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The map label for this gene is hdl IVa [H]

Identifier: 110633217

GI number: 110633217

Start: 954645

End: 955307

Strand: Reverse

Name: hdl IVa [H]

Synonym: Meso_0860

Alternate gene names: 110633217

Gene position: 955307-954645 (Counterclockwise)

Preceding gene: 110633219

Following gene: 110633216

Centisome position: 21.65

GC content: 60.18

Gene sequence:

>663_bases
ATGCGATTTTCAGCCTTTGTCTTTGATGCTTACGGCACGGTTTTCGACGTGCATTCGGCCGTCCGCCGCCATGCGGGCGA
TATAGGGCCGGCAGGCCAGACGCTTTCGGAAATCTGGCGTGCCAAGCAGCTCGAATATTCGTGGATCGGCACGCTCATGG
ATGACTATGCCGATTTTTGGGTGCTGACGGAGCGCGCGCTCGATTTCGCCTTCAAGAAGGTGCCCTCCGCTGATCCGGCG
CTGAAGCAGAAGCTTCTGGAGGCCTATTGGCGCCTCGACTGTTACCCGGAGGTTCCCGCCGTGCTGTCGGCCCTGAAATC
GAGCGGCGCGAGAATTTCCATCCTGTCGAACGGCTCGCCGGAAATGCTCGAAGCGGCGCTGCGTTCCTCCGCGCTCGATA
CGGTCGTGGATGATGTCTTTTCCGCTGACATGGTGGGCAAGTTCAAGACGCATCCGGCCGTCTACGAACTCGTTACCACC
GCGCTCAGGGTCTATCCGGACGCGGTCTCCTTCCAGTCCGCTAACCGGTGGGATGTGGCAGGCGCCGGCAGCTTCGGTTT
CCGCACGGTCTGGATCAACCGCAGCGATCAGCCGGACGAATACCACGAATATCCGCCGCAACTCATCCTTCCGTCATTGA
AGGGTCTGCTGACCGACCGATGA

Upstream 100 bases:

>100_bases
CTCTTTATGTGCAACGCTCCGGAAAGCTTCAGCCTTTGGAAAGCTTTTCCCGGAATTCTCCGTGGTGCCCGCGCGATGAC
GTCTGGGTCAGGATAGCAGA

Downstream 100 bases:

>100_bases
CCGATTCGTGACCCGACGTGCGTTGCACAATTGCAATAGGCGGCGAACAATATGGCCAGGATTAAGTTTCCAGCTTGCTT
CCGACGCAACAAGGTTGGAT

Product: haloacid dehalogenase, type II

Products: NA

Alternate protein names: 2-haloalkanoic acid dehalogenase IVA; Halocarboxylic acid halidohydrolase IVA; L-2-haloacid dehalogenase IVA [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRFSAFVFDAYGTVFDVHSAVRRHAGDIGPAGQTLSEIWRAKQLEYSWIGTLMDDYADFWVLTERALDFAFKKVPSADPA
LKQKLLEAYWRLDCYPEVPAVLSALKSSGARISILSNGSPEMLEAALRSSALDTVVDDVFSADMVGKFKTHPAVYELVTT
ALRVYPDAVSFQSANRWDVAGAGSFGFRTVWINRSDQPDEYHEYPPQLILPSLKGLLTDR

Sequences:

>Translated_220_residues
MRFSAFVFDAYGTVFDVHSAVRRHAGDIGPAGQTLSEIWRAKQLEYSWIGTLMDDYADFWVLTERALDFAFKKVPSADPA
LKQKLLEAYWRLDCYPEVPAVLSALKSSGARISILSNGSPEMLEAALRSSALDTVVDDVFSADMVGKFKTHPAVYELVTT
ALRVYPDAVSFQSANRWDVAGAGSFGFRTVWINRSDQPDEYHEYPPQLILPSLKGLLTDR
>Mature_220_residues
MRFSAFVFDAYGTVFDVHSAVRRHAGDIGPAGQTLSEIWRAKQLEYSWIGTLMDDYADFWVLTERALDFAFKKVPSADPA
LKQKLLEAYWRLDCYPEVPAVLSALKSSGARISILSNGSPEMLEAALRSSALDTVVDDVFSADMVGKFKTHPAVYELVTT
ALRVYPDAVSFQSANRWDVAGAGSFGFRTVWINRSDQPDEYHEYPPQLILPSLKGLLTDR

Specific function: Catalyzes the hydrolytic dehalogenation of small (S)-2- haloalkanoic acids to yield the corresponding (R)-2- hydroxyalkanoic acids. Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-3 [H]

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. S-2- haloalkanoic acid dehalogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006388
- InterPro:   IPR006402
- InterPro:   IPR006328
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.8.1.2 [H]

Molecular weight: Translated: 24563; Mature: 24563

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSAFVFDAYGTVFDVHSAVRRHAGDIGPAGQTLSEIWRAKQLEYSWIGTLMDDYADFW
CCCHHEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
VLTERALDFAFKKVPSADPALKQKLLEAYWRLDCYPEVPAVLSALKSSGARISILSNGSP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCH
EMLEAALRSSALDTVVDDVFSADMVGKFKTHPAVYELVTTALRVYPDAVSFQSANRWDVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
GAGSFGFRTVWINRSDQPDEYHEYPPQLILPSLKGLLTDR
CCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFSAFVFDAYGTVFDVHSAVRRHAGDIGPAGQTLSEIWRAKQLEYSWIGTLMDDYADFW
CCCHHEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
VLTERALDFAFKKVPSADPALKQKLLEAYWRLDCYPEVPAVLSALKSSGARISILSNGSP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCH
EMLEAALRSSALDTVVDDVFSADMVGKFKTHPAVYELVTTALRVYPDAVSFQSANRWDVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHCCCCCCCCCCC
GAGSFGFRTVWINRSDQPDEYHEYPPQLILPSLKGLLTDR
CCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1376111 [H]