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The map label for this gene is mprB [H]

Identifier: 108801264

GI number: 108801264

Start: 4567264

End: 4568811

Strand: Reverse

Name: mprB [H]

Synonym: Mmcs_4300

Alternate gene names: 108801264

Gene position: 4568811-4567264 (Counterclockwise)

Preceding gene: 108801265

Following gene: 108801263

Centisome position: 80.08

GC content: 69.25

Gene sequence:

>1548_bases
ATGACCCTGCCACCTCCACCGTCGCGGCTGAAACCCCCGCGCAACACCAGTTCCCTGTCGTTGCGGTGGCGAGTGATGCT
GTTGGCGATGTCGATGGTGGCGATGGTCGTGGTGCTGATGTCGGTCGCCGTGTACGCCGTCGTGTCCCGGGCGCTCTACG
ACGACATCGACAACCAACTGCACAGCCGCGCGCGCCTGCTGATCGAGAGCGGCTCGTTGGCCGCCGACCCCGGTAAGGCG
ATCGAGGGCACCGCGTACTCGGACGTCAACGCGATGCTGGTGAACCCGGGCCGGTCGATCTACACCGCCAACCAGCAGGG
GCAGACGCTTCCGCTCGGTGAGGCCGAGAAGGACGTCATCTCCGGTGAGCTGCTGCTGTCGCTGCGGACGGCGAACCATC
AGCGCATCCTCGCCGTGCATCTCACCAACGGCAGTTCGCTCCTCATCTCCAAGAGCCTGGCGCCGACGGGTCAGGTGCTC
GGCCGCCTCGGCACGGTGCTGCTGATCGTCGGCGGGGTCGGGGTGGCGGTCGCGGCCATCGCGGGCGGGATGGTCGCCAG
GGCGGGGCTGCGGCCGGTGGGCCGCTTGACCCAGGCGGCCGAACGGGTGGCCCGCACCGACGATCTGCGACCCATCCCGG
TCTTCGGCAGCGACGAATTGGCCCGTCTCACCGAGGCGTTCAACATGATGCTGCGGGCGCTGACGGAGTCGCGCGAACGG
CAGGCGCGGTTGGTGTCCGACGCCGGCCACGAACTGCGCACCCCGCTGACGTCTCTGCGCACCAACGTCGAACTGCTGAT
GGCCTCGCAGGCCCCGGGCGCGCCCCGGCTGCCCGAGGAGGAGATGGCCGGGCTGCGGGCCGATGTGATCGCCCAGATCG
AGGAACTGTCCACGCTGGTGGGCGATCTGGTCGACCTCACCCGCGACGAAGCGGGCGGGGTGGTCTACGAGACCGTCGAC
ATGGCCGAGGTGGTCGACCGCAGCCTCGAGCGAGTTCGGCGGCGGCGCAACGACATCGAGTTCGACGTCAACGTCGTCGG
CTGGCAGGTCTACGGCGACGCCGCGGGGCTGGCCCGGGCCGTGCTCAATCTCCTTGACAATGCGGCGAAGTGGAGCCCGC
CCGGTGGTCGGGTCGGAGTCCGCCTGACCCAGACGGATCCGGTCCACGCCGAACTCGTCGTATCCGACCAGGGCCCGGGG
ATACCGGAAGCCGAACGCAGGCTGGTGTTCGAGCGGTTCTACCGTTCGACGGCTGCGCGCGCGATGCCCGGCTCCGGACT
CGGCTTGGCGATCGTCAAACAGGTCGTCCTCAAACACGGTGGCGCACTGCGGGTCGAGGACACGGTGCCGGGCGGCAACC
CGCCGGGCACCTCGTTCTACGTGATGCTGCCGGGCCGTCCGCTGACCCCGGGCGGTAACGGAACCGCGCCGGTGCCGGCG
GCGCAGTTCGACCCCGATATGCGTTCGGCCGGCTCGCGCGCGGACCGACGGGTGATCAAGAACACTGAGACGAACGGCAA
GTCTCGGTCCGCTTCGAAGGAACTCTAA

Upstream 100 bases:

>100_bases
ACATCGGCTATCTGCGCCGGAAGACCGAAGCGTCCGGGGAGCCGCGACTGATCCACACCGTGCGCGGTGTGGGGTACGTG
CTCCGCGAGACGCCCCCCTG

Downstream 100 bases:

>100_bases
GTGGATTCTCAGTCCATCTGGGCACTGTGAGGACAAGTACTTCGTTAAACGAACTGTCGGACCACTCACCAGGAGAGCAT
CGAAGCGACATGACGAACCA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTLPPPPSRLKPPRNTSSLSLRWRVMLLAMSMVAMVVVLMSVAVYAVVSRALYDDIDNQLHSRARLLIESGSLAADPGKA
IEGTAYSDVNAMLVNPGRSIYTANQQGQTLPLGEAEKDVISGELLLSLRTANHQRILAVHLTNGSSLLISKSLAPTGQVL
GRLGTVLLIVGGVGVAVAAIAGGMVARAGLRPVGRLTQAAERVARTDDLRPIPVFGSDELARLTEAFNMMLRALTESRER
QARLVSDAGHELRTPLTSLRTNVELLMASQAPGAPRLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDEAGGVVYETVD
MAEVVDRSLERVRRRRNDIEFDVNVVGWQVYGDAAGLARAVLNLLDNAAKWSPPGGRVGVRLTQTDPVHAELVVSDQGPG
IPEAERRLVFERFYRSTAARAMPGSGLGLAIVKQVVLKHGGALRVEDTVPGGNPPGTSFYVMLPGRPLTPGGNGTAPVPA
AQFDPDMRSAGSRADRRVIKNTETNGKSRSASKEL

Sequences:

>Translated_515_residues
MTLPPPPSRLKPPRNTSSLSLRWRVMLLAMSMVAMVVVLMSVAVYAVVSRALYDDIDNQLHSRARLLIESGSLAADPGKA
IEGTAYSDVNAMLVNPGRSIYTANQQGQTLPLGEAEKDVISGELLLSLRTANHQRILAVHLTNGSSLLISKSLAPTGQVL
GRLGTVLLIVGGVGVAVAAIAGGMVARAGLRPVGRLTQAAERVARTDDLRPIPVFGSDELARLTEAFNMMLRALTESRER
QARLVSDAGHELRTPLTSLRTNVELLMASQAPGAPRLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDEAGGVVYETVD
MAEVVDRSLERVRRRRNDIEFDVNVVGWQVYGDAAGLARAVLNLLDNAAKWSPPGGRVGVRLTQTDPVHAELVVSDQGPG
IPEAERRLVFERFYRSTAARAMPGSGLGLAIVKQVVLKHGGALRVEDTVPGGNPPGTSFYVMLPGRPLTPGGNGTAPVPA
AQFDPDMRSAGSRADRRVIKNTETNGKSRSASKEL
>Mature_514_residues
TLPPPPSRLKPPRNTSSLSLRWRVMLLAMSMVAMVVVLMSVAVYAVVSRALYDDIDNQLHSRARLLIESGSLAADPGKAI
EGTAYSDVNAMLVNPGRSIYTANQQGQTLPLGEAEKDVISGELLLSLRTANHQRILAVHLTNGSSLLISKSLAPTGQVLG
RLGTVLLIVGGVGVAVAAIAGGMVARAGLRPVGRLTQAAERVARTDDLRPIPVFGSDELARLTEAFNMMLRALTESRERQ
ARLVSDAGHELRTPLTSLRTNVELLMASQAPGAPRLPEEEMAGLRADVIAQIEELSTLVGDLVDLTRDEAGGVVYETVDM
AEVVDRSLERVRRRRNDIEFDVNVVGWQVYGDAAGLARAVLNLLDNAAKWSPPGGRVGVRLTQTDPVHAELVVSDQGPGI
PEAERRLVFERFYRSTAARAMPGSGLGLAIVKQVVLKHGGALRVEDTVPGGNPPGTSFYVMLPGRPLTPGGNGTAPVPAA
QFDPDMRSAGSRADRRVIKNTETNGKSRSASKEL

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=26.4437689969605, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=36.7965367965368, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=26.1648745519713, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=31.3653136531365, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790861, Length=324, Percent_Identity=30.2469135802469, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=28.5223367697594, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=291, Percent_Identity=28.8659793814433, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=292, Percent_Identity=28.0821917808219, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=472, Percent_Identity=25.2118644067797, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=312, Percent_Identity=25.9615384615385, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=26.0683760683761, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=512, Percent_Identity=22.4609375, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=243, Percent_Identity=25.5144032921811, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=294, Percent_Identity=25.5102040816327, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=25.974025974026, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55012; Mature: 54881

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPPPPSRLKPPRNTSSLSLRWRVMLLAMSMVAMVVVLMSVAVYAVVSRALYDDIDNQL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSRARLLIESGSLAADPGKAIEGTAYSDVNAMLVNPGRSIYTANQQGQTLPLGEAEKDVI
HHHHHHEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHH
SGELLLSLRTANHQRILAVHLTNGSSLLISKSLAPTGQVLGRLGTVLLIVGGVGVAVAAI
CCHHEEEEECCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGGMVARAGLRPVGRLTQAAERVARTDDLRPIPVFGSDELARLTEAFNMMLRALTESRER
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QARLVSDAGHELRTPLTSLRTNVELLMASQAPGAPRLPEEEMAGLRADVIAQIEELSTLV
HHHHHHHCCHHHHCCHHHHHCCCEEEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHH
GDLVDLTRDEAGGVVYETVDMAEVVDRSLERVRRRRNDIEFDVNVVGWQVYGDAAGLARA
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHH
VLNLLDNAAKWSPPGGRVGVRLTQTDPVHAELVVSDQGPGIPEAERRLVFERFYRSTAAR
HHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
AMPGSGLGLAIVKQVVLKHGGALRVEDTVPGGNPPGTSFYVMLPGRPLTPGGNGTAPVPA
CCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
AQFDPDMRSAGSRADRRVIKNTETNGKSRSASKEL
CCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLPPPPSRLKPPRNTSSLSLRWRVMLLAMSMVAMVVVLMSVAVYAVVSRALYDDIDNQL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSRARLLIESGSLAADPGKAIEGTAYSDVNAMLVNPGRSIYTANQQGQTLPLGEAEKDVI
HHHHHHEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHH
SGELLLSLRTANHQRILAVHLTNGSSLLISKSLAPTGQVLGRLGTVLLIVGGVGVAVAAI
CCHHEEEEECCCCCEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGGMVARAGLRPVGRLTQAAERVARTDDLRPIPVFGSDELARLTEAFNMMLRALTESRER
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QARLVSDAGHELRTPLTSLRTNVELLMASQAPGAPRLPEEEMAGLRADVIAQIEELSTLV
HHHHHHHCCHHHHCCHHHHHCCCEEEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHH
GDLVDLTRDEAGGVVYETVDMAEVVDRSLERVRRRRNDIEFDVNVVGWQVYGDAAGLARA
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHH
VLNLLDNAAKWSPPGGRVGVRLTQTDPVHAELVVSDQGPGIPEAERRLVFERFYRSTAAR
HHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
AMPGSGLGLAIVKQVVLKHGGALRVEDTVPGGNPPGTSFYVMLPGRPLTPGGNGTAPVPA
CCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
AQFDPDMRSAGSRADRRVIKNTETNGKSRSASKEL
CCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA