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The map label for this gene is trpE [H]

Identifier: 109946657

GI number: 109946657

Start: 21455

End: 22957

Strand: Reverse

Name: trpE [H]

Synonym: Hac_0018

Alternate gene names: 109946657

Gene position: 22957-21455 (Counterclockwise)

Preceding gene: 109946658

Following gene: 109946656

Centisome position: 1.48

GC content: 38.86

Gene sequence:

>1503_bases
ATGATTAGTCTCATAGAAAAAGCCCCTTACATTCCCTACCCCCTAGCTCTTTATGAAAAATTAGAGCGCCAACACACCTT
GCTTTTTGAAAGCGCTGAGATTGAGAGCAAAGCGCACACTAAATCCCTGTTGATGGCTAAAGCTTGTTTGAAGCTAATTT
GCAATCACAATGTCGTAACTATCACCAGCTTGACGGCTAATGGCGGAGCGTTTTTGCAAAAATTGAGCGCGTTTTTTAAA
ATGCCCATAAAAGACAATACCCTAACTTTAACTTACACGCAAGACAAAAAAGCCAAAGATGAGTTTTCTAAACTCTTTGA
GCCTAGCCCTTTTGACGCTTTAAGGGGGCTTTTTAAAAGCGTTAAAACAAACCCCAAACACCCCTTTACGCTTTTAAGTG
CGGGCGTGTTTTCTTTTGAAATGCTCAATTTCTTTGAAGATTTACCCCATTTAAAAGCAAAAGACAACACAGCACATGAT
TTTATTTTTTTCGTCGCGCAAAATTTGATCATTATCGATCACAAAGAAAAAAGCGCTGAAATTTTGGGGGCGTGTTTTGA
TGAGCGCTTTAAAACAGAGATAGCTAAAGAATTACAAGATTTAAAAGAGTTGGCTAAAAACATTAAAAGCGACTTTATCC
CTAAAAAATCTGAGCAAAGCACAGAAGTTAGTGTTAGTTGCGGCGATAGCGAGTTTGAAAAAAAAGTGTTATCCTTACAA
GAAGAAATTAAAAAGGGCGAGATTTTTCAAGCGGTATTATCGCGCAGTTTTTACATGGAGTGCTTGGAGGGTTTGAGCGC
GTATTATCATTTAAAGCTAACTAACCCTAGCCCTTATATGTTTTATATCAAAGATAGCGATTTTATTCTTTTTGGGGCAA
GCCCTGAGAGCGCCTTGAAGTACAACGCTTTAACGAATATGGCTGAAATTTACCCCATTGCTGGCACTCGTTTGAGGGGT
AAGGATAAAGAAGGGAATATTGATTACGATTTAGATAGTAAAATGGAATTTGATTTGCAACACGACTTTAAAGAAAGGGC
TGAACACATCATGCTAGTGGATTTAGCCAGAAACGACATGGCCAGAGTTTCAAAAAAGCGCTATTGCGATAAGCTTTTAA
AAGTGGATAAATATTCTAATGTCATGCATTTAGTTTCAAGGGTTGTGGGGGAATTGAAAAAAGGGTGCGATAGTTTGCAT
GCTTATAGGAGTTTTATGAACGCCGGTACGCTTAGCGGAGCGCCTAAAATCTCTGCAATTAAACTCATTTACCAATTAGA
AAATCAAAGAAGAGGCTCTTATGGAGGGAGTGTGGGTTATCTGAATAGCGAAGGGTCTATGGATTCTTGTATCACTATCC
GTTCATGTTTTGTCAAAAACAATCAAGCTGTGATCCAAGCAGGAGCTGGCATCGTTTTAGATAGCGTGCCACAAAATGAA
GCGGATGAAACAAAAGCCAAAGCTAAAGCCCTTATTGATGCGATCAGGAAAACAAGCTTATGA

Upstream 100 bases:

>100_bases
GGATACAAATTTTTCTTGTTATTGCGTTTGAATAGCCAATTTAGAGTCCATTTATCTATTTATTGTAGAATACGGCTTCA
TTTTTAATTTGAAGCAAGCG

Downstream 100 bases:

>100_bases
AAATCTTTTTTATAGATAATTTTGATTCTTTCTCTTATAACTTGGTGTATGAATTGGAGTGCTTGGGTTATGAAGTGGCT
GTTTATCAAAACGATATTGA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MISLIEKAPYIPYPLALYEKLERQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNVVTITSLTANGGAFLQKLSAFFK
MPIKDNTLTLTYTQDKKAKDEFSKLFEPSPFDALRGLFKSVKTNPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHD
FIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIAKELQDLKELAKNIKSDFIPKKSEQSTEVSVSCGDSEFEKKVLSLQ
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALKYNALTNMAEIYPIAGTRLRG
KDKEGNIDYDLDSKMEFDLQHDFKERAEHIMLVDLARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLH
AYRSFMNAGTLSGAPKISAIKLIYQLENQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNQAVIQAGAGIVLDSVPQNE
ADETKAKAKALIDAIRKTSL

Sequences:

>Translated_500_residues
MISLIEKAPYIPYPLALYEKLERQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNVVTITSLTANGGAFLQKLSAFFK
MPIKDNTLTLTYTQDKKAKDEFSKLFEPSPFDALRGLFKSVKTNPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHD
FIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIAKELQDLKELAKNIKSDFIPKKSEQSTEVSVSCGDSEFEKKVLSLQ
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALKYNALTNMAEIYPIAGTRLRG
KDKEGNIDYDLDSKMEFDLQHDFKERAEHIMLVDLARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLH
AYRSFMNAGTLSGAPKISAIKLIYQLENQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNQAVIQAGAGIVLDSVPQNE
ADETKAKAKALIDAIRKTSL
>Mature_500_residues
MISLIEKAPYIPYPLALYEKLERQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNVVTITSLTANGGAFLQKLSAFFK
MPIKDNTLTLTYTQDKKAKDEFSKLFEPSPFDALRGLFKSVKTNPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHD
FIFFVAQNLIIIDHKEKSAEILGACFDERFKTEIAKELQDLKELAKNIKSDFIPKKSEQSTEVSVSCGDSEFEKKVLSLQ
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALKYNALTNMAEIYPIAGTRLRG
KDKEGNIDYDLDSKMEFDLQHDFKERAEHIMLVDLARNDMARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLH
AYRSFMNAGTLSGAPKISAIKLIYQLENQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNQAVIQAGAGIVLDSVPQNE
ADETKAKAKALIDAIRKTSL

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=497, Percent_Identity=46.6800804828974, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1788114, Length=397, Percent_Identity=27.7078085642317, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1786809, Length=220, Percent_Identity=28.6363636363636, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=281, Percent_Identity=43.4163701067616, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324361, Length=374, Percent_Identity=22.192513368984, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56331; Mature: 56331

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLIEKAPYIPYPLALYEKLERQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNVVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ITSLTANGGAFLQKLSAFFKMPIKDNTLTLTYTQDKKAKDEFSKLFEPSPFDALRGLFKS
EEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHH
VKTNPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHDFIFFVAQNLIIIDHKEKSAE
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHH
ILGACFDERFKTEIAKELQDLKELAKNIKSDFIPKKSEQSTEVSVSCGDSEFEKKVLSLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALK
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCHHHH
YNALTNMAEIYPIAGTRLRGKDKEGNIDYDLDSKMEFDLQHDFKERAEHIMLVDLARNDM
HHHHHHHHHHEECCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEHHHHHH
ARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
KLIYQLENQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNQAVIQAGAGIVLDSVPQNE
HHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCC
ADETKAKAKALIDAIRKTSL
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISLIEKAPYIPYPLALYEKLERQHTLLFESAEIESKAHTKSLLMAKACLKLICNHNVVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ITSLTANGGAFLQKLSAFFKMPIKDNTLTLTYTQDKKAKDEFSKLFEPSPFDALRGLFKS
EEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHH
VKTNPKHPFTLLSAGVFSFEMLNFFEDLPHLKAKDNTAHDFIFFVAQNLIIIDHKEKSAE
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCEEEEECCCHHHH
ILGACFDERFKTEIAKELQDLKELAKNIKSDFIPKKSEQSTEVSVSCGDSEFEKKVLSLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
EEIKKGEIFQAVLSRSFYMECLEGLSAYYHLKLTNPSPYMFYIKDSDFILFGASPESALK
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCHHHH
YNALTNMAEIYPIAGTRLRGKDKEGNIDYDLDSKMEFDLQHDFKERAEHIMLVDLARNDM
HHHHHHHHHHEECCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEEEEEEHHHHHH
ARVSKKRYCDKLLKVDKYSNVMHLVSRVVGELKKGCDSLHAYRSFMNAGTLSGAPKISAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
KLIYQLENQRRGSYGGSVGYLNSEGSMDSCITIRSCFVKNNQAVIQAGAGIVLDSVPQNE
HHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCCC
ADETKAKAKALIDAIRKTSL
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]