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The map label for this gene is ksgA [H]

Identifier: 108801227

GI number: 108801227

Start: 4529316

End: 4530200

Strand: Reverse

Name: ksgA [H]

Synonym: Mmcs_4263

Alternate gene names: 108801227

Gene position: 4530200-4529316 (Counterclockwise)

Preceding gene: 108801228

Following gene: 108801226

Centisome position: 79.4

GC content: 66.89

Gene sequence:

>885_bases
GTGACAATCCGACTACTCGGGCGCACCGAGATCCGGCGCCTTGCGAAGGACATCGATTTTCGCCCGCGCAAGTCGTTCGG
GCAAAATTTCGTCCATGACGCCAACACCGTGCGCCGGATCGTCTCGGCCTCCGGTGTGCACCGCCATGACCACGTCCTCA
AGGTGGGTCCCGGCCTCGGTTCGCTGACGCTGGCGCTGCTCGATCGCGGCGCGCACGTGACGGCGGTGGAGATCGATCCG
CTGCTCGCGCAACAGCTTCCCACGACGATCGCCGATCATTCGCACAGCGAGATCAACCGTCTGACGGTCCTCAACCAGGA
CATCCTGACGCTGATGCCGTCGGATCTGGAGAACCAGCCGACCGCGCTGGTCGCCAACCTGCCGTACAACGTCGCGGTGC
CGGCCCTGCTCCATCTGCTCGCCGAATTCCCGACGATCCGCTCGGTGATGGTCATGGTCCAGGCCGAGGTGGCCGAGCGC
CTGGCCGCCGATCCGGGCGGTAAGGATTACGGCGTGCCGAGCGCGAAGGTGCGGTTCTACGGCAACGTCCGCCGCTACGG
GATGGTCTCGCCGACGGTGTTCTGGCCCATCCCGCGGGTGTATTCGGGATTGGTCCGCATCGACCGCTACGAGACCTCGC
CGTGGCCGACCGACGCCGATTTCCGCGCCCAGGTCTTCGATCTGATCGACATCGCGTTCGCGCAGCGCCGCAAGACCTCG
CGCAACGCGTTCGCCGAGTGGGCCGGGTCCGGTAACGAATCCGCCCGCCGCCTCCTGGCCGCCAGCATCGACCCGTCGCG
ACGGGGTGAGACCCTTGCGATCGCGGACTTCGTCCGGTTGCTGCAGCGCTCCGGAGAAGCCGAGGAACAGGTCCGCGTCC
AGTAG

Upstream 100 bases:

>100_bases
ATCTGGCAACAAGAGAAGAACAGATCGCGATTGCTGAGGTCACGCGGGCGAGGCAAGGCTGGGGAGCCTGGCCCACGTGT
AGTGGAAGGTTGGGGGCGTC

Downstream 100 bases:

>100_bases
TGCCGGTCTGGCCTGCCGCTGGAGTTTGCACCGTCCACATGCGGCGATAGTGTCGAGCGGTGCGCAACGGCAACACCGCC
TCCGAGTGGGTGCCCACCGG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTIRLLGRTEIRRLAKDIDFRPRKSFGQNFVHDANTVRRIVSASGVHRHDHVLKVGPGLGSLTLALLDRGAHVTAVEIDP
LLAQQLPTTIADHSHSEINRLTVLNQDILTLMPSDLENQPTALVANLPYNVAVPALLHLLAEFPTIRSVMVMVQAEVAER
LAADPGGKDYGVPSAKVRFYGNVRRYGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDADFRAQVFDLIDIAFAQRRKTS
RNAFAEWAGSGNESARRLLAASIDPSRRGETLAIADFVRLLQRSGEAEEQVRVQ

Sequences:

>Translated_294_residues
MTIRLLGRTEIRRLAKDIDFRPRKSFGQNFVHDANTVRRIVSASGVHRHDHVLKVGPGLGSLTLALLDRGAHVTAVEIDP
LLAQQLPTTIADHSHSEINRLTVLNQDILTLMPSDLENQPTALVANLPYNVAVPALLHLLAEFPTIRSVMVMVQAEVAER
LAADPGGKDYGVPSAKVRFYGNVRRYGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDADFRAQVFDLIDIAFAQRRKTS
RNAFAEWAGSGNESARRLLAASIDPSRRGETLAIADFVRLLQRSGEAEEQVRVQ
>Mature_293_residues
TIRLLGRTEIRRLAKDIDFRPRKSFGQNFVHDANTVRRIVSASGVHRHDHVLKVGPGLGSLTLALLDRGAHVTAVEIDPL
LAQQLPTTIADHSHSEINRLTVLNQDILTLMPSDLENQPTALVANLPYNVAVPALLHLLAEFPTIRSVMVMVQAEVAERL
AADPGGKDYGVPSAKVRFYGNVRRYGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDADFRAQVFDLIDIAFAQRRKTSR
NAFAEWAGSGNESARRLLAASIDPSRRGETLAIADFVRLLQRSGEAEEQVRVQ

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=280, Percent_Identity=29.6428571428571, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI156415992, Length=308, Percent_Identity=28.2467532467532, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786236, Length=262, Percent_Identity=34.3511450381679, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25146882, Length=213, Percent_Identity=31.924882629108, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25141369, Length=312, Percent_Identity=25, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324989, Length=227, Percent_Identity=28.1938325991189, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358017, Length=223, Percent_Identity=30.9417040358744, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 32704; Mature: 32573

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRLLGRTEIRRLAKDIDFRPRKSFGQNFVHDANTVRRIVSASGVHRHDHVLKVGPGLG
CEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCH
SLTLALLDRGAHVTAVEIDPLLAQQLPTTIADHSHSEINRLTVLNQDILTLMPSDLENQP
HHHHHHHHCCCEEEEEECCHHHHHHCCHHHHCCCHHHHHHHHHCCHHHHHHCCCCCCCCC
TALVANLPYNVAVPALLHLLAEFPTIRSVMVMVQAEVAERLAADPGGKDYGVPSAKVRFY
CEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
GNVRRYGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDADFRAQVFDLIDIAFAQRRKTS
ECHHHCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RNAFAEWAGSGNESARRLLAASIDPSRRGETLAIADFVRLLQRSGEAEEQVRVQ
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCHHHEECC
>Mature Secondary Structure 
TIRLLGRTEIRRLAKDIDFRPRKSFGQNFVHDANTVRRIVSASGVHRHDHVLKVGPGLG
EEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCH
SLTLALLDRGAHVTAVEIDPLLAQQLPTTIADHSHSEINRLTVLNQDILTLMPSDLENQP
HHHHHHHHCCCEEEEEECCHHHHHHCCHHHHCCCHHHHHHHHHCCHHHHHHCCCCCCCCC
TALVANLPYNVAVPALLHLLAEFPTIRSVMVMVQAEVAERLAADPGGKDYGVPSAKVRFY
CEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
GNVRRYGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDADFRAQVFDLIDIAFAQRRKTS
ECHHHCCCCCCHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RNAFAEWAGSGNESARRLLAASIDPSRRGETLAIADFVRLLQRSGEAEEQVRVQ
HHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA