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The map label for this gene is gppA [H]

Identifier: 110632832

GI number: 110632832

Start: 519523

End: 520764

Strand: Reverse

Name: gppA [H]

Synonym: Meso_0471

Alternate gene names: 110632832

Gene position: 520764-519523 (Counterclockwise)

Preceding gene: 110632833

Following gene: 110632831

Centisome position: 11.8

GC content: 65.78

Gene sequence:

>1242_bases
GTGGGCAGCGGACGGGATCCGGTCACGAGTCCCGCATCTGTTGACATTCCGCAGCCGAAACGAAAACGCAGGAGAAGGCG
CAAGCGCGGCGTGTTCGTGCGCGGAGCCGAGCCTTGCGCCGACAGGAAAGCCGCGCCACAGAAGGCGCCTGCCCTCACAC
CGCAGCCTGCACCCGCAGAATTTGCGCGAAGGAGCAAGGCTTATGCTGCCCGGCTTTCAAGCTCCCCTGATGCCGATGCG
CTTTATGCCGCCCTTGATCTTGGCACCAACAATTGCCGGCTGCTGGTCGCTACGCCGGGCAGGCCGGGCCGCTTCCGCGT
TGTGGACGCGTTCTCGCGTATCGTTCGGCTGGGCGAAGGGCTCGCGGCCAGCGGACGGTTGAGTGACGCCGCGATGGAGC
GGGCGGTAGAGGCTCTTTCCGTCTGTGCGCAGAAGCTGGACGGCCGGAGTTTGGCCGGCGTGCGCATGATTGCGACGGAG
GCCTGCCGCGCCGCGGAGAACGGGCCTCACTTCATCGAACGCGTACGCCGCGAAACCGGTCTCGACCTTGAGATCATCGA
CCGGCGCACCGAGGCTCGGCTCGCCGTTTCCGGCTGCGGTTCTCTCGTTTCACGCGATACGGATGGCGTCGTCCTGTTCG
ACATCGGTGGCGGTTCGTCGGAAATCGCGCTGATCGATCTCTCACGCCATCGCACGCCCCGGCTCGCCGACCACATCTTA
TCCTGGACTTCCCTGCCGACCGGCGTCGTCTCGCTGGCGGAACGTTTTGGCGGCCGCGTCGTCACGCCGGTGATTTTCGA
GGCCATGGTGTCCCACGTCTCCGAAATGCTGGCCCAGTTCGATGGCGGCACAAGGCTTGCCCATGTGGCCGGCAGCGGCA
AGTTCCACCTGCTGGGCACTTCCGGCACGGTGACGACGCTTGCAGGCGTTCATCTGGGTCTCAAGCGATACGACCGGAGG
CGGGTGGACGGGCTTTGGATGGAGCGCGCCAGCGTCGACCGCATCATCGACACGATCCTGAACTGGAGCTTCGACGAGCG
TAGAGCCAATCCGTGCATCGGGCTGGAGCGTGCTGACCTCGTGCTCGCTGGATGCGCCATTCTGGAGGCTATACGCCGTC
ATTGGCCGGCAGAGCGCCTGCGGGTCGCCGACCGGGGCCTGAGGGAGGGCATGCTCAACGAGATGATGGCGCGCGACGGT
GTTTGGCGGCGCCGAAAGCAGAACGGAGCATGCCCGGCGTGA

Upstream 100 bases:

>100_bases
GCTGCGCGGCGCGGAAGGATAGACGGTGGACGACCACGGAAAAGGTGACGCGCCACCGGTCGCGGAGTTCCTTCGCGATC
ACGCGTCAACCGGGGGCGGC

Downstream 100 bases:

>100_bases
CGAAGGAGAAGAAGGCTGGCTCCGGGACGCGCGTCCTGAAAACGCGGGTCAAGAAGAAGCGGGGCTTGAAGAGCTCGTCC
CGGCGCTGGCTGGAGCGGCA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MGSGRDPVTSPASVDIPQPKRKRRRRRKRGVFVRGAEPCADRKAAPQKAPALTPQPAPAEFARRSKAYAARLSSSPDADA
LYAALDLGTNNCRLLVATPGRPGRFRVVDAFSRIVRLGEGLAASGRLSDAAMERAVEALSVCAQKLDGRSLAGVRMIATE
ACRAAENGPHFIERVRRETGLDLEIIDRRTEARLAVSGCGSLVSRDTDGVVLFDIGGGSSEIALIDLSRHRTPRLADHIL
SWTSLPTGVVSLAERFGGRVVTPVIFEAMVSHVSEMLAQFDGGTRLAHVAGSGKFHLLGTSGTVTTLAGVHLGLKRYDRR
RVDGLWMERASVDRIIDTILNWSFDERRANPCIGLERADLVLAGCAILEAIRRHWPAERLRVADRGLREGMLNEMMARDG
VWRRRKQNGACPA

Sequences:

>Translated_413_residues
MGSGRDPVTSPASVDIPQPKRKRRRRRKRGVFVRGAEPCADRKAAPQKAPALTPQPAPAEFARRSKAYAARLSSSPDADA
LYAALDLGTNNCRLLVATPGRPGRFRVVDAFSRIVRLGEGLAASGRLSDAAMERAVEALSVCAQKLDGRSLAGVRMIATE
ACRAAENGPHFIERVRRETGLDLEIIDRRTEARLAVSGCGSLVSRDTDGVVLFDIGGGSSEIALIDLSRHRTPRLADHIL
SWTSLPTGVVSLAERFGGRVVTPVIFEAMVSHVSEMLAQFDGGTRLAHVAGSGKFHLLGTSGTVTTLAGVHLGLKRYDRR
RVDGLWMERASVDRIIDTILNWSFDERRANPCIGLERADLVLAGCAILEAIRRHWPAERLRVADRGLREGMLNEMMARDG
VWRRRKQNGACPA
>Mature_412_residues
GSGRDPVTSPASVDIPQPKRKRRRRRKRGVFVRGAEPCADRKAAPQKAPALTPQPAPAEFARRSKAYAARLSSSPDADAL
YAALDLGTNNCRLLVATPGRPGRFRVVDAFSRIVRLGEGLAASGRLSDAAMERAVEALSVCAQKLDGRSLAGVRMIATEA
CRAAENGPHFIERVRRETGLDLEIIDRRTEARLAVSGCGSLVSRDTDGVVLFDIGGGSSEIALIDLSRHRTPRLADHILS
WTSLPTGVVSLAERFGGRVVTPVIFEAMVSHVSEMLAQFDGGTRLAHVAGSGKFHLLGTSGTVTTLAGVHLGLKRYDRRR
VDGLWMERASVDRIIDTILNWSFDERRANPCIGLERADLVLAGCAILEAIRRHWPAERLRVADRGLREGMLNEMMARDGV
WRRRKQNGACPA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=318, Percent_Identity=27.3584905660377, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994966, Length=322, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 44975; Mature: 44844

Theoretical pI: Translated: 10.95; Mature: 10.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSGRDPVTSPASVDIPQPKRKRRRRRKRGVFVRGAEPCADRKAAPQKAPALTPQPAPAE
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHH
FARRSKAYAARLSSSPDADALYAALDLGTNNCRLLVATPGRPGRFRVVDAFSRIVRLGEG
HHHHHHHHHHHHCCCCCHHHHHHHEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC
LAASGRLSDAAMERAVEALSVCAQKLDGRSLAGVRMIATEACRAAENGPHFIERVRRETG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHC
LDLEIIDRRTEARLAVSGCGSLVSRDTDGVVLFDIGGGSSEIALIDLSRHRTPRLADHIL
CCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHH
SWTSLPTGVVSLAERFGGRVVTPVIFEAMVSHVSEMLAQFDGGTRLAHVAGSGKFHLLGT
HHHCCCHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEC
SGTVTTLAGVHLGLKRYDRRRVDGLWMERASVDRIIDTILNWSFDERRANPCIGLERADL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHH
VLAGCAILEAIRRHWPAERLRVADRGLREGMLNEMMARDGVWRRRKQNGACPA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
>Mature Secondary Structure 
GSGRDPVTSPASVDIPQPKRKRRRRRKRGVFVRGAEPCADRKAAPQKAPALTPQPAPAE
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHH
FARRSKAYAARLSSSPDADALYAALDLGTNNCRLLVATPGRPGRFRVVDAFSRIVRLGEG
HHHHHHHHHHHHCCCCCHHHHHHHEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC
LAASGRLSDAAMERAVEALSVCAQKLDGRSLAGVRMIATEACRAAENGPHFIERVRRETG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHC
LDLEIIDRRTEARLAVSGCGSLVSRDTDGVVLFDIGGGSSEIALIDLSRHRTPRLADHIL
CCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHH
SWTSLPTGVVSLAERFGGRVVTPVIFEAMVSHVSEMLAQFDGGTRLAHVAGSGKFHLLGT
HHHCCCHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEC
SGTVTTLAGVHLGLKRYDRRRVDGLWMERASVDRIIDTILNWSFDERRANPCIGLERADL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHH
VLAGCAILEAIRRHWPAERLRVADRGLREGMLNEMMARDGVWRRRKQNGACPA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA