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The map label for this gene is atsA [H]

Identifier: 108800928

GI number: 108800928

Start: 4222589

End: 4224970

Strand: Reverse

Name: atsA [H]

Synonym: Mmcs_3964

Alternate gene names: 108800928

Gene position: 4224970-4222589 (Counterclockwise)

Preceding gene: 108800929

Following gene: 108800923

Centisome position: 74.05

GC content: 67.13

Gene sequence:

>2382_bases
ATGTCCGATTCGTCACCCCAGAACACCGGACAGCAGGCAGCGGCCGCGGTGCGGCGCGACGTGCTTCCGATCCCGGATCC
CCGACACGTCGGGTTGACGACGTACGACGCGAAGGATCCGAATACGACGTATCCGCCGATAACGCGGCTGCGCCCACCCG
ACGGTGCGCCGAATGTGCTGATCGTGCTGATCGACGACGTGGGTTTCGGCGCGAGTTCGGCCTTCGGCGGCCCGTGCCGC
ACACCGGTCGCGGAGCGGCTGGCGGCCAACGGTGTGAAACTCAACCGCTTCCACACCACCGCGCTGTGCTCGCCGACGCG
CCAGGCGCTGCTCACCGGACGCAACCACCACTCGGTGGGGATGGGCGGTGTCACCGAGATCGCGACGTCCGCGCCGGGAT
ACAGCAGCATCCGGCCGAAGGACAAGGCGCCGATCTCGGAAACGCTTCGGCTCAACGGATACTCGACGAGTCAGTTCGGC
AAGTGCCACGAGGTCCCGGTGTGGGAGGTGTCGCCGGTCGGGCCGTTCGACCAGTGGCCCACCGGGTCGGGGTTCGAGCA
CTTCTACGGGTTCGTCGGCGGCGAGGCCAACCAGTACTACCCCGGACTGTACGAGGGCACCACACCCGTCGAACCGGCCA
AGACGCCCGAGCAGGGTTACACCCTGACCGAGGACCTCGCCGACCGGGCGATCACCTGGGTGCGCCAACAGCAGGCGCTC
ACCCCGGACAAGCCGTTCTTCATGTATTTCGCGCCCGGTGCCACCCACGCGCCACACCACGTGCCCCGGGAGTGGTCCGA
CCGGTACCGCGGCGAGTTCGACGCCGGCTGGGACGTGTTGCGCGAGCAGATCTTCGCCCGCCAGAAGGAACTCGGCGTGA
TCCCGCAGGACGCCGAGCTGACCCGGCGCCACGACGAGATCCCCGGCTGGGACGACATGCCCGACCGGCTCAAGCCGGTG
CTCGCCCGGCAGATGGAGATCTATGCCGGCTTCATGGAGCAGACCGACCACGAGGTCGGGCGGCTGATCGACGCGGTCGA
CGGCCTCGGCGCACTCGACAACACGCTGATCTACTACATCATCGGCGACAACGGCGCGTCGGCGGAGGGCACGCCGAACG
GGTGCTTCAACGAGATGTGCACGCTCAACGGGCTGGCCGGGATCGAGACCGAGGATTTCCTGCTGTCCAAGATCGACGAC
TTCGGCACGCCGGACGCGTACAACCACTATGCGGTGGGCTGGGCGCACGCCCTGTGCGCGCCGTATCAGTGGACCAAGCA
GGTCGCCTCCCACTGGGGCGGCACCCGCAACGGCACGATCGTGCACTGGCCCGCGGGGATCGACGCCGTCGGCCAGACCC
GCGACCAGTTCCACCACGTGATCGACGTCGTGCCAACGATTCTCGAGGCGGCCGACATCCCCGCACCACTGATGGTCAAC
GGCATCGCGCAGGCGCCCATCGAGGGCTTCAGCATGATGTCGACGCTGCGGGCCGCCGATGCCGCCGAGACCCACCGGGT
GCAGTACTTCGAGATGTTCGGCAACCGCGGCATCTACCACGACGGTTGGACGGCGGTCACCAAACACCGGACGCCGTGGC
TGTCCGACCAGCCGGCGCTCGAGGACGACGTCTGGGAGCTGTACGGGCCGGGCGACTGGACCCAGGCGCACGACCTGGCG
GCCGATGATCCGGCGAAACTCGCCGAACTACAGCGTCTCTGGCTCATCGAGGCGGTCAAGTACGACGTGTTGCCGATCGA
CGACAGGTCGTACGAGCGCTTCAACCCGGACATCTCCGGGCGGCCGGTGCTCATCACCGGCAGCACCCAGACGATCTTCC
CCGGTATGCGGCTGATGGAGAGCTGCGTGCTCAACATCAAGAACAAGTCGCATTCGGTGACGGCCGAGCTGTCGGTGCCC
GAGTCCGGTGCGCAGGGGGTGGTGGTCAGCCAGGGCGGCGGTGTCGGTGGTTGGTGTCTGTACGCGCACGAGGGCCGGTT
GAAATACTGTTACAACTTCCTCGGCATCGAGTACTACTACGTCACCGCCGAGGCTCCGCTCTCGGCCGGCGATCACCTCC
TGCGTATGGAATTCGCCTACGACGGTGGGGGTTTGGGCAAGGGCGGCACCGTCACGCTCTTCTGTGACGGTGAAGCCGTC
GGGACGGGGCGGGTCGACCAGAGCGAGCCGATGGCGTTCTCCGCCGACGAGATGTGCGACGTCGGCTCGGACAGCGGCTC
GCCGACGTCACCCGACTACGGGCCGCACGACAACGCTTTCACCGGCCGAATCGACTGGGTGAAGATCGATATCGGCGCCG
CCGACCACGACCACCTGATCACCGCGGAGGACAAGCTGAACATCGCGATGTCGCGGCAGTGA

Upstream 100 bases:

>100_bases
GACGGCGCGTCGAAAACCCCGAATCGCCGACTCGGTGCGGCATATGGTGGGCCGAACTCGGGCTCCAAGAGCGTGGTCCG
GGAAACCGCGGAGGCCGACC

Downstream 100 bases:

>100_bases
TCAGCCCGCCGGCTGCGACTCCGATCATGGCCGGTACCAGGAACTCTGAGAGCATCGCGCGTTCCTCGCCCTCGTCGCCG
CCGGGGAACAGCAGCAGCGA

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 793; Mature: 792

Protein sequence:

>793_residues
MSDSSPQNTGQQAAAAVRRDVLPIPDPRHVGLTTYDAKDPNTTYPPITRLRPPDGAPNVLIVLIDDVGFGASSAFGGPCR
TPVAERLAANGVKLNRFHTTALCSPTRQALLTGRNHHSVGMGGVTEIATSAPGYSSIRPKDKAPISETLRLNGYSTSQFG
KCHEVPVWEVSPVGPFDQWPTGSGFEHFYGFVGGEANQYYPGLYEGTTPVEPAKTPEQGYTLTEDLADRAITWVRQQQAL
TPDKPFFMYFAPGATHAPHHVPREWSDRYRGEFDAGWDVLREQIFARQKELGVIPQDAELTRRHDEIPGWDDMPDRLKPV
LARQMEIYAGFMEQTDHEVGRLIDAVDGLGALDNTLIYYIIGDNGASAEGTPNGCFNEMCTLNGLAGIETEDFLLSKIDD
FGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTIVHWPAGIDAVGQTRDQFHHVIDVVPTILEAADIPAPLMVN
GIAQAPIEGFSMMSTLRAADAAETHRVQYFEMFGNRGIYHDGWTAVTKHRTPWLSDQPALEDDVWELYGPGDWTQAHDLA
ADDPAKLAELQRLWLIEAVKYDVLPIDDRSYERFNPDISGRPVLITGSTQTIFPGMRLMESCVLNIKNKSHSVTAELSVP
ESGAQGVVVSQGGGVGGWCLYAHEGRLKYCYNFLGIEYYYVTAEAPLSAGDHLLRMEFAYDGGGLGKGGTVTLFCDGEAV
GTGRVDQSEPMAFSADEMCDVGSDSGSPTSPDYGPHDNAFTGRIDWVKIDIGAADHDHLITAEDKLNIAMSRQ

Sequences:

>Translated_793_residues
MSDSSPQNTGQQAAAAVRRDVLPIPDPRHVGLTTYDAKDPNTTYPPITRLRPPDGAPNVLIVLIDDVGFGASSAFGGPCR
TPVAERLAANGVKLNRFHTTALCSPTRQALLTGRNHHSVGMGGVTEIATSAPGYSSIRPKDKAPISETLRLNGYSTSQFG
KCHEVPVWEVSPVGPFDQWPTGSGFEHFYGFVGGEANQYYPGLYEGTTPVEPAKTPEQGYTLTEDLADRAITWVRQQQAL
TPDKPFFMYFAPGATHAPHHVPREWSDRYRGEFDAGWDVLREQIFARQKELGVIPQDAELTRRHDEIPGWDDMPDRLKPV
LARQMEIYAGFMEQTDHEVGRLIDAVDGLGALDNTLIYYIIGDNGASAEGTPNGCFNEMCTLNGLAGIETEDFLLSKIDD
FGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTIVHWPAGIDAVGQTRDQFHHVIDVVPTILEAADIPAPLMVN
GIAQAPIEGFSMMSTLRAADAAETHRVQYFEMFGNRGIYHDGWTAVTKHRTPWLSDQPALEDDVWELYGPGDWTQAHDLA
ADDPAKLAELQRLWLIEAVKYDVLPIDDRSYERFNPDISGRPVLITGSTQTIFPGMRLMESCVLNIKNKSHSVTAELSVP
ESGAQGVVVSQGGGVGGWCLYAHEGRLKYCYNFLGIEYYYVTAEAPLSAGDHLLRMEFAYDGGGLGKGGTVTLFCDGEAV
GTGRVDQSEPMAFSADEMCDVGSDSGSPTSPDYGPHDNAFTGRIDWVKIDIGAADHDHLITAEDKLNIAMSRQ
>Mature_792_residues
SDSSPQNTGQQAAAAVRRDVLPIPDPRHVGLTTYDAKDPNTTYPPITRLRPPDGAPNVLIVLIDDVGFGASSAFGGPCRT
PVAERLAANGVKLNRFHTTALCSPTRQALLTGRNHHSVGMGGVTEIATSAPGYSSIRPKDKAPISETLRLNGYSTSQFGK
CHEVPVWEVSPVGPFDQWPTGSGFEHFYGFVGGEANQYYPGLYEGTTPVEPAKTPEQGYTLTEDLADRAITWVRQQQALT
PDKPFFMYFAPGATHAPHHVPREWSDRYRGEFDAGWDVLREQIFARQKELGVIPQDAELTRRHDEIPGWDDMPDRLKPVL
ARQMEIYAGFMEQTDHEVGRLIDAVDGLGALDNTLIYYIIGDNGASAEGTPNGCFNEMCTLNGLAGIETEDFLLSKIDDF
GTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTIVHWPAGIDAVGQTRDQFHHVIDVVPTILEAADIPAPLMVNG
IAQAPIEGFSMMSTLRAADAAETHRVQYFEMFGNRGIYHDGWTAVTKHRTPWLSDQPALEDDVWELYGPGDWTQAHDLAA
DDPAKLAELQRLWLIEAVKYDVLPIDDRSYERFNPDISGRPVLITGSTQTIFPGMRLMESCVLNIKNKSHSVTAELSVPE
SGAQGVVVSQGGGVGGWCLYAHEGRLKYCYNFLGIEYYYVTAEAPLSAGDHLLRMEFAYDGGGLGKGGTVTLFCDGEAVG
TGRVDQSEPMAFSADEMCDVGSDSGSPTSPDYGPHDNAFTGRIDWVKIDIGAADHDHLITAEDKLNIAMSRQ

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI59797060, Length=221, Percent_Identity=29.4117647058824, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI109389362, Length=221, Percent_Identity=27.6018099547511, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI31742482, Length=350, Percent_Identity=25.4285714285714, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI38569407, Length=230, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI38569405, Length=334, Percent_Identity=24.251497005988, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4503899, Length=461, Percent_Identity=24.295010845987, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI157266309, Length=338, Percent_Identity=28.1065088757396, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI53831991, Length=479, Percent_Identity=24.6346555323591, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI146229331, Length=242, Percent_Identity=29.7520661157025, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI146229329, Length=242, Percent_Identity=29.7520661157025, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI6005990, Length=242, Percent_Identity=29.7520661157025, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI146229324, Length=242, Percent_Identity=29.7520661157025, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI71852584, Length=346, Percent_Identity=24.2774566473988, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI71852586, Length=156, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666175, Length=525, Percent_Identity=24, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281366397, Length=323, Percent_Identity=23.8390092879257, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281366395, Length=323, Percent_Identity=23.8390092879257, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666163, Length=323, Percent_Identity=23.8390092879257, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 86763; Mature: 86631

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00523 SULFATASE_1 ; PS00501 SPASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSSPQNTGQQAAAAVRRDVLPIPDPRHVGLTTYDAKDPNTTYPPITRLRPPDGAPNVL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEE
IVLIDDVGFGASSAFGGPCRTPVAERLAANGVKLNRFHTTALCSPTRQALLTGRNHHSVG
EEEEECCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEEEEHHHCCHHHHHHHCCCCCCCCC
MGGVTEIATSAPGYSSIRPKDKAPISETLRLNGYSTSQFGKCHEVPVWEVSPVGPFDQWP
CCCHHHHHHCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCEECCCCCCCCCCC
TGSGFEHFYGFVGGEANQYYPGLYEGTTPVEPAKTPEQGYTLTEDLADRAITWVRQQQAL
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCC
TPDKPFFMYFAPGATHAPHHVPREWSDRYRGEFDAGWDVLREQIFARQKELGVIPQDAEL
CCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
TRRHDEIPGWDDMPDRLKPVLARQMEIYAGFMEQTDHEVGRLIDAVDGLGALDNTLIYYI
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
IGDNGASAEGTPNGCFNEMCTLNGLAGIETEDFLLSKIDDFGTPDAYNHYAVGWAHALCA
ECCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
PYQWTKQVASHWGGTRNGTIVHWPAGIDAVGQTRDQFHHVIDVVPTILEAADIPAPLMVN
CHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHC
GIAQAPIEGFSMMSTLRAADAAETHRVQYFEMFGNRGIYHDGWTAVTKHRTPWLSDQPAL
CHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCEEECCCCCCCCCCCCC
EDDVWELYGPGDWTQAHDLAADDPAKLAELQRLWLIEAVKYDVLPIDDRSYERFNPDISG
CCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCHHHCCCCCCC
RPVLITGSTQTIFPGMRLMESCVLNIKNKSHSVTAELSVPESGAQGVVVSQGGGVGGWCL
CEEEEECCCHHHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCCEEEE
YAHEGRLKYCYNFLGIEYYYVTAEAPLSAGDHLLRMEFAYDGGGLGKGGTVTLFCDGEAV
EEECCCHHHHHHHHCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCCC
GTGRVDQSEPMAFSADEMCDVGSDSGSPTSPDYGPHDNAFTGRIDWVKIDIGAADHDHLI
CCCCCCCCCCCEECHHHHHCCCCCCCCCCCCCCCCCCCCEECEEEEEEEEECCCCCCCEE
TAEDKLNIAMSRQ
EECCCCCEEECCC
>Mature Secondary Structure 
SDSSPQNTGQQAAAAVRRDVLPIPDPRHVGLTTYDAKDPNTTYPPITRLRPPDGAPNVL
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEE
IVLIDDVGFGASSAFGGPCRTPVAERLAANGVKLNRFHTTALCSPTRQALLTGRNHHSVG
EEEEECCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEEEEHHHCCHHHHHHHCCCCCCCCC
MGGVTEIATSAPGYSSIRPKDKAPISETLRLNGYSTSQFGKCHEVPVWEVSPVGPFDQWP
CCCHHHHHHCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCEECCCCCCCCCCC
TGSGFEHFYGFVGGEANQYYPGLYEGTTPVEPAKTPEQGYTLTEDLADRAITWVRQQQAL
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCC
TPDKPFFMYFAPGATHAPHHVPREWSDRYRGEFDAGWDVLREQIFARQKELGVIPQDAEL
CCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
TRRHDEIPGWDDMPDRLKPVLARQMEIYAGFMEQTDHEVGRLIDAVDGLGALDNTLIYYI
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
IGDNGASAEGTPNGCFNEMCTLNGLAGIETEDFLLSKIDDFGTPDAYNHYAVGWAHALCA
ECCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
PYQWTKQVASHWGGTRNGTIVHWPAGIDAVGQTRDQFHHVIDVVPTILEAADIPAPLMVN
CHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHC
GIAQAPIEGFSMMSTLRAADAAETHRVQYFEMFGNRGIYHDGWTAVTKHRTPWLSDQPAL
CHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEECCCCEEECCCCCCCCCCCCC
EDDVWELYGPGDWTQAHDLAADDPAKLAELQRLWLIEAVKYDVLPIDDRSYERFNPDISG
CCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCHHHCCCCCCC
RPVLITGSTQTIFPGMRLMESCVLNIKNKSHSVTAELSVPESGAQGVVVSQGGGVGGWCL
CEEEEECCCHHHHCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCCEEEE
YAHEGRLKYCYNFLGIEYYYVTAEAPLSAGDHLLRMEFAYDGGGLGKGGTVTLFCDGEAV
EEECCCHHHHHHHHCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCCC
GTGRVDQSEPMAFSADEMCDVGSDSGSPTSPDYGPHDNAFTGRIDWVKIDIGAADHDHLI
CCCCCCCCCCCEECHHHHHCCCCCCCCCCCCCCCCCCCCEECEEEEEEEEECCCCCCCEE
TAEDKLNIAMSRQ
EECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]