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The map label for this gene is pdhA [H]

Identifier: 108800592

GI number: 108800592

Start: 3871021

End: 3872091

Strand: Reverse

Name: pdhA [H]

Synonym: Mmcs_3626

Alternate gene names: 108800592

Gene position: 3872091-3871021 (Counterclockwise)

Preceding gene: 108800593

Following gene: 108800591

Centisome position: 67.87

GC content: 71.99

Gene sequence:

>1071_bases
ATGGCCGGCGTCGAGTTGGACCCCGTGCAGCTGGTGGGTGCCGATGGCTCACCGAGCGCACAGCAGCGCTACAGCCGCGA
CCTGCCTCCGGAGACCCTGGCCTGGCTCTACGAGACGATGGTCGTCACCCGCGACCTCGACACGGAGTTCGTCCACCTGC
AGCGCCAGGGTGAGCTCGCGCTCTACGCCTCGTGCCGCGGCCAGGAGGCCGCCCAGATCGGCGCCACCGCCTGCCTGCGC
AAGACCGACTGGCTGTTCCCGCAGTACCGGGAGATCGGGGCGTTCCTGCTGCGCGGCATCGCCCCGGCGCAGATGGCCGC
GGTGTGGCGCGGCAAATGGCACGGCGGTCTGGAGTTCACCGCTAAGTGCTGTGCGCCGATCTCGATTCCGATCGGCACCC
AGGGTCTGCACGCGGTCGGCGCCGCGATGGCCGCGCAGCGCCTCGGCGAGGACTCGGTGACGGTGGCGTTCCTCGGCGAC
GGCGCCACCAGCGAGGGCGACGTCCACGAGGCGATGAACCTGGCCGCGGTCTACCAGGTGCCGTGCGTGTTCTTCGTGCA
GAACAACCAGTGGGCCATCTCGGTGCCGGTGCAGCGCCAGGTGGCCGGGCCGTCGATCGCCCACCGAGCCGCCGGCTACG
GCATGCCCGGCGTGCGGGTCGACGGCAACGACGTGCTGGCGTGTTTCGCGGTGATGTCCGAGGCGGCCGCCCGCGCCCGC
GCCGGCGGCGGGCCGACGCTGATCGAGGCGGTCACCTACCGGCTGGGCCCGCACACCACCTCCGACGACCCCACCCGGTA
CCGCGACCAGTCCGAGGTGGACCGGTGGCGGGCACGCGATCCGATCCCGCGCTACCGCACGTACCTGCAGGGCGCCGGGG
TGTGGTCCGAACGGCTGGAGGAACGGGTGGCGGCTCGCTCGAAGCGGCTGCGCGCGGAGTTGCGCGACGCGGTGGTCGGG
GCGCCCGACTTCGATGTCTCAGAGGTGTTCGACACCGTCTACCACGACATCACCCCGGACCTCGCCGAGCAGCGCGACCG
GTTGCTCGCCGAACTGGCGAAGGAGGCGTGA

Upstream 100 bases:

>100_bases
GCAGCCCTACACCAGGGTTCCTGCTCTGACCGCCACACGCTGAGCACCTGAAGTCGTCGGACGGCGAAACATGCCGTCGA
TGCGACCTGAAGGAGGCGGT

Downstream 100 bases:

>100_bases
CATGACCCAACTCATCGAACGGCCCACCGGCGCAGACGATCACGACCGGTTCTTCACCGACGTCCCGACCGTCACCGAAC
TGACCATGGTGCAGGCCATC

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MAGVELDPVQLVGADGSPSAQQRYSRDLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLR
KTDWLFPQYREIGAFLLRGIAPAQMAAVWRGKWHGGLEFTAKCCAPISIPIGTQGLHAVGAAMAAQRLGEDSVTVAFLGD
GATSEGDVHEAMNLAAVYQVPCVFFVQNNQWAISVPVQRQVAGPSIAHRAAGYGMPGVRVDGNDVLACFAVMSEAAARAR
AGGGPTLIEAVTYRLGPHTTSDDPTRYRDQSEVDRWRARDPIPRYRTYLQGAGVWSERLEERVAARSKRLRAELRDAVVG
APDFDVSEVFDTVYHDITPDLAEQRDRLLAELAKEA

Sequences:

>Translated_356_residues
MAGVELDPVQLVGADGSPSAQQRYSRDLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLR
KTDWLFPQYREIGAFLLRGIAPAQMAAVWRGKWHGGLEFTAKCCAPISIPIGTQGLHAVGAAMAAQRLGEDSVTVAFLGD
GATSEGDVHEAMNLAAVYQVPCVFFVQNNQWAISVPVQRQVAGPSIAHRAAGYGMPGVRVDGNDVLACFAVMSEAAARAR
AGGGPTLIEAVTYRLGPHTTSDDPTRYRDQSEVDRWRARDPIPRYRTYLQGAGVWSERLEERVAARSKRLRAELRDAVVG
APDFDVSEVFDTVYHDITPDLAEQRDRLLAELAKEA
>Mature_355_residues
AGVELDPVQLVGADGSPSAQQRYSRDLPPETLAWLYETMVVTRDLDTEFVHLQRQGELALYASCRGQEAAQIGATACLRK
TDWLFPQYREIGAFLLRGIAPAQMAAVWRGKWHGGLEFTAKCCAPISIPIGTQGLHAVGAAMAAQRLGEDSVTVAFLGDG
ATSEGDVHEAMNLAAVYQVPCVFFVQNNQWAISVPVQRQVAGPSIAHRAAGYGMPGVRVDGNDVLACFAVMSEAAARARA
GGGPTLIEAVTYRLGPHTTSDDPTRYRDQSEVDRWRARDPIPRYRTYLQGAGVWSERLEERVAARSKRLRAELRDAVVGA
PDFDVSEVFDTVYHDITPDLAEQRDRLLAELAKEA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=337, Percent_Identity=37.3887240356083, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI258645172, Length=337, Percent_Identity=37.3887240356083, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4885543, Length=255, Percent_Identity=32.5490196078431, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4505685, Length=291, Percent_Identity=30.9278350515464, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI291084742, Length=291, Percent_Identity=30.9278350515464, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI291084744, Length=259, Percent_Identity=32.046332046332, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI291084757, Length=285, Percent_Identity=28.4210526315789, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563357, Length=353, Percent_Identity=35.6940509915014, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI86563355, Length=353, Percent_Identity=35.6940509915014, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17536047, Length=345, Percent_Identity=26.9565217391304, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564172, Length=345, Percent_Identity=26.9565217391304, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=28.1645569620253, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21355903, Length=345, Percent_Identity=33.6231884057971, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24639740, Length=351, Percent_Identity=28.4900284900285, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639744, Length=351, Percent_Identity=28.7749287749288, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571106, Length=351, Percent_Identity=28.7749287749288, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639746, Length=319, Percent_Identity=29.153605015674, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24639748, Length=324, Percent_Identity=28.0864197530864, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38854; Mature: 38723

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGVELDPVQLVGADGSPSAQQRYSRDLPPETLAWLYETMVVTRDLDTEFVHLQRQGELA
CCCCCCCCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHEEECCCCEE
LYASCRGQEAAQIGATACLRKTDWLFPQYREIGAFLLRGIAPAQMAAVWRGKWHGGLEFT
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHH
AKCCAPISIPIGTQGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDVHEAMNLAAVYQV
HHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCC
PCVFFVQNNQWAISVPVQRQVAGPSIAHRAAGYGMPGVRVDGNDVLACFAVMSEAAARAR
CEEEEEECCCEEEECCHHHHHCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHH
AGGGPTLIEAVTYRLGPHTTSDDPTRYRDQSEVDRWRARDPIPRYRTYLQGAGVWSERLE
CCCCHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHH
ERVAARSKRLRAELRDAVVGAPDFDVSEVFDTVYHDITPDLAEQRDRLLAELAKEA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGVELDPVQLVGADGSPSAQQRYSRDLPPETLAWLYETMVVTRDLDTEFVHLQRQGELA
CCCCCCCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHEEECCCCEE
LYASCRGQEAAQIGATACLRKTDWLFPQYREIGAFLLRGIAPAQMAAVWRGKWHGGLEFT
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHH
AKCCAPISIPIGTQGLHAVGAAMAAQRLGEDSVTVAFLGDGATSEGDVHEAMNLAAVYQV
HHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCC
PCVFFVQNNQWAISVPVQRQVAGPSIAHRAAGYGMPGVRVDGNDVLACFAVMSEAAARAR
CEEEEEECCCEEEECCHHHHHCCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHH
AGGGPTLIEAVTYRLGPHTTSDDPTRYRDQSEVDRWRARDPIPRYRTYLQGAGVWSERLE
CCCCHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHH
ERVAARSKRLRAELRDAVVGAPDFDVSEVFDTVYHDITPDLAEQRDRLLAELAKEA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]