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The map label for this gene is mprA [H]

Identifier: 108800890

GI number: 108800890

Start: 4182941

End: 4183705

Strand: Reverse

Name: mprA [H]

Synonym: Mmcs_3926

Alternate gene names: 108800890

Gene position: 4183705-4182941 (Counterclockwise)

Preceding gene: 108800897

Following gene: 108800889

Centisome position: 73.33

GC content: 67.32

Gene sequence:

>765_bases
ATGACCGTGCGAATAATGGAGACCATGAGCCCGAACCAGACCGACACCGACCGGTCGGTCATGCGCCGCGCCGACGGCAA
CCCGGTGCGGGTGCTCGTCGTCGACGACGAACCGGTGCTCGCCGAACTCGTCTCGATGGCGCTGCGTTACGAGGGCTGGG
ACATCGCGACCGCGGGTGACGGCGCGACGGCGATCGCGCTGGCCCGGGAGAACCCGCCCGACGTGGTGGTGCTCGACGTC
ATGCTGCCCGATATGAGCGGGCTCGACGTGCTGGCCAAGCTGCGCGAGCAGATTCCCGGACTGCCGCTGCTGCTGCTGAC
CGCCAAGGATTCGGTCGAGGACCGCATCGCCGGGCTGACCGCCGGCGGCGACGACTACGTCACCAAACCGTTCTCGCTCG
AGGAGGTCGTGCTGCGGCTGCGTGCGCTGTTGCGCCGCACCGGGGTGAGCGAGAGCGGCGGGGCGAAGATCGTCGTCGGC
GATCTGGTGCTCGACGAGGACAGCCATGAGGTGACCCGCGGAGGTGACCCGATCACGCTGACCGCGACGGAGTTCGAACT
GCTGCGGTTCATGATGCGCAACTCCAAACGGGTGCTCTCCAAGGCGCAGATCCTCGACCGTGTGTGGAGCTACGACTTCG
GCGGCCGGTCCAACATCGTCGAGCTGTACGTGTCGTATCTGCGCAAGAAGATCGACAGCGGCCGCGAGCCGATGATCCAC
ACGCTGCGCGGCGCAGGCTATGTCCTCAAACCCGCCGCCCGCTGA

Upstream 100 bases:

>100_bases
CCACTGTGCTTCCGCAGTGTGGGTGCCGGCTGTGCGCGGGGTGTGAATTCCGCGTCTCGGCGTTCACAGCGGGCGCATAT
ACTTCGCACAGTTCGGGCCC

Downstream 100 bases:

>100_bases
GCCGGTCGGCCGCACGCGCTTGTTCTCGCCGCGCACCTGGTCGCTGCGCGGACGGCTGCTGGCCACCCAGATCGTGCTGC
TCGCGCTGGTGTGCGCGGCG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTVRIMETMSPNQTDTDRSVMRRADGNPVRVLVVDDEPVLAELVSMALRYEGWDIATAGDGATAIALARENPPDVVVLDV
MLPDMSGLDVLAKLREQIPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGVSESGGAKIVVG
DLVLDEDSHEVTRGGDPITLTATEFELLRFMMRNSKRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREPMIH
TLRGAGYVLKPAAR

Sequences:

>Translated_254_residues
MTVRIMETMSPNQTDTDRSVMRRADGNPVRVLVVDDEPVLAELVSMALRYEGWDIATAGDGATAIALARENPPDVVVLDV
MLPDMSGLDVLAKLREQIPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGVSESGGAKIVVG
DLVLDEDSHEVTRGGDPITLTATEFELLRFMMRNSKRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREPMIH
TLRGAGYVLKPAAR
>Mature_253_residues
TVRIMETMSPNQTDTDRSVMRRADGNPVRVLVVDDEPVLAELVSMALRYEGWDIATAGDGATAIALARENPPDVVVLDVM
LPDMSGLDVLAKLREQIPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGVSESGGAKIVVGD
LVLDEDSHEVTRGGDPITLTATEFELLRFMMRNSKRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREPMIHT
LRGAGYVLKPAAR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=39.9103139013453, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.9369369369369, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=35.5555555555556, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.7713004484305, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=34.0909090909091, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.7777777777778, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=32.4200913242009, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=30.6666666666667, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=34.9137931034483, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=30.5676855895196, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=30.1724137931034, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=30.3964757709251, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=37.6146788990826, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=30.2521008403361, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=31.9327731092437, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788905, Length=103, Percent_Identity=33.0097087378641, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790299, Length=107, Percent_Identity=30.8411214953271, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=119, Percent_Identity=31.9327731092437, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788521, Length=120, Percent_Identity=35.8333333333333, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=32.1739130434783, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27937; Mature: 27805

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRIMETMSPNQTDTDRSVMRRADGNPVRVLVVDDEPVLAELVSMALRYEGWDIATAGD
CEEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCC
GATAIALARENPPDVVVLDVMLPDMSGLDVLAKLREQIPGLPLLLLTAKDSVEDRIAGLT
CCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHEEC
AGGDDYVTKPFSLEEVVLRLRALLRRTGVSESGGAKIVVGDLVLDEDSHEVTRGGDPITL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHCCCCCEEE
TATEFELLRFMMRNSKRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREPMIH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
TLRGAGYVLKPAAR
HHCCCCEEECCCCC
>Mature Secondary Structure 
TVRIMETMSPNQTDTDRSVMRRADGNPVRVLVVDDEPVLAELVSMALRYEGWDIATAGD
EEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCC
GATAIALARENPPDVVVLDVMLPDMSGLDVLAKLREQIPGLPLLLLTAKDSVEDRIAGLT
CCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHEEC
AGGDDYVTKPFSLEEVVLRLRALLRRTGVSESGGAKIVVGDLVLDEDSHEVTRGGDPITL
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHCCCCCEEE
TATEFELLRFMMRNSKRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDSGREPMIH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
TLRGAGYVLKPAAR
HHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA