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The map label for this gene is pdhB [H]

Identifier: 108800591

GI number: 108800591

Start: 3869970

End: 3871019

Strand: Reverse

Name: pdhB [H]

Synonym: Mmcs_3625

Alternate gene names: 108800591

Gene position: 3871019-3869970 (Counterclockwise)

Preceding gene: 108800592

Following gene: 108800590

Centisome position: 67.85

GC content: 68.95

Gene sequence:

>1050_bases
ATGACCCAACTCATCGAACGGCCCACCGGCGCAGACGATCACGACCGGTTCTTCACCGACGTCCCGACCGTCACCGAACT
GACCATGGTGCAGGCCATCAACCGGGCTTTACACGATGCGATGGCCGCCGACGACCGCGTGCTGGTCTTCGGGGAGGACG
TCGCGACCCTCGGCGGGGTGTTCCGGGTGACCGACGGCCTGTCCGAGACCTTCGGTGAGCAGCGGTGTTTCGATACGCCG
CTGGCCGAGTCGGCGATCGTCGGCATCGCGATCGGGATGGCGATCCGCGGTTTCGTCCCGGTGCCCGAGATCCAGTTCGA
CGGGTTCGCCGCACCGGCGTTCGACCAGGTGGTCAGCCACCTCGCCAAGTACCGGATGCGCACCCGCGGCGATGTCGACA
TGCCGGTGACCATCCGCATCCCGTCGTTCGGCGGAATCGGTGCGGTGGAACATCATTCGGAATCGACCGAGACGTACTGG
CTGCACACCGCGGGCCTCAAGGTCGTGACACCGTCGAGTCCGACCGACGCGTACTGGCTGCTGCGGCACGCGATCGCCGC
CCGCGACCCGGTGATCTACCTGGAACCGAAACGACGGTACTGGGCGCGGGGGGCCGTGGACACCACCGAGCCCGGCCTGC
CGATCGGGCGGGCCGCAGTGCGCCGCGAGGGCACCGACGTCACGGTCCTCACGTACGGGCCGCTGGTCGCGACGGCGCTG
TCCGCCGCCGAACACGCCGCGGCTGAGTCGGACTGGTCGCTGGAGGTCGTCGATCTGCGGTCGCTCAACCCGCTCGACTT
CGACACCGTGGCGGCGTCGGTGGGCAAGACGGGCCGCGCGGTGGTGATGCACGAGGGTCCGCGGACACTGGGCTTCGGCG
CCGAACTGGCGGCACGGATCTCCGAGGAGCTGTTCTACGACCTGGAGGCGCCGGTGTTGCGCGCCACCGGGTTCGACACC
CCGTATCCACCGGCCCGGCTGGAGAAGCTGTGGTTACCGGGGGTGGACCGGTTGCTCGACTGCGTCCAGCGGACCCTGGA
GATGCCATGA

Upstream 100 bases:

>100_bases
GATGTCTCAGAGGTGTTCGACACCGTCTACCACGACATCACCCCGGACCTCGCCGAGCAGCGCGACCGGTTGCTCGCCGA
ACTGGCGAAGGAGGCGTGAC

Downstream 100 bases:

>100_bases
CCGTGCAGGAGTTCCTGGTGCCGGATCTGGGTGAGGGTCTGCAGGACGCGACGATCACCTCGTGGGCGGTCGATGTCGGT
GACGAGGTCGAGCTGAACCA

Product: transketolase central subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTQLIERPTGADDHDRFFTDVPTVTELTMVQAINRALHDAMAADDRVLVFGEDVATLGGVFRVTDGLSETFGEQRCFDTP
LAESAIVGIAIGMAIRGFVPVPEIQFDGFAAPAFDQVVSHLAKYRMRTRGDVDMPVTIRIPSFGGIGAVEHHSESTETYW
LHTAGLKVVTPSSPTDAYWLLRHAIAARDPVIYLEPKRRYWARGAVDTTEPGLPIGRAAVRREGTDVTVLTYGPLVATAL
SAAEHAAAESDWSLEVVDLRSLNPLDFDTVAASVGKTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAPVLRATGFDT
PYPPARLEKLWLPGVDRLLDCVQRTLEMP

Sequences:

>Translated_349_residues
MTQLIERPTGADDHDRFFTDVPTVTELTMVQAINRALHDAMAADDRVLVFGEDVATLGGVFRVTDGLSETFGEQRCFDTP
LAESAIVGIAIGMAIRGFVPVPEIQFDGFAAPAFDQVVSHLAKYRMRTRGDVDMPVTIRIPSFGGIGAVEHHSESTETYW
LHTAGLKVVTPSSPTDAYWLLRHAIAARDPVIYLEPKRRYWARGAVDTTEPGLPIGRAAVRREGTDVTVLTYGPLVATAL
SAAEHAAAESDWSLEVVDLRSLNPLDFDTVAASVGKTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAPVLRATGFDT
PYPPARLEKLWLPGVDRLLDCVQRTLEMP
>Mature_348_residues
TQLIERPTGADDHDRFFTDVPTVTELTMVQAINRALHDAMAADDRVLVFGEDVATLGGVFRVTDGLSETFGEQRCFDTPL
AESAIVGIAIGMAIRGFVPVPEIQFDGFAAPAFDQVVSHLAKYRMRTRGDVDMPVTIRIPSFGGIGAVEHHSESTETYWL
HTAGLKVVTPSSPTDAYWLLRHAIAARDPVIYLEPKRRYWARGAVDTTEPGLPIGRAAVRREGTDVTVLTYGPLVATALS
AAEHAAAESDWSLEVVDLRSLNPLDFDTVAASVGKTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAPVLRATGFDTP
YPPARLEKLWLPGVDRLLDCVQRTLEMP

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=40.4907975460123, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=40.4907975460123, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI156564403, Length=339, Percent_Identity=33.6283185840708, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI291084858, Length=340, Percent_Identity=32.9411764705882, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1786622, Length=195, Percent_Identity=29.7435897435897, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17506935, Length=326, Percent_Identity=40.4907975460123, Blast_Score=224, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17538422, Length=336, Percent_Identity=34.8214285714286, Blast_Score=197, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6319698, Length=348, Percent_Identity=33.3333333333333, Blast_Score=185, Evalue=7e-48,
Organism=Drosophila melanogaster, GI160714828, Length=333, Percent_Identity=41.1411411411411, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI160714832, Length=333, Percent_Identity=41.1411411411411, Blast_Score=230, Evalue=9e-61,
Organism=Drosophila melanogaster, GI21358145, Length=353, Percent_Identity=36.5439093484419, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24650940, Length=353, Percent_Identity=36.5439093484419, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24650943, Length=142, Percent_Identity=33.8028169014084, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650945, Length=142, Percent_Identity=33.8028169014084, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38086; Mature: 37954

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLIERPTGADDHDRFFTDVPTVTELTMVQAINRALHDAMAADDRVLVFGEDVATLGGV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCH
FRVTDGLSETFGEQRCFDTPLAESAIVGIAIGMAIRGFVPVPEIQFDGFAAPAFDQVVSH
HHHHCCHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
LAKYRMRTRGDVDMPVTIRIPSFGGIGAVEHHSESTETYWLHTAGLKVVTPSSPTDAYWL
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHHH
LRHAIAARDPVIYLEPKRRYWARGAVDTTEPGLPIGRAAVRREGTDVTVLTYGPLVATAL
HHHHHHHCCCEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECHHHHHHH
SAAEHAAAESDWSLEVVDLRSLNPLDFDTVAASVGKTGRAVVMHEGPRTLGFGAELAARI
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHH
SEELFYDLEAPVLRATGFDTPYPPARLEKLWLPGVDRLLDCVQRTLEMP
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQLIERPTGADDHDRFFTDVPTVTELTMVQAINRALHDAMAADDRVLVFGEDVATLGGV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCH
FRVTDGLSETFGEQRCFDTPLAESAIVGIAIGMAIRGFVPVPEIQFDGFAAPAFDQVVSH
HHHHCCHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
LAKYRMRTRGDVDMPVTIRIPSFGGIGAVEHHSESTETYWLHTAGLKVVTPSSPTDAYWL
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHHH
LRHAIAARDPVIYLEPKRRYWARGAVDTTEPGLPIGRAAVRREGTDVTVLTYGPLVATAL
HHHHHHHCCCEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECHHHHHHH
SAAEHAAAESDWSLEVVDLRSLNPLDFDTVAASVGKTGRAVVMHEGPRTLGFGAELAARI
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHH
SEELFYDLEAPVLRATGFDTPYPPARLEKLWLPGVDRLLDCVQRTLEMP
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA