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The map label for this gene is ribH [H]

Identifier: 110633491

GI number: 110633491

Start: 1245414

End: 1245884

Strand: Direct

Name: ribH [H]

Synonym: Meso_1138

Alternate gene names: 110633491

Gene position: 1245414-1245884 (Clockwise)

Preceding gene: 110633490

Following gene: 110633492

Centisome position: 28.23

GC content: 61.57

Gene sequence:

>471_bases
ATGACAGACAAGACGAAACTCCTCATCGTCGAAGCGCGCTTTTACGATGACTTGGCCGATGGCCTGCTGAATTCCGCGAA
GGAAGCCTTGGACGAGGCGGGCGCCTCCTTTGATCTCGTGACCGTCCCCGGCGCACTGGAGATCCCCGGGGCGATCGCTC
TCGCGCATCAGGCTGCGCAGAAGAATGGCCGTCGCTATGACGGTTTTGTCGCGCTCGGCTGCGTCATTCGTGGTGAGACC
TACCATTTCGAGATCGTTTCGAACGAATCGGCGCGCGGCCTCATGGACCTGACGGTGAAGGAGGGGCTTGCTATCGGCAA
CGGCATCCTCACGGTCGAGAATGAGGAGCAGGCTTGGGAGCGGGTGAAAGGCCGTCCCGAGACCGGGACAATCGAAGGAG
CCGGGAAGGGGCGTGCGGCCGCCGAGGCCGCGCTTCGAATGATTGAACTCAAGAAACGCCTTGGAGCGTGA

Upstream 100 bases:

>100_bases
TCAAAAGGTCAATCTTGAGGTCGATACCATGGCCCGCTACGCCGCGCGTCTTGCGGAGGCGGCGAAAGAGGCCTAATCGG
CTGCTCTCCCGGAGATAAAG

Downstream 100 bases:

>100_bases
ACCTTGACCACCCCCTCTAAAAGCCCTGCCGAAAACTTCCGCCCCGCCAACAAGCGCGGCGCCGCACGACTTGCTGCGGT
GCAGGCGCTTTATCAAATGG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain [H]

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MTDKTKLLIVEARFYDDLADGLLNSAKEALDEAGASFDLVTVPGALEIPGAIALAHQAAQKNGRRYDGFVALGCVIRGET
YHFEIVSNESARGLMDLTVKEGLAIGNGILTVENEEQAWERVKGRPETGTIEGAGKGRAAAEAALRMIELKKRLGA

Sequences:

>Translated_156_residues
MTDKTKLLIVEARFYDDLADGLLNSAKEALDEAGASFDLVTVPGALEIPGAIALAHQAAQKNGRRYDGFVALGCVIRGET
YHFEIVSNESARGLMDLTVKEGLAIGNGILTVENEEQAWERVKGRPETGTIEGAGKGRAAAEAALRMIELKKRLGA
>Mature_155_residues
TDKTKLLIVEARFYDDLADGLLNSAKEALDEAGASFDLVTVPGALEIPGAIALAHQAAQKNGRRYDGFVALGCVIRGETY
HFEIVSNESARGLMDLTVKEGLAIGNGILTVENEEQAWERVKGRPETGTIEGAGKGRAAAEAALRMIELKKRLGA

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786617, Length=159, Percent_Identity=39.622641509434, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324429, Length=149, Percent_Identity=30.8724832214765, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002180 [H]

Pfam domain/function: PF00885 DMRL_synthase [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 16655; Mature: 16524

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKTKLLIVEARFYDDLADGLLNSAKEALDEAGASFDLVTVPGALEIPGAIALAHQAAQ
CCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
KNGRRYDGFVALGCVIRGETYHFEIVSNESARGLMDLTVKEGLAIGNGILTVENEEQAWE
HCCCCCCCEEEEEEEEECCEEEEEEECCCCCCCEEEEHHHCCEEECCCEEEEECHHHHHH
RVKGRPETGTIEGAGKGRAAAEAALRMIELKKRLGA
HHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDKTKLLIVEARFYDDLADGLLNSAKEALDEAGASFDLVTVPGALEIPGAIALAHQAAQ
CCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
KNGRRYDGFVALGCVIRGETYHFEIVSNESARGLMDLTVKEGLAIGNGILTVENEEQAWE
HCCCCCCCEEEEEEEEECCEEEEEEECCCCCCCEEEEHHHCCEEECCCEEEEECHHHHHH
RVKGRPETGTIEGAGKGRAAAEAALRMIELKKRLGA
HHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]