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The map label for this gene is serA [H]

Identifier: 109947057

GI number: 109947057

Start: 402098

End: 403672

Strand: Reverse

Name: serA [H]

Synonym: Hac_0455

Alternate gene names: 109947057

Gene position: 403672-402098 (Counterclockwise)

Preceding gene: 109947058

Following gene: 109947056

Centisome position: 25.98

GC content: 38.98

Gene sequence:

>1575_bases
ATGTATCAAGTAGCCATTTGCGACCCCATCCATGCCAAAGGCATTCAAATTTTAGAAGCTCAAAAAGATATTGTTTTGCA
TGATTATTCCAAATGCTCTAAAAATGAGCTTTTAGAAAAACTCATTCCTATGGATGCACTCATCACTCGTAGCATGACCC
CTATCACAAGCGATTTTTTAAAGCCTCTAACCCATTTAAAATCCATTGTAAGAGCGGGTGTAGGAGTGGATAATATTGAT
TTAGAAAGTTGCTCTCAAAAAGGCATTGTAGTGATGAATATCCCTACCGCTAACACGATCGCCGCTGTGGAATTGACCAT
GGCGCATTTAATTAATGCGGTGCGATTGTTTCCTTGTGCGAATGATCAAATCAAACACCAAAGGCTATGGAAGAGAGAAG
ATTGGTATGGAACGGAATTGAAAAATAAAAAGCTAGGCATTATTGGTTTTGGGAATATTGGCTCTAGGGTGGGCATTAGA
GCAAAAGCGTTTGAAATGGAAGTTCTAGCCTATGACCCTTATATCCCTTCTTCAAAAGCCACTGATTTAGGAGTCATTTA
CACAAAAAATTTTGAAGATATTTTACAATGCGACATGATCACTATCCACACCCCTAAAAATAAAGAAACCATTAACATGA
TAGGCACTAAAGAGATTGAACGCATGAAAAAAGGGGTTATCTTGATCAATTGCGCTAGGGGTGGGCTTTATAGTGAAGAC
GCTCTTTATGAAGCTTTAGAAACTAAAAAAGTGCGTTGGCTTGGCATTGATGTTTTTTCTAAAGAGCCAGGTATTCATAA
CAAGCTTTTAGACTTGCCTAATGTTTATGCGACCCCCCATATTGGTGCAAACACTTTAGAATCCCAAGAAGAAATTTCCA
AGCAAGCCGCCCAAGGGGTTATGGAATCTTTAAGGGGTTCAAGCCATCCGCATGCCCTAAATTTACCCATGCAAGCTTTT
GATGCCAGCACTAAAGCCTACTTGAATTTAGCTCAAAAACTAGGTTATTTTTCCAGTCAAATCCATAAGAGCGTGTGCCA
AAAGATTGATTTTAGTCTTTGTGGAGAGATCAATCAATTTAAAGACGCTCTTGTTGCTTTCATGTTAGTGGGGGTATTAA
AACCCATTGTAGGGGATAAAATCAATTACATTAACGCCCCCTTTGTAGCCAAAGAAAGAGGCATTGAAATCAAGGTTAGC
CTTAAAGAAAGTGCTTTACCTTATAAAAACATGCTCTCTTTAACCCTAAATGCAACTAATGGTGCGATCAGCGTGAGCGG
CACGGTGTTTGAAGAGGATATTTTAAAACTCACTGAGATTGATGGGTTTCATATTGATATAGAGCCAAAGGGCAAAATGC
TTTTATTTAGGAATACGGATATTCCAGGCGTTATCGGAAGCGTGGGGAATGTATTTGCTAGACATGGCATTAATATCGCT
GACTTTCGTTTGGGGCGCAACACGCAAAAAGAAGCCCTAGCGCTCATTATTGTAGATGAAGAGGTTTCTTTGGAAGTTTT
AGAAGAGCTTAAAAACATTCCTGCGTGTTTAAGCGTTCATTATGTGGTTATTTAA

Upstream 100 bases:

>100_bases
CATCGTCTATTTAGATGAAAATAAAAAAGAACGCTTTTTAGCTGATTTAGACTACTATAAAATACGCTATCATGCTGTTT
TTTAAATTCAAAGGATAAAA

Downstream 100 bases:

>100_bases
GCATGCGAGATTTTGTAAAGCTTTTAAAAGAGCATAATGAATTAGAAATCATTGACGCTCCCCTTGAAGTGGATTTAGAA
ATCGCTCATTTGGCTTATAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCSKNELLEKLIPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRLFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYSED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASTKAYLNLAQKLGYFSSQIHKSVCQKIDFSLCGEINQFKDALVAFMLVGVLKPIVGDKINYINAPFVAKERGIEIKVS
LKESALPYKNMLSLTLNATNGAISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNVFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Sequences:

>Translated_524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCSKNELLEKLIPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRLFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYSED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASTKAYLNLAQKLGYFSSQIHKSVCQKIDFSLCGEINQFKDALVAFMLVGVLKPIVGDKINYINAPFVAKERGIEIKVS
LKESALPYKNMLSLTLNATNGAISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNVFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
>Mature_524_residues
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCSKNELLEKLIPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNID
LESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRLFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIR
AKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYSED
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAF
DASTKAYLNLAQKLGYFSSQIHKSVCQKIDFSLCGEINQFKDALVAFMLVGVLKPIVGDKINYINAPFVAKERGIEIKVS
LKESALPYKNMLSLTLNATNGAISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNVFARHGINIA
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=396, Percent_Identity=34.0909090909091, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI61743967, Length=285, Percent_Identity=32.6315789473684, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI145580578, Length=285, Percent_Identity=32.280701754386, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4557499, Length=285, Percent_Identity=32.280701754386, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4557497, Length=285, Percent_Identity=32.6315789473684, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI145580575, Length=285, Percent_Identity=32.280701754386, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=30.1960784313725, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789279, Length=320, Percent_Identity=32.8125, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87082289, Length=266, Percent_Identity=28.9473684210526, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=28.2442748091603, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=29.6577946768061, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=26.4227642276423, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=307, Percent_Identity=37.785016286645, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=28.1746031746032, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=337, Percent_Identity=28.1899109792285, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=27.82874617737, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=30.0429184549356, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=284, Percent_Identity=28.8732394366197, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=33.1428571428571, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=285, Percent_Identity=23.5087719298246, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=30.2702702702703, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI19921140, Length=313, Percent_Identity=35.7827476038339, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24646446, Length=286, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646448, Length=286, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646452, Length=286, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646450, Length=286, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI62472511, Length=286, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=29.4117647058824, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=28.4345047923323, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=29.9363057324841, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=25.2396166134185, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58071; Mature: 58071

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCSKNELLEKLIPMDALITRSMTPITSDFL
CEEEEECCCCCCCCEEEEECCCCEEEECHHHCCHHHHHHHHCCHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRLFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEECCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYSED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEEECCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASTKAYLNLAQKLGYFSSQIHKSVCQKIDFSLCGEINQF
HHHHCCCCCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHH
KDALVAFMLVGVLKPIVGDKINYINAPFVAKERGIEIKVSLKESALPYKNMLSLTLNATN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCEEEEEEECCC
GAISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNVFARHGINIA
CEEEECCCCHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCSKNELLEKLIPMDALITRSMTPITSDFL
CEEEEECCCCCCCCEEEEECCCCEEEECHHHCCHHHHHHHHCCHHHHHHCCCCCHHHHHH
KPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRLFPCA
HHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHEECCC
NDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKA
CCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCCCCC
TDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGTKEIERMKKGVILINCARGGLYSED
CCEEEEEECCHHHHHHCCEEEEECCCCCCEEEECCHHHHHHHHCCEEEEEECCCCCCCHH
ALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV
HHHHHHHHCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MESLRGSSHPHALNLPMQAFDASTKAYLNLAQKLGYFSSQIHKSVCQKIDFSLCGEINQF
HHHHCCCCCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHH
KDALVAFMLVGVLKPIVGDKINYINAPFVAKERGIEIKVSLKESALPYKNMLSLTLNATN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCEEEEEEECCC
GAISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNVFARHGINIA
CEEEECCCCHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
DFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
EEECCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]