Click here to switch to the map view.

The map label for this gene is mazG [H]

Identifier: 110633963

GI number: 110633963

Start: 1734970

End: 1735773

Strand: Direct

Name: mazG [H]

Synonym: Meso_1611

Alternate gene names: 110633963

Gene position: 1734970-1735773 (Clockwise)

Preceding gene: 110633962

Following gene: 110633973

Centisome position: 39.32

GC content: 60.07

Gene sequence:

>804_bases
ATGAAACCGTCCAAGGACATTTCCCGACTGATCGAGATCATGGCCGCGCTCCGTGATCCGGATTCCGGCTGCCCGTGGGA
CGTGCAGCAGAATTTTTCGACCATCGCACCCTATACGATTGAGGAGGCCTACGAGGTTCTCGACGCCGTCCAGCGCGATG
ATATGCAAGACTTGCGTGACGAGCTGGGTGATCTGCTTCTTCAGGTCGTTTTCCACGCCCGCATGGCGGAGGAAGCCGGT
CACTTCGACTTCGGCGATGTCGTCGAGGCGATCACGACGAAGATGATCCGCCGCCACCCGCATGTGTTCGGGGATGACGA
TGCACGTGAGGCCGGGATGGCCAAGGGCATGTGGGAACGCATCAAGGCGGAAGAGAAAGCCGAGCGCCGGCGCCGCGGCG
GGCAGACCGAGCGCGGCTACCTGGACGATGTGACGGTCGCCCTGCCCGCCTTGATGCGAGCGCTGAAGCTTCAGGAAAAA
GCGTCACGTGTCGGTTTCGACTGGGGTGCCGCCCGACCGATTCTCGACAAGATAGAGGAAGAGATCGGTGAACTGCGGCA
GGAAATGGAGGCAGGCAGGCAGCCAGCCATTGCGGGGGAGTTCGGGGATCTCCTTTTTGCAACGGTCAATCTCGGCCGGC
ATTTGGGTGTCGATCCCGAGAGCGCGCTACGAAGCACCAATGAGAAATTCCGCACCCGCTTTCATTCTGTCGAACGGCGC
TTGCGCGAAGAAGGTAAGGCGCTCGGCGCTGCCTCACTTGAGGAAATGGAAGCGCACTGGCAGGAAGCGAAGAAGATTAA
ATAA

Upstream 100 bases:

>100_bases
AAATTCAATGACAATCCTCCGCCATTGCGCGACCGAGAAGCTTGAGAACCGGGCGGATGCGCGATACGGCTTCGCCATCA
CCATACGGAGCCCTCGCCCG

Downstream 100 bases:

>100_bases
TCCTCCCTACCCTTTGTTATTCCTAGATAATCTCCGGCTAATTTCCTCACGCGCCGCTTGAGTAGCGCGAATTTTCACTG
TGGAGCCGCCGTCCTCGTTG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MKPSKDISRLIEIMAALRDPDSGCPWDVQQNFSTIAPYTIEEAYEVLDAVQRDDMQDLRDELGDLLLQVVFHARMAEEAG
HFDFGDVVEAITTKMIRRHPHVFGDDDAREAGMAKGMWERIKAEEKAERRRRGGQTERGYLDDVTVALPALMRALKLQEK
ASRVGFDWGAARPILDKIEEEIGELRQEMEAGRQPAIAGEFGDLLFATVNLGRHLGVDPESALRSTNEKFRTRFHSVERR
LREEGKALGAASLEEMEAHWQEAKKIK

Sequences:

>Translated_267_residues
MKPSKDISRLIEIMAALRDPDSGCPWDVQQNFSTIAPYTIEEAYEVLDAVQRDDMQDLRDELGDLLLQVVFHARMAEEAG
HFDFGDVVEAITTKMIRRHPHVFGDDDAREAGMAKGMWERIKAEEKAERRRRGGQTERGYLDDVTVALPALMRALKLQEK
ASRVGFDWGAARPILDKIEEEIGELRQEMEAGRQPAIAGEFGDLLFATVNLGRHLGVDPESALRSTNEKFRTRFHSVERR
LREEGKALGAASLEEMEAHWQEAKKIK
>Mature_267_residues
MKPSKDISRLIEIMAALRDPDSGCPWDVQQNFSTIAPYTIEEAYEVLDAVQRDDMQDLRDELGDLLLQVVFHARMAEEAG
HFDFGDVVEAITTKMIRRHPHVFGDDDAREAGMAKGMWERIKAEEKAERRRRGGQTERGYLDDVTVALPALMRALKLQEK
ASRVGFDWGAARPILDKIEEEIGELRQEMEAGRQPAIAGEFGDLLFATVNLGRHLGVDPESALRSTNEKFRTRFHSVERR
LREEGKALGAASLEEMEAHWQEAKKIK

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=261, Percent_Identity=51.3409961685824, Blast_Score=268, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30301; Mature: 30301

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSKDISRLIEIMAALRDPDSGCPWDVQQNFSTIAPYTIEEAYEVLDAVQRDDMQDLRD
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHCHHHHHHH
ELGDLLLQVVFHARMAEEAGHFDFGDVVEAITTKMIRRHPHVFGDDDAREAGMAKGMWER
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
IKAEEKAERRRRGGQTERGYLDDVTVALPALMRALKLQEKASRVGFDWGAARPILDKIEE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
EIGELRQEMEAGRQPAIAGEFGDLLFATVNLGRHLGVDPESALRSTNEKFRTRFHSVERR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LREEGKALGAASLEEMEAHWQEAKKIK
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPSKDISRLIEIMAALRDPDSGCPWDVQQNFSTIAPYTIEEAYEVLDAVQRDDMQDLRD
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHCHHHHHHH
ELGDLLLQVVFHARMAEEAGHFDFGDVVEAITTKMIRRHPHVFGDDDAREAGMAKGMWER
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
IKAEEKAERRRRGGQTERGYLDDVTVALPALMRALKLQEKASRVGFDWGAARPILDKIEE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
EIGELRQEMEAGRQPAIAGEFGDLLFATVNLGRHLGVDPESALRSTNEKFRTRFHSVERR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LREEGKALGAASLEEMEAHWQEAKKIK
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]