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The map label for this gene is lexA

Identifier: 110633994

GI number: 110633994

Start: 1769184

End: 1769894

Strand: Direct

Name: lexA

Synonym: Meso_1642

Alternate gene names: 110633994

Gene position: 1769184-1769894 (Clockwise)

Preceding gene: 110633993

Following gene: 110633997

Centisome position: 40.1

GC content: 60.2

Gene sequence:

>711_bases
ATGCTTACGCGCAAACAGCACGAGCTGCTGCTTTTCATTCATGCACGTCTCAAGGAGACGGGCATACCGCCCTCATTCGA
TGAGATGAAAGAGGCACTGGATCTTGCCTCCAAGTCCGGTATTCACCGGCTGATTACGGCACTGGAGGAGCGCGGCTTCA
TTCGCCGCCTGCCGAACCGCGCCCGTGCATTGGAGGTGTTGCGGCTTCCCGATTCGATCGCTCCAGGGCTCGCGGCGCCG
CGCAAATTCTCGCCCAGCGTCATCGAAGGCGGCCAGGGCCGTAGCTCTCCCGCGCCTAGGCCCGCCGCCAATAATGACGA
CGAAACGAGCGTTGTTTCGATTCCGGTCATGGGGCGGATCGCCGCGGGTGTGCCGATCGATGCCATTCAGCACCGGACTC
ATTCGATCGGCGTCCCACCGGACATGATCACCGGCGGCGAGCACTATGCATTGGAGGTCAAGGGCGATTCGATGATCGAA
GCCGGCATTTTCGACGGCGATACGGTCATCATTCGGCAGACCCAGGCGGCAAATCCCGGCGACATCGTCGTTGCTTTGGT
GGATGAAGAGGAAGCCACCTTGAAGCGCTTTCGCCGCAAAGGCGCATCGATTGCGCTGGAGGCTGCCAATCCTGCCTATG
AAACACGCATATTCGGACCTGATCGCGTGAAGGTGCAAGGCAGGCTGGTGGGACTGATTCGCCGGTACTAA

Upstream 100 bases:

>100_bases
AGTGCGCGGGAATAACCATTTGATTTTGATGTTGCGGAACACAACTCGAACATATAGTGTATGTTCTGGGTTTGTTTATG
ACTGATTCCGGGTGGGTCCC

Downstream 100 bases:

>100_bases
ACGGGAGCGGGCAGTGAGGGCCTTCCCCGTTCCGGGCTATTCGCGCCCTGAGACGTTGAGGAGTCGCGTCCGCTTTTTCA
GCACCATCAGTGTCGTATAG

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MLTRKQHELLLFIHARLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLAAP
RKFSPSVIEGGQGRSSPAPRPAANNDDETSVVSIPVMGRIAAGVPIDAIQHRTHSIGVPPDMITGGEHYALEVKGDSMIE
AGIFDGDTVIIRQTQAANPGDIVVALVDEEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKVQGRLVGLIRRY

Sequences:

>Translated_236_residues
MLTRKQHELLLFIHARLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLAAP
RKFSPSVIEGGQGRSSPAPRPAANNDDETSVVSIPVMGRIAAGVPIDAIQHRTHSIGVPPDMITGGEHYALEVKGDSMIE
AGIFDGDTVIIRQTQAANPGDIVVALVDEEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKVQGRLVGLIRRY
>Mature_236_residues
MLTRKQHELLLFIHARLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLAAP
RKFSPSVIEGGQGRSSPAPRPAANNDDETSVVSIPVMGRIAAGVPIDAIQHRTHSIGVPPDMITGGEHYALEVKGDSMIE
AGIFDGDTVIIRQTQAANPGDIVVALVDEEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKVQGRLVGLIRRY

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=235, Percent_Identity=25.1063829787234, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_MESSB (Q11HT8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674202.1
- ProteinModelPortal:   Q11HT8
- SMR:   Q11HT8
- STRING:   Q11HT8
- MEROPS:   S24.001
- GeneID:   4179241
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1642
- NMPDR:   fig|266779.1.peg.388
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   LEPANAR
- PhylomeDB:   Q11HT8
- ProtClustDB:   PRK00215
- BioCyc:   MSP266779:MESO_1642-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 25703; Mature: 25703

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: ACT_SITE 157-157 ACT_SITE 195-195

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRKQHELLLFIHARLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNR
CCCCCCCCEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCH
ARALEVLRLPDSIAPGLAAPRKFSPSVIEGGQGRSSPAPRPAANNDDETSVVSIPVMGRI
HHHHHHHCCCCHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHH
AAGVPIDAIQHRTHSIGVPPDMITGGEHYALEVKGDSMIEAGIFDGDTVIIRQTQAANPG
HCCCCHHHHHHCCCCCCCCCCCEECCCEEEEEECCCCEEEECCCCCCEEEEEECCCCCCC
DIVVALVDEEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKVQGRLVGLIRRY
CEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCEEEECCCCEEEEHHHHEEHHHCC
>Mature Secondary Structure
MLTRKQHELLLFIHARLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNR
CCCCCCCCEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCH
ARALEVLRLPDSIAPGLAAPRKFSPSVIEGGQGRSSPAPRPAANNDDETSVVSIPVMGRI
HHHHHHHCCCCHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHH
AAGVPIDAIQHRTHSIGVPPDMITGGEHYALEVKGDSMIEAGIFDGDTVIIRQTQAANPG
HCCCCHHHHHHCCCCCCCCCCCEECCCEEEEEECCCCEEEECCCCCCEEEEEECCCCCCC
DIVVALVDEEEATLKRFRRKGASIALEAANPAYETRIFGPDRVKVQGRLVGLIRRY
CEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCEEEECCCCEEEEHHHHEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA