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The map label for this gene is moaC [H]

Identifier: 110633992

GI number: 110633992

Start: 1767378

End: 1767896

Strand: Direct

Name: moaC [H]

Synonym: Meso_1640

Alternate gene names: 110633992

Gene position: 1767378-1767896 (Clockwise)

Preceding gene: 110633991

Following gene: 110633993

Centisome position: 40.05

GC content: 63.58

Gene sequence:

>519_bases
ATGGCCAATGAAGCCGGGAGCAGGCTAACCCATCTGCGTGCCGATGGCCGCGCTGAGATGGTCGATATCGGCGCCAAGCA
GGAGACCGAGCGCGCGGCGATTGCAGCCGGCGCCGTGGTCATGGCGCCCGAGACGCTCCAGGCAATCCTCAAAGGGGATG
CAAAAAAGGGCGATGTGATCGCTGTCGCGAGGATCGCCGGGATCATGGCCGCCAAGAAGACACATGATTTGATCCCGCTT
TGCCATCCCCTGGCGCTTACGAAGGTTGCGGTGGAGATCGCTCCGGATGAATCGCTGCCGGGGCTTCGCGTCGAGGCGAC
GGCCCGTATCACCGGCAAAACAGGCGTGGAGATGGAAGCGTTGACCGCCGTGTCCGTCGCCTGCCTCACGATCTACGATA
TGGCGAAGGCGCTGGACAAGGCCATGGTCATCACGGACATCCGCCTTGTGGAGAAGCGGGGCGGCAAGTCGGGAACCTGG
CGCATGGAGGACGCCGGTCATGGCGCTGCTTCGCGTTGA

Upstream 100 bases:

>100_bases
CCACATTCCTTGTGGGCGAAAGCCTGATGCGCCAGAACGATGTCGAGGCCGCAACGCGGAGCCTTCTTGGCCTACAGCGG
AATATCGAGGCAGTGAGCTG

Downstream 100 bases:

>100_bases
AGATGCCCTCCGGCGTGCGCTTGATGGAATAGATATCCTTCCTGCCGAGGAAGTGCCGCTTGCCGAGGCGGCAGAGCGTA
TCCTTGCATGCGATTTGAAA

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MANEAGSRLTHLRADGRAEMVDIGAKQETERAAIAAGAVVMAPETLQAILKGDAKKGDVIAVARIAGIMAAKKTHDLIPL
CHPLALTKVAVEIAPDESLPGLRVEATARITGKTGVEMEALTAVSVACLTIYDMAKALDKAMVITDIRLVEKRGGKSGTW
RMEDAGHGAASR

Sequences:

>Translated_172_residues
MANEAGSRLTHLRADGRAEMVDIGAKQETERAAIAAGAVVMAPETLQAILKGDAKKGDVIAVARIAGIMAAKKTHDLIPL
CHPLALTKVAVEIAPDESLPGLRVEATARITGKTGVEMEALTAVSVACLTIYDMAKALDKAMVITDIRLVEKRGGKSGTW
RMEDAGHGAASR
>Mature_171_residues
ANEAGSRLTHLRADGRAEMVDIGAKQETERAAIAAGAVVMAPETLQAILKGDAKKGDVIAVARIAGIMAAKKTHDLIPLC
HPLALTKVAVEIAPDESLPGLRVEATARITGKTGVEMEALTAVSVACLTIYDMAKALDKAMVITDIRLVEKRGGKSGTWR
MEDAGHGAASR

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family [H]

Homologues:

Organism=Escherichia coli, GI1787001, Length=157, Percent_Identity=58.5987261146497, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=45.6375838926174, Blast_Score=135, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574490, Length=157, Percent_Identity=50.3184713375796, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574492, Length=144, Percent_Identity=50.6944444444444, Blast_Score=136, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC [H]

EC number: NA

Molecular weight: Translated: 17994; Mature: 17863

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEAGSRLTHLRADGRAEMVDIGAKQETERAAIAAGAVVMAPETLQAILKGDAKKGDVI
CCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHCEEEECHHHHHHHHCCCCCCCCEE
AVARIAGIMAAKKTHDLIPLCHPLALTKVAVEIAPDESLPGLRVEATARITGKTGVEMEA
EHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEEEEEEECCCCCCCHHH
LTAVSVACLTIYDMAKALDKAMVITDIRLVEKRGGKSGTWRMEDAGHGAASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
ANEAGSRLTHLRADGRAEMVDIGAKQETERAAIAAGAVVMAPETLQAILKGDAKKGDVI
CCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHCEEEECHHHHHHHHCCCCCCCCEE
AVARIAGIMAAKKTHDLIPLCHPLALTKVAVEIAPDESLPGLRVEATARITGKTGVEMEA
EHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEEEEEEECCCCCCCHHH
LTAVSVACLTIYDMAKALDKAMVITDIRLVEKRGGKSGTWRMEDAGHGAASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]