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The map label for this gene is cusS [H]

Identifier: 108800889

GI number: 108800889

Start: 4181368

End: 4182966

Strand: Reverse

Name: cusS [H]

Synonym: Mmcs_3925

Alternate gene names: 108800889

Gene position: 4182966-4181368 (Counterclockwise)

Preceding gene: 108800890

Following gene: 108800888

Centisome position: 73.32

GC content: 74.3

Gene sequence:

>1599_bases
ATGTCCTCAAACCCGCCGCCCGCTGAGCCGGTCGGCCGCACGCGCTTGTTCTCGCCGCGCACCTGGTCGCTGCGCGGACG
GCTGCTGGCCACCCAGATCGTGCTGCTCGCGCTGGTGTGCGCGGCGGTCGGGGTGGGCACCGAACTCGCGCTGCAGCGGT
TCCTGGTCAACCAGCTCGACACCCAGCTCGACGAGACCGCCCGCCGGTCGGTCGGCCTGTTCGCGTTCGGCCCGCCGCCA
CCTCCGCTGATGTTGCCTGCGCCGCGGTTCCCCCCGCCGCCGGGCTTCCCGCACCGGCGGATCATCCGCGACGACAGCGG
ACCCGGGCCGGCGTTCCTCAACGCGCCGGGCCAAGCGGCGCGCACGGTCGGTGCGGTCGTCGACCGCGGCACCGCCGTCG
ACGCCGGTGTCATCACCGCCGACGGCGAACGCGTCGAGGTCAGCGGCACCGCGGCCGGGCAGCTCGCCGGGGTGCCCGCC
GACGAGGTCCCGCGCACCCTCGCCCTCGACGGCCTCGGCCGGTACCGGGTGATCGCGCTGCCGGCGCGGGGTCCGGCGGA
GGTGATCGTCACCGGACTGCCGATGTCCGACGTCGACGACACCCTGCTCACCGTGCTCGTGATCTTCTGCGTGGTCGCGG
CGATCGCGCTGATCGGCGCCACCGCGGCGGGGGTGTGGATCATCCGCAGGCAGTTGGCGCCGCTGTCGCGGGTGTCGGCG
GCCGCGCGCGAGGTCGCCGACCTCGAACTCGACCGCGGCGAGGTGCGGTTACCCACGCCGATCGTCACCGTCGACCCGGC
GAGCGCGCACACCGAGGTCGGCCAGCTCGGGACGTCGCTGAACCGGATGCTCGACCGGATCGCCGGGGCGCTGTCGGCGC
GGCACGCCAGCGAGACCCGGGTGCGTCAGTTCGTCGCCGACGCCAGCCACGAGCTGCGCACCCCGCTGGCCGCCATCCGC
GGCTACACCGAACTGGCGCAGCGGCATTCCGATGCGCTGCCCGGCGACGTCGCGCACGCGATGAACCGGGTGGAATCCGA
GACGGCGCGGATGACGCGCCTGGTCGAGGACATGCTGCTGCTGGCGCGCCTCGACGACGGCCGGCCCCTGGAGCGCGAGC
CGGTCGACCTGTCGCGGTTGGTCGTCGACGCGGTGAGCGACGCGCACGCCGCCGGTCCCGACCACGTCTGGTCGCTGGAG
CTGCCCGAGGAGCCGGTGGTGGTCGACGGCGACGAGGCGCGACTGCATCAGGTGCTGGGCAACCTGCTCGCCAATGCGCG
GGTCCACACACCGGCGGGCACCACCGTCGTCACGGCATTGGCGGTCGGTGCCGACGGCGGCGCCGTGCTGACCGTGACCG
ACGACGGCCCCGGCATCCCGCCGTCGCTGCAGCCGGAGATCTTCGAGCGGTTCGCCCGCGGTGACTCGTCGCGGTCGCGC
CGCGGCGGCAGCACCGGGCTGGGCCTGGCCATCGTCGCGGCGGTGGTCAAGGCGCACAGCGGGACCATCGAGGTGGACAG
CGCGCCGGGCCGCACCGAGTTCGTGGTGAGGTTGCCGGGCGCACAGCTGACACACAGGGAAGACCAATCCGGCGCCTAG

Upstream 100 bases:

>100_bases
GGCGGCCGGTCCAACATCGTCGAGCTGTACGTGTCGTATCTGCGCAAGAAGATCGACAGCGGCCGCGAGCCGATGATCCA
CACGCTGCGCGGCGCAGGCT

Downstream 100 bases:

>100_bases
TCCGGGTGGCCACCATGGGTCGAGTGACCCTGACCCTTGACGCCGAGCAGACGCAGAATCGCCCGAATGATCGCCCGAGA
GCGCGATTCTCTGTCTGGTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSSNPPPAEPVGRTRLFSPRTWSLRGRLLATQIVLLALVCAAVGVGTELALQRFLVNQLDTQLDETARRSVGLFAFGPPP
PPLMLPAPRFPPPPGFPHRRIIRDDSGPGPAFLNAPGQAARTVGAVVDRGTAVDAGVITADGERVEVSGTAAGQLAGVPA
DEVPRTLALDGLGRYRVIALPARGPAEVIVTGLPMSDVDDTLLTVLVIFCVVAAIALIGATAAGVWIIRRQLAPLSRVSA
AAREVADLELDRGEVRLPTPIVTVDPASAHTEVGQLGTSLNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIR
GYTELAQRHSDALPGDVAHAMNRVESETARMTRLVEDMLLLARLDDGRPLEREPVDLSRLVVDAVSDAHAAGPDHVWSLE
LPEEPVVVDGDEARLHQVLGNLLANARVHTPAGTTVVTALAVGADGGAVLTVTDDGPGIPPSLQPEIFERFARGDSSRSR
RGGSTGLGLAIVAAVVKAHSGTIEVDSAPGRTEFVVRLPGAQLTHREDQSGA

Sequences:

>Translated_532_residues
MSSNPPPAEPVGRTRLFSPRTWSLRGRLLATQIVLLALVCAAVGVGTELALQRFLVNQLDTQLDETARRSVGLFAFGPPP
PPLMLPAPRFPPPPGFPHRRIIRDDSGPGPAFLNAPGQAARTVGAVVDRGTAVDAGVITADGERVEVSGTAAGQLAGVPA
DEVPRTLALDGLGRYRVIALPARGPAEVIVTGLPMSDVDDTLLTVLVIFCVVAAIALIGATAAGVWIIRRQLAPLSRVSA
AAREVADLELDRGEVRLPTPIVTVDPASAHTEVGQLGTSLNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIR
GYTELAQRHSDALPGDVAHAMNRVESETARMTRLVEDMLLLARLDDGRPLEREPVDLSRLVVDAVSDAHAAGPDHVWSLE
LPEEPVVVDGDEARLHQVLGNLLANARVHTPAGTTVVTALAVGADGGAVLTVTDDGPGIPPSLQPEIFERFARGDSSRSR
RGGSTGLGLAIVAAVVKAHSGTIEVDSAPGRTEFVVRLPGAQLTHREDQSGA
>Mature_531_residues
SSNPPPAEPVGRTRLFSPRTWSLRGRLLATQIVLLALVCAAVGVGTELALQRFLVNQLDTQLDETARRSVGLFAFGPPPP
PLMLPAPRFPPPPGFPHRRIIRDDSGPGPAFLNAPGQAARTVGAVVDRGTAVDAGVITADGERVEVSGTAAGQLAGVPAD
EVPRTLALDGLGRYRVIALPARGPAEVIVTGLPMSDVDDTLLTVLVIFCVVAAIALIGATAAGVWIIRRQLAPLSRVSAA
AREVADLELDRGEVRLPTPIVTVDPASAHTEVGQLGTSLNRMLDRIAGALSARHASETRVRQFVADASHELRTPLAAIRG
YTELAQRHSDALPGDVAHAMNRVESETARMTRLVEDMLLLARLDDGRPLEREPVDLSRLVVDAVSDAHAAGPDHVWSLEL
PEEPVVVDGDEARLHQVLGNLLANARVHTPAGTTVVTALAVGADGGAVLTVTDDGPGIPPSLQPEIFERFARGDSSRSRR
GGSTGLGLAIVAAVVKAHSGTIEVDSAPGRTEFVVRLPGAQLTHREDQSGA

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=323, Percent_Identity=31.8885448916409, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=32.5757575757576, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=32.5757575757576, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=31.3008130081301, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1787894, Length=301, Percent_Identity=31.2292358803987, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=32.6693227091633, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=31.1688311688312, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=31, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790551, Length=243, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789403, Length=380, Percent_Identity=30, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=33.4763948497854, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=32.7800829875519, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788279, Length=320, Percent_Identity=25, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=29.004329004329, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=30.9734513274336, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=322, Percent_Identity=25.776397515528, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI48994928, Length=218, Percent_Identity=28.8990825688073, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=259, Percent_Identity=25.8687258687259, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55883; Mature: 55752

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNPPPAEPVGRTRLFSPRTWSLRGRLLATQIVLLALVCAAVGVGTELALQRFLVNQLD
CCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TQLDETARRSVGLFAFGPPPPPLMLPAPRFPPPPGFPHRRIIRDDSGPGPAFLNAPGQAA
HHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCHHH
RTVGAVVDRGTAVDAGVITADGERVEVSGTAAGQLAGVPADEVPRTLALDGLGRYRVIAL
HHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCHHHCCCEEECCCCCCEEEEEE
PARGPAEVIVTGLPMSDVDDTLLTVLVIFCVVAAIALIGATAAGVWIIRRQLAPLSRVSA
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AAREVADLELDRGEVRLPTPIVTVDPASAHTEVGQLGTSLNRMLDRIAGALSARHASETR
HHHHHHHHCCCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQFVADASHELRTPLAAIRGYTELAQRHSDALPGDVAHAMNRVESETARMTRLVEDMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LARLDDGRPLEREPVDLSRLVVDAVSDAHAAGPDHVWSLELPEEPVVVDGDEARLHQVLG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCHHHHHHHHH
NLLANARVHTPAGTTVVTALAVGADGGAVLTVTDDGPGIPPSLQPEIFERFARGDSSRSR
HHHHCCEEECCCCCHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCHHC
RGGSTGLGLAIVAAVVKAHSGTIEVDSAPGRTEFVVRLPGAQLTHREDQSGA
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSNPPPAEPVGRTRLFSPRTWSLRGRLLATQIVLLALVCAAVGVGTELALQRFLVNQLD
CCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TQLDETARRSVGLFAFGPPPPPLMLPAPRFPPPPGFPHRRIIRDDSGPGPAFLNAPGQAA
HHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCHHH
RTVGAVVDRGTAVDAGVITADGERVEVSGTAAGQLAGVPADEVPRTLALDGLGRYRVIAL
HHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCHHHCCCEEECCCCCCEEEEEE
PARGPAEVIVTGLPMSDVDDTLLTVLVIFCVVAAIALIGATAAGVWIIRRQLAPLSRVSA
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AAREVADLELDRGEVRLPTPIVTVDPASAHTEVGQLGTSLNRMLDRIAGALSARHASETR
HHHHHHHHCCCCCCEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQFVADASHELRTPLAAIRGYTELAQRHSDALPGDVAHAMNRVESETARMTRLVEDMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LARLDDGRPLEREPVDLSRLVVDAVSDAHAAGPDHVWSLELPEEPVVVDGDEARLHQVLG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEECCCHHHHHHHHH
NLLANARVHTPAGTTVVTALAVGADGGAVLTVTDDGPGIPPSLQPEIFERFARGDSSRSR
HHHHCCEEECCCCCHHHHHEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCHHC
RGGSTGLGLAIVAAVVKAHSGTIEVDSAPGRTEFVVRLPGAQLTHREDQSGA
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]