQQHAIAGAARSALEA
GAHIVVTLGGASVGERDLVRQVLTDEGMELDFWKIAMRPGKPLMFGRFGETRVLGLPGNPVSSFICAHLFLRPMIARLSG
RIFRADLRPAKLGKALKANDERQDYLRALVEEHTDGSVATPFETQDSSMLTTLARSNGLIIREPHAPAAEAGTLCTVLML
R

Sequences:

>Translated_401_residues
MALLRVEDALRRALDGIDILPAEEVPLAEAAERILACDLKARRTQPPFDASAMDGYAVRAADIESPPATLAVIGESAAGL
RFSGRVGPGEAVRIFTGAPVPVGADTILLQENASALEADRISALEPALPGRHIRIAGLDFKESDVLLGKGRLLDPAAIAL
AAAGGHAQLPVVRRPLVALIATGDELVPPDTVPGADQIIASNHFGIGALAKLDGADVLDLGIVPDQQHAIAGAARSALEA
GAHIVVTLGGASVGERDLVRQVLTDEGMELDFWKIAMRPGKPLMFGRFGETRVLGLPGNPVSSFICAHLFLRPMIARLSG
RIFRADLRPAKLGKALKANDERQDYLRALVEEHTDGSVATPFETQDSSMLTTLARSNGLIIREPHAPAAEAGTLCTVLML
R
>Mature_400_residues
ALLRVEDALRRALDGIDILPAEEVPLAEAAERILACDLKARRTQPPFDASAMDGYAVRAADIESPPATLAVIGESAAGLR
FSGRVGPGEAVRIFTGAPVPVGADTILLQENASALEADRISALEPALPGRHIRIAGLDFKESDVLLGKGRLLDPAAIALA
AAGGHAQLPVVRRPLVALIATGDELVPPDTVPGADQIIASNHFGIGALAKLDGADVLDLGIVPDQQHAIAGAARSALEAG
AHIVVTLGGASVGERDLVRQVLTDEGMELDFWKIAMRPGKPLMFGRFGETRVLGLPGNPVSSFICAHLFLRPMIARLSGR
IFRADLRPAKLGKALKANDERQDYLRALVEEHTDGSVATPFETQDSSMLTTLARSNGLIIREPHAPAAEAGTLCTVLMLR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=401, Percent_Identity=33.1670822942643, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI10880983, Length=401, Percent_Identity=33.1670822942643, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1787049, Length=387, Percent_Identity=35.6589147286822, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147659, Length=361, Percent_Identity=31.5789473684211, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=370, Percent_Identity=25.9459459459459, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136978, Length=374, Percent_Identity=28.0748663101604, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24638841, Length=374, Percent_Identity=28.0748663101604, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42208; Mature: 42077

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLRVEDALRRALDGIDILPAEEVPLAEAAERILACDLKARRTQPPFDASAMDGYAVRA
CEEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEEEE
ADIESPPATLAVIGESAAGLRFSGRVGPGEAVRIFTGAPVPVGADTILLQENASALEADR
ECCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHH
ISALEPALPGRHIRIAGLDFKESDVLLGKGRLLDPAAIALAAAGGHAQLPVVRRPLVALI
HHHCCCCCCCCEEEEEECCCCCCCEEEECCCCCCHHHHEEEECCCCCCCCHHHCCEEEEE
ATGDELVPPDTVPGADQIIASNHFGIGALAKLDGADVLDLGIVPDQQHAIAGAARSALEA
ECCCCCCCCCCCCCCHHEEECCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHC
GAHIVVTLGGASVGERDLVRQVLTDEGMELDFWKIAMRPGKPLMFGRFGETRVLGLPGNP
CCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCH
VSSFICAHLFLRPMIARLSGRIFRADLRPAKLGKALKANDERQDYLRALVEEHTDGSVAT
HHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCHHHHCCCHHHHHHHHHHHHCCCCCEEC
PFETQDSSMLTTLARSNGLIIREPHAPAAEAGTLCTVLMLR
CCCCCCCHHHHHHHHCCCEEEECCCCCCCHHCCEEEEEEEC
>Mature Secondary Structure 
ALLRVEDALRRALDGIDILPAEEVPLAEAAERILACDLKARRTQPPFDASAMDGYAVRA
EEEHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEEEE
ADIESPPATLAVIGESAAGLRFSGRVGPGEAVRIFTGAPVPVGADTILLQENASALEADR
ECCCCCCCEEEEEECCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHH
ISALEPALPGRHIRIAGLDFKESDVLLGKGRLLDPAAIALAAAGGHAQLPVVRRPLVALI
HHHCCCCCCCCEEEEEECCCCCCCEEEECCCCCCHHHHEEEECCCCCCCCHHHCCEEEEE
ATGDELVPPDTVPGADQIIASNHFGIGALAKLDGADVLDLGIVPDQQHAIAGAARSALEA
ECCCCCCCCCCCCCCHHEEECCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHC
GAHIVVTLGGASVGERDLVRQVLTDEGMELDFWKIAMRPGKPLMFGRFGETRVLGLPGNP
CCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCH
VSSFICAHLFLRPMIARLSGRIFRADLRPAKLGKALKANDERQDYLRALVEEHTDGSVAT
HHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCHHHHCCCHHHHHHHHHHHHCCCCCEEC
PFETQDSSMLTTLARSNGLIIREPHAPAAEAGTLCTVLMLR
CCCCCCCHHHHHHHHCCCEEEECCCCCCCHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]