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The map label for this gene is mprA [H]

Identifier: 108801265

GI number: 108801265

Start: 4568811

End: 4569503

Strand: Reverse

Name: mprA [H]

Synonym: Mmcs_4301

Alternate gene names: 108801265

Gene position: 4569503-4568811 (Counterclockwise)

Preceding gene: 108801266

Following gene: 108801264

Centisome position: 80.09

GC content: 68.83

Gene sequence:

>693_bases
GTGCCTGTGCGCATACTTGTCGTCGACGACGATCGCGCGGTGCGAGAATCCCTGCGCCGGTCCCTGTCCTTCAACGGATA
TTCGGTCGAGTTGGCCCAGGACGGTGTCGAAGCTCTCGACCTGATCGCCAACAACCGGCCCGACGCCGTGGTGCTGGACG
TGATGATGCCCCGGCTCGACGGCCTCGAGGTGTGCCGGCAGCTTCGCAGCACCGGCGACGACCTGCCGATCCTGGTGCTG
ACGGCCCGTGACTCGGTGTCCGAGCGGGTCGCCGGACTCGATGCCGGCGCCGACGACTACCTGCCCAAACCGTTCGCGCT
CGAGGAACTGCTCGCGCGGATGCGGGCCCTGCTGCGCCGCACCTCCCCCGACGAGGGCCCCGATTCCCCGGCGCTGACCT
TTCTCGATCTGACCCTGGACCCGGTCACCCGCGAGGTGACCCGCGGGTCCCGGCAGATCAGCCTCACCCGCACCGAGTTC
GCGTTGCTGGAGATGCTGATCGCCAATCCGCGCCGCGTGCTCACCCGCAGCCGCATCCTCGAGGAAGTGTGGGGCTTCGA
CTTCCCGACCTCGGGGAACGCGCTCGAGGTGTACATCGGCTATCTGCGCCGGAAGACCGAAGCGTCCGGGGAGCCGCGAC
TGATCCACACCGTGCGCGGTGTGGGGTACGTGCTCCGCGAGACGCCCCCCTGA

Upstream 100 bases:

>100_bases
GGCCGCCCGTCTGGGGCTCATCGACCTCGATCGTCGCTAGACGACTTCGGGACGTCAGCGGCGCGCCTCTCAGCGCTCTC
TCAGCCGTTGAGGTGAAACT

Downstream 100 bases:

>100_bases
TGACCCTGCCACCTCCACCGTCGCGGCTGAAACCCCCGCGCAACACCAGTTCCCTGTCGTTGCGGTGGCGAGTGATGCTG
TTGGCGATGTCGATGGTGGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDLIANNRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTSPDEGPDSPALTFLDLTLDPVTREVTRGSRQISLTRTEF
ALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEASGEPRLIHTVRGVGYVLRETPP

Sequences:

>Translated_230_residues
MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDLIANNRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVL
TARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTSPDEGPDSPALTFLDLTLDPVTREVTRGSRQISLTRTEF
ALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEASGEPRLIHTVRGVGYVLRETPP
>Mature_229_residues
PVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDLIANNRPDAVVLDVMMPRLDGLEVCRQLRSTGDDLPILVLT
ARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTSPDEGPDSPALTFLDLTLDPVTREVTRGSRQISLTRTEFA
LLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYIGYLRRKTEASGEPRLIHTVRGVGYVLRETPP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=42.2907488986784, Blast_Score=176, Evalue=8e-46,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=41.3333333333333, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=40.9090909090909, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.4615384615385, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=39.0350877192982, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.8888888888889, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=36.322869955157, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=36.6071428571429, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=39.4618834080717, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=38.8646288209607, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.3008849557522, Blast_Score=113, Evalue=8e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=31.1688311688312, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=29.9145299145299, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=38.2113821138211, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=36.1111111111111, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=36.6336633663366, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=131, Percent_Identity=35.1145038167939, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=39.8230088495575, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=38.4615384615385, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=34.1463414634146, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788905, Length=122, Percent_Identity=29.5081967213115, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25699; Mature: 25568

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDLIANNRPDAVVLDVMMPRLD
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEEEHHHHHCCCC
GLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TSPDEGPDSPALTFLDLTLDPVTREVTRGSRQISLTRTEFALLEMLIANPRRVLTRSRIL
CCCCCCCCCCCEEEEEEECCHHHHHHHCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHH
EEVWGFDFPTSGNALEVYIGYLRRKTEASGEPRLIHTVRGVGYVLRETPP
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCC
>Mature Secondary Structure 
PVRILVVDDDRAVRESLRRSLSFNGYSVELAQDGVEALDLIANNRPDAVVLDVMMPRLD
CEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEEEHHHHHCCCC
GLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRR
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TSPDEGPDSPALTFLDLTLDPVTREVTRGSRQISLTRTEFALLEMLIANPRRVLTRSRIL
CCCCCCCCCCCEEEEEEECCHHHHHHHCCCCEEEEHHHHHHHHHHHHHCHHHHHHHHHHH
EEVWGFDFPTSGNALEVYIGYLRRKTEASGEPRLIHTVRGVGYVLRETPP
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA